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The map label for this gene is fadD [C]

Identifier: 83594838

GI number: 83594838

Start: 4036633

End: 4038600

Strand: Reverse

Name: fadD [C]

Synonym: Rru_A3509

Alternate gene names: 83594838

Gene position: 4038600-4036633 (Counterclockwise)

Preceding gene: 83594839

Following gene: 83594837

Centisome position: 92.78

GC content: 66.46

Gene sequence:

>1968_bases
ATGGCATCCAGACGTTCCCGCCGCGCCCCCGAGTATGCCGATGTCCACCGGCTCGACACCTTTCCCAAGGTTCTGGCCGA
CAACGCCAAACGCTTCCCCCAGGATATCGCACTGCGGGAAAAGGATCTGGGGATCTGGAAAGAGGTCACCTGGGCCGAGT
ACGGGCTCATGGTGCGGCTTTACGCCCTGGGGCTGAAGGATCTGGGGGTAGAGCGCGGGCAGGTGATCGCCCTGCTTGGC
GCCAACCGCCCCGAATGGCTTTGGGGCGAGATCGCCGCCCATGCCCTGGGCTGCGCCTCGCTTGGCATCTACAAGGACGT
GCTCGACGACGAGGCGGACTACCTGCTGGCCCATTCCGGCGCCGTGGCGGTGATCGCCGAGGACGAGGAGCAGGTTGACA
AGCTGCTGACCCTGGCGGCGCGGGTGCCCAGCCTGCGCCATATCGTTTATTGCGATCCCCGGGGCTTGCGCAAATACAGC
GATCCCCGGCTGATTTCGCAAGACGACCTCAAGGCCCGGGGCCGCGCCCTCGACGCCCGCGACCCCGGGCTTTACGAGCG
CGAGGTGGCGGCGGGCCATGGCGACGACGTGGCGGTGCTGTGCACCACCTCGGGCACCACGGCGCGGCCCAAGCTGGCGA
TGCTCCAGGCCGGGGCCTTCCTGCGCCATTGCCTTGATTACCTCGAGGCCGATCCGCGCCATCCCGGCGATGATTACGTC
TCGGTGCTGCCGCTGCCCTGGATCATGGAGCAGGTCTATGCGGTCGGTCAGGCGCTGATTGCGCGCGGCATCGTCAACTT
CGTCGAGGAGGAGGCGACCACCATGGCCGATCTGCGCGAGATCGGCCCGCGCTTCGTTCTGCTCGCCCCCCGCGTTTGGG
AGGGGATCGCCGCCGATGTGCGGGCGCGGATGATGGACGCCAGCCCCTTCAAGCGGGCGATGTTCGAGATCGGCATGGGC
CTTGGCAAACGGGCGCTGGCGCGCAACCGCCGCTCCTGGCTGGCCGAGGCGCTGCTGTTTCGCGCCTTGCGCGACCGCTT
GGGCTTTTCCTTCCTGACCAGCGCCGCCACCGGCGGCGCGGCGATGGGGCCGGAGACCTTTTCGTTTTTCCATGCCATGG
GGGTGCCGCTCAAGCAGCTCTATGGCCAGACCGAACTGGCCGGGGCCTATGTCATCCACCGCGCCGGCGACATCGATCCC
GAAACCGTCGGCCTGCCCTTCGCCAAATCGGCGGTGCGCATCGACAACCCCGATGCCGAGGGGGTGGGCGAGATCCTCGG
CCGCGACCAGGGGCTGTTCGCCGGGTATTTCGGAGCGGGCGACGCCACGGCGATCGATGACCTGCGCGATGGCTGGCTCC
ATACCGGCGACGCCGGCTTCCTGAAAAAAGAAAACGGCCATCTGGTGGTGATCGACCGGGTGAAGGATCTGGCGGTGATG
AGCAATGGCGTGCGCTTCAGCCCGCAGTTCATCGAAAACAAGCTGAAATTCTCGGCCTTCATCGCCGAGGCGGTGATCCT
GGGGCGCGACCGGCCCTATCTGGCCGCCATCATCTGCATCCGCTGGTCAATCCTGGCCAAATGGGCCGAACAGCGGGCGA
TTTCCTTTACCGGCTATTCCAGCCTCGCCGCCCGGCCCGAGGTGTATGCCCTGCTGCGCGCCGAGGTCGAGCGGGTCAAC
GCCAGCCTGCCCGCCGCCCAGCGCGTGCGCAAGTTCTTGCTGCTCTACAAGGAGCTTGATCCCGACGACGGCGAGCTGAC
GCGCACGCGCAAGGTGCGGCGCGGCGTGGTCGCCGAGAAATACGCCAAGGAGATCACCGCCCTTTACCAGGGGGACGACG
CCGTCGACATCGATACCCATATCACCTTCCAGGATGGCACGACGGCGCGCATCCAGACCCGTCTTAAGGTGGAAACCCTG
ATTTCGGCCGATGAGAACGGCCCGATTGCGTCAAAGGCCGCGGAATGA

Upstream 100 bases:

>100_bases
CGGCGATCATGGCCCATCCCCAGGTGCGCCGGGCCTATCTCGGCGAGAACGACGACGACGCGGCGGTGCCACCCGCCAAG
ACCGCCGGGGAGACCGCCTG

Downstream 100 bases:

>100_bases
CCGGATAGTCACCTCAAAATCCGCCCAGGAAGCCGAAAAAAGGCTCCGGGCGCCGCCGCAAGGCGCGCAGACAGGGAGGA
CGACGCATGAACGGGGAGCT

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 655; Mature: 654

Protein sequence:

>655_residues
MASRRSRRAPEYADVHRLDTFPKVLADNAKRFPQDIALREKDLGIWKEVTWAEYGLMVRLYALGLKDLGVERGQVIALLG
ANRPEWLWGEIAAHALGCASLGIYKDVLDDEADYLLAHSGAVAVIAEDEEQVDKLLTLAARVPSLRHIVYCDPRGLRKYS
DPRLISQDDLKARGRALDARDPGLYEREVAAGHGDDVAVLCTTSGTTARPKLAMLQAGAFLRHCLDYLEADPRHPGDDYV
SVLPLPWIMEQVYAVGQALIARGIVNFVEEEATTMADLREIGPRFVLLAPRVWEGIAADVRARMMDASPFKRAMFEIGMG
LGKRALARNRRSWLAEALLFRALRDRLGFSFLTSAATGGAAMGPETFSFFHAMGVPLKQLYGQTELAGAYVIHRAGDIDP
ETVGLPFAKSAVRIDNPDAEGVGEILGRDQGLFAGYFGAGDATAIDDLRDGWLHTGDAGFLKKENGHLVVIDRVKDLAVM
SNGVRFSPQFIENKLKFSAFIAEAVILGRDRPYLAAIICIRWSILAKWAEQRAISFTGYSSLAARPEVYALLRAEVERVN
ASLPAAQRVRKFLLLYKELDPDDGELTRTRKVRRGVVAEKYAKEITALYQGDDAVDIDTHITFQDGTTARIQTRLKVETL
ISADENGPIASKAAE

Sequences:

>Translated_655_residues
MASRRSRRAPEYADVHRLDTFPKVLADNAKRFPQDIALREKDLGIWKEVTWAEYGLMVRLYALGLKDLGVERGQVIALLG
ANRPEWLWGEIAAHALGCASLGIYKDVLDDEADYLLAHSGAVAVIAEDEEQVDKLLTLAARVPSLRHIVYCDPRGLRKYS
DPRLISQDDLKARGRALDARDPGLYEREVAAGHGDDVAVLCTTSGTTARPKLAMLQAGAFLRHCLDYLEADPRHPGDDYV
SVLPLPWIMEQVYAVGQALIARGIVNFVEEEATTMADLREIGPRFVLLAPRVWEGIAADVRARMMDASPFKRAMFEIGMG
LGKRALARNRRSWLAEALLFRALRDRLGFSFLTSAATGGAAMGPETFSFFHAMGVPLKQLYGQTELAGAYVIHRAGDIDP
ETVGLPFAKSAVRIDNPDAEGVGEILGRDQGLFAGYFGAGDATAIDDLRDGWLHTGDAGFLKKENGHLVVIDRVKDLAVM
SNGVRFSPQFIENKLKFSAFIAEAVILGRDRPYLAAIICIRWSILAKWAEQRAISFTGYSSLAARPEVYALLRAEVERVN
ASLPAAQRVRKFLLLYKELDPDDGELTRTRKVRRGVVAEKYAKEITALYQGDDAVDIDTHITFQDGTTARIQTRLKVETL
ISADENGPIASKAAE
>Mature_654_residues
ASRRSRRAPEYADVHRLDTFPKVLADNAKRFPQDIALREKDLGIWKEVTWAEYGLMVRLYALGLKDLGVERGQVIALLGA
NRPEWLWGEIAAHALGCASLGIYKDVLDDEADYLLAHSGAVAVIAEDEEQVDKLLTLAARVPSLRHIVYCDPRGLRKYSD
PRLISQDDLKARGRALDARDPGLYEREVAAGHGDDVAVLCTTSGTTARPKLAMLQAGAFLRHCLDYLEADPRHPGDDYVS
VLPLPWIMEQVYAVGQALIARGIVNFVEEEATTMADLREIGPRFVLLAPRVWEGIAADVRARMMDASPFKRAMFEIGMGL
GKRALARNRRSWLAEALLFRALRDRLGFSFLTSAATGGAAMGPETFSFFHAMGVPLKQLYGQTELAGAYVIHRAGDIDPE
TVGLPFAKSAVRIDNPDAEGVGEILGRDQGLFAGYFGAGDATAIDDLRDGWLHTGDAGFLKKENGHLVVIDRVKDLAVMS
NGVRFSPQFIENKLKFSAFIAEAVILGRDRPYLAAIICIRWSILAKWAEQRAISFTGYSSLAARPEVYALLRAEVERVNA
SLPAAQRVRKFLLLYKELDPDDGELTRTRKVRRGVVAEKYAKEITALYQGDDAVDIDTHITFQDGTTARIQTRLKVETLI
SADENGPIASKAAE

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI83745141, Length=633, Percent_Identity=27.172195892575, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI27477105, Length=617, Percent_Identity=26.742301458671, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI42794756, Length=575, Percent_Identity=27.1304347826087, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI42794760, Length=575, Percent_Identity=27.1304347826087, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI42794758, Length=575, Percent_Identity=27.1304347826087, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI40807491, Length=568, Percent_Identity=26.5845070422535, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI57165412, Length=569, Percent_Identity=25.4833040421793, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI57165410, Length=573, Percent_Identity=25.3054101221641, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI4758332, Length=618, Percent_Identity=22.6537216828479, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI12669909, Length=618, Percent_Identity=22.6537216828479, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI42794754, Length=601, Percent_Identity=23.4608985024958, Blast_Score=117, Evalue=5e-26,
Organism=Homo sapiens, GI42794752, Length=601, Percent_Identity=23.4608985024958, Blast_Score=117, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17541856, Length=573, Percent_Identity=26.0034904013962, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17510401, Length=590, Percent_Identity=24.0677966101695, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI193204819, Length=625, Percent_Identity=23.04, Blast_Score=129, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17564090, Length=523, Percent_Identity=25.6214149139579, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI25147511, Length=599, Percent_Identity=23.3722871452421, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17553312, Length=598, Percent_Identity=23.2441471571906, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17556552, Length=555, Percent_Identity=20.9009009009009, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320852, Length=640, Percent_Identity=22.34375, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323903, Length=592, Percent_Identity=22.1283783783784, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322182, Length=619, Percent_Identity=20.1938610662359, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921316, Length=653, Percent_Identity=26.1868300153139, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17933690, Length=631, Percent_Identity=25.5150554675119, Blast_Score=183, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24666501, Length=606, Percent_Identity=26.2376237623762, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24666497, Length=606, Percent_Identity=26.2376237623762, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI281366413, Length=606, Percent_Identity=26.2376237623762, Blast_Score=170, Evalue=3e-42,
Organism=Drosophila melanogaster, GI62471681, Length=607, Percent_Identity=22.4052718286656, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI62471687, Length=607, Percent_Identity=22.4052718286656, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24586634, Length=607, Percent_Identity=22.4052718286656, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI22026970, Length=607, Percent_Identity=22.4052718286656, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI62471689, Length=607, Percent_Identity=22.4052718286656, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI62471679, Length=606, Percent_Identity=22.1122112211221, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI62471683, Length=606, Percent_Identity=22.1122112211221, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI62471685, Length=606, Percent_Identity=22.1122112211221, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24586636, Length=606, Percent_Identity=22.1122112211221, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 72263; Mature: 72131

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASRRSRRAPEYADVHRLDTFPKVLADNAKRFPQDIALREKDLGIWKEVTWAEYGLMVRL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
YALGLKDLGVERGQVIALLGANRPEWLWGEIAAHALGCASLGIYKDVLDDEADYLLAHSG
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
AVAVIAEDEEQVDKLLTLAARVPSLRHIVYCDPRGLRKYSDPRLISQDDLKARGRALDAR
EEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCC
DPGLYEREVAAGHGDDVAVLCTTSGTTARPKLAMLQAGAFLRHCLDYLEADPRHPGDDYV
CCCCCHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
SVLPLPWIMEQVYAVGQALIARGIVNFVEEEATTMADLREIGPRFVLLAPRVWEGIAADV
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHH
RARMMDASPFKRAMFEIGMGLGKRALARNRRSWLAEALLFRALRDRLGFSFLTSAATGGA
HHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCC
AMGPETFSFFHAMGVPLKQLYGQTELAGAYVIHRAGDIDPETVGLPFAKSAVRIDNPDAE
CCCCHHHHHHHHHCCCHHHHCCCHHHCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCC
GVGEILGRDQGLFAGYFGAGDATAIDDLRDGWLHTGDAGFLKKENGHLVVIDRVKDLAVM
HHHHHHCCCCCCEEEECCCCCCHHHHHHHCCCEECCCCCCEEECCCCEEEEECHHHHHHH
SNGVRFSPQFIENKLKFSAFIAEAVILGRDRPYLAAIICIRWSILAKWAEQRAISFTGYS
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCH
SLAARPEVYALLRAEVERVNASLPAAQRVRKFLLLYKELDPDDGELTRTRKVRRGVVAEK
HHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
YAKEITALYQGDDAVDIDTHITFQDGTTARIQTRLKVETLISADENGPIASKAAE
HHHHHHHHHCCCCCEEECEEEEECCCCCEEHEEHEEEEHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ASRRSRRAPEYADVHRLDTFPKVLADNAKRFPQDIALREKDLGIWKEVTWAEYGLMVRL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHH
YALGLKDLGVERGQVIALLGANRPEWLWGEIAAHALGCASLGIYKDVLDDEADYLLAHSG
HHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
AVAVIAEDEEQVDKLLTLAARVPSLRHIVYCDPRGLRKYSDPRLISQDDLKARGRALDAR
EEEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHCCCCCCCC
DPGLYEREVAAGHGDDVAVLCTTSGTTARPKLAMLQAGAFLRHCLDYLEADPRHPGDDYV
CCCCCHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
SVLPLPWIMEQVYAVGQALIARGIVNFVEEEATTMADLREIGPRFVLLAPRVWEGIAADV
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHH
RARMMDASPFKRAMFEIGMGLGKRALARNRRSWLAEALLFRALRDRLGFSFLTSAATGGA
HHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCC
AMGPETFSFFHAMGVPLKQLYGQTELAGAYVIHRAGDIDPETVGLPFAKSAVRIDNPDAE
CCCCHHHHHHHHHCCCHHHHCCCHHHCCEEEEEECCCCCCCCCCCCCCCCEEEECCCCCC
GVGEILGRDQGLFAGYFGAGDATAIDDLRDGWLHTGDAGFLKKENGHLVVIDRVKDLAVM
HHHHHHCCCCCCEEEECCCCCCHHHHHHHCCCEECCCCCCEEECCCCEEEEECHHHHHHH
SNGVRFSPQFIENKLKFSAFIAEAVILGRDRPYLAAIICIRWSILAKWAEQRAISFTGYS
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCEEEECCCH
SLAARPEVYALLRAEVERVNASLPAAQRVRKFLLLYKELDPDDGELTRTRKVRRGVVAEK
HHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
YAKEITALYQGDDAVDIDTHITFQDGTTARIQTRLKVETLISADENGPIASKAAE
HHHHHHHHHCCCCCEEECEEEEECCCCCEEHEEHEEEEHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]