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The map label for this gene is yhfN [H]

Identifier: 83590079

GI number: 83590079

Start: 1269775

End: 1271016

Strand: Reverse

Name: yhfN [H]

Synonym: Moth_1231

Alternate gene names: 83590079

Gene position: 1271016-1269775 (Counterclockwise)

Preceding gene: 83590080

Following gene: 83590076

Centisome position: 48.35

GC content: 58.86

Gene sequence:

>1242_bases
ATGAGTGCCAGGGCTGGCATTATCTGGTCCACCCTGTTAATCATGGCCGCCATCTTGAGCCTGGTCTTCATCTTCTTTAC
CCTCTTACCGGGGCAGATACCGGCTGCAGTCTGGCAGTATTTCACCCCGGCCGAAGTGGAAAGGGCGCGGCGTTACCAGC
AGATCATGGGCCTGGTGGCCATCCTGGCTTTCCTGGCCAAAACGGCCTTCCTGGTCTGGCTGGTCTACAGCACCCGCTCC
GGCGCCTGGTCCGAGAGGGTTCTGCGCCTGACAGGCGGGCGCTATTATCCGGCCCTGCTGGTGTACTTCTGCCTGATATG
GTTGCTACTGAAAGCCATTGGCCTGCCTTTTAACTTTTACGGCAGCTTCATCGTCCAGCACCAGTGGGGCCTGGCCACCC
AGAGCCTGGCCTCCTGGTGGAGCGATTACCTCAAGGGTTCCCTCCTGGACCTGGTCCTGTCCGGAGCCGGCGTACTTCTC
CTTTTCTGGGCTACCGGTCGCTGGCCCTGCACCTGGTGGGTGGCCGCCGGCCTCTTCCTGTCAGCCTGGCTCTTTATTTC
CACCTTCATCTGGCCCTTGATCATCGCTCCCATTTTTAACCGCTTCCAGCCGGTTACCGCGGGACCGATAAAGACCATGG
TCACCCGCCTGGCCAACCGAGCCGGCCTGAAAATAGACCAGATCCTGATCATGGACGCCAGCCGCCGGACTACCACGGCC
AACGCCTATTTTACCGGCCTGGGGGCCACCAAACGCATCGTCCTCTATGACACCCTGGTGGATAACTATCCCAGCGATGA
AGTTGAAGCGGTAATCGCCCATGAAATAGCCCACTGGCAACGAGGCCATATAATCAGGGGATCCCTGTGGGGCATACTGG
CCAATTTCTTTCTCACGGGGCTTCTGTATGCCGTATTAAGGGTCACATTTACCTACGAAATCACCCGGCCGGGACCATAC
CCGCCCCAAATCCTGATAGTCATACTCCTCTTCCTGCAACTGGTTTCCTTCCTGGGCCAACCCATCCAGAATGCCATTTC
CCGCAGCTATGAAACCGAAGCCGACCAGGTAGCTCTGGAACTTACCGGCAACCCCGGAGCCATGATCCGTCTCCAGGTGG
ATCTGGCCCGGAAAAATCTGGCCGACGTGGCCCCCCCGGCCTTTATCGAATGGCTGACCTATTCCCACCCAGCCACCCTG
AAGAGAATCCGGGCGGCGGAGGCTTACCCCCGCGGGCAATAA

Upstream 100 bases:

>100_bases
TTATGCCGCGTATACCCGCGGGTAGGAATAAGGGAGATAAGAACGAATATGATAGTGCATAAAGCAAGGCTATGCCTAAA
AACAGAGGGGGAAAATAGCA

Downstream 100 bases:

>100_bases
AAACCGCAGGCCTGGCCTTCCGGCCGCACCTTATTTACCGCCTTAACGAGGGCCTCTTTGCCGGCCTGCCAGATAAAATC
CCCGGCCCGGAGGTGGGCCG

Product: Ste24 endopeptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSARAGIIWSTLLIMAAILSLVFIFFTLLPGQIPAAVWQYFTPAEVERARRYQQIMGLVAILAFLAKTAFLVWLVYSTRS
GAWSERVLRLTGGRYYPALLVYFCLIWLLLKAIGLPFNFYGSFIVQHQWGLATQSLASWWSDYLKGSLLDLVLSGAGVLL
LFWATGRWPCTWWVAAGLFLSAWLFISTFIWPLIIAPIFNRFQPVTAGPIKTMVTRLANRAGLKIDQILIMDASRRTTTA
NAYFTGLGATKRIVLYDTLVDNYPSDEVEAVIAHEIAHWQRGHIIRGSLWGILANFFLTGLLYAVLRVTFTYEITRPGPY
PPQILIVILLFLQLVSFLGQPIQNAISRSYETEADQVALELTGNPGAMIRLQVDLARKNLADVAPPAFIEWLTYSHPATL
KRIRAAEAYPRGQ

Sequences:

>Translated_413_residues
MSARAGIIWSTLLIMAAILSLVFIFFTLLPGQIPAAVWQYFTPAEVERARRYQQIMGLVAILAFLAKTAFLVWLVYSTRS
GAWSERVLRLTGGRYYPALLVYFCLIWLLLKAIGLPFNFYGSFIVQHQWGLATQSLASWWSDYLKGSLLDLVLSGAGVLL
LFWATGRWPCTWWVAAGLFLSAWLFISTFIWPLIIAPIFNRFQPVTAGPIKTMVTRLANRAGLKIDQILIMDASRRTTTA
NAYFTGLGATKRIVLYDTLVDNYPSDEVEAVIAHEIAHWQRGHIIRGSLWGILANFFLTGLLYAVLRVTFTYEITRPGPY
PPQILIVILLFLQLVSFLGQPIQNAISRSYETEADQVALELTGNPGAMIRLQVDLARKNLADVAPPAFIEWLTYSHPATL
KRIRAAEAYPRGQ
>Mature_412_residues
SARAGIIWSTLLIMAAILSLVFIFFTLLPGQIPAAVWQYFTPAEVERARRYQQIMGLVAILAFLAKTAFLVWLVYSTRSG
AWSERVLRLTGGRYYPALLVYFCLIWLLLKAIGLPFNFYGSFIVQHQWGLATQSLASWWSDYLKGSLLDLVLSGAGVLLL
FWATGRWPCTWWVAAGLFLSAWLFISTFIWPLIIAPIFNRFQPVTAGPIKTMVTRLANRAGLKIDQILIMDASRRTTTAN
AYFTGLGATKRIVLYDTLVDNYPSDEVEAVIAHEIAHWQRGHIIRGSLWGILANFFLTGLLYAVLRVTFTYEITRPGPYP
PQILIVILLFLQLVSFLGQPIQNAISRSYETEADQVALELTGNPGAMIRLQVDLARKNLADVAPPAFIEWLTYSHPATLK
RIRAAEAYPRGQ

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=450, Percent_Identity=25.1111111111111, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17505484, Length=385, Percent_Identity=27.2727272727273, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322577, Length=315, Percent_Identity=32.0634920634921, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI19922414, Length=324, Percent_Identity=28.0864197530864, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24654305, Length=306, Percent_Identity=26.797385620915, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 46452; Mature: 46321

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARAGIIWSTLLIMAAILSLVFIFFTLLPGQIPAAVWQYFTPAEVERARRYQQIMGLVA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ILAFLAKTAFLVWLVYSTRSGAWSERVLRLTGGRYYPALLVYFCLIWLLLKAIGLPFNFY
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
GSFIVQHQWGLATQSLASWWSDYLKGSLLDLVLSGAGVLLLFWATGRWPCTWWVAAGLFL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
SAWLFISTFIWPLIIAPIFNRFQPVTAGPIKTMVTRLANRAGLKIDQILIMDASRRTTTA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEHEEEEECCCCCEEC
NAYFTGLGATKRIVLYDTLVDNYPSDEVEAVIAHEIAHWQRGHIIRGSLWGILANFFLTG
CCEEECCCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHH
LLYAVLRVTFTYEITRPGPYPPQILIVILLFLQLVSFLGQPIQNAISRSYETEADQVALE
HHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHEEEE
LTGNPGAMIRLQVDLARKNLADVAPPAFIEWLTYSHPATLKRIRAAEAYPRGQ
EECCCCEEEEEEEHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SARAGIIWSTLLIMAAILSLVFIFFTLLPGQIPAAVWQYFTPAEVERARRYQQIMGLVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ILAFLAKTAFLVWLVYSTRSGAWSERVLRLTGGRYYPALLVYFCLIWLLLKAIGLPFNFY
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHH
GSFIVQHQWGLATQSLASWWSDYLKGSLLDLVLSGAGVLLLFWATGRWPCTWWVAAGLFL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
SAWLFISTFIWPLIIAPIFNRFQPVTAGPIKTMVTRLANRAGLKIDQILIMDASRRTTTA
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEHEEEEECCCCCEEC
NAYFTGLGATKRIVLYDTLVDNYPSDEVEAVIAHEIAHWQRGHIIRGSLWGILANFFLTG
CCEEECCCCCCEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHH
LLYAVLRVTFTYEITRPGPYPPQILIVILLFLQLVSFLGQPIQNAISRSYETEADQVALE
HHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHEEEE
LTGNPGAMIRLQVDLARKNLADVAPPAFIEWLTYSHPATLKRIRAAEAYPRGQ
EECCCCEEEEEEEHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]