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The map label for this gene is cofH [H]

Identifier: 83590680

GI number: 83590680

Start: 1904263

End: 1905384

Strand: Reverse

Name: cofH [H]

Synonym: Moth_1846

Alternate gene names: 83590680

Gene position: 1905384-1904263 (Counterclockwise)

Preceding gene: 83590681

Following gene: 83590679

Centisome position: 72.48

GC content: 60.07

Gene sequence:

>1122_bases
TTGCCCACCACCACGGCAGAATTTATACGCCGGGAGCTCTCCCGGGGGGAACTGGCGGACATAGCTGCCAGGGTATATGC
CGGGGAAAGGCTGACCCGGGAGGACGGTATACGTCTCTGGGAGAGTCAGGACCTCCTTGGTATTGGCTACCTGGCCGACC
TGGCCCGGCAGCGGACCTGCGGTGATACCGTATATTTTATTAATAATGCCCACATCAATTATACCAATATCTGTCAAAAT
CTCTGCGATTTATGTGCCTTTGGGAGACAGACAGGTACTCCGGGGGCTTATACCCTCACCCTGGCGGAGATTGAAGCGAA
GGCCAGGGCGGCGGCTGCCGCAGGTGTCACCGAGATCCATATTGTCGGCGGCCTGAATCCGGAATTACCCTATGATTACT
ACCTGGAACTAATCCGAACCGTGCGCCGGGCGGCACCCGGGGCCTGCATCCAGGCCTTTGACGCTGTGGAAATTGACTTT
ATAGCCTCCCGGGCCGGGCGCCCCGTAGCTGACGTCCTCCAGGAACTCCGGCAGGCGGGCCTGGACTCCCTTCCCGGGGG
TGGGGCCGAAGTTTTTGCCCCGGAGGTGCGCCGGCGCCTTTGCGCCAAAAAGATCGATGGACAGCGATGGCTCCAGATCC
ACGAGACGGCCCACCGGCTGGGCATACCCACCAACGCTACCATGCTCTACGGCCACCTGGAGACGGCAGCCGACCGGGTG
GATCACCTCCTGGCCCTCCGGGAACTCCAGGACCGGACAGGGGGCTTCCTGGCTTTTATTCCCCTGGCCTTTCACCCGGC
CAACACGGCCTTCAGCAACCTGCCGGGAACCACCGGCGTAGATGACTTGAAGATGTTGGCCATCAGCCGCCTGCTTCTGG
ACAACTTCCGTCACATCAAAGCCTTCTGGATTATGATTGGGCCGAAGTTAGCCCAGGTGGCCCTGCATTTTGGGGTAAAC
GACCTGGACGGTACCGTCCGGGAAGAGCATATCTTTCACGACGCCGGGGCTGAAACGCCCCAGTACCAGCCTGCTGAAAG
CTTTTTACAGAGTATCCGGGCGGCCGGCCGGATCCCGGTGGAAAGGGATACTTTATACCGGGAAATCCGCCGCTATGCCT
GA

Upstream 100 bases:

>100_bases
CCCTGGACAGCGATTGCGGCTGCGCCGACCTGCGCAAGCCGACTCTTTTACGCCCGGAAAATATCGGCAAGCACCCCTTA
TGAAAGGAGTGGGAAAGGCC

Downstream 100 bases:

>100_bases
AAAGGAGGATAGCTATGGACTGGCCCCGGCTGGGACGGGTGGGTTACCTGAACTGCCTGCCCCTGTTTTACCCCCTGGAG
ACAGGGCGGGTAAAATTACC

Product: hypothetical protein

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MPTTTAEFIRRELSRGELADIAARVYAGERLTREDGIRLWESQDLLGIGYLADLARQRTCGDTVYFINNAHINYTNICQN
LCDLCAFGRQTGTPGAYTLTLAEIEAKARAAAAAGVTEIHIVGGLNPELPYDYYLELIRTVRRAAPGACIQAFDAVEIDF
IASRAGRPVADVLQELRQAGLDSLPGGGAEVFAPEVRRRLCAKKIDGQRWLQIHETAHRLGIPTNATMLYGHLETAADRV
DHLLALRELQDRTGGFLAFIPLAFHPANTAFSNLPGTTGVDDLKMLAISRLLLDNFRHIKAFWIMIGPKLAQVALHFGVN
DLDGTVREEHIFHDAGAETPQYQPAESFLQSIRAAGRIPVERDTLYREIRRYA

Sequences:

>Translated_373_residues
MPTTTAEFIRRELSRGELADIAARVYAGERLTREDGIRLWESQDLLGIGYLADLARQRTCGDTVYFINNAHINYTNICQN
LCDLCAFGRQTGTPGAYTLTLAEIEAKARAAAAAGVTEIHIVGGLNPELPYDYYLELIRTVRRAAPGACIQAFDAVEIDF
IASRAGRPVADVLQELRQAGLDSLPGGGAEVFAPEVRRRLCAKKIDGQRWLQIHETAHRLGIPTNATMLYGHLETAADRV
DHLLALRELQDRTGGFLAFIPLAFHPANTAFSNLPGTTGVDDLKMLAISRLLLDNFRHIKAFWIMIGPKLAQVALHFGVN
DLDGTVREEHIFHDAGAETPQYQPAESFLQSIRAAGRIPVERDTLYREIRRYA
>Mature_372_residues
PTTTAEFIRRELSRGELADIAARVYAGERLTREDGIRLWESQDLLGIGYLADLARQRTCGDTVYFINNAHINYTNICQNL
CDLCAFGRQTGTPGAYTLTLAEIEAKARAAAAAGVTEIHIVGGLNPELPYDYYLELIRTVRRAAPGACIQAFDAVEIDFI
ASRAGRPVADVLQELRQAGLDSLPGGGAEVFAPEVRRRLCAKKIDGQRWLQIHETAHRLGIPTNATMLYGHLETAADRVD
HLLALRELQDRTGGFLAFIPLAFHPANTAFSNLPGTTGVDDLKMLAISRLLLDNFRHIKAFWIMIGPKLAQVALHFGVND
LDGTVREEHIFHDAGAETPQYQPAESFLQSIRAAGRIPVERDTLYREIRRYA

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR019940
- InterPro:   IPR006638
- InterPro:   IPR020050
- InterPro:   IPR005244
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41307; Mature: 41175

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTTAEFIRRELSRGELADIAARVYAGERLTREDGIRLWESQDLLGIGYLADLARQRTC
CCCCHHHHHHHHHCCCHHHHHHHHHHHCCHHCHHHCCEEECCCCCHHHHHHHHHHHHHCC
GDTVYFINNAHINYTNICQNLCDLCAFGRQTGTPGAYTLTLAEIEAKARAAAAAGVTEIH
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEE
IVGGLNPELPYDYYLELIRTVRRAAPGACIQAFDAVEIDFIASRAGRPVADVLQELRQAG
EEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCC
LDSLPGGGAEVFAPEVRRRLCAKKIDGQRWLQIHETAHRLGIPTNATMLYGHLETAADRV
CCCCCCCCCHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHH
DHLLALRELQDRTGGFLAFIPLAFHPANTAFSNLPGTTGVDDLKMLAISRLLLDNFRHIK
HHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AFWIMIGPKLAQVALHFGVNDLDGTVREEHIFHDAGAETPQYQPAESFLQSIRAAGRIPV
HHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCC
ERDTLYREIRRYA
HHHHHHHHHHHCC
>Mature Secondary Structure 
PTTTAEFIRRELSRGELADIAARVYAGERLTREDGIRLWESQDLLGIGYLADLARQRTC
CCCHHHHHHHHHCCCHHHHHHHHHHHCCHHCHHHCCEEECCCCCHHHHHHHHHHHHHCC
GDTVYFINNAHINYTNICQNLCDLCAFGRQTGTPGAYTLTLAEIEAKARAAAAAGVTEIH
CCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCEEEE
IVGGLNPELPYDYYLELIRTVRRAAPGACIQAFDAVEIDFIASRAGRPVADVLQELRQAG
EEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHCC
LDSLPGGGAEVFAPEVRRRLCAKKIDGQRWLQIHETAHRLGIPTNATMLYGHLETAADRV
CCCCCCCCCHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHH
DHLLALRELQDRTGGFLAFIPLAFHPANTAFSNLPGTTGVDDLKMLAISRLLLDNFRHIK
HHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AFWIMIGPKLAQVALHFGVNDLDGTVREEHIFHDAGAETPQYQPAESFLQSIRAAGRIPV
HHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCC
ERDTLYREIRRYA
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]