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The map label for this gene is cobB [H]

Identifier: 83594974

GI number: 83594974

Start: 4185499

End: 4186230

Strand: Reverse

Name: cobB [H]

Synonym: Rru_A3645

Alternate gene names: 83594974

Gene position: 4186230-4185499 (Counterclockwise)

Preceding gene: 83594976

Following gene: 83594973

Centisome position: 96.17

GC content: 68.03

Gene sequence:

>732_bases
ATGACCGGTCTGCTGCCTTGCCCCATCGTCATCCTGACCGGGGCCGGTGTTTCCAAGGAATCGGGACTGGACACCTTCCG
CGATCGCGATGGCGTCTGGGCGCGGGTGCGGCTGGAGGACGTGGCGACCCCCGAAGGCTTCGCCCGCGACCCCGCCCTGG
TCCAGGCCTTTTATAACGACCGCCGGCGCGGCCTGCTTGATCCGAGTTGCCTGCCCAATCCCGCCCACGAGGCCCTGGCC
CGCCTGGAGCGCGAGTGGCCCGACGAGGTGCTGATCGTCACCCAGAACATCGACGATCTGCACGAGCGAGCCGGATCGCG
CCAGCTTATCCACATGCACGGCGAATTGACCAAGGCGCGCTGCCTGGACTGCGGCGCGGTGCTCGACTGGCGGGCCGATC
TGGGCGAAAGCGACGGCTGCCCGGCCTGCGCCACGGTCGGGACCTTACGGCCCCATATCGTGTGGTTCGGGGAAATTCCC
CTCGAAATGGAGCGCATTCAAGACGCCCTCTCGACCTGCGGGCTGTTCCTCTCGATCGGCACCTCCGGCAACGTCTATCC
GGCCGCCGGCTTCGTCCGTCAGGCCCGCTTCGAGGGCGCGGCCCATACGGTCGAACTGAACCTGGAACCCAGCCTGGGGG
CGACGCTGTTCGAGGAAAGCCTGTATGGCCCGGCCAGCGAGGTGGTTCCGGCCTATGTGGAGCGCTTGCTGGGCGCCGTG
GCCGGGCGATGA

Upstream 100 bases:

>100_bases
AAGAATACGATGCATCGGTTCCCTCTCCGGGCCGTTTCCCTGGCCCGCCCTGTTTTACCACGGCGCCCAAGGGATGGCGA
AAAAAGGAAAGATGATAGTC

Downstream 100 bases:

>100_bases
CGCCTCCGGACGCGGAGGCCGAGGCGGCGCTGGCGGCCGTCGTCGCCCGGGCCGAGGCCTGCACCCTCTGCGCCGCCCAT
CTGCCGCTCGGCCCCCGGCC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTGLLPCPIVILTGAGVSKESGLDTFRDRDGVWARVRLEDVATPEGFARDPALVQAFYNDRRRGLLDPSCLPNPAHEALA
RLEREWPDEVLIVTQNIDDLHERAGSRQLIHMHGELTKARCLDCGAVLDWRADLGESDGCPACATVGTLRPHIVWFGEIP
LEMERIQDALSTCGLFLSIGTSGNVYPAAGFVRQARFEGAAHTVELNLEPSLGATLFEESLYGPASEVVPAYVERLLGAV
AGR

Sequences:

>Translated_243_residues
MTGLLPCPIVILTGAGVSKESGLDTFRDRDGVWARVRLEDVATPEGFARDPALVQAFYNDRRRGLLDPSCLPNPAHEALA
RLEREWPDEVLIVTQNIDDLHERAGSRQLIHMHGELTKARCLDCGAVLDWRADLGESDGCPACATVGTLRPHIVWFGEIP
LEMERIQDALSTCGLFLSIGTSGNVYPAAGFVRQARFEGAAHTVELNLEPSLGATLFEESLYGPASEVVPAYVERLLGAV
AGR
>Mature_242_residues
TGLLPCPIVILTGAGVSKESGLDTFRDRDGVWARVRLEDVATPEGFARDPALVQAFYNDRRRGLLDPSCLPNPAHEALAR
LEREWPDEVLIVTQNIDDLHERAGSRQLIHMHGELTKARCLDCGAVLDWRADLGESDGCPACATVGTLRPHIVWFGEIPL
EMERIQDALSTCGLFLSIGTSGNVYPAAGFVRQARFEGAAHTVELNLEPSLGATLFEESLYGPASEVVPAYVERLLGAVA
GR

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=231, Percent_Identity=38.961038961039, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI6912664, Length=249, Percent_Identity=36.5461847389558, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI13787215, Length=242, Percent_Identity=37.1900826446281, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI7657575, Length=251, Percent_Identity=31.0756972111554, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI6912662, Length=260, Percent_Identity=29.2307692307692, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI308199517, Length=229, Percent_Identity=60.2620087336244, Blast_Score=281, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17541892, Length=202, Percent_Identity=31.6831683168317, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571445, Length=188, Percent_Identity=32.4468085106383, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137536, Length=218, Percent_Identity=30.7339449541284, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26417; Mature: 26286

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLLPCPIVILTGAGVSKESGLDTFRDRDGVWARVRLEDVATPEGFARDPALVQAFYND
CCCCCCCCEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
RRRGLLDPSCLPNPAHEALARLEREWPDEVLIVTQNIDDLHERAGSRQLIHMHGELTKAR
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHCCCCCEEEEECCCHHHHH
CLDCGAVLDWRADLGESDGCPACATVGTLRPHIVWFGEIPLEMERIQDALSTCGLFLSIG
HHHCCHHEEHHHCCCCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHEEEEEC
TSGNVYPAAGFVRQARFEGAAHTVELNLEPSLGATLFEESLYGPASEVVPAYVERLLGAV
CCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
AGR
CCC
>Mature Secondary Structure 
TGLLPCPIVILTGAGVSKESGLDTFRDRDGVWARVRLEDVATPEGFARDPALVQAFYND
CCCCCCCEEEEECCCCCCCCCCCHHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHH
RRRGLLDPSCLPNPAHEALARLEREWPDEVLIVTQNIDDLHERAGSRQLIHMHGELTKAR
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHCCCCCEEEEECCCHHHHH
CLDCGAVLDWRADLGESDGCPACATVGTLRPHIVWFGEIPLEMERIQDALSTCGLFLSIG
HHHCCHHEEHHHCCCCCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHEEEEEC
TSGNVYPAAGFVRQARFEGAAHTVELNLEPSLGATLFEESLYGPASEVVPAYVERLLGAV
CCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
AGR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]