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The map label for this gene is trpA [H]

Identifier: 83594757

GI number: 83594757

Start: 3945911

End: 3946726

Strand: Direct

Name: trpA [H]

Synonym: Rru_A3428

Alternate gene names: 83594757

Gene position: 3945911-3946726 (Clockwise)

Preceding gene: 83594756

Following gene: 83594759

Centisome position: 90.65

GC content: 69.98

Gene sequence:

>816_bases
GTGAGCGCCACCACGCCGACCACCGATCGCCTCTCCCGCCGCTTCGCCGCCCTCAAGGCCGAAGGCCGGGGGGGCCTTGT
CACCTATGTCATGGCCGGCGATCCCGACCAGGAAACGGCCCTCGCCCTGATGCGCGGCCTGCCCGGCGCCGGGGCCGATA
TCATCGAATTGGGAATGCCGTTTTCCGATCCGATGGCCGATGGCCCGGCGATCCAGGCCGCCGCCCTGCGCGCCCTGGCC
GCCGGGATGACCCTGACGGGGACCTTGGAAACCCTGAAGGCGTTCCGCGCCACCGATGATGACACCCCGGTGGTTCTGAT
GGGCTATTACAATCCCATCCATTATTACGGGGCCGAGGCCTTCGCCCGCGACGCCGCCCTGGCCGGCGCCGACGGCCTGA
TCATCGTCGACCTGCCGCCCGAGGAGGCCGACGAGCTTCTACCCTTCCTGCGCGCCCAGGGTCTGCATCTGATCATGCTG
GCGACGCCGACCACCGATGAGGCGCGGCTGCCGGCGATTCTCGAGCGGGCGAGCGGGTTTCTTTATTATGTTTCGATCGC
CGGCATCACCGGAACGGCCGCCGCCGATGCCGGGGGCGTCGCCCAGGCGGTCGCCCGCATCCGCCGGAAAACCGATCTGC
CGATCGCCATCGGCTTTGGCGTATCCACCCCGGCCCAGGCGGCGACGATGGCGCGGGTCGGTGATGCCGCCGTGGTCGGT
TCGGCCATTGTCCGCCGGCTGGCCGAGGGCGGGGACGTGCTGGGCTTCGTTGGCGAATTGGCCGGCGCCCTGCGCAAGGT
CGACGCGGCGGGGTAA

Upstream 100 bases:

>100_bases
CGGCCGATCATCTGATGGTGGTCAGCCTGTCGGGGCGCGGCGACAAGGACGTGGGGACGATCGCCAAGGTTCTGGGCAGT
GATTTCAAGGGAATGATGCC

Downstream 100 bases:

>100_bases
ATCAAATCACCCGCGCCCGGAGAGCGGCTGTTTTGGCTCGTCCCCGGGCGCCGGGCGCGATGCCTGATCTAGGGCGGGGA
GCGTGCAATCAGATTCACGC

Product: tryptophan synthase, alpha chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MSATTPTTDRLSRRFAALKAEGRGGLVTYVMAGDPDQETALALMRGLPGAGADIIELGMPFSDPMADGPAIQAAALRALA
AGMTLTGTLETLKAFRATDDDTPVVLMGYYNPIHYYGAEAFARDAALAGADGLIIVDLPPEEADELLPFLRAQGLHLIML
ATPTTDEARLPAILERASGFLYYVSIAGITGTAAADAGGVAQAVARIRRKTDLPIAIGFGVSTPAQAATMARVGDAAVVG
SAIVRRLAEGGDVLGFVGELAGALRKVDAAG

Sequences:

>Translated_271_residues
MSATTPTTDRLSRRFAALKAEGRGGLVTYVMAGDPDQETALALMRGLPGAGADIIELGMPFSDPMADGPAIQAAALRALA
AGMTLTGTLETLKAFRATDDDTPVVLMGYYNPIHYYGAEAFARDAALAGADGLIIVDLPPEEADELLPFLRAQGLHLIML
ATPTTDEARLPAILERASGFLYYVSIAGITGTAAADAGGVAQAVARIRRKTDLPIAIGFGVSTPAQAATMARVGDAAVVG
SAIVRRLAEGGDVLGFVGELAGALRKVDAAG
>Mature_270_residues
SATTPTTDRLSRRFAALKAEGRGGLVTYVMAGDPDQETALALMRGLPGAGADIIELGMPFSDPMADGPAIQAAALRALAA
GMTLTGTLETLKAFRATDDDTPVVLMGYYNPIHYYGAEAFARDAALAGADGLIIVDLPPEEADELLPFLRAQGLHLIMLA
TPTTDEARLPAILERASGFLYYVSIAGITGTAAADAGGVAQAVARIRRKTDLPIAIGFGVSTPAQAATMARVGDAAVVGS
AIVRRLAEGGDVLGFVGELAGALRKVDAAG

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=245, Percent_Identity=35.9183673469388, Blast_Score=131, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6321412, Length=238, Percent_Identity=45.3781512605042, Blast_Score=207, Evalue=2e-54,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 27797; Mature: 27666

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATTPTTDRLSRRFAALKAEGRGGLVTYVMAGDPDQETALALMRGLPGAGADIIELGMP
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCHHHEECCC
FSDPMADGPAIQAAALRALAAGMTLTGTLETLKAFRATDDDTPVVLMGYYNPIHYYGAEA
CCCCCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCCCCEEEEECCCCHHHHCHHH
FARDAALAGADGLIIVDLPPEEADELLPFLRAQGLHLIMLATPTTDEARLPAILERASGF
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCE
LYYVSIAGITGTAAADAGGVAQAVARIRRKTDLPIAIGFGVSTPAQAATMARVGDAAVVG
EEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCHHHHH
SAIVRRLAEGGDVLGFVGELAGALRKVDAAG
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SATTPTTDRLSRRFAALKAEGRGGLVTYVMAGDPDQETALALMRGLPGAGADIIELGMP
CCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCHHHEECCC
FSDPMADGPAIQAAALRALAAGMTLTGTLETLKAFRATDDDTPVVLMGYYNPIHYYGAEA
CCCCCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCCCCEEEEECCCCHHHHCHHH
FARDAALAGADGLIIVDLPPEEADELLPFLRAQGLHLIMLATPTTDEARLPAILERASGF
HHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCE
LYYVSIAGITGTAAADAGGVAQAVARIRRKTDLPIAIGFGVSTPAQAATMARVGDAAVVG
EEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCHHHHH
SAIVRRLAEGGDVLGFVGELAGALRKVDAAG
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA