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The map label for this gene is dxr [H]

Identifier: 83718433

GI number: 83718433

Start: 2303715

End: 2304911

Strand: Direct

Name: dxr [H]

Synonym: BTH_I2033

Alternate gene names: 83718433

Gene position: 2303715-2304911 (Clockwise)

Preceding gene: 83719326

Following gene: 83720752

Centisome position: 60.48

GC content: 69.34

Gene sequence:

>1197_bases
ATGCAAAAACGTCTGACATTGCTCGGTTCGACGGGCTCGATCGGAGACAGCACGCTCGATGTCGTCACGCGTCATCCGGA
GCGCTTCGCGGTTCATGCGCTCACGGCCCACCGCAACGGCGACAAGCTCGTCGCCCAGTGCCTGCGCTTTGCGCCCGACG
TCGCGGTGGTCGGCGACGCCGAAACCGCCGCGCGGGTCGAGGCGCAATTGCGCGCCGCGGGCAGCAAGACCCAGGTCGCG
TACGGCAAGCAGGCGCTCGTCGACGTATCGAAGAGCGACGGCTGCGACACCGTCGTCGCGGCGATCGTCGGCGCGGCGGG
GCTCGCGCCGAGCCTCGCCGCCGCACGCGCGGGCAAGCGCATCCTGCTCGCGAACAAGGAGGCGCTCGTGATGTCGGGCG
CGATCTTCATGGACGCGGTGCGCGATCACGGCGCGATCCTGTTGCCCGTCGACAGCGAGCACAACGCGATCTTCCAGTGC
ATGCCGCGCGACGCGGCCGAGCATGGCGGGATCGCGAAGATCATCGTGACCGCGTCGGGCGGCCCGTTCCGCACGCGCGA
GCCCGTGACGCTCGCGAGCGTCACGCCCGACGAGGCGTGCAAGCATCCGAACTGGGTGATGGGCCGCAAGATCTCCGTCG
ATTCCGCGACGATGATGAACAAGGGCCTCGAGGTGATCGAGGCGCACTGGCTGTTCGGCCTGCCGAGCGAGCGCATCGAC
GTGTTGATCCACCCGCAGAGCGTGATCCATTCGCTCGTGTCATATTGCGACGGCTCGGTGCTCGCGCAACTCGGCAATCC
GGACATGCGCACGCCGATCGCGCATGCGCTCGCGTTTCCCGAGCGTGTCGACGCGGGCGTCGCGCAGCTCGATCTCGCGC
AGATTGCGACGCTCACGTTCGAGAAGCCCGACTACGCGCGCTTTCCGTGTCTCGCGCTCGCCATCGATGCGCTCGAGGCG
GGCGGCGTCGCGAGCGCGGCGCTCAATGCGGCCAACGAGATCGCGGTCGACGCGTTCCTGTCGCGCCGCATCCGCTTCAC
CGCGATCGCGCAGACGGTCGACGCGGTGCTGAGCGGGCTGTCCAATCGTACGCCGAGCGGCCTCGACGACGTGATCGGCG
CGGACGCCGACGCGCGCCGCGCGGCGACGGCGTTCATCGACAAGCTGCCCGCGCCCAGCGTCGAGCGAGCCGCCTGA

Upstream 100 bases:

>100_bases
GCCTGCTGCCGGGCCACGGCGGCGTGCTCGACCGCGTCGACGCGCTGTTGCCCGTGCTGCCGCTCGCGATGCTGCTGCTC
GGTTAAAACTAGACTCTATT

Downstream 100 bases:

>100_bases
ATGGAGTCGACACGCTCATGAACGTGCTGGTCGAACTGATCGCGTTTGCTGTGGCGATCGGCGTGCTGGTCGTCGTGCAT
GAGTACGGGCATTACCGCGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQKRLTLLGSTGSIGDSTLDVVTRHPERFAVHALTAHRNGDKLVAQCLRFAPDVAVVGDAETAARVEAQLRAAGSKTQVA
YGKQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKRILLANKEALVMSGAIFMDAVRDHGAILLPVDSEHNAIFQC
MPRDAAEHGGIAKIIVTASGGPFRTREPVTLASVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFGLPSERID
VLIHPQSVIHSLVSYCDGSVLAQLGNPDMRTPIAHALAFPERVDAGVAQLDLAQIATLTFEKPDYARFPCLALAIDALEA
GGVASAALNAANEIAVDAFLSRRIRFTAIAQTVDAVLSGLSNRTPSGLDDVIGADADARRAATAFIDKLPAPSVERAA

Sequences:

>Translated_398_residues
MQKRLTLLGSTGSIGDSTLDVVTRHPERFAVHALTAHRNGDKLVAQCLRFAPDVAVVGDAETAARVEAQLRAAGSKTQVA
YGKQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKRILLANKEALVMSGAIFMDAVRDHGAILLPVDSEHNAIFQC
MPRDAAEHGGIAKIIVTASGGPFRTREPVTLASVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFGLPSERID
VLIHPQSVIHSLVSYCDGSVLAQLGNPDMRTPIAHALAFPERVDAGVAQLDLAQIATLTFEKPDYARFPCLALAIDALEA
GGVASAALNAANEIAVDAFLSRRIRFTAIAQTVDAVLSGLSNRTPSGLDDVIGADADARRAATAFIDKLPAPSVERAA
>Mature_398_residues
MQKRLTLLGSTGSIGDSTLDVVTRHPERFAVHALTAHRNGDKLVAQCLRFAPDVAVVGDAETAARVEAQLRAAGSKTQVA
YGKQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKRILLANKEALVMSGAIFMDAVRDHGAILLPVDSEHNAIFQC
MPRDAAEHGGIAKIIVTASGGPFRTREPVTLASVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFGLPSERID
VLIHPQSVIHSLVSYCDGSVLAQLGNPDMRTPIAHALAFPERVDAGVAQLDLAQIATLTFEKPDYARFPCLALAIDALEA
GGVASAALNAANEIAVDAFLSRRIRFTAIAQTVDAVLSGLSNRTPSGLDDVIGADADARRAATAFIDKLPAPSVERAA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=56.7088607594937, Blast_Score=430, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41724; Mature: 41724

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKRLTLLGSTGSIGDSTLDVVTRHPERFAVHALTAHRNGDKLVAQCLRFAPDVAVVGDA
CCCEEEEEECCCCCCCHHHHHHHCCCCHHEEEEEECCCCCHHHHHHHHHHCCCEEEECCC
ETAARVEAQLRAAGSKTQVAYGKQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKR
HHHHHHHHHHHHCCCCCEECCCCHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCE
ILLANKEALVMSGAIFMDAVRDHGAILLPVDSEHNAIFQCMPRDAAEHGGIAKIIVTASG
EEEECCCCCEEECHHHHHHHHCCCEEEEEECCCCCCEEEECCCHHHHCCCEEEEEEEECC
GPFRTREPVTLASVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFGLPSERID
CCCCCCCCEEEEECCCHHHHCCCCCCCCCEECCCHHHHHHCCHHHHHHHHHCCCCCCCEE
VLIHPQSVIHSLVSYCDGSVLAQLGNPDMRTPIAHALAFPERVDAGVAQLDLAQIATLTF
EEECCHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHCHHHHHCCHHHHHHHHHHHEEE
EKPDYARFPCLALAIDALEAGGVASAALNAANEIAVDAFLSRRIRFTAIAQTVDAVLSGL
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SNRTPSGLDDVIGADADARRAATAFIDKLPAPSVERAA
CCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQKRLTLLGSTGSIGDSTLDVVTRHPERFAVHALTAHRNGDKLVAQCLRFAPDVAVVGDA
CCCEEEEEECCCCCCCHHHHHHHCCCCHHEEEEEECCCCCHHHHHHHHHHCCCEEEECCC
ETAARVEAQLRAAGSKTQVAYGKQALVDVSKSDGCDTVVAAIVGAAGLAPSLAAARAGKR
HHHHHHHHHHHHCCCCCEECCCCHHEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCE
ILLANKEALVMSGAIFMDAVRDHGAILLPVDSEHNAIFQCMPRDAAEHGGIAKIIVTASG
EEEECCCCCEEECHHHHHHHHCCCEEEEEECCCCCCEEEECCCHHHHCCCEEEEEEEECC
GPFRTREPVTLASVTPDEACKHPNWVMGRKISVDSATMMNKGLEVIEAHWLFGLPSERID
CCCCCCCCEEEEECCCHHHHCCCCCCCCCEECCCHHHHHHCCHHHHHHHHHCCCCCCCEE
VLIHPQSVIHSLVSYCDGSVLAQLGNPDMRTPIAHALAFPERVDAGVAQLDLAQIATLTF
EEECCHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHCHHHHHCCHHHHHHHHHHHEEE
EKPDYARFPCLALAIDALEAGGVASAALNAANEIAVDAFLSRRIRFTAIAQTVDAVLSGL
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SNRTPSGLDDVIGADADARRAATAFIDKLPAPSVERAA
CCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA