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The map label for this gene is phoQ [H]

Identifier: 83594518

GI number: 83594518

Start: 3677198

End: 3678568

Strand: Direct

Name: phoQ [H]

Synonym: Rru_A3188

Alternate gene names: 83594518

Gene position: 3677198-3678568 (Clockwise)

Preceding gene: 83594517

Following gene: 83594519

Centisome position: 84.48

GC content: 71.99

Gene sequence:

>1371_bases
TTGTGGTTGGCCGGCGCCCTGGCGGCGACCTATCTGGTCATTTCCTATGCGGTGGCCGAAACCCTGGAGCGCGGCTTTGA
CGAGACCCTGGCCGCCCTGGTCGATACCCTGACGGCGGCGGCCGAGATCACCGACGACGGTACCCTGGTTCTTCTGCGCG
ATCCCGGCGATCCGCGGTTCACCCGCGCCTATTCGGGATGGTACTGGCAAATGACCTGGGGCGATCAGGTGGTGCGCTCG
CGCTCGCTTTGGGATCAGACCCTGGTGCGCGGCGAACACGCCAGCGACGCCATCCATATCCACCGGGAACGCGATCCGCG
TGGCCGCCCGCTCGAGGTGGTCGAGCGCGATATCTTTCCGCCCCGCCCCGCCGCCGGCACCCCGCCGCCATCCCTGCCGG
CGCAGCCGGTTCATGTGATGGTGGCGGGCGATCGCACCGGCATCGAGGGTGAAATCGCCCGCCTGCAAGGGCTGTTGGCG
CTGTGTCTGGCCGGGCTTGGCGGTGGGTTGCTGGCGGCGACCTTCGCCCAGGTCTCCTATGGCCTGCGCCCTTTGGACCG
CCTGCGGGCGGCCTTGCACCGGGCCCGCGACGATCCGTCGCTACGCCTGGAGGAGACCCAGCCCGGCGAACTGGCGCCGC
TGGCCCAGGCGCTCAACGCCCTGCTCGACCACAACGCCTCGCTGATCGACCGGGCGCGCGCCCATGTCGGCAATCTGGCC
CATGGCCTGAAAACGCCGCTCGCGGTATTGCGCAGCGCCGCCGATGACGGCCCCACCGTCGAGGCCGACATGGTGCGCGC
CCAGACCGCGACCATGGGCCGGCTGGTCGAACGCCACCTGGCCCGCGCCCGCGCCAGCGTCGGCCAGACCGCCATCTTCA
GCGCTCGCGCGCCGATCCTCGCCGCCGCCCGCCGCGTTGGCGCCACCATGGCCCTGATCCATTGCCGGCCGCTCGACATC
ACCATCGACGGCGCCGAGGACGCGGCCTTTCCCGGCGCCGGCGACGACCTGCTCGAGATCCTTGGCAATCTGATGGACAA
CGCCTGCAAATGGGCCAAGGCCCGGGTCGCCGTCCATGCCGGGCGCGAGGCCGGGCGGATCATCCTGACGGTTGAAGACG
ACGGTCCCGGCTTGGCCGAGGACGAGGCGCGGACCGCGCCGCGCCGGGGCGCCCGCCTCGACGACAGCCTGCCCGGCCAT
GGCCTGGGGCTTGATATCGTCGCCGATCTCGCCGCCCTCCATGGCGCGACGCTGACGCTTGACCGCTCGCGGCTGGGCGG
CCTGCGGGCGACGCTGCGTCTGCCGCCGGCCGGCTGGGGGGACAAGCCCGCCGACCCCAGGGACAAGGGGCGGTCGCGCC
CGGCGGAATAA

Upstream 100 bases:

>100_bases
TCGGCTATCGGCTGGAAGCCGAAAGCGCCCCCCCCGATCAAGGGGCGCTCCGCTGAGACCGCCGCGCTCGCTGCGCCGCC
GCCTGCTGGTCGCGGGCGGC

Downstream 100 bases:

>100_bases
GGCGTCCAGCCAAGCCTTTTCCCGGAAAAAAGCAACCAATGCATGGTCCTTGCCGTTTCTTTCTCATCAGACAGTCGGCA
TTCGCAGACAGTCGGAGGAT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MWLAGALAATYLVISYAVAETLERGFDETLAALVDTLTAAAEITDDGTLVLLRDPGDPRFTRAYSGWYWQMTWGDQVVRS
RSLWDQTLVRGEHASDAIHIHRERDPRGRPLEVVERDIFPPRPAAGTPPPSLPAQPVHVMVAGDRTGIEGEIARLQGLLA
LCLAGLGGGLLAATFAQVSYGLRPLDRLRAALHRARDDPSLRLEETQPGELAPLAQALNALLDHNASLIDRARAHVGNLA
HGLKTPLAVLRSAADDGPTVEADMVRAQTATMGRLVERHLARARASVGQTAIFSARAPILAAARRVGATMALIHCRPLDI
TIDGAEDAAFPGAGDDLLEILGNLMDNACKWAKARVAVHAGREAGRIILTVEDDGPGLAEDEARTAPRRGARLDDSLPGH
GLGLDIVADLAALHGATLTLDRSRLGGLRATLRLPPAGWGDKPADPRDKGRSRPAE

Sequences:

>Translated_456_residues
MWLAGALAATYLVISYAVAETLERGFDETLAALVDTLTAAAEITDDGTLVLLRDPGDPRFTRAYSGWYWQMTWGDQVVRS
RSLWDQTLVRGEHASDAIHIHRERDPRGRPLEVVERDIFPPRPAAGTPPPSLPAQPVHVMVAGDRTGIEGEIARLQGLLA
LCLAGLGGGLLAATFAQVSYGLRPLDRLRAALHRARDDPSLRLEETQPGELAPLAQALNALLDHNASLIDRARAHVGNLA
HGLKTPLAVLRSAADDGPTVEADMVRAQTATMGRLVERHLARARASVGQTAIFSARAPILAAARRVGATMALIHCRPLDI
TIDGAEDAAFPGAGDDLLEILGNLMDNACKWAKARVAVHAGREAGRIILTVEDDGPGLAEDEARTAPRRGARLDDSLPGH
GLGLDIVADLAALHGATLTLDRSRLGGLRATLRLPPAGWGDKPADPRDKGRSRPAE
>Mature_456_residues
MWLAGALAATYLVISYAVAETLERGFDETLAALVDTLTAAAEITDDGTLVLLRDPGDPRFTRAYSGWYWQMTWGDQVVRS
RSLWDQTLVRGEHASDAIHIHRERDPRGRPLEVVERDIFPPRPAAGTPPPSLPAQPVHVMVAGDRTGIEGEIARLQGLLA
LCLAGLGGGLLAATFAQVSYGLRPLDRLRAALHRARDDPSLRLEETQPGELAPLAQALNALLDHNASLIDRARAHVGNLA
HGLKTPLAVLRSAADDGPTVEADMVRAQTATMGRLVERHLARARASVGQTAIFSARAPILAAARRVGATMALIHCRPLDI
TIDGAEDAAFPGAGDDLLEILGNLMDNACKWAKARVAVHAGREAGRIILTVEDDGPGLAEDEARTAPRRGARLDDSLPGH
GLGLDIVADLAALHGATLTLDRSRLGGLRATLRLPPAGWGDKPADPRDKGRSRPAE

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=277, Percent_Identity=26.3537906137184, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=28, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1787894, Length=251, Percent_Identity=26.6932270916335, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790861, Length=274, Percent_Identity=29.5620437956204, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48634; Mature: 48634

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWLAGALAATYLVISYAVAETLERGFDETLAALVDTLTAAAEITDDGTLVLLRDPGDPRF
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCE
TRAYSGWYWQMTWGDQVVRSRSLWDQTLVRGEHASDAIHIHRERDPRGRPLEVVERDIFP
EEEECCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHCCCC
PRPAAGTPPPSLPAQPVHVMVAGDRTGIEGEIARLQGLLALCLAGLGGGLLAATFAQVSY
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GLRPLDRLRAALHRARDDPSLRLEETQPGELAPLAQALNALLDHNASLIDRARAHVGNLA
CCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
HGLKTPLAVLRSAADDGPTVEADMVRAQTATMGRLVERHLARARASVGQTAIFSARAPIL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHH
AAARRVGATMALIHCRPLDITIDGAEDAAFPGAGDDLLEILGNLMDNACKWAKARVAVHA
HHHHHHCCEEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GREAGRIILTVEDDGPGLAEDEARTAPRRGARLDDSLPGHGLGLDIVADLAALHGATLTL
CCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEE
DRSRLGGLRATLRLPPAGWGDKPADPRDKGRSRPAE
EHHHCCCCEEEEECCCCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MWLAGALAATYLVISYAVAETLERGFDETLAALVDTLTAAAEITDDGTLVLLRDPGDPRF
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCE
TRAYSGWYWQMTWGDQVVRSRSLWDQTLVRGEHASDAIHIHRERDPRGRPLEVVERDIFP
EEEECCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHCCCC
PRPAAGTPPPSLPAQPVHVMVAGDRTGIEGEIARLQGLLALCLAGLGGGLLAATFAQVSY
CCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
GLRPLDRLRAALHRARDDPSLRLEETQPGELAPLAQALNALLDHNASLIDRARAHVGNLA
CCCHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
HGLKTPLAVLRSAADDGPTVEADMVRAQTATMGRLVERHLARARASVGQTAIFSARAPIL
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHH
AAARRVGATMALIHCRPLDITIDGAEDAAFPGAGDDLLEILGNLMDNACKWAKARVAVHA
HHHHHHCCEEEEEEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GREAGRIILTVEDDGPGLAEDEARTAPRRGARLDDSLPGHGLGLDIVADLAALHGATLTL
CCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEE
DRSRLGGLRATLRLPPAGWGDKPADPRDKGRSRPAE
EHHHCCCCEEEEECCCCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]