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The map label for this gene is glmS [H]

Identifier: 83591066

GI number: 83591066

Start: 2347311

End: 2349131

Strand: Reverse

Name: glmS [H]

Synonym: Moth_2245

Alternate gene names: 83591066

Gene position: 2349131-2347311 (Counterclockwise)

Preceding gene: 83591067

Following gene: 83591065

Centisome position: 89.36

GC content: 62.05

Gene sequence:

>1821_bases
ATGTGCGGTATCGTAGGTTATCTGGGCCCGCGCCCGGCGGTCCCCATATTGGTTCAGGGACTGGAAAGGCTGGAATACCG
GGGCTATGATTCTGCCGGGATAGCGGTATTGAATGGTGGAGGATTGGTAGTCGAAAAGAGCGCGGGCAAGCTACATGTCC
TGAAGAGCCGTCTCAATGGCAATCTCGCCGGTGCCCGGGTGGGGATTGGTCACACCCGCTGGGCCACCCATGGCCGGCCG
TCCGATGTCAACGCCCATCCCCATCTAGATTGCACGGGCAGGATTGCCGTCGTCCATAACGGGATCATCGAAAACTACCA
GGAACTGCGCCAGGAACTGGCGGCTAAAGGCCATCGCTTTATATCCGAAACCGATACAGAAGTCCTGGCCCACCTGGTGG
AAGAGTTCTATACCGGCGATCTCCTCCAGGCGGTATTCAAGATGCTGCCCGTTCTTCGAGGCTCCTACGCCCTGGCTGTC
ATGAGCGCCGATCATCCCCGGGAACTGGTAGGCGCGCGCCAGGACAGCCCCTTAATCGTCGGCCTGGCTGCAGGGGAAAC
CTACCTGGCCTCCGATATCCCGGCCCTGCTGCCTTATACCCGGGATAATTACATCCTGGAGAACGGTGAAGTGGCCTGGA
TCACCCCCGGGGAAGTGACCGTTTACGACGCCGACGGCAGCCGCAAGTCCAAGGAGGTCTTCCACGTGGCCTGGGACCTC
CAGGCGGCGGAAAAGGGCGGTTATGCCCACTTTATGCTGAAAGAGATCCACGAGCAGCCGCGGGCCTTAAGGGATACCCT
GGCTGGCCGCCTGCAAGATGACGGGCGGGTACGCCTGGAAGGAGTTAACTTCACACCGGAGGAAGCGGCGGCCCTGGAAA
AAGTGGCCATCATTGCCTGCGGTACGGCCCACTACGCCGGCATGGTGGGTAAATATCTCCTGGAGAAGCTCCTGCGCCTG
CCGGTGGAAGACGACGTGGCCTCGGAATTTCGCTACCGGGAACCGATCCTCAACGAGCATACCCTGGGCCTGGTCATCAG
CCAATCGGGCGAAACGGCCGACACCCTGGCCAGCCTGCGGGAGGCTAAAAAAGCCGGGGCACCGGTGCTGGCCATTACCA
ACGTCGTCGGCAGTTCGGTAGCCCGGGAAGCCGATCACGTCATCTATACCTGGGCCGGCCCGGAGATTGCCGTGGCGTCC
ACTAAAGCGTATCTCACCCAGGTAGCATCGCTGTACCTCCTGGCCCTGCACCTGGGCGAGAAAAGGAGCCATGCTCCCTG
GGCGCAGGAAATCGCCGGGGGCCTTAAGGACCTGCCCGGCCAGGTGGAAGAAGTTTTAAAGCTGGAACCACGGATAAAGG
AACTGGCCGGCCGGATAGCACCCCACGAGCACGCCTTCTTTATCGGCCGCGGCCTGGATTACCCCGTCTCCCTGGAGGGA
TCCCTGAAGCTAAAGGAGATCTCCTACCTGCACGCCGAGGCTTATGCGGCCGGGGAACTGAAGCACGGCACCCTGGCATT
GATCGAAGAGGGTACGCCCGTTATCGCCCTGGCCACCCAGGCCGAGCTCCTAGAGAAGATGCTCAGCAACATCAAGGAAG
TCAAGGCCCGGGGCGCCTGGGTCCTGGCCCTCACCCAGGAGGGTAACACAGCCGTGGCCGAAGAGGCCGACGCCGTCCTC
TACCTGCCGCCGGTACCATCTATCCTGGCGCCGGCGGTGACGGTGGTGCCCCTGCAACTCCTGGCCTACTACACCGCCGT
CGCCCGCGGCTGCGACGTCGACAAACCCCGAAACCTGGCCAAGAGCGTGACGGTGGAGTAG

Upstream 100 bases:

>100_bases
GACAAAGGCGTTACAAAACCCGGGAGCAATCCCGGGGACAAAGGGCGCCGGGTAACCCTTTACCTCTCCCTGATTAAAAA
ATAAAGGGAGAGTGAGCTTT

Downstream 100 bases:

>100_bases
GGGCATTGGAGGATGGCGCTTTTGTCGGTGTTAATAAAGTTTGAGAATCTGACAATAGAGTTTGCGAATGGCTTTATTAA
AGTTTGAGAATCAAATGTCT

Product: glutamine--fructose-6-phosphate transaminase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MCGIVGYLGPRPAVPILVQGLERLEYRGYDSAGIAVLNGGGLVVEKSAGKLHVLKSRLNGNLAGARVGIGHTRWATHGRP
SDVNAHPHLDCTGRIAVVHNGIIENYQELRQELAAKGHRFISETDTEVLAHLVEEFYTGDLLQAVFKMLPVLRGSYALAV
MSADHPRELVGARQDSPLIVGLAAGETYLASDIPALLPYTRDNYILENGEVAWITPGEVTVYDADGSRKSKEVFHVAWDL
QAAEKGGYAHFMLKEIHEQPRALRDTLAGRLQDDGRVRLEGVNFTPEEAAALEKVAIIACGTAHYAGMVGKYLLEKLLRL
PVEDDVASEFRYREPILNEHTLGLVISQSGETADTLASLREAKKAGAPVLAITNVVGSSVAREADHVIYTWAGPEIAVAS
TKAYLTQVASLYLLALHLGEKRSHAPWAQEIAGGLKDLPGQVEEVLKLEPRIKELAGRIAPHEHAFFIGRGLDYPVSLEG
SLKLKEISYLHAEAYAAGELKHGTLALIEEGTPVIALATQAELLEKMLSNIKEVKARGAWVLALTQEGNTAVAEEADAVL
YLPPVPSILAPAVTVVPLQLLAYYTAVARGCDVDKPRNLAKSVTVE

Sequences:

>Translated_606_residues
MCGIVGYLGPRPAVPILVQGLERLEYRGYDSAGIAVLNGGGLVVEKSAGKLHVLKSRLNGNLAGARVGIGHTRWATHGRP
SDVNAHPHLDCTGRIAVVHNGIIENYQELRQELAAKGHRFISETDTEVLAHLVEEFYTGDLLQAVFKMLPVLRGSYALAV
MSADHPRELVGARQDSPLIVGLAAGETYLASDIPALLPYTRDNYILENGEVAWITPGEVTVYDADGSRKSKEVFHVAWDL
QAAEKGGYAHFMLKEIHEQPRALRDTLAGRLQDDGRVRLEGVNFTPEEAAALEKVAIIACGTAHYAGMVGKYLLEKLLRL
PVEDDVASEFRYREPILNEHTLGLVISQSGETADTLASLREAKKAGAPVLAITNVVGSSVAREADHVIYTWAGPEIAVAS
TKAYLTQVASLYLLALHLGEKRSHAPWAQEIAGGLKDLPGQVEEVLKLEPRIKELAGRIAPHEHAFFIGRGLDYPVSLEG
SLKLKEISYLHAEAYAAGELKHGTLALIEEGTPVIALATQAELLEKMLSNIKEVKARGAWVLALTQEGNTAVAEEADAVL
YLPPVPSILAPAVTVVPLQLLAYYTAVARGCDVDKPRNLAKSVTVE
>Mature_606_residues
MCGIVGYLGPRPAVPILVQGLERLEYRGYDSAGIAVLNGGGLVVEKSAGKLHVLKSRLNGNLAGARVGIGHTRWATHGRP
SDVNAHPHLDCTGRIAVVHNGIIENYQELRQELAAKGHRFISETDTEVLAHLVEEFYTGDLLQAVFKMLPVLRGSYALAV
MSADHPRELVGARQDSPLIVGLAAGETYLASDIPALLPYTRDNYILENGEVAWITPGEVTVYDADGSRKSKEVFHVAWDL
QAAEKGGYAHFMLKEIHEQPRALRDTLAGRLQDDGRVRLEGVNFTPEEAAALEKVAIIACGTAHYAGMVGKYLLEKLLRL
PVEDDVASEFRYREPILNEHTLGLVISQSGETADTLASLREAKKAGAPVLAITNVVGSSVAREADHVIYTWAGPEIAVAS
TKAYLTQVASLYLLALHLGEKRSHAPWAQEIAGGLKDLPGQVEEVLKLEPRIKELAGRIAPHEHAFFIGRGLDYPVSLEG
SLKLKEISYLHAEAYAAGELKHGTLALIEEGTPVIALATQAELLEKMLSNIKEVKARGAWVLALTQEGNTAVAEEADAVL
YLPPVPSILAPAVTVVPLQLLAYYTAVARGCDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=681, Percent_Identity=37.0044052863436, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI4826742, Length=682, Percent_Identity=37.0967741935484, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI29570798, Length=251, Percent_Identity=27.8884462151394, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=48.0392156862745, Blast_Score=539, Evalue=1e-154,
Organism=Escherichia coli, GI1788651, Length=198, Percent_Identity=30.8080808080808, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082251, Length=311, Percent_Identity=22.8295819935691, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532899, Length=501, Percent_Identity=36.3273453093812, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=38.8372093023256, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17539970, Length=431, Percent_Identity=38.7470997679814, Blast_Score=288, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6322745, Length=431, Percent_Identity=38.0510440835267, Blast_Score=290, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6323731, Length=427, Percent_Identity=30.9133489461358, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6323730, Length=205, Percent_Identity=38.5365853658537, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21357745, Length=686, Percent_Identity=36.8804664723032, Blast_Score=417, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65476; Mature: 65476

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYLGPRPAVPILVQGLERLEYRGYDSAGIAVLNGGGLVVEKSAGKLHVLKSRLNG
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEHHHHHHCC
NLAGARVGIGHTRWATHGRPSDVNAHPHLDCTGRIAVVHNGIIENYQELRQELAAKGHRF
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCHH
ISETDTEVLAHLVEEFYTGDLLQAVFKMLPVLRGSYALAVMSADHPRELVGARQDSPLIV
HHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCCCCCCEEE
GLAAGETYLASDIPALLPYTRDNYILENGEVAWITPGEVTVYDADGSRKSKEVFHVAWDL
EEECCCEEHHCCCHHHCCCCCCCEEEECCCEEEECCCEEEEEECCCCCCCCEEEEEEEEE
QAAEKGGYAHFMLKEIHEQPRALRDTLAGRLQDDGRVRLEGVNFTPEEAAALEKVAIIAC
EHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHEEEEEE
GTAHYAGMVGKYLLEKLLRLPVEDDVASEFRYREPILNEHTLGLVISQSGETADTLASLR
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHH
EAKKAGAPVLAITNVVGSSVAREADHVIYTWAGPEIAVASTKAYLTQVASLYLLALHLGE
HHHHCCCCEEEHHHHHHHHHHHCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHCC
KRSHAPWAQEIAGGLKDLPGQVEEVLKLEPRIKELAGRIAPHEHAFFIGRGLDYPVSLEG
CCCCCCHHHHHHCHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
SLKLKEISYLHAEAYAAGELKHGTLALIEEGTPVIALATQAELLEKMLSNIKEVKARGAW
CEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCEE
VLALTQEGNTAVAEEADAVLYLPPVPSILAPAVTVVPLQLLAYYTAVARGCDVDKPRNLA
EEEEECCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
KSVTVE
HHCCCC
>Mature Secondary Structure
MCGIVGYLGPRPAVPILVQGLERLEYRGYDSAGIAVLNGGGLVVEKSAGKLHVLKSRLNG
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCEEHHHHHHCC
NLAGARVGIGHTRWATHGRPSDVNAHPHLDCTGRIAVVHNGIIENYQELRQELAAKGHRF
CCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCHH
ISETDTEVLAHLVEEFYTGDLLQAVFKMLPVLRGSYALAVMSADHPRELVGARQDSPLIV
HHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHCCCCCCCEEE
GLAAGETYLASDIPALLPYTRDNYILENGEVAWITPGEVTVYDADGSRKSKEVFHVAWDL
EEECCCEEHHCCCHHHCCCCCCCEEEECCCEEEECCCEEEEEECCCCCCCCEEEEEEEEE
QAAEKGGYAHFMLKEIHEQPRALRDTLAGRLQDDGRVRLEGVNFTPEEAAALEKVAIIAC
EHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHEEEEEE
GTAHYAGMVGKYLLEKLLRLPVEDDVASEFRYREPILNEHTLGLVISQSGETADTLASLR
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHH
EAKKAGAPVLAITNVVGSSVAREADHVIYTWAGPEIAVASTKAYLTQVASLYLLALHLGE
HHHHCCCCEEEHHHHHHHHHHHCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHHHCC
KRSHAPWAQEIAGGLKDLPGQVEEVLKLEPRIKELAGRIAPHEHAFFIGRGLDYPVSLEG
CCCCCCHHHHHHCHHHCCCHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCCCC
SLKLKEISYLHAEAYAAGELKHGTLALIEEGTPVIALATQAELLEKMLSNIKEVKARGAW
CEEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHCCEE
VLALTQEGNTAVAEEADAVLYLPPVPSILAPAVTVVPLQLLAYYTAVARGCDVDKPRNLA
EEEEECCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
KSVTVE
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]