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The map label for this gene is lss [H]

Identifier: 83591238

GI number: 83591238

Start: 2544351

End: 2545778

Strand: Reverse

Name: lss [H]

Synonym: Moth_2422

Alternate gene names: 83591238

Gene position: 2545778-2544351 (Counterclockwise)

Preceding gene: 83591239

Following gene: 83591237

Centisome position: 96.84

GC content: 55.04

Gene sequence:

>1428_bases
ATGCCGCCGCCAGATAAGCTACCGCAGCTAGCGGCCAGCGTAGGGCGCTTCCTAAAAAAGCTGCCCTTACGGTGGGCAGG
AATAAGGGATAATAAAGGAAAAAGAGTATTAGTAATAACTGGTATTTTAGCCGGCGGCCTGCTCTTAGCAGCCTGGCACC
AGCTTACAACCCCGAATGCCCTGGCTGTTTTCATCAACGGCCAGCAGGTGGCAATAGTAGCCACCCGGGAACAGTTCAAC
CGGGCCTTACAGGAGATCCTAAAAGAACGAGGGGCTGGCAGTTACCAGGGTGTGCGCTATACCGATCAGGTAGATTTTAA
AGCAGTCCGGGCCAATCCGCAGGAAGTTATAGCGGAGGAACAATTAAAAAGCCTCCTGGCCGAAAGATTGCACCTGGTGG
CGGCGGCAACGGTCATTACCATTGACGGGCAGCCGCGGCTGGTTTTGAAAGACGATGCTACCGCTGACGCTGTTCTGGCC
GCGTTTAAACAGGCCTTTGAACCACCGGCGGCTATAGGGCAGGTCCAGGAGGTCAAATTTTTGGAACAAGTGGCTTACGA
GCACCGCCAGGCCAGTCCGGAAGAGATTTTAAGCCCGGAAGCGGCCCTTGCCAAGTTGAAGGGAACAGCAGCCAGCAGTA
GCACCTATACTGTTAAAGAAGGGGATTCCCTCTGGTCCATTGCCAGGGAACATAACCTGCTGGTTGACGACATTAAAAGG
GCCAACCCCGAGATCCAGGGAGAACGCCTGGATATCGGGCAGCAATTGAAACTGACAACAGTACAACCATTGCTTCAGGT
GATGGTTGTTTATAATCAGGATATCAAGGAACCGGTACCCTTTGAAACCCGGGTAGAAAAAACGGCTGACCTTTTACGAG
GCCAGGAAAAGATAATTCAGGAGGGCACAGAGGGCGAACAACTGGTTACTTACCAAGTAGTGACCAGAAATGGTGTGGTC
GTAGACAAAAAGATACTTCGGCAGCAGGTCCTTACGGAACCGGTTGCCCGGGTGGTACAGCAGGGTACGGGGGTAACAGC
CCTGGCTTCCCGGAGCGGCGGTTCCGGGCTCCTGGCCTGGCCCATCCGCGGGTATATCACTTCCCCCTATGGCTACCGGG
GTAGCGAGTTTCACTCAGGCCTGGATATTGCGGGCAGTATCGGCGAACCGGTGGGAGCGGCTGCAGGCGGAGTAGTTGTT
AGCACCGGTTACGACGGTGGCTACGGTCGGATGGTAGTAATCGACCATGGTGGCCTGGTTACCAGGTATGCCCATTTATC
TGGTTACAATGTAAGGCCGGGCCAGCGGGTATCTCAAGGCCAGATCATCGGTTATGTAGGGGTTAGCGGCCGTACCACAG
GCCCCCACCTGCACTTTGAGGTCCTGGTCGGAGGCAGCTTCCGCAACCCGGCCAGTTATCTGAGGTGA

Upstream 100 bases:

>100_bases
AAAATGGCGGGAAAATTTTGTTGAGGGGGCAGGATTCCTGGCAAGTGAGGTAGAATATTTTTATTTACGGGTTATTTTTT
TGGAGACGAGGAGGAATGCC

Downstream 100 bases:

>100_bases
AAGTTGTCATAGCCCCCAAGATATCTATAACGCTTTGGCGGAAAACCATCAGTGAATAAGATAGCCATAATCATCCTTAC
GGACAAGCCGTAAGGATTTT

Product: peptidase M23B

Products: NA

Alternate protein names: Glycyl-glycine endopeptidase [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MPPPDKLPQLAASVGRFLKKLPLRWAGIRDNKGKRVLVITGILAGGLLLAAWHQLTTPNALAVFINGQQVAIVATREQFN
RALQEILKERGAGSYQGVRYTDQVDFKAVRANPQEVIAEEQLKSLLAERLHLVAAATVITIDGQPRLVLKDDATADAVLA
AFKQAFEPPAAIGQVQEVKFLEQVAYEHRQASPEEILSPEAALAKLKGTAASSSTYTVKEGDSLWSIAREHNLLVDDIKR
ANPEIQGERLDIGQQLKLTTVQPLLQVMVVYNQDIKEPVPFETRVEKTADLLRGQEKIIQEGTEGEQLVTYQVVTRNGVV
VDKKILRQQVLTEPVARVVQQGTGVTALASRSGGSGLLAWPIRGYITSPYGYRGSEFHSGLDIAGSIGEPVGAAAGGVVV
STGYDGGYGRMVVIDHGGLVTRYAHLSGYNVRPGQRVSQGQIIGYVGVSGRTTGPHLHFEVLVGGSFRNPASYLR

Sequences:

>Translated_475_residues
MPPPDKLPQLAASVGRFLKKLPLRWAGIRDNKGKRVLVITGILAGGLLLAAWHQLTTPNALAVFINGQQVAIVATREQFN
RALQEILKERGAGSYQGVRYTDQVDFKAVRANPQEVIAEEQLKSLLAERLHLVAAATVITIDGQPRLVLKDDATADAVLA
AFKQAFEPPAAIGQVQEVKFLEQVAYEHRQASPEEILSPEAALAKLKGTAASSSTYTVKEGDSLWSIAREHNLLVDDIKR
ANPEIQGERLDIGQQLKLTTVQPLLQVMVVYNQDIKEPVPFETRVEKTADLLRGQEKIIQEGTEGEQLVTYQVVTRNGVV
VDKKILRQQVLTEPVARVVQQGTGVTALASRSGGSGLLAWPIRGYITSPYGYRGSEFHSGLDIAGSIGEPVGAAAGGVVV
STGYDGGYGRMVVIDHGGLVTRYAHLSGYNVRPGQRVSQGQIIGYVGVSGRTTGPHLHFEVLVGGSFRNPASYLR
>Mature_474_residues
PPPDKLPQLAASVGRFLKKLPLRWAGIRDNKGKRVLVITGILAGGLLLAAWHQLTTPNALAVFINGQQVAIVATREQFNR
ALQEILKERGAGSYQGVRYTDQVDFKAVRANPQEVIAEEQLKSLLAERLHLVAAATVITIDGQPRLVLKDDATADAVLAA
FKQAFEPPAAIGQVQEVKFLEQVAYEHRQASPEEILSPEAALAKLKGTAASSSTYTVKEGDSLWSIAREHNLLVDDIKRA
NPEIQGERLDIGQQLKLTTVQPLLQVMVVYNQDIKEPVPFETRVEKTADLLRGQEKIIQEGTEGEQLVTYQVVTRNGVVV
DKKILRQQVLTEPVARVVQQGTGVTALASRSGGSGLLAWPIRGYITSPYGYRGSEFHSGLDIAGSIGEPVGAAAGGVVVS
TGYDGGYGRMVVIDHGGLVTRYAHLSGYNVRPGQRVSQGQIIGYVGVSGRTTGPHLHFEVLVGGSFRNPASYLR

Specific function: Lyses staphylococcal cells by hydrolyzing the polyglycine interpeptide bridges of the peptidoglycan [H]

COG id: COG0739

COG function: function code M; Membrane proteins related to metalloendopeptidases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M23B family [H]

Homologues:

Organism=Escherichia coli, GI87081989, Length=94, Percent_Identity=43.6170212765958, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789099, Length=268, Percent_Identity=28.7313432835821, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87082297, Length=135, Percent_Identity=36.2962962962963, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011055
- InterPro:   IPR016047
- InterPro:   IPR002886
- InterPro:   IPR003646
- InterPro:   IPR013667 [H]

Pfam domain/function: PF01551 Peptidase_M23; PF08460 SH3_5 [H]

EC number: =3.4.24.75 [H]

Molecular weight: Translated: 51367; Mature: 51236

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS51109 G5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPDKLPQLAASVGRFLKKLPLRWAGIRDNKGKRVLVITGILAGGLLLAAWHQLTTPNA
CCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCE
LAVFINGQQVAIVATREQFNRALQEILKERGAGSYQGVRYTDQVDFKAVRANPQEVIAEE
EEEEECCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEECCCHHHHHHHH
QLKSLLAERLHLVAAATVITIDGQPRLVLKDDATADAVLAAFKQAFEPPAAIGQVQEVKF
HHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCHHHCHHHHHHH
LEQVAYEHRQASPEEILSPEAALAKLKGTAASSSTYTVKEGDSLWSIAREHNLLVDDIKR
HHHHHHHHHCCCHHHHHCCHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHH
ANPEIQGERLDIGQQLKLTTVQPLLQVMVVYNQDIKEPVPFETRVEKTADLLRGQEKIIQ
CCCCCCCCEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHH
EGTEGEQLVTYQVVTRNGVVVDKKILRQQVLTEPVARVVQQGTGVTALASRSGGSGLLAW
CCCCCCEEEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEE
PIRGYITSPYGYRGSEFHSGLDIAGSIGEPVGAAAGGVVVSTGYDGGYGRMVVIDHGGLV
ECCCEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCEE
TRYAHLSGYNVRPGQRVSQGQIIGYVGVSGRTTGPHLHFEVLVGGSFRNPASYLR
EEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHCC
>Mature Secondary Structure 
PPPDKLPQLAASVGRFLKKLPLRWAGIRDNKGKRVLVITGILAGGLLLAAWHQLTTPNA
CCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCE
LAVFINGQQVAIVATREQFNRALQEILKERGAGSYQGVRYTDQVDFKAVRANPQEVIAEE
EEEEECCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCCEECCCCCEEEECCCHHHHHHHH
QLKSLLAERLHLVAAATVITIDGQPRLVLKDDATADAVLAAFKQAFEPPAAIGQVQEVKF
HHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCHHHCHHHHHHH
LEQVAYEHRQASPEEILSPEAALAKLKGTAASSSTYTVKEGDSLWSIAREHNLLVDDIKR
HHHHHHHHHCCCHHHHHCCHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHH
ANPEIQGERLDIGQQLKLTTVQPLLQVMVVYNQDIKEPVPFETRVEKTADLLRGQEKIIQ
CCCCCCCCEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHHH
EGTEGEQLVTYQVVTRNGVVVDKKILRQQVLTEPVARVVQQGTGVTALASRSGGSGLLAW
CCCCCCEEEEEEEEECCCEEECHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEE
PIRGYITSPYGYRGSEFHSGLDIAGSIGEPVGAAAGGVVVSTGYDGGYGRMVVIDHGGLV
ECCCEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCEE
TRYAHLSGYNVRPGQRVSQGQIIGYVGVSGRTTGPHLHFEVLVGGSFRNPASYLR
EEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3547405; 9106216 [H]