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The map label for this gene is polX [H]

Identifier: 83590583

GI number: 83590583

Start: 1801134

End: 1803086

Strand: Reverse

Name: polX [H]

Synonym: Moth_1748

Alternate gene names: 83590583

Gene position: 1803086-1801134 (Counterclockwise)

Preceding gene: 83590584

Following gene: 83590582

Centisome position: 68.59

GC content: 66.1

Gene sequence:

>1953_bases
TTGACCAACCTGGAGCTGGCCTGGGCCCTGGCGGAAATGGGCGACTTGCTGGAGTTAAAGGGGGAGGAGCCCTTTAAGGT
GCGGGCCTACCATCGTGCCGCCCGTTCCCTGGAGAACCTGGAGGAAGAGGCGGCCGATCTATACGCCCGCGGCGCCCTGG
AGGAGATACCCGGCGTGGGCAAGAACCTGGCCAAAAAGCTCGCCGAACTCCTGACTACAGGCCGCTCTACCTTTCTCGAC
AATCTCCGCCGGGAAGTGCCGCCGGGCCTGCGGGAGATGCTGGCCATCCCGGGGCTGGGCAGCCGTACCGTCCGCCAGAT
TCACCAGGGACTGGGGATTACGACCCTGGCTGAGCTGGAACAGGCGGCCCGGGAGAGGCGCATCCGCACCCTGCCGGGTC
TGGGCAGCAAGACGGAACTGGCCATTCTGCGGGGGCTGGAGATGCTGCGGGAGGTCCAGGACCGGGTACCCCTGGGGGTG
GCCCGGCCCCTGGCCCTGTTGTTGCGGGCTCAACTCCTGGCCCTGCCGGGGGTGGTCCGGGCGGAAATAGCCGGGAGCGT
CCGCCGCGGTAAAGAAATGGTGGGGGATATTGATCTGGTGGCCGCCGTCGAGCCGGACAACCAGGTGGCGGCAGTCCTGG
TCCGCCACCCCCAGGTCAAGGAAGTCCTGGCCAGGGAACCGGACCGCCTGGCCCTGCAGACGAACCTGGGCCTGAAGATC
GAAGTGATCATGGTTCCCCCGGAGGATTTCCCGGCCACCCTCTTTTATGCCACCGGGTCAAAGGCGCATCGCCGGGCCCT
GCTTCGCCTGGCCGCCGAAAGAGGCCTTGGGGCGGCCGACCTGGGCCTGGTTACCCCGCGCTGGCTGGCCGAGGAGGAGG
ACGTGCTGGCCGGGGGAACTACGGAAGCCCCGGGAAAGGGCGGCGGGTCCCATGGGGAAGCAGCTGCCGCCTTTGCAACA
TCCGGGGCGACGGCTAAGGAGGATACCCCCGGGGTCGCCGGCGGTGCTCCTGGTACCGGCGTCCCCCCTGCACACGCCGG
CGCACCCCTTACACATGCCGGTACCGGGACCAATGCACGGGAAGAACACGCCGGGGTGAGGGAGCCGGTTGAAGCTGCCT
TTTACCAGCGCCTGGGTTTACCTTACATCGTCCCCGAACTCCGGGAAGACCGGGGAGAGCTCGCAGCCGCCCGGCGGGGG
GAACTGCCCCACCTTGTTACCCTCGCCGATATCCGTGGCGACCTGCATATGCACAGCCGCTACAGCGACGGAGTGGAGAC
CATTGCCGCCATGGCCGCGGCAGCCAGGGCCAGGGGCTACCAGTATATCGCCATCACCGACCACTCCCGCTCCCTGACGG
TGGCCCGGGGCCTGAGCCTTGAACAGTTAAAGGCCCAGCGGGAAGAGATTGCCCGCCTGAATGAGGAACTGGAAGGCATC
ACCATCCTGGCCGGGATCGAAGTGGACATCCTGGCCGACGGCCGCCTGGACTACGAAGATGAGGTTTTAAAGGAATTCGA
TCTGGTTATCGCCTCCATCCATTCCGGCTTCCGCCAGGAGAGGGAGCAAATCATGGCCCGCCTGGAAGCGGCCCTGCGCA
ACCCTTATGTGGATATCCTGGGACACCCCACCGGCCGCATGCTGGGCCGGCGGCAGCCCTACGCCGTAGATGTCAAGAGG
GTTATAGAACTGGCGGCGGAGACGGGGACCATCCTGGAGATCAACGCCAGCCCCGAACGGCTGGATCTAAACGATACCTC
GGCCCGCCTGGCCAAAGAATACGGCGTACCCATCGCCATTGATACCGATGCCCATGACCCTCACCGTCTCGCGGACATGG
AGTACGGCGTCCTCACCGCCCGGCGCGGTTGGCTGGAACCCGCGGACGTAGTCAACACCTGGGAACTGGAACGGCTGCTG
GCCGGGTTGAAGCGGAACAGGCACGGGGCGTAA

Upstream 100 bases:

>100_bases
AGGTGGCCGTCCTCGCCGCGTTGAATATTGCCGACGAGCTCTACAAAGTACAGCAGGATTACGACACCCTGGTGAAATTG
ATACAGGAGGAAAAACAGGG

Downstream 100 bases:

>100_bases
AACAGTATTTAAAAATAGAGGCCACCAGGTTAACCCTGGCGGCCTTTAACTTATGGCGGTAAACCCTGCACCTTTTGTCA
ACCCTGGAAATCATGGTATA

Product: PHP-like

Products: NA

Alternate protein names: DNA polymerase type-X; 3'-5' exodeoxyribonuclease; 3'-5' exonuclease [H]

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MTNLELAWALAEMGDLLELKGEEPFKVRAYHRAARSLENLEEEAADLYARGALEEIPGVGKNLAKKLAELLTTGRSTFLD
NLRREVPPGLREMLAIPGLGSRTVRQIHQGLGITTLAELEQAARERRIRTLPGLGSKTELAILRGLEMLREVQDRVPLGV
ARPLALLLRAQLLALPGVVRAEIAGSVRRGKEMVGDIDLVAAVEPDNQVAAVLVRHPQVKEVLAREPDRLALQTNLGLKI
EVIMVPPEDFPATLFYATGSKAHRRALLRLAAERGLGAADLGLVTPRWLAEEEDVLAGGTTEAPGKGGGSHGEAAAAFAT
SGATAKEDTPGVAGGAPGTGVPPAHAGAPLTHAGTGTNAREEHAGVREPVEAAFYQRLGLPYIVPELREDRGELAAARRG
ELPHLVTLADIRGDLHMHSRYSDGVETIAAMAAAARARGYQYIAITDHSRSLTVARGLSLEQLKAQREEIARLNEELEGI
TILAGIEVDILADGRLDYEDEVLKEFDLVIASIHSGFRQEREQIMARLEAALRNPYVDILGHPTGRMLGRRQPYAVDVKR
VIELAAETGTILEINASPERLDLNDTSARLAKEYGVPIAIDTDAHDPHRLADMEYGVLTARRGWLEPADVVNTWELERLL
AGLKRNRHGA

Sequences:

>Translated_650_residues
MTNLELAWALAEMGDLLELKGEEPFKVRAYHRAARSLENLEEEAADLYARGALEEIPGVGKNLAKKLAELLTTGRSTFLD
NLRREVPPGLREMLAIPGLGSRTVRQIHQGLGITTLAELEQAARERRIRTLPGLGSKTELAILRGLEMLREVQDRVPLGV
ARPLALLLRAQLLALPGVVRAEIAGSVRRGKEMVGDIDLVAAVEPDNQVAAVLVRHPQVKEVLAREPDRLALQTNLGLKI
EVIMVPPEDFPATLFYATGSKAHRRALLRLAAERGLGAADLGLVTPRWLAEEEDVLAGGTTEAPGKGGGSHGEAAAAFAT
SGATAKEDTPGVAGGAPGTGVPPAHAGAPLTHAGTGTNAREEHAGVREPVEAAFYQRLGLPYIVPELREDRGELAAARRG
ELPHLVTLADIRGDLHMHSRYSDGVETIAAMAAAARARGYQYIAITDHSRSLTVARGLSLEQLKAQREEIARLNEELEGI
TILAGIEVDILADGRLDYEDEVLKEFDLVIASIHSGFRQEREQIMARLEAALRNPYVDILGHPTGRMLGRRQPYAVDVKR
VIELAAETGTILEINASPERLDLNDTSARLAKEYGVPIAIDTDAHDPHRLADMEYGVLTARRGWLEPADVVNTWELERLL
AGLKRNRHGA
>Mature_649_residues
TNLELAWALAEMGDLLELKGEEPFKVRAYHRAARSLENLEEEAADLYARGALEEIPGVGKNLAKKLAELLTTGRSTFLDN
LRREVPPGLREMLAIPGLGSRTVRQIHQGLGITTLAELEQAARERRIRTLPGLGSKTELAILRGLEMLREVQDRVPLGVA
RPLALLLRAQLLALPGVVRAEIAGSVRRGKEMVGDIDLVAAVEPDNQVAAVLVRHPQVKEVLAREPDRLALQTNLGLKIE
VIMVPPEDFPATLFYATGSKAHRRALLRLAAERGLGAADLGLVTPRWLAEEEDVLAGGTTEAPGKGGGSHGEAAAAFATS
GATAKEDTPGVAGGAPGTGVPPAHAGAPLTHAGTGTNAREEHAGVREPVEAAFYQRLGLPYIVPELREDRGELAAARRGE
LPHLVTLADIRGDLHMHSRYSDGVETIAAMAAAARARGYQYIAITDHSRSLTVARGLSLEQLKAQREEIARLNEELEGIT
ILAGIEVDILADGRLDYEDEVLKEFDLVIASIHSGFRQEREQIMARLEAALRNPYVDILGHPTGRMLGRRQPYAVDVKRV
IELAAETGTILEINASPERLDLNDTSARLAKEYGVPIAIDTDAHDPHRLADMEYGVLTARRGWLEPADVVNTWELERLLA
GLKRNRHGA

Specific function: Strictly DNA-template-directed DNA polymerase, preferentially acting on DNA structures containing gaps from one to a few nucleotides and bearing a phosphate group at the 5' end of the downstream DNA. The fact that PolX is able to conduct filling of a sing

COG id: COG1387

COG function: function code ER; Histidinol phosphatase and related hydrolases of the PHP family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PHP family [H]

Homologues:

Organism=Homo sapiens, GI7019491, Length=303, Percent_Identity=24.4224422442244, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI291463287, Length=303, Percent_Identity=24.4224422442244, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI291463291, Length=265, Percent_Identity=26.0377358490566, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002054
- InterPro:   IPR010996
- InterPro:   IPR003583
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR016195
- InterPro:   IPR022311 [H]

Pfam domain/function: PF02811 PHP [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 70440; Mature: 70309

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLELAWALAEMGDLLELKGEEPFKVRAYHRAARSLENLEEEAADLYARGALEEIPGVG
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCC
KNLAKKLAELLTTGRSTFLDNLRREVPPGLREMLAIPGLGSRTVRQIHQGLGITTLAELE
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
QAARERRIRTLPGLGSKTELAILRGLEMLREVQDRVPLGVARPLALLLRAQLLALPGVVR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHH
AEIAGSVRRGKEMVGDIDLVAAVEPDNQVAAVLVRHPQVKEVLAREPDRLALQTNLGLKI
HHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCEEE
EVIMVPPEDFPATLFYATGSKAHRRALLRLAAERGLGAADLGLVTPRWLAEEEDVLAGGT
EEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHCCCCCEECCCC
TEAPGKGGGSHGEAAAAFATSGATAKEDTPGVAGGAPGTGVPPAHAGAPLTHAGTGTNAR
CCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
EEHAGVREPVEAAFYQRLGLPYIVPELREDRGELAAARRGELPHLVTLADIRGDLHMHSR
HHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCHHHHHH
YSDGVETIAAMAAAARARGYQYIAITDHSRSLTVARGLSLEQLKAQREEIARLNEELEGI
HHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCE
TILAGIEVDILADGRLDYEDEVLKEFDLVIASIHSGFRQEREQIMARLEAALRNPYVDIL
EEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
GHPTGRMLGRRQPYAVDVKRVIELAAETGTILEINASPERLDLNDTSARLAKEYGVPIAI
CCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCEECCCCHHHHHHHHCCCCEEE
DTDAHDPHRLADMEYGVLTARRGWLEPADVVNTWELERLLAGLKRNRHGA
ECCCCCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TNLELAWALAEMGDLLELKGEEPFKVRAYHRAARSLENLEEEAADLYARGALEEIPGVG
CCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCC
KNLAKKLAELLTTGRSTFLDNLRREVPPGLREMLAIPGLGSRTVRQIHQGLGITTLAELE
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHH
QAARERRIRTLPGLGSKTELAILRGLEMLREVQDRVPLGVARPLALLLRAQLLALPGVVR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHH
AEIAGSVRRGKEMVGDIDLVAAVEPDNQVAAVLVRHPQVKEVLAREPDRLALQTNLGLKI
HHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEEECCCHHHHHHHCCCCCEEEEECCCEEE
EVIMVPPEDFPATLFYATGSKAHRRALLRLAAERGLGAADLGLVTPRWLAEEEDVLAGGT
EEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCHHHCCCCCHHHCCCCCEECCCC
TEAPGKGGGSHGEAAAAFATSGATAKEDTPGVAGGAPGTGVPPAHAGAPLTHAGTGTNAR
CCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
EEHAGVREPVEAAFYQRLGLPYIVPELREDRGELAAARRGELPHLVTLADIRGDLHMHSR
HHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEHHHCCCHHHHHH
YSDGVETIAAMAAAARARGYQYIAITDHSRSLTVARGLSLEQLKAQREEIARLNEELEGI
HHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCE
TILAGIEVDILADGRLDYEDEVLKEFDLVIASIHSGFRQEREQIMARLEAALRNPYVDIL
EEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEC
GHPTGRMLGRRQPYAVDVKRVIELAAETGTILEINASPERLDLNDTSARLAKEYGVPIAI
CCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCEECCCCHHHHHHHHCCCCEEE
DTDAHDPHRLADMEYGVLTARRGWLEPADVVNTWELERLLAGLKRNRHGA
ECCCCCCHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]