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The map label for this gene is cysK [H]

Identifier: 83590542

GI number: 83590542

Start: 1742489

End: 1743409

Strand: Reverse

Name: cysK [H]

Synonym: Moth_1706

Alternate gene names: 83590542

Gene position: 1743409-1742489 (Counterclockwise)

Preceding gene: 83590543

Following gene: 83590540

Centisome position: 66.32

GC content: 60.04

Gene sequence:

>921_bases
ATGAAGATAGCCCGGGATGTTACCCAGTTGATAGGGCAGACGCCGATCCTGCGCCTGAACCGCCTGGTAGAGGACGGGAT
GGAGGTATACTTAAAAATCGAGTTTTTTAATCCTGGAGGCAGTGTTAAGGACCGCATTGCCCTCAGCATGATTACCGCTG
CGGAAGCCGACGGCCGCTTGAAACCCGGGGATACCATTGTCGAGCCCACAAGTGGTAATACGGGTATCGGCCTGGCCATG
GTGGCGGCCGTACGGGGTTACCGCCTGATCCTGGTTATGCCGGAAACAATGAGTATTGAGAGGCGCAAGCTCCTGGCGGC
CTATGGGGCGGAGTTCGTCCTGACTCCGGGAAACCTGGGGATGAAGGGGGCTGTAGATAAAGCAAATGAACTGGTACGGG
AGAACCCCGGTTACTTTATGCCCCAGCAGTTTGAAAATCCGGCCAACCCGGCCATCCACCGCCAGACCACGGCCAGGGAG
ATCCTGGAGCAAATGGACGGTAAAGTAGACGCCTTTGTGGCCGGCGTCGGGACCGGGGGTACCCTCACCGGGGTGGGTGA
GGTCCTGAAAAAGGAAATCCCGGGGGTAAGGATTGTAGCTGTGGAACCGGCGGCTTCACCGGTCCTTTCTGGAGGCCAGC
CAGGACCCCATAAGATTCAGGGTATAGGTGCCGGCTTTGTCCCGCCGGTCTTGCGCCGGGAGGTGGTTGACGAGATAATC
ACCGTCACCAACGAAGACGCTATGGAAACGGCCCGGCGCCTGGCACGGGAGGAAGGCCTGCTGGTGGGCATCTCTTCGGG
CGCCGCTGCTTTTGCCGCCCTCCAAGTGGCCCGGCGCCTGGGCCGGGGGAAAAGGGTACTGGCCATCGCCCCCGACACCG
GCGAGCGCTACCTGAGTACGGAGTTGTTCAAGATAGGCTAA

Upstream 100 bases:

>100_bases
ACTATAGTTGCCGTGGCTTTTTTACTTGACAGGCCCATGACCAGGGATTAAAATGTAAATAATTCCGATATAAATACTTA
GTTATAAGGAGGAAGGCAGC

Downstream 100 bases:

>100_bases
GGGAAAACGGCAGGCCGGTGGCCTGCCGTTTCTACTGCTATGAAGTTCTACTGGCCGATGAATTCCTGGACCCAGTAGTG
GCCATAGCTGCCGCCGCTGG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKIARDVTQLIGQTPILRLNRLVEDGMEVYLKIEFFNPGGSVKDRIALSMITAAEADGRLKPGDTIVEPTSGNTGIGLAM
VAAVRGYRLILVMPETMSIERRKLLAAYGAEFVLTPGNLGMKGAVDKANELVRENPGYFMPQQFENPANPAIHRQTTARE
ILEQMDGKVDAFVAGVGTGGTLTGVGEVLKKEIPGVRIVAVEPAASPVLSGGQPGPHKIQGIGAGFVPPVLRREVVDEII
TVTNEDAMETARRLAREEGLLVGISSGAAAFAALQVARRLGRGKRVLAIAPDTGERYLSTELFKIG

Sequences:

>Translated_306_residues
MKIARDVTQLIGQTPILRLNRLVEDGMEVYLKIEFFNPGGSVKDRIALSMITAAEADGRLKPGDTIVEPTSGNTGIGLAM
VAAVRGYRLILVMPETMSIERRKLLAAYGAEFVLTPGNLGMKGAVDKANELVRENPGYFMPQQFENPANPAIHRQTTARE
ILEQMDGKVDAFVAGVGTGGTLTGVGEVLKKEIPGVRIVAVEPAASPVLSGGQPGPHKIQGIGAGFVPPVLRREVVDEII
TVTNEDAMETARRLAREEGLLVGISSGAAAFAALQVARRLGRGKRVLAIAPDTGERYLSTELFKIG
>Mature_306_residues
MKIARDVTQLIGQTPILRLNRLVEDGMEVYLKIEFFNPGGSVKDRIALSMITAAEADGRLKPGDTIVEPTSGNTGIGLAM
VAAVRGYRLILVMPETMSIERRKLLAAYGAEFVLTPGNLGMKGAVDKANELVRENPGYFMPQQFENPANPAIHRQTTARE
ILEQMDGKVDAFVAGVGTGGTLTGVGEVLKKEIPGVRIVAVEPAASPVLSGGQPGPHKIQGIGAGFVPPVLRREVVDEII
TVTNEDAMETARRLAREEGLLVGISSGAAAFAALQVARRLGRGKRVLAIAPDTGERYLSTELFKIG

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=312, Percent_Identity=47.1153846153846, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI295821200, Length=312, Percent_Identity=47.1153846153846, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4557415, Length=312, Percent_Identity=47.1153846153846, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI11345492, Length=289, Percent_Identity=30.7958477508651, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1788754, Length=312, Percent_Identity=56.4102564102564, Blast_Score=287, Evalue=5e-79,
Organism=Escherichia coli, GI2367138, Length=296, Percent_Identity=44.5945945945946, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=49.3288590604027, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=53.2679738562092, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17562970, Length=305, Percent_Identity=48.1967213114754, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=48.3333333333333, Blast_Score=259, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17561720, Length=305, Percent_Identity=47.5409836065574, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=48.8262910798122, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=313, Percent_Identity=39.6166134185303, Blast_Score=180, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=311, Percent_Identity=36.3344051446945, Blast_Score=164, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=45.6896551724138, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996324, Length=332, Percent_Identity=25.9036144578313, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539800, Length=335, Percent_Identity=24.1791044776119, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=38.7301587301587, Blast_Score=206, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=36.5030674846626, Blast_Score=157, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24643623, Length=309, Percent_Identity=43.6893203883495, Blast_Score=229, Evalue=1e-60,
Organism=Drosophila melanogaster, GI20129101, Length=309, Percent_Identity=43.6893203883495, Blast_Score=229, Evalue=1e-60,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32620; Mature: 32620

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIARDVTQLIGQTPILRLNRLVEDGMEVYLKIEFFNPGGSVKDRIALSMITAAEADGRL
CCHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCC
KPGDTIVEPTSGNTGIGLAMVAAVRGYRLILVMPETMSIERRKLLAAYGAEFVLTPGNLG
CCCCCEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCC
MKGAVDKANELVRENPGYFMPQQFENPANPAIHRQTTAREILEQMDGKVDAFVAGVGTGG
CCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCC
TLTGVGEVLKKEIPGVRIVAVEPAASPVLSGGQPGPHKIQGIGAGFVPPVLRREVVDEII
CHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHH
TVTNEDAMETARRLAREEGLLVGISSGAAAFAALQVARRLGRGKRVLAIAPDTGERYLST
HCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
ELFKIG
HHEECC
>Mature Secondary Structure
MKIARDVTQLIGQTPILRLNRLVEDGMEVYLKIEFFNPGGSVKDRIALSMITAAEADGRL
CCHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCC
KPGDTIVEPTSGNTGIGLAMVAAVRGYRLILVMPETMSIERRKLLAAYGAEFVLTPGNLG
CCCCCEECCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCCEEECCCCCC
MKGAVDKANELVRENPGYFMPQQFENPANPAIHRQTTAREILEQMDGKVDAFVAGVGTGG
CCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCC
TLTGVGEVLKKEIPGVRIVAVEPAASPVLSGGQPGPHKIQGIGAGFVPPVLRREVVDEII
CHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHH
TVTNEDAMETARRLAREEGLLVGISSGAAAFAALQVARRLGRGKRVLAIAPDTGERYLST
HCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHH
ELFKIG
HHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA