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The map label for this gene is purE [H]

Identifier: 83590883

GI number: 83590883

Start: 2145065

End: 2145589

Strand: Reverse

Name: purE [H]

Synonym: Moth_2053

Alternate gene names: 83590883

Gene position: 2145589-2145065 (Counterclockwise)

Preceding gene: 83590884

Following gene: 83590882

Centisome position: 81.62

GC content: 64.38

Gene sequence:

>525_bases
ATGAACCTGGCACATGTTGGTATTGTTATGGGCAGCGACTCCGACCTGCCAATTATGGCCCGGGCAGCGGCCATGCTGGA
CCGTTTCCAGATTCCTTATGAAGTAAGAATCCTCTCGGCCCACCGTTCCCCGGACGCCGCCCTGGATTACGCCCGCAATG
CTGCCGGCCGGGGGCTCAAAGTCATTATCGCCGGCGCCGGGGGCGCGGCCCACCTGGCCGGCGTCCTGGCCGCAGTCACC
ACCCTACCGGTAATCGGCGTCCCCATCCGCACGGCGGCCCTGGGCGGCGTCGATTCCCTCTATGCCATGGTCCAGATGCC
CCGGGGCATCCCGGTGGCCACGGTGGCCATTGACGGCGCAACCAACGCCGCCATACTCGCGGCCCAGATCCTGGCCGTCC
ACAATGACGCCCTTCAGGAGCGGCTGGCGGCCTATAAGCAGGAACTGGCCCAGGAAGTGGCGGTCAAAGATGCCCGGCTG
GCGCAACTGGGTATTGAAGGTTATCTGGGGGAGGAGAAAAAATGA

Upstream 100 bases:

>100_bases
CGGTGAGAGTTAAATTATATTTAAATACAGGGTGGTAGCAAAAAGGATAGAGGGGGCTGATCAAATAGATGCTAAAATAT
AGGGAAGGAGAAGAAATTTG

Downstream 100 bases:

>100_bases
TCGAGCGCTATACCCTGCCGGAAATGGGTAAAATTTGGGAACCGGAGCACAAGTTCCGCACCTGGCTGGCCATTGAGATC
TATGCCTGCGAGGCCTGGGC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MNLAHVGIVMGSDSDLPIMARAAAMLDRFQIPYEVRILSAHRSPDAALDYARNAAGRGLKVIIAGAGGAAHLAGVLAAVT
TLPVIGVPIRTAALGGVDSLYAMVQMPRGIPVATVAIDGATNAAILAAQILAVHNDALQERLAAYKQELAQEVAVKDARL
AQLGIEGYLGEEKK

Sequences:

>Translated_174_residues
MNLAHVGIVMGSDSDLPIMARAAAMLDRFQIPYEVRILSAHRSPDAALDYARNAAGRGLKVIIAGAGGAAHLAGVLAAVT
TLPVIGVPIRTAALGGVDSLYAMVQMPRGIPVATVAIDGATNAAILAAQILAVHNDALQERLAAYKQELAQEVAVKDARL
AQLGIEGYLGEEKK
>Mature_174_residues
MNLAHVGIVMGSDSDLPIMARAAAMLDRFQIPYEVRILSAHRSPDAALDYARNAAGRGLKVIIAGAGGAAHLAGVLAAVT
TLPVIGVPIRTAALGGVDSLYAMVQMPRGIPVATVAIDGATNAAILAAQILAVHNDALQERLAAYKQELAQEVAVKDARL
AQLGIEGYLGEEKK

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=142, Percent_Identity=32.3943661971831, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI5453539, Length=142, Percent_Identity=32.3943661971831, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI119220559, Length=142, Percent_Identity=32.3943661971831, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786734, Length=154, Percent_Identity=53.2467532467532, Blast_Score=136, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6324702, Length=164, Percent_Identity=53.6585365853659, Blast_Score=182, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 18013; Mature: 18013

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLAHVGIVMGSDSDLPIMARAAAMLDRFQIPYEVRILSAHRSPDAALDYARNAAGRGLK
CCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCEE
VIIAGAGGAAHLAGVLAAVTTLPVIGVPIRTAALGGVDSLYAMVQMPRGIPVATVAIDGA
EEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCC
TNAAILAAQILAVHNDALQERLAAYKQELAQEVAVKDARLAQLGIEGYLGEEKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNLAHVGIVMGSDSDLPIMARAAAMLDRFQIPYEVRILSAHRSPDAALDYARNAAGRGLK
CCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCCCCEE
VIIAGAGGAAHLAGVLAAVTTLPVIGVPIRTAALGGVDSLYAMVQMPRGIPVATVAIDGA
EEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCC
TNAAILAAQILAVHNDALQERLAAYKQELAQEVAVKDARLAQLGIEGYLGEEKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]