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The map label for this gene is cysK [H]

Identifier: 83590830

GI number: 83590830

Start: 2086328

End: 2087686

Strand: Reverse

Name: cysK [H]

Synonym: Moth_2000

Alternate gene names: 83590830

Gene position: 2087686-2086328 (Counterclockwise)

Preceding gene: 83590831

Following gene: 83590829

Centisome position: 79.42

GC content: 55.7

Gene sequence:

>1359_bases
ATGGCGGGCAAGATTCCCTTTGGCCCCACCTTTGCCGAAATGGCTGATCCGTCGCTGATCGATCCGGCCCTGCGGCAAAG
GGCCCTGAAGGCTCTCAAGGAGGATGAACTGGATCCTGTTAACCTCTTCAACATTACCTGGAAGGACGCCAACAACCAGG
TAAGAAAGATGGTCCTGCCTCCCGAGGTGACCGGGGTTGATGCCAATATCGTCGTTCTCCTGGGGCGAGGCTTCCCATCC
GGTTCCCATAAGGTTGGCCCGGCCTACGCTACTTTGATTGAAGGCTGTGTTGACGGCGTCATCAAGCCCGGCGAGCATAC
CATCCTGGGACCTTCCACGGGCAATTTCGGCATCGGTGTCGCCTATATCAGCAGGCTCCTCGGTTTCCGGGCGATAGTTA
TTATGCCCGACAACATGAGCAAGGAACGCTACGAGCGCATTCGTAAATACGGCGGCGAACTGGACCTGACCCCAGGTACC
GAGTCCGACGTCATCCTGACCCTGCAGCGGACCTATGAATTAAAGAAAGATCCCAAGAACTTTGCCCTGGCCCAGTTTGA
ACTCCTGCCCAATTACCGCTTCCACCGGCATGTGACCGGTAATGCCGCCATCGAAGCCGTGCAGGGCATCGGTAACGGCC
GTATTGCCGCCTTTACCTCGGCGCCCGGTTCAGCAGGGACCCTGGGTGCCGGCGACCAGATTAAGAAGGTTTTCCCCGAG
TGTAAAGTCGCAGCCCTGGAGCCCTATGAGTGCTCCACCCTCTATAATGGCGGTCGCGGCCAGCACCGCATCGAGGGTAT
CGGCGATAAGATGTGCACCCTCATCCACAATGTCTTGAATACCGACTTTATCGTCCTGATCCATGACGAGGATACCGTCC
GCGGCTTGAAGGTCTTCCAGGATGGGACGGAGACCTTGATCAAGATGGGGGTCAAAGAGGCCGACGCCCTGGCCCTGCGG
GATAACTTCGGTCCCTCCGGTATCTGCAACATCCTGGGGGCTATTAAAATAGCCAAGTACCTGCGCCTTGGTCCCGGTGA
CAATGTAGTTACCGTAGCTACTGACGGCTTTGATCGTTATCCTTCGGTACTGGAAAACCTGGCCGAACGTACCCTGGAGA
TTGAGGACTTTGTCCTGGAGCGCTGGTTTAATGACATTTTCCTCAAGGCCAGCACCCATTATATTGTTGATACCCGCAAG
CCGGAAGCCAAGGAACGCCTCTTCCAGCAGAAGGAAAAAGACTGGTTGCCCTTCGGGTATACCAGGGAATACCTTGACTC
CATGAAGAGCCAGTCCTTCTGGGACGACGAGTACGCCAAGATTGAATACTACGACGCCAAGATTAAAGAGATGCGCTAG

Upstream 100 bases:

>100_bases
TCCCAGAAGGAGGGTTTATTTTATACATGTCGAACTATACAATAAGTGTGGATGAAGTTTTTTGCATTCAGTAACATTAC
ATTTAACTGGAGGGATTTAT

Downstream 100 bases:

>100_bases
GGAAGCTTTGAGAGATACAATTTAACGGGGGATATGTCCCGGTGCGAGCCAGGTCATAGTGACCAGGGGCATATCCCATC
CGTGTATTTTCAGGGGGAAT

Product: pyridoxal-5'-phosphate-dependent enzyme, beta subunit

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MAGKIPFGPTFAEMADPSLIDPALRQRALKALKEDELDPVNLFNITWKDANNQVRKMVLPPEVTGVDANIVVLLGRGFPS
GSHKVGPAYATLIEGCVDGVIKPGEHTILGPSTGNFGIGVAYISRLLGFRAIVIMPDNMSKERYERIRKYGGELDLTPGT
ESDVILTLQRTYELKKDPKNFALAQFELLPNYRFHRHVTGNAAIEAVQGIGNGRIAAFTSAPGSAGTLGAGDQIKKVFPE
CKVAALEPYECSTLYNGGRGQHRIEGIGDKMCTLIHNVLNTDFIVLIHDEDTVRGLKVFQDGTETLIKMGVKEADALALR
DNFGPSGICNILGAIKIAKYLRLGPGDNVVTVATDGFDRYPSVLENLAERTLEIEDFVLERWFNDIFLKASTHYIVDTRK
PEAKERLFQQKEKDWLPFGYTREYLDSMKSQSFWDDEYAKIEYYDAKIKEMR

Sequences:

>Translated_452_residues
MAGKIPFGPTFAEMADPSLIDPALRQRALKALKEDELDPVNLFNITWKDANNQVRKMVLPPEVTGVDANIVVLLGRGFPS
GSHKVGPAYATLIEGCVDGVIKPGEHTILGPSTGNFGIGVAYISRLLGFRAIVIMPDNMSKERYERIRKYGGELDLTPGT
ESDVILTLQRTYELKKDPKNFALAQFELLPNYRFHRHVTGNAAIEAVQGIGNGRIAAFTSAPGSAGTLGAGDQIKKVFPE
CKVAALEPYECSTLYNGGRGQHRIEGIGDKMCTLIHNVLNTDFIVLIHDEDTVRGLKVFQDGTETLIKMGVKEADALALR
DNFGPSGICNILGAIKIAKYLRLGPGDNVVTVATDGFDRYPSVLENLAERTLEIEDFVLERWFNDIFLKASTHYIVDTRK
PEAKERLFQQKEKDWLPFGYTREYLDSMKSQSFWDDEYAKIEYYDAKIKEMR
>Mature_451_residues
AGKIPFGPTFAEMADPSLIDPALRQRALKALKEDELDPVNLFNITWKDANNQVRKMVLPPEVTGVDANIVVLLGRGFPSG
SHKVGPAYATLIEGCVDGVIKPGEHTILGPSTGNFGIGVAYISRLLGFRAIVIMPDNMSKERYERIRKYGGELDLTPGTE
SDVILTLQRTYELKKDPKNFALAQFELLPNYRFHRHVTGNAAIEAVQGIGNGRIAAFTSAPGSAGTLGAGDQIKKVFPEC
KVAALEPYECSTLYNGGRGQHRIEGIGDKMCTLIHNVLNTDFIVLIHDEDTVRGLKVFQDGTETLIKMGVKEADALALRD
NFGPSGICNILGAIKIAKYLRLGPGDNVVTVATDGFDRYPSVLENLAERTLEIEDFVLERWFNDIFLKASTHYIVDTRKP
EAKERLFQQKEKDWLPFGYTREYLDSMKSQSFWDDEYAKIEYYDAKIKEMR

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=301, Percent_Identity=25.2491694352159, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI295821200, Length=301, Percent_Identity=25.2491694352159, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI4557415, Length=301, Percent_Identity=25.2491694352159, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI2367138, Length=295, Percent_Identity=30.8474576271186, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562970, Length=205, Percent_Identity=31.7073170731707, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI32566674, Length=205, Percent_Identity=31.7073170731707, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17535051, Length=267, Percent_Identity=29.2134831460674, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115535073, Length=258, Percent_Identity=28.6821705426357, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17561720, Length=301, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321594, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24643623, Length=177, Percent_Identity=29.3785310734463, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20129101, Length=177, Percent_Identity=29.3785310734463, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 50301; Mature: 50170

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGKIPFGPTFAEMADPSLIDPALRQRALKALKEDELDPVNLFNITWKDANNQVRKMVLP
CCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEECC
PEVTGVDANIVVLLGRGFPSGSHKVGPAYATLIEGCVDGVIKPGEHTILGPSTGNFGIGV
CCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHH
AYISRLLGFRAIVIMPDNMSKERYERIRKYGGELDLTPGTESDVILTLQRTYELKKDPKN
HHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCEEEEEEEHHHHHCCCCH
FALAQFELLPNYRFHRHVTGNAAIEAVQGIGNGRIAAFTSAPGSAGTLGAGDQIKKVFPE
HEEEEEEECCCCCEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCC
CKVAALEPYECSTLYNGGRGQHRIEGIGDKMCTLIHNVLNTDFIVLIHDEDTVRGLKVFQ
CCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
DGTETLIKMGVKEADALALRDNFGPSGICNILGAIKIAKYLRLGPGDNVVTVATDGFDRY
HHHHHHHHHCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
PSVLENLAERTLEIEDFVLERWFNDIFLKASTHYIVDTRKPEAKERLFQQKEKDWLPFGY
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCHHHHHHHHHHHCCCCCCCC
TREYLDSMKSQSFWDDEYAKIEYYDAKIKEMR
HHHHHHHHHCCCCCCCCCCEEEEECCHHHCCC
>Mature Secondary Structure 
AGKIPFGPTFAEMADPSLIDPALRQRALKALKEDELDPVNLFNITWKDANNQVRKMVLP
CCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEECC
PEVTGVDANIVVLLGRGFPSGSHKVGPAYATLIEGCVDGVIKPGEHTILGPSTGNFGIGV
CCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHH
AYISRLLGFRAIVIMPDNMSKERYERIRKYGGELDLTPGTESDVILTLQRTYELKKDPKN
HHHHHHHCCEEEEEECCCCCHHHHHHHHHCCCEEECCCCCCCCEEEEEEEHHHHHCCCCH
FALAQFELLPNYRFHRHVTGNAAIEAVQGIGNGRIAAFTSAPGSAGTLGAGDQIKKVFPE
HEEEEEEECCCCCEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHHCCC
CKVAALEPYECSTLYNGGRGQHRIEGIGDKMCTLIHNVLNTDFIVLIHDEDTVRGLKVFQ
CCEEEECCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
DGTETLIKMGVKEADALALRDNFGPSGICNILGAIKIAKYLRLGPGDNVVTVATDGFDRY
HHHHHHHHHCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
PSVLENLAERTLEIEDFVLERWFNDIFLKASTHYIVDTRKPEAKERLFQQKEKDWLPFGY
HHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEECCCCHHHHHHHHHHHCCCCCCCC
TREYLDSMKSQSFWDDEYAKIEYYDAKIKEMR
HHHHHHHHHCCCCCCCCCCEEEEECCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA