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The map label for this gene is trxA [H]

Identifier: 83594762

GI number: 83594762

Start: 3951788

End: 3952102

Strand: Reverse

Name: trxA [H]

Synonym: Rru_A3433

Alternate gene names: 83594762

Gene position: 3952102-3951788 (Counterclockwise)

Preceding gene: 83594763

Following gene: 83594761

Centisome position: 90.79

GC content: 61.27

Gene sequence:

>315_bases
ATGAAGCAGGTTTCCGACGCCTCTTTCGAAGAGGATGTCCTGAAGGCCGATGGTCCCGTGCTGGTGGACTTCTGGGCGGA
ATGGTGCGGCCCCTGCCGCCAGATCGCCCCGGCTCTCGAAGAGCTGGCCACCGCGCTTGGCGACAAAGTGACCGTGGCCA
AGATCAACATCGATGAAAACCCGCAAACCCCGTCGAAATACGGCGTGCGCGGCATTCCGACGCTGATGATCTTCAAGGAC
GGTCAAGTCGCCGCGACCAAGATCGGCGCCCTGCCCAAGACCAAGCTGTTTGAGTGGGTCGAAGCCTCGGTCTGA

Upstream 100 bases:

>100_bases
TTGACGGGGCCGCTCAGGCGCCCCTACATTTGGCTCGGAGAACCGGCCGGGCGACCCTTTCCCCTTGGTCTCCTCGCCGC
GATATCAAAGGATAGTGATC

Downstream 100 bases:

>100_bases
GGTTTGGCGTCCTCCCCGCCTGACGAACGGCCCTTTGCGAAGGGCCGTTTTCGTTTGGGCAAAGCCCGCCTTGACGGGCT
CCCGTCCACGGGATCGAATG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 104

Protein sequence:

>104_residues
MKQVSDASFEEDVLKADGPVLVDFWAEWCGPCRQIAPALEELATALGDKVTVAKINIDENPQTPSKYGVRGIPTLMIFKD
GQVAATKIGALPKTKLFEWVEASV

Sequences:

>Translated_104_residues
MKQVSDASFEEDVLKADGPVLVDFWAEWCGPCRQIAPALEELATALGDKVTVAKINIDENPQTPSKYGVRGIPTLMIFKD
GQVAATKIGALPKTKLFEWVEASV
>Mature_104_residues
MKQVSDASFEEDVLKADGPVLVDFWAEWCGPCRQIAPALEELATALGDKVTVAKINIDENPQTPSKYGVRGIPTLMIFKD
GQVAATKIGALPKTKLFEWVEASV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361657, Length=94, Percent_Identity=41.4893617021277, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI21361403, Length=81, Percent_Identity=37.037037037037, Blast_Score=72, Evalue=9e-14,
Organism=Homo sapiens, GI5031973, Length=76, Percent_Identity=36.8421052631579, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI4758304, Length=82, Percent_Identity=41.4634146341463, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=61.7647058823529, Blast_Score=141, Evalue=9e-36,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=44.6808510638298, Blast_Score=96, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=38.7096774193548, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=87, Percent_Identity=40.2298850574713, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=34.4444444444444, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=101, Percent_Identity=33.6633663366337, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=103, Percent_Identity=28.1553398058252, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=82, Percent_Identity=36.5853658536585, Blast_Score=65, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=90, Percent_Identity=36.6666666666667, Blast_Score=65, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=35.2272727272727, Blast_Score=64, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639826, Length=77, Percent_Identity=44.1558441558442, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=34.375, Blast_Score=79, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17648013, Length=81, Percent_Identity=40.7407407407407, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583090, Length=81, Percent_Identity=40.7407407407407, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921434, Length=76, Percent_Identity=38.1578947368421, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=45.9016393442623, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11305; Mature: 11305

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQVSDASFEEDVLKADGPVLVDFWAEWCGPCRQIAPALEELATALGDKVTVAKINIDEN
CCCCCCCCCHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
PQTPSKYGVRGIPTLMIFKDGQVAATKIGALPKTKLFEWVEASV
CCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MKQVSDASFEEDVLKADGPVLVDFWAEWCGPCRQIAPALEELATALGDKVTVAKINIDEN
CCCCCCCCCHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
PQTPSKYGVRGIPTLMIFKDGQVAATKIGALPKTKLFEWVEASV
CCCCCCCCCCCCCEEEEEECCCEEEHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3129411 [H]