Click here to switch to the map view.

The map label for this gene is argH

Identifier: 83591105

GI number: 83591105

Start: 2395356

End: 2396750

Strand: Reverse

Name: argH

Synonym: Moth_2284

Alternate gene names: 83591105

Gene position: 2396750-2395356 (Counterclockwise)

Preceding gene: 83591106

Following gene: 83591104

Centisome position: 91.17

GC content: 62.15

Gene sequence:

>1395_bases
ATGAAACTCTGGGGCGGACGTTTTACCAGGACAACCGACCGGCTGGTGGAGGATTTCCACTCCTCCATCAGCTTTGACCA
GCGCCTCTATAAAGAGGATATAGCCGGTTCTATCGCCCACGCCCGCATGCTGGCAGCGGTGGGCCTCATCACACCGGCCG
AAGGTGAAGCCATTATCAAAGGCCTGGAGGAAATCCGGGCCGACATCGAGGCGGGCCGGGTGACCTTCGACGTGGGCGCC
GAGGACATCCACATGAACATCGAAAAGCTCCTCACCGAGCGCATCGGCGAGGCTGGCAAGAAGCTGCACACGGCTCGCAG
CCGCAACGACCAGGTGGCCCTGGACCTGCGGCTCTATTTAAAAGAAGAGATTCCTGCCGTCAAAAAGCTCCTGGCCGGCC
TGCAGCAGGTCCTGGTGGATCTGGCCGCGCAGCACCTTCAGACAATCATGCCCGGCTATACCCACCTGCAGAAGGCCCAG
CCCGTCACCCTGGCCCACCACCTGATGGCCTACTTTGAGATGTTCTACCGTGACCAGCAGCGCCTGGACGATTGCCTTGA
CAGGGTCGACGTCATGCCCCTGGGCGCCGGGGCCCTGGCCGGTACCACCCTGCCTATCGACCGGGAGCTGGTTGCCCGGG
AGCTGGGCTTTAAGGCTATCAGCGCCAATTCCCTGGACGCCGTTAGCGACCGCGATTTCGTGGTCGAGTTCCTGGCAGCC
GCCTCCCTTATTATGATGCACCTGAGTCGCCTGGCAGAAGAGGTCATTTTCTGGTCCAGCGAGGAGTTCGGTTTTCTGGA
ACTGGATGACGCCTACAGCACCGGTTCCAGTATGATGCCACAAAAGAAAAACCCTGATGTCGCCGAACTGGTACGGGGTA
AGACCGGCCGGGTGTACGGCCACCTCATGGGCATGCTGGCGGTTTTAAAGGGCCTGCCCCTGGCCTACAACAAGGACCTG
CAGGAGGATAAGGAAGCCCTCTTTGACACCCTGGACACCGTCAAGGGCTGTCTCATGGTCTTTACCCCCATGCTGGCCAC
GGCCAGGTTCCGGGTGGAGCGCATGCGGGCCGACGCCTCCCGGGGGTTTGCCGCGGCTACCGATGTGGCCGAGTACCTGG
TGCGTAAGGGCCTGCCCTTCCGCGAGGCCCATGCCGTGGTCGGTTCCCTGGTCCTCCACTGCCTCCGGGAGGGCCGCAGC
TTCCAGGATTTAAGCCTGGAGGAGTGGCAGTCCTTCTCGCCGCTGTTTGACAATGATATTTTCGGGTGCCTCGAGGCCGA
GGCCTGCGTCAACGGCCGCAACCTCCCCGGCGGCCCGGCCCCGGAGGCCGTGGGGAAAGCCATAGAGCGGGCCAGGGAGA
TCCTTGCCGGGATTCAGGCTGGACTTTCAAGATAG

Upstream 100 bases:

>100_bases
GACCATAAGGACGCCACCGGTTTCATCAACCTCTTCGGCCTGCCCTTGAAGGTACGGGCGCTGATGGAACAAAAAACTGG
ACTGAGATAGGAGTATTTCT

Downstream 100 bases:

>100_bases
GGAGGGTAGCGGGTGACCAGAATCATTACCTGCGACGAGATTACCAGGGCGGTGGCCGACCTCTGCCGGCAGGCCAATTA
CTACCTGGGGGAGGACGTGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKLWGGRFTRTTDRLVEDFHSSISFDQRLYKEDIAGSIAHARMLAAVGLITPAEGEAIIKGLEEIRADIEAGRVTFDVGA
EDIHMNIEKLLTERIGEAGKKLHTARSRNDQVALDLRLYLKEEIPAVKKLLAGLQQVLVDLAAQHLQTIMPGYTHLQKAQ
PVTLAHHLMAYFEMFYRDQQRLDDCLDRVDVMPLGAGALAGTTLPIDRELVARELGFKAISANSLDAVSDRDFVVEFLAA
ASLIMMHLSRLAEEVIFWSSEEFGFLELDDAYSTGSSMMPQKKNPDVAELVRGKTGRVYGHLMGMLAVLKGLPLAYNKDL
QEDKEALFDTLDTVKGCLMVFTPMLATARFRVERMRADASRGFAAATDVAEYLVRKGLPFREAHAVVGSLVLHCLREGRS
FQDLSLEEWQSFSPLFDNDIFGCLEAEACVNGRNLPGGPAPEAVGKAIERAREILAGIQAGLSR

Sequences:

>Translated_464_residues
MKLWGGRFTRTTDRLVEDFHSSISFDQRLYKEDIAGSIAHARMLAAVGLITPAEGEAIIKGLEEIRADIEAGRVTFDVGA
EDIHMNIEKLLTERIGEAGKKLHTARSRNDQVALDLRLYLKEEIPAVKKLLAGLQQVLVDLAAQHLQTIMPGYTHLQKAQ
PVTLAHHLMAYFEMFYRDQQRLDDCLDRVDVMPLGAGALAGTTLPIDRELVARELGFKAISANSLDAVSDRDFVVEFLAA
ASLIMMHLSRLAEEVIFWSSEEFGFLELDDAYSTGSSMMPQKKNPDVAELVRGKTGRVYGHLMGMLAVLKGLPLAYNKDL
QEDKEALFDTLDTVKGCLMVFTPMLATARFRVERMRADASRGFAAATDVAEYLVRKGLPFREAHAVVGSLVLHCLREGRS
FQDLSLEEWQSFSPLFDNDIFGCLEAEACVNGRNLPGGPAPEAVGKAIERAREILAGIQAGLSR
>Mature_464_residues
MKLWGGRFTRTTDRLVEDFHSSISFDQRLYKEDIAGSIAHARMLAAVGLITPAEGEAIIKGLEEIRADIEAGRVTFDVGA
EDIHMNIEKLLTERIGEAGKKLHTARSRNDQVALDLRLYLKEEIPAVKKLLAGLQQVLVDLAAQHLQTIMPGYTHLQKAQ
PVTLAHHLMAYFEMFYRDQQRLDDCLDRVDVMPLGAGALAGTTLPIDRELVARELGFKAISANSLDAVSDRDFVVEFLAA
ASLIMMHLSRLAEEVIFWSSEEFGFLELDDAYSTGSSMMPQKKNPDVAELVRGKTGRVYGHLMGMLAVLKGLPLAYNKDL
QEDKEALFDTLDTVKGCLMVFTPMLATARFRVERMRADASRGFAAATDVAEYLVRKGLPFREAHAVVGSLVLHCLREGRS
FQDLSLEEWQSFSPLFDNDIFGCLEAEACVNGRNLPGGPAPEAVGKAIERAREILAGIQAGLSR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=459, Percent_Identity=45.7516339869281, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI68303542, Length=459, Percent_Identity=45.7516339869281, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI68303549, Length=459, Percent_Identity=43.7908496732026, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI68303547, Length=459, Percent_Identity=42.9193899782135, Blast_Score=370, Evalue=1e-102,
Organism=Escherichia coli, GI1790398, Length=453, Percent_Identity=49.2273730684327, Blast_Score=446, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6321806, Length=461, Percent_Identity=45.3362255965293, Blast_Score=383, Evalue=1e-107,
Organism=Drosophila melanogaster, GI221473854, Length=443, Percent_Identity=43.7923250564334, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78706858, Length=443, Percent_Identity=43.7923250564334, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_MOOTA (Q2RG68)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_431114.1
- ProteinModelPortal:   Q2RG68
- SMR:   Q2RG68
- STRING:   Q2RG68
- GeneID:   3831316
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2284
- NMPDR:   fig|264732.9.peg.2321
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   Q2RG68
- BioCyc:   MTHE264732:MOTH_2284-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51321; Mature: 51321

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWGGRFTRTTDRLVEDFHSSISFDQRLYKEDIAGSIAHARMLAAVGLITPAEGEAIIK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GLEEIRADIEAGRVTFDVGAEDIHMNIEKLLTERIGEAGKKLHTARSRNDQVALDLRLYL
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHH
KEEIPAVKKLLAGLQQVLVDLAAQHLQTIMPGYTHLQKAQPVTLAHHLMAYFEMFYRDQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RLDDCLDRVDVMPLGAGALAGTTLPIDRELVARELGFKAISANSLDAVSDRDFVVEFLAA
HHHHHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHH
ASLIMMHLSRLAEEVIFWSSEEFGFLELDDAYSTGSSMMPQKKNPDVAELVRGKTGRVYG
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHH
HLMGMLAVLKGLPLAYNKDLQEDKEALFDTLDTVKGCLMVFTPMLATARFRVERMRADAS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGFAAATDVAEYLVRKGLPFREAHAVVGSLVLHCLREGRSFQDLSLEEWQSFSPLFDNDI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCH
FGCLEAEACVNGRNLPGGPAPEAVGKAIERAREILAGIQAGLSR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLWGGRFTRTTDRLVEDFHSSISFDQRLYKEDIAGSIAHARMLAAVGLITPAEGEAIIK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GLEEIRADIEAGRVTFDVGAEDIHMNIEKLLTERIGEAGKKLHTARSRNDQVALDLRLYL
HHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHH
KEEIPAVKKLLAGLQQVLVDLAAQHLQTIMPGYTHLQKAQPVTLAHHLMAYFEMFYRDQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RLDDCLDRVDVMPLGAGALAGTTLPIDRELVARELGFKAISANSLDAVSDRDFVVEFLAA
HHHHHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHHHHH
ASLIMMHLSRLAEEVIFWSSEEFGFLELDDAYSTGSSMMPQKKNPDVAELVRGKTGRVYG
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHH
HLMGMLAVLKGLPLAYNKDLQEDKEALFDTLDTVKGCLMVFTPMLATARFRVERMRADAS
HHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGFAAATDVAEYLVRKGLPFREAHAVVGSLVLHCLREGRSFQDLSLEEWQSFSPLFDNDI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCH
FGCLEAEACVNGRNLPGGPAPEAVGKAIERAREILAGIQAGLSR
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA