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The map label for this gene is zraS [H]

Identifier: 83589986

GI number: 83589986

Start: 1167024

End: 1167728

Strand: Reverse

Name: zraS [H]

Synonym: Moth_1138

Alternate gene names: 83589986

Gene position: 1167728-1167024 (Counterclockwise)

Preceding gene: 83589987

Following gene: 83589985

Centisome position: 44.42

GC content: 48.37

Gene sequence:

>705_bases
ATGGTTTATTCCTTTCCGGAAGAAGATCGGGAATATCTAACAGAAAAGCTGGCCATCATCGGTGAACTGGCCGCTGGTAT
GGCCCATGAAATCCGTAATCCCTTGACTTCTATCAGGGGGTTTCTCCAATTACTCCGGAGTAAATACGACCCCGGGGCAC
CAGAACAGGAATACTTCGAAATCATGCTGGACGAACTCGATCGCATAAATAATATTATTAAGGAATTCCTTTCCCTGTCC
AAACCCTCTCAACCCCAGTTGCAGATAGTATCCTTCGACCAGCTGGTGACCGAGGCTTTACTCCTGGCGGAGCAGGAAGC
CATCATGAATGAAGTAAAACTGGAGCAACACCTGGCCCATGATCTGCCCCTTTTATGCCTGGATCCCGCCCAGATTAAAC
AGGTGATCCTGAACCTCACTTCCAACGCCCTCCACGCTGCCGGTCCGGGGGGCAAGGTAACCGTCTGCTGTTATTTAGAT
AAAAAAGCGAAGGAGGTAGTTACCACCATTAGTGATACTGGTCCCGGGATCCTCCCGGATCAGCTCAAGCTAATTTTTGA
GCCCTTTTATACCACCAAGGAAAATGGCACCGGCCTGGGTTTAACCTTAAGCAACCGTATCATCAAGGGCCATGGTGGTA
AAATAAAGGTTAAAAGTAAAGTGGGAGAGGGGAGTTGTTTCAGCATCCATTTACCTGCATCTTAA

Upstream 100 bases:

>100_bases
TGGGACAAAAAGTAGCTGAATGATAATCACCGGGAAGGAGAAATTGAACATGGTGTGGAACTAATATTTTTCAGGCCGAG
TTCCAGGGAGTGAGAGGATC

Downstream 100 bases:

>100_bases
AAACTGGAACCAGTGGATAAAGTGGATAACATTGTAGATAACTTCTATTGATGTCATATTATGGATGGTGGAGAAATGAA
AATTACCGACAATGCCCGGA

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MVYSFPEEDREYLTEKLAIIGELAAGMAHEIRNPLTSIRGFLQLLRSKYDPGAPEQEYFEIMLDELDRINNIIKEFLSLS
KPSQPQLQIVSFDQLVTEALLLAEQEAIMNEVKLEQHLAHDLPLLCLDPAQIKQVILNLTSNALHAAGPGGKVTVCCYLD
KKAKEVVTTISDTGPGILPDQLKLIFEPFYTTKENGTGLGLTLSNRIIKGHGGKIKVKSKVGEGSCFSIHLPAS

Sequences:

>Translated_234_residues
MVYSFPEEDREYLTEKLAIIGELAAGMAHEIRNPLTSIRGFLQLLRSKYDPGAPEQEYFEIMLDELDRINNIIKEFLSLS
KPSQPQLQIVSFDQLVTEALLLAEQEAIMNEVKLEQHLAHDLPLLCLDPAQIKQVILNLTSNALHAAGPGGKVTVCCYLD
KKAKEVVTTISDTGPGILPDQLKLIFEPFYTTKENGTGLGLTLSNRIIKGHGGKIKVKSKVGEGSCFSIHLPAS
>Mature_234_residues
MVYSFPEEDREYLTEKLAIIGELAAGMAHEIRNPLTSIRGFLQLLRSKYDPGAPEQEYFEIMLDELDRINNIIKEFLSLS
KPSQPQLQIVSFDQLVTEALLLAEQEAIMNEVKLEQHLAHDLPLLCLDPAQIKQVILNLTSNALHAAGPGGKVTVCCYLD
KKAKEVVTTISDTGPGILPDQLKLIFEPFYTTKENGTGLGLTLSNRIIKGHGGKIKVKSKVGEGSCFSIHLPAS

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=219, Percent_Identity=42.4657534246575, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1790436, Length=227, Percent_Identity=39.2070484581498, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1790300, Length=220, Percent_Identity=33.6363636363636, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI87081816, Length=217, Percent_Identity=31.3364055299539, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=26.8518518518519, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=28.6995515695067, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=28.6995515695067, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=235, Percent_Identity=26.8085106382979, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=28.5087719298246, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI145693157, Length=219, Percent_Identity=28.310502283105, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=258, Percent_Identity=26.3565891472868, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789149, Length=234, Percent_Identity=25.6410256410256, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1786783, Length=229, Percent_Identity=26.2008733624454, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789808, Length=217, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788393, Length=221, Percent_Identity=25.7918552036199, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 25812; Mature: 25812

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVYSFPEEDREYLTEKLAIIGELAAGMAHEIRNPLTSIRGFLQLLRSKYDPGAPEQEYFE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IMLDELDRINNIIKEFLSLSKPSQPQLQIVSFDQLVTEALLLAEQEAIMNEVKLEQHLAH
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLPLLCLDPAQIKQVILNLTSNALHAAGPGGKVTVCCYLDKKAKEVVTTISDTGPGILPD
CCCEEEECHHHHHHHHHHHHHCHHCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCCCCHH
QLKLIFEPFYTTKENGTGLGLTLSNRIIKGHGGKIKVKSKVGEGSCFSIHLPAS
HHHHHHHHHHCCCCCCCEEEEEECCCEEECCCCEEEEEEECCCCCEEEEECCCC
>Mature Secondary Structure
MVYSFPEEDREYLTEKLAIIGELAAGMAHEIRNPLTSIRGFLQLLRSKYDPGAPEQEYFE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
IMLDELDRINNIIKEFLSLSKPSQPQLQIVSFDQLVTEALLLAEQEAIMNEVKLEQHLAH
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLPLLCLDPAQIKQVILNLTSNALHAAGPGGKVTVCCYLDKKAKEVVTTISDTGPGILPD
CCCEEEECHHHHHHHHHHHHHCHHCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCCCCHH
QLKLIFEPFYTTKENGTGLGLTLSNRIIKGHGGKIKVKSKVGEGSCFSIHLPAS
HHHHHHHHHHCCCCCCCEEEEEECCCEEECCCCEEEEEEECCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]