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The map label for this gene is hisS

Identifier: 83590513

GI number: 83590513

Start: 1714054

End: 1715325

Strand: Reverse

Name: hisS

Synonym: Moth_1677

Alternate gene names: 83590513

Gene position: 1715325-1714054 (Counterclockwise)

Preceding gene: 83590514

Following gene: 83590512

Centisome position: 65.25

GC content: 63.76

Gene sequence:

>1272_bases
ATGTTAACCAGTCGCCCGCGGGGCACGGAAGATATCCTGCCGGAAGAGGTCGGCCGCTGGTATCTCCTGGAGAACACGGC
CCGGGAGGTCAGCCGCCTCTACGGCTACCGGGAGATCCGGACGCCCATCTTTGAACATACCGAGCTTTTTAACCGCGGCG
TGGGGGATACCAGCGATATCGTCGAAAAGGAGATGTACACCTTCATTGATCGCGGTGACCGCAGCCTGACCCTGAGGCCG
GAAGGCACGGCCCCGGTGGTACGGGCCTTTGTGGAACACAGCCTGGAGGCCCGCGGCCTGCCGGTAAAGCTGTTCTACCT
GGGGCCCATGTTCCGCTACGGCCGGCCCCAGGCCGGACGGCTGCGCCAGTTTCATCAATTCGGCGTCGAGGCCTTTGGTT
CCCGGGACCCGGCCCTGGACGCCGAGGTCATCGCCCTGGCCATGGATTTTTATACCCGCCTGGGGCTAAAGGACCTGGAG
CTGCATCTAAACAGTGTCGGATGCCCGGCCTGCCGCCCGGCCCACCGGGAGAAACTCAAGGCCTACCTGCGTCCCCGCCT
GGAAGAGCTCTGTCCTACCTGTCAGGGCCGCTTCGAGCGCAACCCCCTGCGGATCTTTGACTGCAAGAGCCCGGCTTGCC
AGGAGATTGTCAGGGAGGCGCCCACGGTGACCGCTTCCCTGTGCCCCGATTGCGCCGGGCACTTTCACCGGGTCCAGGAG
TATTTGAAAGCCCTGGGTATCGAATTTATTCTGGACGAGCATTTGGTCCGGGGGCTGGACTACTATACCAAGACGGCCTT
TGAAATTATGGTGAAGGGTATCGGCGCCCAGAGCTCCATTGGCGGCGGCGGCCGCTACGACGGCCTGGTGGCGGCCCTGG
GTGGCAAGCAGGTACCGGGGATTGGTTTTGGCTTAGGCCTGGAGCGGGTCCTGCTGGCCCTGGAGATCCAAGGCCAGGAA
CCGCCGCCGGAGGGGGGAGTGGACGTCCTGGTGGTGACTGCCGGCACCGGCGTGGACCTGGCGGCCTTCCGTTTACTGGC
CGGCCTTAGAGCCGCCGGCATCCGGGCCGATAAGGATTACCTGGAACGCAGCCTCAAGGGCCAGATGAAGTATGCCAATC
GCTACCCGGCCAGGATGGCGGTAATCCTGGGCGAGGAAGAGCTGGCCCGGGGCCGGGTTTCAGTACGCCGCCTGGACGCC
GGCAGCCAGGAAGAGGTCCCCCTGGCAGCGGTAGTAGATTATTGCAGGAAAATGAAGGAGAGTGGATGGTAG

Upstream 100 bases:

>100_bases
CCCTGGAGGTTTACCCGGGTCACGGTCCAGCCTCAACTATCGGCGCCGAACGGGTGGATAACCCCTTCTTCACTTAATCC
ATTATTTTGGGAGGACGGTC

Downstream 100 bases:

>100_bases
TGGTTGAGGGTTTGGCCGGACTCCACCGCAGCCACGGCTGCGGGGAGTTGACGGCGGCTGATGCCGGCAAGGAAGTCACC
CTGATGGGCTGGGTCCACCG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLTSRPRGTEDILPEEVGRWYLLENTAREVSRLYGYREIRTPIFEHTELFNRGVGDTSDIVEKEMYTFIDRGDRSLTLRP
EGTAPVVRAFVEHSLEARGLPVKLFYLGPMFRYGRPQAGRLRQFHQFGVEAFGSRDPALDAEVIALAMDFYTRLGLKDLE
LHLNSVGCPACRPAHREKLKAYLRPRLEELCPTCQGRFERNPLRIFDCKSPACQEIVREAPTVTASLCPDCAGHFHRVQE
YLKALGIEFILDEHLVRGLDYYTKTAFEIMVKGIGAQSSIGGGGRYDGLVAALGGKQVPGIGFGLGLERVLLALEIQGQE
PPPEGGVDVLVVTAGTGVDLAAFRLLAGLRAAGIRADKDYLERSLKGQMKYANRYPARMAVILGEEELARGRVSVRRLDA
GSQEEVPLAAVVDYCRKMKESGW

Sequences:

>Translated_423_residues
MLTSRPRGTEDILPEEVGRWYLLENTAREVSRLYGYREIRTPIFEHTELFNRGVGDTSDIVEKEMYTFIDRGDRSLTLRP
EGTAPVVRAFVEHSLEARGLPVKLFYLGPMFRYGRPQAGRLRQFHQFGVEAFGSRDPALDAEVIALAMDFYTRLGLKDLE
LHLNSVGCPACRPAHREKLKAYLRPRLEELCPTCQGRFERNPLRIFDCKSPACQEIVREAPTVTASLCPDCAGHFHRVQE
YLKALGIEFILDEHLVRGLDYYTKTAFEIMVKGIGAQSSIGGGGRYDGLVAALGGKQVPGIGFGLGLERVLLALEIQGQE
PPPEGGVDVLVVTAGTGVDLAAFRLLAGLRAAGIRADKDYLERSLKGQMKYANRYPARMAVILGEEELARGRVSVRRLDA
GSQEEVPLAAVVDYCRKMKESGW
>Mature_423_residues
MLTSRPRGTEDILPEEVGRWYLLENTAREVSRLYGYREIRTPIFEHTELFNRGVGDTSDIVEKEMYTFIDRGDRSLTLRP
EGTAPVVRAFVEHSLEARGLPVKLFYLGPMFRYGRPQAGRLRQFHQFGVEAFGSRDPALDAEVIALAMDFYTRLGLKDLE
LHLNSVGCPACRPAHREKLKAYLRPRLEELCPTCQGRFERNPLRIFDCKSPACQEIVREAPTVTASLCPDCAGHFHRVQE
YLKALGIEFILDEHLVRGLDYYTKTAFEIMVKGIGAQSSIGGGGRYDGLVAALGGKQVPGIGFGLGLERVLLALEIQGQE
PPPEGGVDVLVVTAGTGVDLAAFRLLAGLRAAGIRADKDYLERSLKGQMKYANRYPARMAVILGEEELARGRVSVRRLDA
GSQEEVPLAAVVDYCRKMKESGW

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI15029520, Length=448, Percent_Identity=26.1160714285714, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI6996014, Length=442, Percent_Identity=25.5656108597285, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788861, Length=415, Percent_Identity=41.6867469879518, Blast_Score=322, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI71993693, Length=462, Percent_Identity=22.9437229437229, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71993686, Length=462, Percent_Identity=22.9437229437229, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24643061, Length=471, Percent_Identity=25.0530785562633, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24643059, Length=490, Percent_Identity=24.0816326530612, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_MOOTA (Q2RHW0)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_430522.1
- ProteinModelPortal:   Q2RHW0
- SMR:   Q2RHW0
- STRING:   Q2RHW0
- GeneID:   3831948
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_1677
- NMPDR:   fig|264732.9.peg.1675
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- PhylomeDB:   Q2RHW0
- BioCyc:   MTHE264732:MOTH_1677-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 47090; Mature: 47090

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSRPRGTEDILPEEVGRWYLLENTAREVSRLYGYREIRTPIFEHTELFNRGVGDTSDI
CCCCCCCCCHHCCHHHHCCEEEEHHHHHHHHHHHCHHHHHCHHHHHHHHHHCCCCCHHHH
VEKEMYTFIDRGDRSLTLRPEGTAPVVRAFVEHSLEARGLPVKLFYLGPMFRYGRPQAGR
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCHHH
LRQFHQFGVEAFGSRDPALDAEVIALAMDFYTRLGLKDLELHLNSVGCPACRPAHREKLK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHH
AYLRPRLEELCPTCQGRFERNPLRIFDCKSPACQEIVREAPTVTASLCPDCAGHFHRVQE
HHHHHHHHHHCHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHCHHHHHHHHHHHH
YLKALGIEFILDEHLVRGLDYYTKTAFEIMVKGIGAQSSIGGGGRYDGLVAALGGKQVPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCC
IGFGLGLERVLLALEIQGQEPPPEGGVDVLVVTAGTGVDLAAFRLLAGLRAAGIRADKDY
CCHHHHHHHHHHHHEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHH
LERSLKGQMKYANRYPARMAVILGEEELARGRVSVRRLDAGSQEEVPLAAVVDYCRKMKE
HHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
SGW
CCC
>Mature Secondary Structure
MLTSRPRGTEDILPEEVGRWYLLENTAREVSRLYGYREIRTPIFEHTELFNRGVGDTSDI
CCCCCCCCCHHCCHHHHCCEEEEHHHHHHHHHHHCHHHHHCHHHHHHHHHHCCCCCHHHH
VEKEMYTFIDRGDRSLTLRPEGTAPVVRAFVEHSLEARGLPVKLFYLGPMFRYGRPQAGR
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCHHH
LRQFHQFGVEAFGSRDPALDAEVIALAMDFYTRLGLKDLELHLNSVGCPACRPAHREKLK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHH
AYLRPRLEELCPTCQGRFERNPLRIFDCKSPACQEIVREAPTVTASLCPDCAGHFHRVQE
HHHHHHHHHHCHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHCHHHHHHHHHHHH
YLKALGIEFILDEHLVRGLDYYTKTAFEIMVKGIGAQSSIGGGGRYDGLVAALGGKQVPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEECCCCCCCC
IGFGLGLERVLLALEIQGQEPPPEGGVDVLVVTAGTGVDLAAFRLLAGLRAAGIRADKDY
CCHHHHHHHHHHHHEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHH
LERSLKGQMKYANRYPARMAVILGEEELARGRVSVRRLDAGSQEEVPLAAVVDYCRKMKE
HHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHH
SGW
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA