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The map label for this gene is pdp [H]

Identifier: 83591096

GI number: 83591096

Start: 2382738

End: 2384045

Strand: Reverse

Name: pdp [H]

Synonym: Moth_2275

Alternate gene names: 83591096

Gene position: 2384045-2382738 (Counterclockwise)

Preceding gene: 83591097

Following gene: 83591095

Centisome position: 90.69

GC content: 63.91

Gene sequence:

>1308_bases
ATGCAGATGCTTGACTTAATCCGTCGCAAGCGGGAGGGCCAGGCCCTGGCCCCAGCCGAAATTGAGGCCATGATACGGGA
TTATACGGCCGGGATAATCCCCGACTATCAGATGGCAGCCTTTCTCATGGCCGTCTATTTTCGCGGCCTGGACCGGGAGG
AAACGGCGGCCCTCACCAGGGCCATGATAGCCTCGGGGGAACAGATTGAGTGGAGTTCCATCCCGGGGGTGAAGGTCGAC
AAGCACAGTACCGGAGGTGTGGCCGACACCACCACCTTGGTCCTGGCGCCCCTGGTGGCCGCCGCCGGAGTGCCGGTAGT
TAAGATGTCCGGCCGCGGCCTGGGACACACTGGGGGCACTATTGACAAACTGGAATCCATCCCCGGCTTCAGGGTGCAGC
TGACGCGGGAAGAGATGATTCGCCAGGTAAAGGAGATCGGCCTGGCCGTCACTGCTCCCACGGGGAAGCTGGCCCCGGCT
GACGGCAAGCTCTACGCCCTGCGGGACGTCACAGCGACTGTTGAGAGCATACCCCTCATTGCCAGCAGTGTAATGAGCAA
AAAGATCGCCGCTGGCGCCGACGCCATAGTCCTCGATGTCAAGGTTGGCAGCGGCGCCTTTATGCCCGACCTGGAGTCGG
CCCGGGAACTGGCCCGGATCATGGTGGATCTGGGCCGGGAGATGGGGCGGCGGGTGGTAGCTGTGATTACCAATATGGAC
GAACCCCTGGGGATGATGGTGGGCAACGCCCTGGAAGTCGGGGAGGCCATCGCCGTTTTATCCGGCGGCGGGCCGCGGGA
GTTGCGGGAGGTTTGCCTCACCCTGGGCAGCCAGATGCTTCTACTGGCCGGGGCTACCGGTAGTGACGGTGAGGCGCGCC
GGCGTCTGGAGGAGCTCCTGGCCGGTGGCGCCGCCCTGGCCAAATTCCGGCGGTTCATTGCCGCCCAGGGCGGCGACCCG
GCGGTAGTCGACCGGCCGGAACTTCTCCCCCGCGCCACGGATCAGGTTACCATTGCCGCCCTAAGCAGCGGCTACATCAG
CGCCGTCCAGGCACGCCTGGTGGGCGAGGCGGCTATGCTCCTGGGGGCCGGGCGAATAACCAAAGAAAGCCCCATCGACC
TGGCGGTTGGTATCGAACTAAAAAAACGTCTGGGAGATTATGTTAACGCCGGCGAGCCCCTGGCTGTATTCCACGTCAAC
GACCGGGCCAACCTGGAGGCAGCCCGGGAGAGATTCCTGGCGGCCTATATTCTGGCCGCCGCACCGCCCACCCCGCAACC
CCTGGTGTATGAGATAATCAGGGGATAA

Upstream 100 bases:

>100_bases
GAAAAAACCTTGATACTATTGACAGAGCATCAAGGTCCTTGTCTGAGTTCCAGTACGGTGGGGGCACCGGGTTTTCAATT
AGCGGGAGGTTTATATAATT

Downstream 100 bases:

>100_bases
ATTCGGGAGCATAGTGGGGACCATCAATATGGCCATTTTTACCATTCTTTGTCGATAAACACTTTATCTGGCCTACACGG
CAAGGACGCGGGAAACCATG

Product: thymidine phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MQMLDLIRRKREGQALAPAEIEAMIRDYTAGIIPDYQMAAFLMAVYFRGLDREETAALTRAMIASGEQIEWSSIPGVKVD
KHSTGGVADTTTLVLAPLVAAAGVPVVKMSGRGLGHTGGTIDKLESIPGFRVQLTREEMIRQVKEIGLAVTAPTGKLAPA
DGKLYALRDVTATVESIPLIASSVMSKKIAAGADAIVLDVKVGSGAFMPDLESARELARIMVDLGREMGRRVVAVITNMD
EPLGMMVGNALEVGEAIAVLSGGGPRELREVCLTLGSQMLLLAGATGSDGEARRRLEELLAGGAALAKFRRFIAAQGGDP
AVVDRPELLPRATDQVTIAALSSGYISAVQARLVGEAAMLLGAGRITKESPIDLAVGIELKKRLGDYVNAGEPLAVFHVN
DRANLEAARERFLAAYILAAAPPTPQPLVYEIIRG

Sequences:

>Translated_435_residues
MQMLDLIRRKREGQALAPAEIEAMIRDYTAGIIPDYQMAAFLMAVYFRGLDREETAALTRAMIASGEQIEWSSIPGVKVD
KHSTGGVADTTTLVLAPLVAAAGVPVVKMSGRGLGHTGGTIDKLESIPGFRVQLTREEMIRQVKEIGLAVTAPTGKLAPA
DGKLYALRDVTATVESIPLIASSVMSKKIAAGADAIVLDVKVGSGAFMPDLESARELARIMVDLGREMGRRVVAVITNMD
EPLGMMVGNALEVGEAIAVLSGGGPRELREVCLTLGSQMLLLAGATGSDGEARRRLEELLAGGAALAKFRRFIAAQGGDP
AVVDRPELLPRATDQVTIAALSSGYISAVQARLVGEAAMLLGAGRITKESPIDLAVGIELKKRLGDYVNAGEPLAVFHVN
DRANLEAARERFLAAYILAAAPPTPQPLVYEIIRG
>Mature_435_residues
MQMLDLIRRKREGQALAPAEIEAMIRDYTAGIIPDYQMAAFLMAVYFRGLDREETAALTRAMIASGEQIEWSSIPGVKVD
KHSTGGVADTTTLVLAPLVAAAGVPVVKMSGRGLGHTGGTIDKLESIPGFRVQLTREEMIRQVKEIGLAVTAPTGKLAPA
DGKLYALRDVTATVESIPLIASSVMSKKIAAGADAIVLDVKVGSGAFMPDLESARELARIMVDLGREMGRRVVAVITNMD
EPLGMMVGNALEVGEAIAVLSGGGPRELREVCLTLGSQMLLLAGATGSDGEARRRLEELLAGGAALAKFRRFIAAQGGDP
AVVDRPELLPRATDQVTIAALSSGYISAVQARLVGEAAMLLGAGRITKESPIDLAVGIELKKRLGDYVNAGEPLAVFHVN
DRANLEAARERFLAAYILAAAPPTPQPLVYEIIRG

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=422, Percent_Identity=44.0758293838863, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI4503445, Length=422, Percent_Identity=44.0758293838863, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI166158922, Length=422, Percent_Identity=44.0758293838863, Blast_Score=312, Evalue=4e-85,
Organism=Escherichia coli, GI1790842, Length=434, Percent_Identity=42.3963133640553, Blast_Score=305, Evalue=5e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 45954; Mature: 45954

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMLDLIRRKREGQALAPAEIEAMIRDYTAGIIPDYQMAAFLMAVYFRGLDREETAALTR
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
AMIASGEQIEWSSIPGVKVDKHSTGGVADTTTLVLAPLVAAAGVPVVKMSGRGLGHTGGT
HHHHCCCCEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
IDKLESIPGFRVQLTREEMIRQVKEIGLAVTAPTGKLAPADGKLYALRDVTATVESIPLI
HHHHHCCCCCEEEECHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHH
ASSVMSKKIAAGADAIVLDVKVGSGAFMPDLESARELARIMVDLGREMGRRVVAVITNMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHCCC
EPLGMMVGNALEVGEAIAVLSGGGPRELREVCLTLGSQMLLLAGATGSDGEARRRLEELL
CCHHHHHCCHHHHCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
AGGAALAKFRRFIAAQGGDPAVVDRPELLPRATDQVTIAALSSGYISAVQARLVGEAAML
HCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHH
LGAGRITKESPIDLAVGIELKKRLGDYVNAGEPLAVFHVNDRANLEAARERFLAAYILAA
HHCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHC
APPTPQPLVYEIIRG
CCCCCCHHHHHHHCC
>Mature Secondary Structure
MQMLDLIRRKREGQALAPAEIEAMIRDYTAGIIPDYQMAAFLMAVYFRGLDREETAALTR
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
AMIASGEQIEWSSIPGVKVDKHSTGGVADTTTLVLAPLVAAAGVPVVKMSGRGLGHTGGT
HHHHCCCCEEECCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
IDKLESIPGFRVQLTREEMIRQVKEIGLAVTAPTGKLAPADGKLYALRDVTATVESIPLI
HHHHHCCCCCEEEECHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHH
ASSVMSKKIAAGADAIVLDVKVGSGAFMPDLESARELARIMVDLGREMGRRVVAVITNMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHCCC
EPLGMMVGNALEVGEAIAVLSGGGPRELREVCLTLGSQMLLLAGATGSDGEARRRLEELL
CCHHHHHCCHHHHCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
AGGAALAKFRRFIAAQGGDPAVVDRPELLPRATDQVTIAALSSGYISAVQARLVGEAAML
HCHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHH
LGAGRITKESPIDLAVGIELKKRLGDYVNAGEPLAVFHVNDRANLEAARERFLAAYILAA
HHCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHC
APPTPQPLVYEIIRG
CCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]