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The map label for this gene is atpA

Identifier: 83591196

GI number: 83591196

Start: 2505324

End: 2506847

Strand: Reverse

Name: atpA

Synonym: Moth_2380

Alternate gene names: 83591196

Gene position: 2506847-2505324 (Counterclockwise)

Preceding gene: 83591197

Following gene: 83591195

Centisome position: 95.36

GC content: 60.37

Gene sequence:

>1524_bases
TTGAGCATTCGACCCGACGAGATAACCAGTATTTTAAAGAACCAGATTGAACAATACCAGCTGGAAGTAGAAATGGCCGA
GGTGGGAACCGTTACCCAGGTCGGTGACGGTATCGCCCGCATCTACGGCCTGGACCGGGCCATGGCCGGCGAGCTGCTGG
AGTTCCCCGGCGATATCTATGGCATGGTCCTGAACCTGGAAGAAGATAACGTCGGCGCCGTTATCCTCGGTCCCTATACC
CATATCAAAGAGGGCGACCAGGTCAAACGTACCGGGCGTATTGTCGAGGTGCCGGTGGGCGAAGCCCTCATCGGCCGGGT
GGTCAACGCCATGGGCCAGCCCATAGACGGCAAGGGGCCTATCCAGACGGATAAATTCCGCCCGGTGGAATCCCCGGCGC
CGGGCGTGGTCTACCGCCAGCCGGTCAATACTCCCTTACAAACGGGCCTCAAGGCCATTGACTCCATGGTCCCCATCGGC
CGCGGTCAGCGGGAGCTGATTATCGGTGACCGCCAGACGGGGAAGACGGCCATTGCCGTGGACACCATCATCAACCAAAA
GGGGCAGAACGTTATCTGCATCTATGTGGCCATCGGCCAGAAGGCTTCTACAGTGGCGGGCGTAGTCCAGCGTCTGGAAG
AGGCCGGAGCTATGGAATATACCATCGTCGTTATGGCTACAGCCAGCGAACCGGCGCCCATGCTCTACATTGCCCCCTAC
GCCGGCTGCACCATGGGCGAATACTTTATGTATGAGCAGCACCGGGACGTTCTCTGCGTTTATGACGACCTTTCCAAGCA
CGCAGCAGCCTACCGGGAACTCTCCCTGCTTCTGCGGCGGCCGCCGGGCCGTGAGGCTTACCCCGGGGATGTCTTCTATC
TCCACTCCCGGTTGCTGGAGCGGGCCGCCCGCCTGAACGACTCCCTGGGTGGCGGTTCCCTCACTGCCCTGCCGGTCATT
GAGACCCAGGCTGGCGATGTCTCCGCTTACATTCCGACCAATGTTATCTCCATCACCGACGGCCAGATCTTCCTGGAGTC
TGATCTCTTCTATGCCGGCCAGCGTCCGGCCATTAACGTCGGCCTCTCGGTATCCCGGGTGGGCGGCGCCGCCCAGATCA
AGGCCATGAAACAGGTGGCCGGCCGCCTGCGCCTGGACCTGGCCCAGTACCGCGAGCTGGCGGCCTTCGCCCAGTTCGGT
TCCGACCTGGATAAAGCCACCCAGGCGAGATTGGCCCGGGGCGAGCGCATGATGGAGATTTTGAAACAAGACCAGTACCA
ACCCATGCCCGTCGAAGAACAGGTGGTCGTCCTCTATGCTGCCGTCAATGGCTTCCTGGACGACCTGCCTGTAGCCCGGG
TGCGCGCCTTTGAAAAGGACTTCCTGCGCTTCCTCCGCAACGAGAGGCCTGAGGTCCTGGCCGGCATCCGCGAAAAACGC
CAGCTGGACGATAACCTCCAGGAACAACTGAAAAAGAGCATTGAAGACTTCAAAGGCAGCTTTACCGCTGCCGGAGAATC
ATAA

Upstream 100 bases:

>100_bases
GCCAGCGTCAAGAAAAAGCTGGAACTCCTGGGTGAACACCTGAAACGGGCTTGAGAGAACGACAGAAAAATCGGACAGGG
CGAAGGGGTGAAAGGTAGAT

Downstream 100 bases:

>100_bases
GGTGGTGAGCCGGCATGGCCCACATGCGTGACCTGAAGCGCCGCATCCGCAGTGTCCAGAGTACCCAGCATATTACCAGG
GCCATGAAGATGGTAGCTGC

Product: ATP synthase F1, alpha subunit

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MSIRPDEITSILKNQIEQYQLEVEMAEVGTVTQVGDGIARIYGLDRAMAGELLEFPGDIYGMVLNLEEDNVGAVILGPYT
HIKEGDQVKRTGRIVEVPVGEALIGRVVNAMGQPIDGKGPIQTDKFRPVESPAPGVVYRQPVNTPLQTGLKAIDSMVPIG
RGQRELIIGDRQTGKTAIAVDTIINQKGQNVICIYVAIGQKASTVAGVVQRLEEAGAMEYTIVVMATASEPAPMLYIAPY
AGCTMGEYFMYEQHRDVLCVYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAARLNDSLGGGSLTALPVI
ETQAGDVSAYIPTNVISITDGQIFLESDLFYAGQRPAINVGLSVSRVGGAAQIKAMKQVAGRLRLDLAQYRELAAFAQFG
SDLDKATQARLARGERMMEILKQDQYQPMPVEEQVVVLYAAVNGFLDDLPVARVRAFEKDFLRFLRNERPEVLAGIREKR
QLDDNLQEQLKKSIEDFKGSFTAAGES

Sequences:

>Translated_507_residues
MSIRPDEITSILKNQIEQYQLEVEMAEVGTVTQVGDGIARIYGLDRAMAGELLEFPGDIYGMVLNLEEDNVGAVILGPYT
HIKEGDQVKRTGRIVEVPVGEALIGRVVNAMGQPIDGKGPIQTDKFRPVESPAPGVVYRQPVNTPLQTGLKAIDSMVPIG
RGQRELIIGDRQTGKTAIAVDTIINQKGQNVICIYVAIGQKASTVAGVVQRLEEAGAMEYTIVVMATASEPAPMLYIAPY
AGCTMGEYFMYEQHRDVLCVYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAARLNDSLGGGSLTALPVI
ETQAGDVSAYIPTNVISITDGQIFLESDLFYAGQRPAINVGLSVSRVGGAAQIKAMKQVAGRLRLDLAQYRELAAFAQFG
SDLDKATQARLARGERMMEILKQDQYQPMPVEEQVVVLYAAVNGFLDDLPVARVRAFEKDFLRFLRNERPEVLAGIREKR
QLDDNLQEQLKKSIEDFKGSFTAAGES
>Mature_506_residues
SIRPDEITSILKNQIEQYQLEVEMAEVGTVTQVGDGIARIYGLDRAMAGELLEFPGDIYGMVLNLEEDNVGAVILGPYTH
IKEGDQVKRTGRIVEVPVGEALIGRVVNAMGQPIDGKGPIQTDKFRPVESPAPGVVYRQPVNTPLQTGLKAIDSMVPIGR
GQRELIIGDRQTGKTAIAVDTIINQKGQNVICIYVAIGQKASTVAGVVQRLEEAGAMEYTIVVMATASEPAPMLYIAPYA
GCTMGEYFMYEQHRDVLCVYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAARLNDSLGGGSLTALPVIE
TQAGDVSAYIPTNVISITDGQIFLESDLFYAGQRPAINVGLSVSRVGGAAQIKAMKQVAGRLRLDLAQYRELAAFAQFGS
DLDKATQARLARGERMMEILKQDQYQPMPVEEQVVVLYAAVNGFLDDLPVARVRAFEKDFLRFLRNERPEVLAGIREKRQ
LDDNLQEQLKKSIEDFKGSFTAAGES

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=505, Percent_Identity=62.1782178217822, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI4757810, Length=505, Percent_Identity=62.1782178217822, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI19913428, Length=303, Percent_Identity=29.7029702970297, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI19913426, Length=302, Percent_Identity=29.1390728476821, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI32189394, Length=310, Percent_Identity=25.4838709677419, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI19913424, Length=257, Percent_Identity=28.0155642023346, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790172, Length=511, Percent_Identity=57.1428571428571, Blast_Score=596, Evalue=1e-171,
Organism=Escherichia coli, GI1788251, Length=324, Percent_Identity=29.320987654321, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790170, Length=299, Percent_Identity=26.4214046822742, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71988063, Length=503, Percent_Identity=62.2266401590457, Blast_Score=624, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71988080, Length=503, Percent_Identity=62.2266401590457, Blast_Score=622, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71988074, Length=503, Percent_Identity=58.051689860835, Blast_Score=568, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17570191, Length=300, Percent_Identity=30.6666666666667, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17510931, Length=291, Percent_Identity=29.2096219931272, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI25144756, Length=393, Percent_Identity=24.6819338422392, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17565854, Length=259, Percent_Identity=28.1853281853282, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71988068, Length=71, Percent_Identity=43.6619718309859, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=506, Percent_Identity=60.0790513833992, Blast_Score=609, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6319603, Length=297, Percent_Identity=30.6397306397306, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322581, Length=405, Percent_Identity=24.4444444444444, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24658560, Length=507, Percent_Identity=60.5522682445759, Blast_Score=609, Evalue=1e-174,
Organism=Drosophila melanogaster, GI281361666, Length=302, Percent_Identity=29.8013245033113, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646341, Length=302, Percent_Identity=29.8013245033113, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136796, Length=302, Percent_Identity=29.8013245033113, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24638766, Length=406, Percent_Identity=25.3694581280788, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574560, Length=389, Percent_Identity=25.9640102827763, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24583988, Length=257, Percent_Identity=29.1828793774319, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583986, Length=257, Percent_Identity=29.1828793774319, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583984, Length=257, Percent_Identity=29.1828793774319, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24583992, Length=257, Percent_Identity=29.1828793774319, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20129479, Length=334, Percent_Identity=27.8443113772455, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_MOOTA (Q2RFX7)

Other databases:

- EMBL:   U64318
- EMBL:   CP000232
- RefSeq:   YP_431205.1
- ProteinModelPortal:   Q2RFX7
- SMR:   Q2RFX7
- STRING:   Q2RFX7
- GeneID:   3832019
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2380
- NMPDR:   fig|264732.9.peg.2412
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- PhylomeDB:   Q2RFX7
- BioCyc:   MTHE264732:MOTH_2380-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55640; Mature: 55508

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRPDEITSILKNQIEQYQLEVEMAEVGTVTQVGDGIARIYGLDRAMAGELLEFPGDIY
CCCCHHHHHHHHHHHHHHHHHEEEHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCEE
GMVLNLEEDNVGAVILGPYTHIKEGDQVKRTGRIVEVPVGEALIGRVVNAMGQPIDGKGP
EEEEEECCCCCCEEEECCCHHCCCCCHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCC
IQTDKFRPVESPAPGVVYRQPVNTPLQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAIAV
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEE
DTIINQKGQNVICIYVAIGQKASTVAGVVQRLEEAGAMEYTIVVMATASEPAPMLYIAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEEECCC
AGCTMGEYFMYEQHRDVLCVYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLE
CCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RAARLNDSLGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLESDLFYAGQRPAINV
HHHHHCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCEEECCCCCEEEE
GLSVSRVGGAAQIKAMKQVAGRLRLDLAQYRELAAFAQFGSDLDKATQARLARGERMMEI
CEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LKQDQYQPMPVEEQVVVLYAAVNGFLDDLPVARVRAFEKDFLRFLRNERPEVLAGIREKR
HHHCCCCCCCCCHHHEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QLDDNLQEQLKKSIEDFKGSFTAAGES
HHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SIRPDEITSILKNQIEQYQLEVEMAEVGTVTQVGDGIARIYGLDRAMAGELLEFPGDIY
CCCHHHHHHHHHHHHHHHHHEEEHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCEE
GMVLNLEEDNVGAVILGPYTHIKEGDQVKRTGRIVEVPVGEALIGRVVNAMGQPIDGKGP
EEEEEECCCCCCEEEECCCHHCCCCCHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCC
IQTDKFRPVESPAPGVVYRQPVNTPLQTGLKAIDSMVPIGRGQRELIIGDRQTGKTAIAV
CCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEE
DTIINQKGQNVICIYVAIGQKASTVAGVVQRLEEAGAMEYTIVVMATASEPAPMLYIAPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCEEEECCC
AGCTMGEYFMYEQHRDVLCVYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLE
CCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
RAARLNDSLGGGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLESDLFYAGQRPAINV
HHHHHCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCEEECCCCCEEEE
GLSVSRVGGAAQIKAMKQVAGRLRLDLAQYRELAAFAQFGSDLDKATQARLARGERMMEI
CEEEHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LKQDQYQPMPVEEQVVVLYAAVNGFLDDLPVARVRAFEKDFLRFLRNERPEVLAGIREKR
HHHCCCCCCCCCHHHEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QLDDNLQEQLKKSIEDFKGSFTAAGES
HHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA