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The map label for this gene is thlA [H]

Identifier: 83590108

GI number: 83590108

Start: 1303632

End: 1304813

Strand: Reverse

Name: thlA [H]

Synonym: Moth_1260

Alternate gene names: 83590108

Gene position: 1304813-1303632 (Counterclockwise)

Preceding gene: 83590109

Following gene: 83590107

Centisome position: 49.64

GC content: 50.59

Gene sequence:

>1182_bases
ATGAAGGATGTTGTTATAGTTAGCGGTGTCAGGACAGCGGTAGGGACCCGTGGTGGTAGCCTGAAGGATATCCACCAGGC
TGACTTGGGTGCCATGGTGATTAAAGAGGCCGTCCGGAGGGCAGGTTTGGAAGGCAACCAGGTTGATGAGGTTATTGTCG
GCAATGTCGGCCAAGTTGCAGAAAACGGTTTTATCGCCAGGATGTGTTCTTTAAAGGCAGGGTTACCTCTGGAGACAACA
GCTTTTTCAGTAAACCGCCAGTGTGGTTCGGGACTGCAGGCCATCAACAGCGCCGTTCAGGAGATTCAAAGTGGCAATGC
TGAAATTGTCGTCGCCTGCGGCACCGAGAATATGAACCAGTTACCCTATTATGTTCGGAAAGCCCGTTATGGTTATGGGT
TTGGCCATGGCCAATTAGAAGACGGTTTGCTTACCATTTTAACCTGGCCCCTGGGACCGTATCCAAATGGTGTCACAGCC
GAAAACATTGCTGAACGTTACCATATCTCCAGGGAAGAACAAGATGCCTTTGCTTTAAAGAGCCAGCAGAAAGCTGAGGC
TGCCATTAAAGCTGGCAAATTTGTGGACGAAATTCTCCCGGTTGAAGTCCCTGCCGGTAAAAGGGAAACCAGGATTTTTG
CCCAGGATGAACATCCTCGTTTTGGCCTCACCATGGAGCAACTGGCAAAATTAAAGCCTGCTTTCCGGGAAGGCGGTACG
GTAACTGCTGGCAATTCTTCGGGTATCAACGACGGCGCTGGAGCAGTAGTTCTAATGACGGCCGAAAAAGCCAACAAACT
TGGCCTCAAGCCCTTACTGCTAATCCGCAGCCAGGCAGTGGCCGGGGTTGATCCAGATGTTATGGGCATCGGTCCTGCCC
CCGCGACTATGAAGGCAGTCGAGAAAGCCGGGCTAACCCTTGCTGATATCGACCTCTTTGAGCTGAATGAAGCTTTTGCC
TCCCAGTCGATTGCCGTTATGCGCATTCTGGGACTTCCCGAAGAAAAGGTAAACGTTAATGGTGGCGCCATCGCCCTGGG
TCACCCCATCGGTGCAACCGGCATTATCTTAACTGTTAAATTACAAAAAGAAATGGTACGTCGCCAGGCTAAATATGGTA
TCGTTACCATGTGTATTGGCGGCGGCCAGGGTATTGCTACGGTCTTTGAAAATATAGCTTAA

Upstream 100 bases:

>100_bases
CGAGTTGCCGAAGAATGCCAATGGCAAAATTGATAAAAAGCTTCTCCGGCAACAGTTTCAATAAAAATGGTAACGCTTCC
AAAAAGAAAGGGGATTTATA

Downstream 100 bases:

>100_bases
ATTACTACGTACCCGATGAAGTAGCTAAACTATAACCCTGGTTTAGCTACTTCATCCCCAATATTACTCAAATAGGGTGA
GGTTATGTTATGAGACGTCC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKDVVIVSGVRTAVGTRGGSLKDIHQADLGAMVIKEAVRRAGLEGNQVDEVIVGNVGQVAENGFIARMCSLKAGLPLETT
AFSVNRQCGSGLQAINSAVQEIQSGNAEIVVACGTENMNQLPYYVRKARYGYGFGHGQLEDGLLTILTWPLGPYPNGVTA
ENIAERYHISREEQDAFALKSQQKAEAAIKAGKFVDEILPVEVPAGKRETRIFAQDEHPRFGLTMEQLAKLKPAFREGGT
VTAGNSSGINDGAGAVVLMTAEKANKLGLKPLLLIRSQAVAGVDPDVMGIGPAPATMKAVEKAGLTLADIDLFELNEAFA
SQSIAVMRILGLPEEKVNVNGGAIALGHPIGATGIILTVKLQKEMVRRQAKYGIVTMCIGGGQGIATVFENIA

Sequences:

>Translated_393_residues
MKDVVIVSGVRTAVGTRGGSLKDIHQADLGAMVIKEAVRRAGLEGNQVDEVIVGNVGQVAENGFIARMCSLKAGLPLETT
AFSVNRQCGSGLQAINSAVQEIQSGNAEIVVACGTENMNQLPYYVRKARYGYGFGHGQLEDGLLTILTWPLGPYPNGVTA
ENIAERYHISREEQDAFALKSQQKAEAAIKAGKFVDEILPVEVPAGKRETRIFAQDEHPRFGLTMEQLAKLKPAFREGGT
VTAGNSSGINDGAGAVVLMTAEKANKLGLKPLLLIRSQAVAGVDPDVMGIGPAPATMKAVEKAGLTLADIDLFELNEAFA
SQSIAVMRILGLPEEKVNVNGGAIALGHPIGATGIILTVKLQKEMVRRQAKYGIVTMCIGGGQGIATVFENIA
>Mature_393_residues
MKDVVIVSGVRTAVGTRGGSLKDIHQADLGAMVIKEAVRRAGLEGNQVDEVIVGNVGQVAENGFIARMCSLKAGLPLETT
AFSVNRQCGSGLQAINSAVQEIQSGNAEIVVACGTENMNQLPYYVRKARYGYGFGHGQLEDGLLTILTWPLGPYPNGVTA
ENIAERYHISREEQDAFALKSQQKAEAAIKAGKFVDEILPVEVPAGKRETRIFAQDEHPRFGLTMEQLAKLKPAFREGGT
VTAGNSSGINDGAGAVVLMTAEKANKLGLKPLLLIRSQAVAGVDPDVMGIGPAPATMKAVEKAGLTLADIDLFELNEAFA
SQSIAVMRILGLPEEKVNVNGGAIALGHPIGATGIILTVKLQKEMVRRQAKYGIVTMCIGGGQGIATVFENIA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=46.8354430379747, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=46.1538461538462, Blast_Score=304, Evalue=8e-83,
Organism=Homo sapiens, GI4501853, Length=394, Percent_Identity=44.9238578680203, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI4557237, Length=394, Percent_Identity=37.5634517766497, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI4504327, Length=426, Percent_Identity=35.2112676056338, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=33.0769230769231, Blast_Score=172, Evalue=4e-43,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=52.5380710659898, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=48.3375959079284, Blast_Score=348, Evalue=2e-97,
Organism=Escherichia coli, GI1787663, Length=405, Percent_Identity=42.2222222222222, Blast_Score=308, Evalue=5e-85,
Organism=Escherichia coli, GI48994986, Length=399, Percent_Identity=42.1052631578947, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=34.2298288508557, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI133906874, Length=393, Percent_Identity=45.8015267175573, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17535921, Length=396, Percent_Identity=36.3636363636364, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=33.0985915492958, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI25147385, Length=393, Percent_Identity=32.0610687022901, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17535917, Length=387, Percent_Identity=26.0981912144703, Blast_Score=127, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=398, Percent_Identity=39.6984924623116, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=38.6934673366834, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=46.1928934010152, Blast_Score=337, Evalue=1e-92,
Organism=Drosophila melanogaster, GI17648125, Length=394, Percent_Identity=45.6852791878173, Blast_Score=314, Evalue=7e-86,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=36.2244897959184, Blast_Score=237, Evalue=8e-63,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=33.8823529411765, Blast_Score=194, Evalue=8e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41487; Mature: 41487

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDVVIVSGVRTAVGTRGGSLKDIHQADLGAMVIKEAVRRAGLEGNQVDEVIVGNVGQVA
CCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHH
ENGFIARMCSLKAGLPLETTAFSVNRQCGSGLQAINSAVQEIQSGNAEIVVACGTENMNQ
HCCHHHHHHHHCCCCCCCHHHEECCHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
LPYYVRKARYGYGFGHGQLEDGLLTILTWPLGPYPNGVTAENIAERYHISREEQDAFALK
CHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
SQQKAEAAIKAGKFVDEILPVEVPAGKRETRIFAQDEHPRFGLTMEQLAKLKPAFREGGT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHCHHHHCCCE
VTAGNSSGINDGAGAVVLMTAEKANKLGLKPLLLIRSQAVAGVDPDVMGIGPAPATMKAV
EECCCCCCCCCCCCEEEEEEECCCCCCCCCHHEEEHHHHHCCCCCCCEECCCCCHHHHHH
EKAGLTLADIDLFELNEAFASQSIAVMRILGLPEEKVNVNGGAIALGHPIGATGIILTVK
HHCCCEEEECHHHHHHHHHHHCCHHHHHHHCCCHHHEECCCCEEEECCCCCCCEEEEEEE
LQKEMVRRQAKYGIVTMCIGGGQGIATVFENIA
HHHHHHHHHHHCCEEEEEEECCCHHHHHHHHCC
>Mature Secondary Structure
MKDVVIVSGVRTAVGTRGGSLKDIHQADLGAMVIKEAVRRAGLEGNQVDEVIVGNVGQVA
CCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHH
ENGFIARMCSLKAGLPLETTAFSVNRQCGSGLQAINSAVQEIQSGNAEIVVACGTENMNQ
HCCHHHHHHHHCCCCCCCHHHEECCHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCC
LPYYVRKARYGYGFGHGQLEDGLLTILTWPLGPYPNGVTAENIAERYHISREEQDAFALK
CHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
SQQKAEAAIKAGKFVDEILPVEVPAGKRETRIFAQDEHPRFGLTMEQLAKLKPAFREGGT
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHCHHHHCCCE
VTAGNSSGINDGAGAVVLMTAEKANKLGLKPLLLIRSQAVAGVDPDVMGIGPAPATMKAV
EECCCCCCCCCCCCEEEEEEECCCCCCCCCHHEEEHHHHHCCCCCCCEECCCCCHHHHHH
EKAGLTLADIDLFELNEAFASQSIAVMRILGLPEEKVNVNGGAIALGHPIGATGIILTVK
HHCCCEEEECHHHHHHHHHHHCCHHHHHHHCCCHHHEECCCCEEEECCCCCCCEEEEEEE
LQKEMVRRQAKYGIVTMCIGGGQGIATVFENIA
HHHHHHHHHHHCCEEEEEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]