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The map label for this gene is yhaU [H]

Identifier: 83590894

GI number: 83590894

Start: 2157647

End: 2158873

Strand: Reverse

Name: yhaU [H]

Synonym: Moth_2065

Alternate gene names: 83590894

Gene position: 2158873-2157647 (Counterclockwise)

Preceding gene: 83590895

Following gene: 83590893

Centisome position: 82.12

GC content: 50.37

Gene sequence:

>1227_bases
ATGCCCGAACAGGTGCTCCTTGAAATCGGGCTAGCATTAGCTATCGTAGCTTTTGCCGGGATCCTTGCCGCCAGGTTCCG
CGTTTCTATTGTACCGCTCTTGATCCTTGCCGGTATGGTTGTCGGCCCTCATGCGCCGGTAATTGGTATCCTGGATTTTC
GCTTTATTAAAAGCGCGCCTTTAATAGATTTTATGGGGCGGGTAGGGATACTCTTTCTCCTTTTCAGCCTCGGCCTGGAG
TTTTCCGTCGGGAGATTATTAAAGGCAGGCCGTTCTATACTGGTGGGCGGGTCCATCTATATGGCCATAAATTTTACCCT
GGGCATGGTTCTACCTATAATTTGGGGTTGGCCGTTGCGGGAAACCCTGGTGGTAGCCGGGCTTATTTCTATTTCCTCAA
GCGCCATTGTTGCCAAGGTTCTGGTTGACCTAAAGCGAACGGCACGGCCGGAAACCGAGATGATCCTGGGGCTTATGTTA
TTCCAGGACGTATTCGTAGCAGTGTATCTATCCATCATTTCCGGTCTGGTCCTTACAGGTTCGGCCTCACCGGCGAGCGT
GTTGAAATCTACCTCCCTTGCCCTGGGATTTATGCTGGGCTTAATTCTCGCCGGCCGCAAACTGGCACCGTTAATTAACA
GGCTGCTTAACGTTCCTTCCGATGAAGTTTTTATGCTCATAGTCTTTGCTTTCCTCACCCTGGTAGCCGGTTTTTCAGAG
ACTATCCATGTGGCGGAAGCTATTGGCGCCTTGCTGGTGGGTTTAATTTTAGCCGAGACAGACCATCTCGACCGCATCGA
GCATATTGTCGTGCCGTTCCGTGATTTTTTCGGGGCCCTGTTTTTTTTCAGCTTCGGTTTGAGCATCGACCCTTTAACCT
TGGGAGGGGCCGTCGGGCCGGTTTTGACTGCCGTAGCGGCAACATTAACAGGCAATTTTCTTGCTGGTATTCTTGCCGGA
CGAATGGCCGGTTATTCGTACCGGGGGTGTACCAATATCGGGCTTACTATTACTCCCCGCGGAGAATTTTCTATCATCCT
CGCCAATCTGGCGAAGACCGGCGGATTACTGCCGGTGCTACAACCCTTCGCAGCCCTGTATGTGTTGCTTATGGCTATTC
TGGGTCCTTTACTTACGAAAGAATCTAAATGGATATACAACCAACTGGCTCACATCTTTGGTTGGCCTGCCTGGAAAGAG
ATAAATAAACCCGATAGAACGATATAA

Upstream 100 bases:

>100_bases
CGGAAGAAATCATCACCCCGGGAGCAACAATTGTGGTTTTAGGGGACAGGAAGCAGGTAAAGGCTTGTAAAGAGCTGATT
TTGCACGGGGGGATATAGTT

Downstream 100 bases:

>100_bases
TTAAGAGGAGACTTGGATAGGCTCCTTATTAAGGTCGACCAGGTTGATTTTACCGACATCGTAGGCGGCAAAAGAAAGAC
CGGCAAACCGAATTTACTCC

Product: Sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 408; Mature: 407

Protein sequence:

>408_residues
MPEQVLLEIGLALAIVAFAGILAARFRVSIVPLLILAGMVVGPHAPVIGILDFRFIKSAPLIDFMGRVGILFLLFSLGLE
FSVGRLLKAGRSILVGGSIYMAINFTLGMVLPIIWGWPLRETLVVAGLISISSSAIVAKVLVDLKRTARPETEMILGLML
FQDVFVAVYLSIISGLVLTGSASPASVLKSTSLALGFMLGLILAGRKLAPLINRLLNVPSDEVFMLIVFAFLTLVAGFSE
TIHVAEAIGALLVGLILAETDHLDRIEHIVVPFRDFFGALFFFSFGLSIDPLTLGGAVGPVLTAVAATLTGNFLAGILAG
RMAGYSYRGCTNIGLTITPRGEFSIILANLAKTGGLLPVLQPFAALYVLLMAILGPLLTKESKWIYNQLAHIFGWPAWKE
INKPDRTI

Sequences:

>Translated_408_residues
MPEQVLLEIGLALAIVAFAGILAARFRVSIVPLLILAGMVVGPHAPVIGILDFRFIKSAPLIDFMGRVGILFLLFSLGLE
FSVGRLLKAGRSILVGGSIYMAINFTLGMVLPIIWGWPLRETLVVAGLISISSSAIVAKVLVDLKRTARPETEMILGLML
FQDVFVAVYLSIISGLVLTGSASPASVLKSTSLALGFMLGLILAGRKLAPLINRLLNVPSDEVFMLIVFAFLTLVAGFSE
TIHVAEAIGALLVGLILAETDHLDRIEHIVVPFRDFFGALFFFSFGLSIDPLTLGGAVGPVLTAVAATLTGNFLAGILAG
RMAGYSYRGCTNIGLTITPRGEFSIILANLAKTGGLLPVLQPFAALYVLLMAILGPLLTKESKWIYNQLAHIFGWPAWKE
INKPDRTI
>Mature_407_residues
PEQVLLEIGLALAIVAFAGILAARFRVSIVPLLILAGMVVGPHAPVIGILDFRFIKSAPLIDFMGRVGILFLLFSLGLEF
SVGRLLKAGRSILVGGSIYMAINFTLGMVLPIIWGWPLRETLVVAGLISISSSAIVAKVLVDLKRTARPETEMILGLMLF
QDVFVAVYLSIISGLVLTGSASPASVLKSTSLALGFMLGLILAGRKLAPLINRLLNVPSDEVFMLIVFAFLTLVAGFSET
IHVAEAIGALLVGLILAETDHLDRIEHIVVPFRDFFGALFFFSFGLSIDPLTLGGAVGPVLTAVAATLTGNFLAGILAGR
MAGYSYRGCTNIGLTITPRGEFSIILANLAKTGGLLPVLQPFAALYVLLMAILGPLLTKESKWIYNQLAHIFGWPAWKEI
NKPDRTI

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=284, Percent_Identity=25.7042253521127, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1786685, Length=359, Percent_Identity=30.3621169916435, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1789749, Length=389, Percent_Identity=24.4215938303342, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786232, Length=294, Percent_Identity=26.8707482993197, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 43622; Mature: 43491

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEQVLLEIGLALAIVAFAGILAARFRVSIVPLLILAGMVVGPHAPVIGILDFRFIKSAP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCC
LIDFMGRVGILFLLFSLGLEFSVGRLLKAGRSILVGGSIYMAINFTLGMVLPIIWGWPLR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCEEEEEHHHHHHHHHHHHCCCCHH
ETLVVAGLISISSSAIVAKVLVDLKRTARPETEMILGLMLFQDVFVAVYLSIISGLVLTG
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
SASPASVLKSTSLALGFMLGLILAGRKLAPLINRLLNVPSDEVFMLIVFAFLTLVAGFSE
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
TIHVAEAIGALLVGLILAETDHLDRIEHIVVPFRDFFGALFFFSFGLSIDPLTLGGAVGP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHH
VLTAVAATLTGNFLAGILAGRMAGYSYRGCTNIGLTITPRGEFSIILANLAKTGGLLPVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHH
QPFAALYVLLMAILGPLLTKESKWIYNQLAHIFGWPAWKEINKPDRTI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHCCCCCCCC
>Mature Secondary Structure 
PEQVLLEIGLALAIVAFAGILAARFRVSIVPLLILAGMVVGPHAPVIGILDFRFIKSAP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCC
LIDFMGRVGILFLLFSLGLEFSVGRLLKAGRSILVGGSIYMAINFTLGMVLPIIWGWPLR
HHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEECCEEEEEHHHHHHHHHHHHCCCCHH
ETLVVAGLISISSSAIVAKVLVDLKRTARPETEMILGLMLFQDVFVAVYLSIISGLVLTG
HHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
SASPASVLKSTSLALGFMLGLILAGRKLAPLINRLLNVPSDEVFMLIVFAFLTLVAGFSE
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHH
TIHVAEAIGALLVGLILAETDHLDRIEHIVVPFRDFFGALFFFSFGLSIDPLTLGGAVGP
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHH
VLTAVAATLTGNFLAGILAGRMAGYSYRGCTNIGLTITPRGEFSIILANLAKTGGLLPVL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHH
QPFAALYVLLMAILGPLLTKESKWIYNQLAHIFGWPAWKEINKPDRTI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]