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The map label for this gene is gmk [H]

Identifier: 83590925

GI number: 83590925

Start: 2191451

End: 2192083

Strand: Reverse

Name: gmk [H]

Synonym: Moth_2099

Alternate gene names: 83590925

Gene position: 2192083-2191451 (Counterclockwise)

Preceding gene: 83590926

Following gene: 83590916

Centisome position: 83.39

GC content: 54.03

Gene sequence:

>633_bases
ATGGAAGAAGAGAGTAAACTTATTGACGGACTCATCATCAATTTTCAAACCCGGGACCGCAGGCCGAGGCCGGGCCTCTT
TTTCATCGTCTCCGGGCCATCCGGGGTGGGCAAGAACACCCTCCTCAACTATGCTCTTCCCAGGGTAGATGGGATTTATT
ACCTGCCTTCCATAACCACCCGGGCGATGCGTTCTGGGGAAACCCAGGGCGCGCCCTATTTTTTTGTCACCAAGGCTGAT
TTTGAAGCCTTAATAGCCGCAGGAGCTTTCCTGGAGTGGAAGAAGATCCATACCGGCGATTATTACGGCACCCACCTGCC
GACAATTACTTACGCCCTGGCCAACGGTTATGACATTATCACCGACATGGACGTCCTGGGATGTATGGAAGTCATGGAGC
GGTTTCCCGAAAATGTCGTTTCCATTTTTATCGCCCCGCCTGATCGGGAGGAACTGCGCCAGCGCCTGGCCGGGAGGGAA
AAGGACGCTTCTGTCGTCGCCAAAAGGCTGGAGCGGGTGGAAATGGAGATGGGCTATATGAAAAAATACCGGCACGTCAT
CGTCAATGACGATCTTGAACGTGCCGGCGGGGAACTGGTCCGGATCCTCCACAGCTACTCTGAACACAAGTAG

Upstream 100 bases:

>100_bases
GTTTGAGAAAAGTGGAATTGCCCCTGCGTATAAGGTATGGTAAAATGTATACACATTAGAGGACTATGTTTTCATAACTC
TTACGGTGTGATAAGCATTG

Downstream 100 bases:

>100_bases
GTATGGTTTAAATTCTGGTAGTCCACGACTAATATGGGGCCCGGAGGTGATTGCCTCTCCGGGCTTTTTGTTAGGGTAGC
GCCTCCTGCTGCAGTTGCCA

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MEEESKLIDGLIINFQTRDRRPRPGLFFIVSGPSGVGKNTLLNYALPRVDGIYYLPSITTRAMRSGETQGAPYFFVTKAD
FEALIAAGAFLEWKKIHTGDYYGTHLPTITYALANGYDIITDMDVLGCMEVMERFPENVVSIFIAPPDREELRQRLAGRE
KDASVVAKRLERVEMEMGYMKKYRHVIVNDDLERAGGELVRILHSYSEHK

Sequences:

>Translated_210_residues
MEEESKLIDGLIINFQTRDRRPRPGLFFIVSGPSGVGKNTLLNYALPRVDGIYYLPSITTRAMRSGETQGAPYFFVTKAD
FEALIAAGAFLEWKKIHTGDYYGTHLPTITYALANGYDIITDMDVLGCMEVMERFPENVVSIFIAPPDREELRQRLAGRE
KDASVVAKRLERVEMEMGYMKKYRHVIVNDDLERAGGELVRILHSYSEHK
>Mature_210_residues
MEEESKLIDGLIINFQTRDRRPRPGLFFIVSGPSGVGKNTLLNYALPRVDGIYYLPSITTRAMRSGETQGAPYFFVTKAD
FEALIAAGAFLEWKKIHTGDYYGTHLPTITYALANGYDIITDMDVLGCMEVMERFPENVVSIFIAPPDREELRQRLAGRE
KDASVVAKRLERVEMEMGYMKKYRHVIVNDDLERAGGELVRILHSYSEHK

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=190, Percent_Identity=35.7894736842105, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI226874833, Length=190, Percent_Identity=35.7894736842105, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI4504221, Length=190, Percent_Identity=35.7894736842105, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI38570142, Length=188, Percent_Identity=30.3191489361702, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1790080, Length=185, Percent_Identity=39.4594594594595, Blast_Score=123, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI193203132, Length=189, Percent_Identity=31.2169312169312, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17508835, Length=189, Percent_Identity=31.2169312169312, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320662, Length=176, Percent_Identity=38.0681818181818, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356141, Length=173, Percent_Identity=34.6820809248555, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23899; Mature: 23899

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEESKLIDGLIINFQTRDRRPRPGLFFIVSGPSGVGKNTLLNYALPRVDGIYYLPSITT
CCCHHHHHHHEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEECCCHHH
RAMRSGETQGAPYFFVTKADFEALIAAGAFLEWKKIHTGDYYGTHLPTITYALANGYDII
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCEEEE
TDMDVLGCMEVMERFPENVVSIFIAPPDREELRQRLAGREKDASVVAKRLERVEMEMGYM
HHHHHHHHHHHHHHCCHHEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KKYRHVIVNDDLERAGGELVRILHSYSEHK
HHHCEEEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEEESKLIDGLIINFQTRDRRPRPGLFFIVSGPSGVGKNTLLNYALPRVDGIYYLPSITT
CCCHHHHHHHEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEECCCHHH
RAMRSGETQGAPYFFVTKADFEALIAAGAFLEWKKIHTGDYYGTHLPTITYALANGYDII
HHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHCCEEEE
TDMDVLGCMEVMERFPENVVSIFIAPPDREELRQRLAGREKDASVVAKRLERVEMEMGYM
HHHHHHHHHHHHHHCCHHEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
KKYRHVIVNDDLERAGGELVRILHSYSEHK
HHHCEEEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA