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The map label for this gene is hslU

Identifier: 83594929

GI number: 83594929

Start: 4141035

End: 4142342

Strand: Direct

Name: hslU

Synonym: Rru_A3600

Alternate gene names: 83594929

Gene position: 4141035-4142342 (Clockwise)

Preceding gene: 83594928

Following gene: 83594938

Centisome position: 95.13

GC content: 65.21

Gene sequence:

>1308_bases
ATGAACGCCTTCACCCCCCGCGAGATCGTTTCCGAGCTTGATCGCCACATCGTCGGGCAGAAGGACGCCAAGCGCGCCGT
CGCCATCGCCCTGCGCAACCGCTGGCGCCGCCAGCAGCTGTCCGAGGCCCTGCGCGACGAGGTGCTGCCCAAGAACATCC
TGATGATCGGGCCCACCGGCGTCGGCAAGACCGAGATCGCCCGCCGTCTGGCCAAACTGGCCCAGGCCCCCTTCCTCAAG
GTCGAGGCCACCAAATTCACCGAGGTCGGCTATGTCGGCCGCGACGTGGAAAGCATCATCCGCGATCTGGTGGAAACCGC
CCTGACCCAGGAGCGCGACCGCCTGCGCAAGCAAGTCAACGCCAAGGCCGAGGCCAACGCCGAGGAGCGGGTGCTCGATG
CCCTGGTCGGCGATCGCGCCTCGCCCGAAACCCGCCAGAAGTTCCGCAAGATGCTGCGCGAAGGCCAGATCAACGACAAG
GAGATCGAGGTTCAGGTCCAAGACAGCGGCGGTGCCCTGCCGACCATGGATATTCCGGGCATGCCCGGGGCCCAGATGGG
CATGCTCAATCTCAACGACATCTTCGGCAAGGCCTTTGGCAACCGCACCAAGGCGCGCAAGATGACGGTCGAAGACTCCC
ACGCCGTTCTGGTGCGCGAGGAGGCCGACAAGCTGCTCGACGAGGAGCAGGTGGTCAAAGCCGCCATCGCCGCCGTCGAG
AACAACGGCATCGTCTTCCTTGATGAAATCGACAAGATCGCCACGGCGTCGGAACGCCGGGGCGGCGACGTCAGCCGCGA
GGGCGTTCAGCGCGACCTGCTGCCGCTGATCGAAGGCACGACGGTTTCAACCAAATACGGTCCGGTGAAGACCGACCACG
TGCTGTTCATCGCCTCGGGCGCCTTCCATACGGCCAAGCCCGCCGATCTGCTGCCCGAACTGCAGGGCCGTTTGCCGATC
CGCGTCGAGTTGAGCGCGCTCAACGCCGGCGATTTCAAGCGCATCCTGCTTGAACCCGAAGCCAGCCTGATCACCCAGTA
CAAGGCCCTGCTGGCGACCGAGGGCGTCACCTTGGAGTTTCCCGACGACACGGTCGAGGCCATCGCCGAGATTGCCACCG
AAATCAACGGCTCGGTCGAAAACATCGGGGCGCGGCGCCTGCATACGGTCCTGGAGCGCCTGCTCGAGGAGATCAGCTTC
ACCGCCACCGACCGTTCGGGCGAAACCATCGTCGTCACCCGCGACATGGTCAAGGAGCGCGTCGGCGCCCTGGCCGCCAA
GGCCGATCTGTCGCGGTTCATCCTGTAA

Upstream 100 bases:

>100_bases
TCAGCGAGGATCTCGATCCCGAGGTCATCGCCCGGCGCTCGCTGGCGATCGCCGCCGATATCTGCATCTACACCAACCAC
AATCTGACCGTGGAAGTCCT

Downstream 100 bases:

>100_bases
ACCGGTGTAGACCGGGGAACCCCTATCGCGGGCGGGCCGATCGACGGGCCGCCCGCAGCAGGGCGCGCAAGGACTCGATC
TCGCCCGGGTCCAGGGTCTC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MNAFTPREIVSELDRHIVGQKDAKRAVAIALRNRWRRQQLSEALRDEVLPKNILMIGPTGVGKTEIARRLAKLAQAPFLK
VEATKFTEVGYVGRDVESIIRDLVETALTQERDRLRKQVNAKAEANAEERVLDALVGDRASPETRQKFRKMLREGQINDK
EIEVQVQDSGGALPTMDIPGMPGAQMGMLNLNDIFGKAFGNRTKARKMTVEDSHAVLVREEADKLLDEEQVVKAAIAAVE
NNGIVFLDEIDKIATASERRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHVLFIASGAFHTAKPADLLPELQGRLPI
RVELSALNAGDFKRILLEPEASLITQYKALLATEGVTLEFPDDTVEAIAEIATEINGSVENIGARRLHTVLERLLEEISF
TATDRSGETIVVTRDMVKERVGALAAKADLSRFIL

Sequences:

>Translated_435_residues
MNAFTPREIVSELDRHIVGQKDAKRAVAIALRNRWRRQQLSEALRDEVLPKNILMIGPTGVGKTEIARRLAKLAQAPFLK
VEATKFTEVGYVGRDVESIIRDLVETALTQERDRLRKQVNAKAEANAEERVLDALVGDRASPETRQKFRKMLREGQINDK
EIEVQVQDSGGALPTMDIPGMPGAQMGMLNLNDIFGKAFGNRTKARKMTVEDSHAVLVREEADKLLDEEQVVKAAIAAVE
NNGIVFLDEIDKIATASERRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHVLFIASGAFHTAKPADLLPELQGRLPI
RVELSALNAGDFKRILLEPEASLITQYKALLATEGVTLEFPDDTVEAIAEIATEINGSVENIGARRLHTVLERLLEEISF
TATDRSGETIVVTRDMVKERVGALAAKADLSRFIL
>Mature_435_residues
MNAFTPREIVSELDRHIVGQKDAKRAVAIALRNRWRRQQLSEALRDEVLPKNILMIGPTGVGKTEIARRLAKLAQAPFLK
VEATKFTEVGYVGRDVESIIRDLVETALTQERDRLRKQVNAKAEANAEERVLDALVGDRASPETRQKFRKMLREGQINDK
EIEVQVQDSGGALPTMDIPGMPGAQMGMLNLNDIFGKAFGNRTKARKMTVEDSHAVLVREEADKLLDEEQVVKAAIAAVE
NNGIVFLDEIDKIATASERRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHVLFIASGAFHTAKPADLLPELQGRLPI
RVELSALNAGDFKRILLEPEASLITQYKALLATEGVTLEFPDDTVEAIAEIATEINGSVENIGARRLHTVLERLLEEISF
TATDRSGETIVVTRDMVKERVGALAAKADLSRFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Escherichia coli, GI1790366, Length=446, Percent_Identity=59.8654708520179, Blast_Score=512, Evalue=1e-146,
Organism=Escherichia coli, GI1786642, Length=104, Percent_Identity=45.1923076923077, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=295, Percent_Identity=30.1694915254237, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71982905, Length=295, Percent_Identity=30.1694915254237, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24648291, Length=242, Percent_Identity=30.9917355371901, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648289, Length=242, Percent_Identity=30.9917355371901, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_RHORT (Q2RNA1)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_428681.1
- ProteinModelPortal:   Q2RNA1
- SMR:   Q2RNA1
- STRING:   Q2RNA1
- GeneID:   3837056
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A3600
- NMPDR:   fig|1085.1.peg.1897
- eggNOG:   COG1220
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- PhylomeDB:   Q2RNA1
- ProtClustDB:   PRK05201
- BioCyc:   RRUB269796:RRU_A3600-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 47983; Mature: 47983

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: BINDING 18-18 BINDING 248-248 BINDING 313-313 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAFTPREIVSELDRHIVGQKDAKRAVAIALRNRWRRQQLSEALRDEVLPKNILMIGPTG
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
VGKTEIARRLAKLAQAPFLKVEATKFTEVGYVGRDVESIIRDLVETALTQERDRLRKQVN
CCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AKAEANAEERVLDALVGDRASPETRQKFRKMLREGQINDKEIEVQVQDSGGALPTMDIPG
CHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC
MPGAQMGMLNLNDIFGKAFGNRTKARKMTVEDSHAVLVREEADKLLDEEQVVKAAIAAVE
CCCCCCCCCCHHHHHHHHHCCCCHHHEEEECCCCEEEEHHHHHHHHCHHHHHHHHHHHHC
NNGIVFLDEIDKIATASERRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHVLFIASG
CCCEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECC
AFHTAKPADLLPELQGRLPIRVELSALNAGDFKRILLEPEASLITQYKALLATEGVTLEF
CCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCHHEEECCHHHHHHHHHHHHHCCCCEEEC
PDDTVEAIAEIATEINGSVENIGARRLHTVLERLLEEISFTATDRSGETIVVTRDMVKER
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEEECCCCCCEEEEEHHHHHHH
VGALAAKADLSRFIL
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MNAFTPREIVSELDRHIVGQKDAKRAVAIALRNRWRRQQLSEALRDEVLPKNILMIGPTG
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
VGKTEIARRLAKLAQAPFLKVEATKFTEVGYVGRDVESIIRDLVETALTQERDRLRKQVN
CCHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
AKAEANAEERVLDALVGDRASPETRQKFRKMLREGQINDKEIEVQVQDSGGALPTMDIPG
CHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCC
MPGAQMGMLNLNDIFGKAFGNRTKARKMTVEDSHAVLVREEADKLLDEEQVVKAAIAAVE
CCCCCCCCCCHHHHHHHHHCCCCHHHEEEECCCCEEEEHHHHHHHHCHHHHHHHHHHHHC
NNGIVFLDEIDKIATASERRGGDVSREGVQRDLLPLIEGTTVSTKYGPVKTDHVLFIASG
CCCEEEEECHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEECC
AFHTAKPADLLPELQGRLPIRVELSALNAGDFKRILLEPEASLITQYKALLATEGVTLEF
CCCCCCCHHHHHHHHCCCCEEEEEEECCCCCCHHEEECCHHHHHHHHHHHHHCCCCEEEC
PDDTVEAIAEIATEINGSVENIGARRLHTVLERLLEEISFTATDRSGETIVVTRDMVKER
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEEECCCCCCEEEEEHHHHHHH
VGALAAKADLSRFIL
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA