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The map label for this gene is livM [H]

Identifier: 83594836

GI number: 83594836

Start: 4034527

End: 4035648

Strand: Reverse

Name: livM [H]

Synonym: Rru_A3507

Alternate gene names: 83594836

Gene position: 4035648-4034527 (Counterclockwise)

Preceding gene: 83594837

Following gene: 83594835

Centisome position: 92.71

GC content: 63.99

Gene sequence:

>1122_bases
ATGGCGACCCTGTCCTTGCGGCCTTGCGGTGACTTCCGCACCAGCTACCGCGCCGATACCAAGATCTTCGACACTCCCAC
CAGCCGCTGGGCGATGGTTGGGTTCCTGTGCGCGCTCTATGGGCTGGTCATCCTGCCCCAGGCCTTTCCGCCTTTGGCAA
GCCTGCCGGTCTTGCGCCTTTTCGCCGATGGCTATGCCCTCTCGCTGGGTATTCAGGTCTGCTACTACGCCATCGCCGCC
CTTGGCCTGAACATCCTGGTCGGCTTCACCGGCCAGATCTCGCTGGGCCATGCCGCCTTCTTCGGGGTCGGTGCTTTTTC
CTCGGCCTGGCTCAACACCCGCGTCGGCTTGCCGGTCCTGGTCTGCATTCCCCTGGCCGGTCTGATGAGCGCCGCCGCCG
GCCTGCTGTTCGGGGCGCCGGCGGCGCGGATCAAGGGGCTTTATCTGGCGATCGCCACCCTGGCCGCCCAGTTCATCATC
GAAGACCTGTTCGTTCGCATGGACTGGTTCACCGGCGGCTCGTCGGGGGCGATGGCCGATACGCCGATGCTGGGATCCTT
CGCCTTCGATAACGACGCCCGCTATTTCCTGCTGTCGCTCAGCTTCACCATCGTCTTGTTCGTCATGGCGGCGAACCTGA
TGCGCTCGCGCGACGGCCGGGCCTTCGTCGCCCTGCGCGACCATTATCTATCGGCCGAGGTGATGGGCATCGCCCTGACC
CGCTACCGGGTGATGTCGTTTGGCATCGCCGCCTTTTATGCCGGCATCGGCGGGGCGCTTTACGGCCATTACCTGATGTT
CGTCTCGGCCGAGGCCTTCACCATTCTGCTGTCGATCCAGTTCCTGGGCATGATCATCATCGGCGGCCTGGGCAGCGTGA
TGGGGGCGATGCTGGGAACGATCTTCATGGTCGCCCTGCCCGAGGTCATGGGGGCGGTGATCGCCGCCTTGCAGACCACC
CAATGGGGCAACCGGCCGGCGGTGATCAACGGCCTGCCGTTCTTCCGCGAAATGGCCATCGGCGCGGCGATCATCTTGTT
CCTGATCTTTGAACCCGATGGCCTCGCCCACCGCTGGCGGCTGATCAAGACCTATTGGAAGCTCTACCCCTTCTCTCACT
AA

Upstream 100 bases:

>100_bases
AATATGCTGACCATCGCGCCGTTCTGGGTGCTGATCGCCATCCTGGTCATCAAGCCCTATGGCTTGTTCGGCACCAAGAA
AATCGAGCGGGTGTAAGGCC

Downstream 100 bases:

>100_bases
CCTTTTTTATCCCCTCGCTTTTTTTTAAAAAAACCAAAGGGCCCGAAGGGTCCGTTCCGGGAGGTTACACAAACCATGAA
GACGGTGCTAAGCGCGACCC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MATLSLRPCGDFRTSYRADTKIFDTPTSRWAMVGFLCALYGLVILPQAFPPLASLPVLRLFADGYALSLGIQVCYYAIAA
LGLNILVGFTGQISLGHAAFFGVGAFSSAWLNTRVGLPVLVCIPLAGLMSAAAGLLFGAPAARIKGLYLAIATLAAQFII
EDLFVRMDWFTGGSSGAMADTPMLGSFAFDNDARYFLLSLSFTIVLFVMAANLMRSRDGRAFVALRDHYLSAEVMGIALT
RYRVMSFGIAAFYAGIGGALYGHYLMFVSAEAFTILLSIQFLGMIIIGGLGSVMGAMLGTIFMVALPEVMGAVIAALQTT
QWGNRPAVINGLPFFREMAIGAAIILFLIFEPDGLAHRWRLIKTYWKLYPFSH

Sequences:

>Translated_373_residues
MATLSLRPCGDFRTSYRADTKIFDTPTSRWAMVGFLCALYGLVILPQAFPPLASLPVLRLFADGYALSLGIQVCYYAIAA
LGLNILVGFTGQISLGHAAFFGVGAFSSAWLNTRVGLPVLVCIPLAGLMSAAAGLLFGAPAARIKGLYLAIATLAAQFII
EDLFVRMDWFTGGSSGAMADTPMLGSFAFDNDARYFLLSLSFTIVLFVMAANLMRSRDGRAFVALRDHYLSAEVMGIALT
RYRVMSFGIAAFYAGIGGALYGHYLMFVSAEAFTILLSIQFLGMIIIGGLGSVMGAMLGTIFMVALPEVMGAVIAALQTT
QWGNRPAVINGLPFFREMAIGAAIILFLIFEPDGLAHRWRLIKTYWKLYPFSH
>Mature_372_residues
ATLSLRPCGDFRTSYRADTKIFDTPTSRWAMVGFLCALYGLVILPQAFPPLASLPVLRLFADGYALSLGIQVCYYAIAAL
GLNILVGFTGQISLGHAAFFGVGAFSSAWLNTRVGLPVLVCIPLAGLMSAAAGLLFGAPAARIKGLYLAIATLAAQFIIE
DLFVRMDWFTGGSSGAMADTPMLGSFAFDNDARYFLLSLSFTIVLFVMAANLMRSRDGRAFVALRDHYLSAEVMGIALTR
YRVMSFGIAAFYAGIGGALYGHYLMFVSAEAFTILLSIQFLGMIIIGGLGSVMGAMLGTIFMVALPEVMGAVIAALQTTQ
WGNRPAVINGLPFFREMAIGAAIILFLIFEPDGLAHRWRLIKTYWKLYPFSH

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=259, Percent_Identity=34.3629343629344, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 40271; Mature: 40140

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLSLRPCGDFRTSYRADTKIFDTPTSRWAMVGFLCALYGLVILPQAFPPLASLPVLRL
CCEECCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FADGYALSLGIQVCYYAIAALGLNILVGFTGQISLGHAAFFGVGAFSSAWLNTRVGLPVL
HHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECHHHHHHHHHHHHHHHHCCCCCHHH
VCIPLAGLMSAAAGLLFGAPAARIKGLYLAIATLAAQFIIEDLFVRMDWFTGGSSGAMAD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCC
TPMLGSFAFDNDARYFLLSLSFTIVLFVMAANLMRSRDGRAFVALRDHYLSAEVMGIALT
CCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHH
RYRVMSFGIAAFYAGIGGALYGHYLMFVSAEAFTILLSIQFLGMIIIGGLGSVMGAMLGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFMVALPEVMGAVIAALQTTQWGNRPAVINGLPFFREMAIGAAIILFLIFEPDGLAHRWR
HHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHEECCCCHHHHHH
LIKTYWKLYPFSH
HHHHHHHHCCCCC
>Mature Secondary Structure 
ATLSLRPCGDFRTSYRADTKIFDTPTSRWAMVGFLCALYGLVILPQAFPPLASLPVLRL
CEECCCCCCCHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
FADGYALSLGIQVCYYAIAALGLNILVGFTGQISLGHAAFFGVGAFSSAWLNTRVGLPVL
HHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEECHHHHHHHHHHHHHHHHCCCCCHHH
VCIPLAGLMSAAAGLLFGAPAARIKGLYLAIATLAAQFIIEDLFVRMDWFTGGSSGAMAD
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCC
TPMLGSFAFDNDARYFLLSLSFTIVLFVMAANLMRSRDGRAFVALRDHYLSAEVMGIALT
CCCCCCEEECCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHH
RYRVMSFGIAAFYAGIGGALYGHYLMFVSAEAFTILLSIQFLGMIIIGGLGSVMGAMLGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFMVALPEVMGAVIAALQTTQWGNRPAVINGLPFFREMAIGAAIILFLIFEPDGLAHRWR
HHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHEECCCCHHHHHH
LIKTYWKLYPFSH
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]