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The map label for this gene is dnaX [H]

Identifier: 83594802

GI number: 83594802

Start: 3996560

End: 3998539

Strand: Reverse

Name: dnaX [H]

Synonym: Rru_A3473

Alternate gene names: 83594802

Gene position: 3998539-3996560 (Counterclockwise)

Preceding gene: 83594803

Following gene: 83594801

Centisome position: 91.86

GC content: 70.51

Gene sequence:

>1980_bases
ATGCGCCCCGTTGACCCGGCCCCCGGTATGAGCGATCAGGTGACACCCGACTCCGAGGCCCCCTCCTCCGAGAAGCCTGC
CGGTTCAAAAGCCACCCCGGCGTCCGCGCCCTACCGTGTTCTCGCCCGCAAATATCGCCCGGCGTCCTTTGACGCCCTGA
TCGGCCAGGAAGCCCTGGTCCGCACCCTGACCAACGCCATCGACAGCGGGCGACTGGCCCAGGCCTGGATGCTGACGGGC
GTGCGCGGGGTGGGCAAGACCACCACCGCCCGGCTGATCGCCCGCGCCCTGAATTGCGTCGGCGCCGATGGCAAGGGGGG
CGTGACCATCACGCCCTGCGGCGTCTGCGAGCATTGCAAGGCGATCGCCGAAGACCGCCATGTCGATGTGCTGGAGATGG
ACGCCGCCAGCCGCACCGGCGTTGGCGATATCCGCGAGATCCTTGATGGCGTGCGCTACCGCCCGGCGGTGGCCCGCACC
AAGGTTTACATCATCGACGAAGTCCACATGCTCTCGACCGCCGCCTTCAACGCCCTGTTGAAGACGCTCGAAGAGCCGCC
CGAGCATGTGAAATTCATTTTCGCCACCACCGAGATCCGCAAGGTCCCGGTCACCGTTCTGTCGCGCTGCCAACGCTTCG
ACCTGCGCCGGGTCAGCGCCGCCGAGCTTTCGGGCCATTTCCTGCGTATCGCCGGGCTGGAAGGCGCCGAGATCGCCCCA
AGCGCCCTGACCCTGATCGCCCGCGCCGCCGATGGATCGGTGCGCGACGGCTTGTCGCTGCTTGATCAGGCGATCGCCCA
TGGCGGCGGCACGGTTTCCGAAGCCCAGGTCGCCGAGATGCTGGGACTGGCCGACCGCGCCCGCATCTTCGACCTGCTCG
ACGCCCTGCTCGCCGGCCGCATCGCCGAAAGCCTCGACCTCCTTGATCGGCAATACGCCCTGGGCGCCGATCCGCTGGTC
ATCGTTCAAGATCTGCTTGATCTCGTCCATTGGATGACGCGGGTGAAGGTGGTGCCGGTCTCGGCCGAGGATGCCGCCGT
TCCCGAGGCCGAGCGCACCCGTGGCCGGGCGATGGCCGAGCGCTTGTCGATGGCGGTGCTGAACCGCTGCTGGCAGATCC
TGCTCAAAGGCCTGGGCGAGGCGCGCGGCGCCCCGGTGCCGCTTCAGGCCGTCGAAATGGTGCTGATCCGTCTGGCCTAT
GCCAGCGACCTGCCCACCCCCGAGGAGGCCTTGAAGATGATCGCCGGCGGTGCCCAGCCCGCCGCCCCCCGCCCGCCGGC
CCCCCACTCGCCCGCCGGTCCCCCCCCCGCCGCGCCGCCTCCCCCTTCGCCGCCGTCCCGGGCCGACGAGCCGCCGCGCC
CGTCCCGCCCGTCGCAATCGAACGCCGGCGGCGGCGCCCTGGCCGTAGCGCCGGTGGAGGTCGCCCCCGATCCCCCGCCC
CCGCCCCCGCCCCCGCCGGCCCCACCGGCCGCCGATCCGGCCGGCGCCTTCGACCCGGTGCCGCGCAGCTTCGCCCTGCT
CGTCGATCTGTTCCGGCGCAAGCGCGAAGCCGTGGTCACCGGCCATCTGTATCGCGATGTCGAACTGGTGGGCTATGATC
CCGAGGCTGGGCTGCTGGAGATCCATCCCCTGCCCGCCGCGCCGGCCAAACTGGCCGGCCAGATCACCCGCCTGCTCGGC
GAATGGACCGGCCGGCGGTGGATGGTGACGCTGACCGACCGTCCCGGACAGCCGACCTTGCATGATGCCACCCAGGCCGA
TATCCATGCCCATCCGCTGGTCAAGGCGGTGCTGGACCGCTTTCCCGGGGCGGTGATCGGAACCATTCGCGAGCATCCCG
GAGCCGTCGCGGCCGAGGCCGATTCGCCCGACCTCCTCGGCGATCCTGGCGAGGCTTATGGCGCGCCCGGCTTCGACACC
CCGGCGGGCGCCGATCCAGACGATCTGTTCGACCCATTCATCGGAGACGACGAGACATGA

Upstream 100 bases:

>100_bases
GCCGTAACGAGTTCGTCGCGGGTCGCGTCCAGTCTTCCACCTTTTCTTCCCCTGTTTTCCGGGGTCGCCCGTCGGCCCCC
TTGTGTTTCCGGGGTCTCCC

Downstream 100 bases:

>100_bases
AAAACATCGGGCAAATGCTCAAGCAGGCCCAGCAGCTGCAAACCCGCATGGCCGAAGTTCAAGAAGAGCTGAAGGCGATG
GACGTCAGCGGCCAGTCGGC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MRPVDPAPGMSDQVTPDSEAPSSEKPAGSKATPASAPYRVLARKYRPASFDALIGQEALVRTLTNAIDSGRLAQAWMLTG
VRGVGKTTTARLIARALNCVGADGKGGVTITPCGVCEHCKAIAEDRHVDVLEMDAASRTGVGDIREILDGVRYRPAVART
KVYIIDEVHMLSTAAFNALLKTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVSAAELSGHFLRIAGLEGAEIAP
SALTLIARAADGSVRDGLSLLDQAIAHGGGTVSEAQVAEMLGLADRARIFDLLDALLAGRIAESLDLLDRQYALGADPLV
IVQDLLDLVHWMTRVKVVPVSAEDAAVPEAERTRGRAMAERLSMAVLNRCWQILLKGLGEARGAPVPLQAVEMVLIRLAY
ASDLPTPEEALKMIAGGAQPAAPRPPAPHSPAGPPPAAPPPPSPPSRADEPPRPSRPSQSNAGGGALAVAPVEVAPDPPP
PPPPPPAPPAADPAGAFDPVPRSFALLVDLFRRKREAVVTGHLYRDVELVGYDPEAGLLEIHPLPAAPAKLAGQITRLLG
EWTGRRWMVTLTDRPGQPTLHDATQADIHAHPLVKAVLDRFPGAVIGTIREHPGAVAAEADSPDLLGDPGEAYGAPGFDT
PAGADPDDLFDPFIGDDET

Sequences:

>Translated_659_residues
MRPVDPAPGMSDQVTPDSEAPSSEKPAGSKATPASAPYRVLARKYRPASFDALIGQEALVRTLTNAIDSGRLAQAWMLTG
VRGVGKTTTARLIARALNCVGADGKGGVTITPCGVCEHCKAIAEDRHVDVLEMDAASRTGVGDIREILDGVRYRPAVART
KVYIIDEVHMLSTAAFNALLKTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVSAAELSGHFLRIAGLEGAEIAP
SALTLIARAADGSVRDGLSLLDQAIAHGGGTVSEAQVAEMLGLADRARIFDLLDALLAGRIAESLDLLDRQYALGADPLV
IVQDLLDLVHWMTRVKVVPVSAEDAAVPEAERTRGRAMAERLSMAVLNRCWQILLKGLGEARGAPVPLQAVEMVLIRLAY
ASDLPTPEEALKMIAGGAQPAAPRPPAPHSPAGPPPAAPPPPSPPSRADEPPRPSRPSQSNAGGGALAVAPVEVAPDPPP
PPPPPPAPPAADPAGAFDPVPRSFALLVDLFRRKREAVVTGHLYRDVELVGYDPEAGLLEIHPLPAAPAKLAGQITRLLG
EWTGRRWMVTLTDRPGQPTLHDATQADIHAHPLVKAVLDRFPGAVIGTIREHPGAVAAEADSPDLLGDPGEAYGAPGFDT
PAGADPDDLFDPFIGDDET
>Mature_659_residues
MRPVDPAPGMSDQVTPDSEAPSSEKPAGSKATPASAPYRVLARKYRPASFDALIGQEALVRTLTNAIDSGRLAQAWMLTG
VRGVGKTTTARLIARALNCVGADGKGGVTITPCGVCEHCKAIAEDRHVDVLEMDAASRTGVGDIREILDGVRYRPAVART
KVYIIDEVHMLSTAAFNALLKTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVSAAELSGHFLRIAGLEGAEIAP
SALTLIARAADGSVRDGLSLLDQAIAHGGGTVSEAQVAEMLGLADRARIFDLLDALLAGRIAESLDLLDRQYALGADPLV
IVQDLLDLVHWMTRVKVVPVSAEDAAVPEAERTRGRAMAERLSMAVLNRCWQILLKGLGEARGAPVPLQAVEMVLIRLAY
ASDLPTPEEALKMIAGGAQPAAPRPPAPHSPAGPPPAAPPPPSPPSRADEPPRPSRPSQSNAGGGALAVAPVEVAPDPPP
PPPPPPAPPAADPAGAFDPVPRSFALLVDLFRRKREAVVTGHLYRDVELVGYDPEAGLLEIHPLPAAPAKLAGQITRLLG
EWTGRRWMVTLTDRPGQPTLHDATQADIHAHPLVKAVLDRFPGAVIGTIREHPGAVAAEADSPDLLGDPGEAYGAPGFDT
PAGADPDDLFDPFIGDDET

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=332, Percent_Identity=22.5903614457831, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI31881687, Length=332, Percent_Identity=22.5903614457831, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1786676, Length=373, Percent_Identity=44.5040214477212, Blast_Score=298, Evalue=5e-82,
Organism=Saccharomyces cerevisiae, GI6324039, Length=225, Percent_Identity=24.8888888888889, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17647857, Length=286, Percent_Identity=24.4755244755245, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859927, Length=318, Percent_Identity=23.8993710691824, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 69538; Mature: 69538

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPVDPAPGMSDQVTPDSEAPSSEKPAGSKATPASAPYRVLARKYRPASFDALIGQEALV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHH
RTLTNAIDSGRLAQAWMLTGVRGVGKTTTARLIARALNCVGADGKGGVTITPCGVCEHCK
HHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHH
AIAEDRHVDVLEMDAASRTGVGDIREILDGVRYRPAVARTKVYIIDEVHMLSTAAFNALL
HHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHEEEEEECHHHHHHHHHHHHHH
KTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVSAAELSGHFLRIAGLEGAEIAP
HHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCH
SALTLIARAADGSVRDGLSLLDQAIAHGGGTVSEAQVAEMLGLADRARIFDLLDALLAGR
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAESLDLLDRQYALGADPLVIVQDLLDLVHWMTRVKVVPVSAEDAAVPEAERTRGRAMAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHH
RLSMAVLNRCWQILLKGLGEARGAPVPLQAVEMVLIRLAYASDLPTPEEALKMIAGGAQP
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
AAPRPPAPHSPAGPPPAAPPPPSPPSRADEPPRPSRPSQSNAGGGALAVAPVEVAPDPPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCC
PPPPPPAPPAADPAGAFDPVPRSFALLVDLFRRKREAVVTGHLYRDVELVGYDPEAGLLE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECEEEEEECCCCCEEE
IHPLPAAPAKLAGQITRLLGEWTGRRWMVTLTDRPGQPTLHDATQADIHAHPLVKAVLDR
EECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
FPGAVIGTIREHPGAVAAEADSPDLLGDPGEAYGAPGFDTPAGADPDDLFDPFIGDDET
CCCCEEHHHHHCCCCEEECCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MRPVDPAPGMSDQVTPDSEAPSSEKPAGSKATPASAPYRVLARKYRPASFDALIGQEALV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHH
RTLTNAIDSGRLAQAWMLTGVRGVGKTTTARLIARALNCVGADGKGGVTITPCGVCEHCK
HHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHH
AIAEDRHVDVLEMDAASRTGVGDIREILDGVRYRPAVARTKVYIIDEVHMLSTAAFNALL
HHHCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCHHHHEEEEEECHHHHHHHHHHHHHH
KTLEEPPEHVKFIFATTEIRKVPVTVLSRCQRFDLRRVSAAELSGHFLRIAGLEGAEIAP
HHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCH
SALTLIARAADGSVRDGLSLLDQAIAHGGGTVSEAQVAEMLGLADRARIFDLLDALLAGR
HHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAESLDLLDRQYALGADPLVIVQDLLDLVHWMTRVKVVPVSAEDAAVPEAERTRGRAMAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCHHHHHHHHHHH
RLSMAVLNRCWQILLKGLGEARGAPVPLQAVEMVLIRLAYASDLPTPEEALKMIAGGAQP
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCC
AAPRPPAPHSPAGPPPAAPPPPSPPSRADEPPRPSRPSQSNAGGGALAVAPVEVAPDPPP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCC
PPPPPPAPPAADPAGAFDPVPRSFALLVDLFRRKREAVVTGHLYRDVELVGYDPEAGLLE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECEEEEEECCCCCEEE
IHPLPAAPAKLAGQITRLLGEWTGRRWMVTLTDRPGQPTLHDATQADIHAHPLVKAVLDR
EECCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
FPGAVIGTIREHPGAVAAEADSPDLLGDPGEAYGAPGFDTPAGADPDDLFDPFIGDDET
CCCCEEHHHHHCCCCEEECCCCCCCCCCCCHHCCCCCCCCCCCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]