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The map label for this gene is hbdA [H]

Identifier: 83594409

GI number: 83594409

Start: 3544824

End: 3545696

Strand: Direct

Name: hbdA [H]

Synonym: Rru_A3079

Alternate gene names: 83594409

Gene position: 3544824-3545696 (Clockwise)

Preceding gene: 83594408

Following gene: 83594410

Centisome position: 81.44

GC content: 60.71

Gene sequence:

>873_bases
ATGGTCGAAAAGATTGGCGTGATCGGCGCTGGCCAGATGGGCAATGGTATCGCCCATATCTGCGCTTTGTCGGGTTATCA
GGTCCAGATGATGGACGTGAACGAGGCCGCGCTCGAACGTGGCATGGGGTCGCTGCGCAGGAATCTCGAACGCCAGCAGG
CCAAGGGCAAGATCTCGCAGGAAGATCTTGAAAGCACCCTGGCGCGGATCACCCCGACCTCGACCATGAAGAGCTTCGAC
GACTGCGATCTGGTGATCGAGGCGGCGACCGAGGACGAAGGCGTCAAGCGCAAGATCCTGGCCGAGTTGTGCCCGGTGCT
CAAGCCGTCGTGCATCGTCGCCTCGAACACCTCGTCGATCTCGATCACCCGTCTCGGCGCCTCGACCGACCGCCCCGAGA
AGTTCATGGGCATGCATTTCATGAACCCGGTGCCGGTGATGAAGCTGGTCGAATTGATCCGCGGCATCGCCACCGGCGAG
GAAACCTTTTCTCTGATCCGCCAGTTGGTTCTGAAGATGGGCAAGATCCCGGTTTCGGCCGAGGATTTCCCCGCCTTCAT
CGTCAACCGCATCCTGCTGCCGATGATCAACGAGGCCGTCTATACCCTGTATGAGGGCGTGGGATCGGTCGATGCCATCG
ATACGGCGATGCGCCTGGGCGCCAACCATCCGATGGGCCCGCTGGAGCTGGCCGATTTCATCGGTCTGGATGTCTGTCTG
GCGGTGATGCACGTTCTTCACGAGGGTTTGGCCGATACCAAATACCGGCCCTGCCCGCTGCTGGTGAAATACGTCGAAGC
CGGCTGGCTGGGTCGCAAGACCGGCAAGGGCTTCTATGACTATTCGGGCGAGACCCCCGTTCCCACCCGTTAA

Upstream 100 bases:

>100_bases
GCTGGTCGCCGACCTGTTTCAGGCCGTGCCCGCGCTGACCGCCGCATTAGACAAATAATCCCGGGGGACGATCCGTCCCC
GCAAGCGGAAAGGCTCCAAG

Downstream 100 bases:

>100_bases
GCCGCGCGATCATCAGGAGACCACGACCGGGGACGGCGCCCAGACGGGGGCCGTCCCCGGTGTTCGTTTGGGCGCCCAAG
GGTGCCCCCTGGACCGGGAG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MVEKIGVIGAGQMGNGIAHICALSGYQVQMMDVNEAALERGMGSLRRNLERQQAKGKISQEDLESTLARITPTSTMKSFD
DCDLVIEAATEDEGVKRKILAELCPVLKPSCIVASNTSSISITRLGASTDRPEKFMGMHFMNPVPVMKLVELIRGIATGE
ETFSLIRQLVLKMGKIPVSAEDFPAFIVNRILLPMINEAVYTLYEGVGSVDAIDTAMRLGANHPMGPLELADFIGLDVCL
AVMHVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGKGFYDYSGETPVPTR

Sequences:

>Translated_290_residues
MVEKIGVIGAGQMGNGIAHICALSGYQVQMMDVNEAALERGMGSLRRNLERQQAKGKISQEDLESTLARITPTSTMKSFD
DCDLVIEAATEDEGVKRKILAELCPVLKPSCIVASNTSSISITRLGASTDRPEKFMGMHFMNPVPVMKLVELIRGIATGE
ETFSLIRQLVLKMGKIPVSAEDFPAFIVNRILLPMINEAVYTLYEGVGSVDAIDTAMRLGANHPMGPLELADFIGLDVCL
AVMHVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGKGFYDYSGETPVPTR
>Mature_290_residues
MVEKIGVIGAGQMGNGIAHICALSGYQVQMMDVNEAALERGMGSLRRNLERQQAKGKISQEDLESTLARITPTSTMKSFD
DCDLVIEAATEDEGVKRKILAELCPVLKPSCIVASNTSSISITRLGASTDRPEKFMGMHFMNPVPVMKLVELIRGIATGE
ETFSLIRQLVLKMGKIPVSAEDFPAFIVNRILLPMINEAVYTLYEGVGSVDAIDTAMRLGANHPMGPLELADFIGLDVCL
AVMHVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGKGFYDYSGETPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=40.8304498269896, Blast_Score=208, Evalue=4e-54,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=39.413680781759, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=34.2756183745583, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=32.4137931034483, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI68989263, Length=290, Percent_Identity=32.4137931034483, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI115430219, Length=229, Percent_Identity=25.764192139738, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=41.5492957746479, Blast_Score=223, Evalue=9e-60,
Organism=Escherichia coli, GI1790281, Length=270, Percent_Identity=35.1851851851852, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=32.9457364341085, Blast_Score=141, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=39.7212543554007, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=39.8601398601399, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=35.5400696864112, Blast_Score=195, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=37.3665480427046, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=37.3665480427046, Blast_Score=177, Evalue=7e-45,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=37.3665480427046, Blast_Score=176, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=37.7224199288256, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71985923, Length=288, Percent_Identity=31.25, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71985930, Length=284, Percent_Identity=28.5211267605634, Blast_Score=128, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=38.2456140350877, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=38.2456140350877, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=38.2456140350877, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI45549573, Length=256, Percent_Identity=26.171875, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129993, Length=240, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31605; Mature: 31605

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKIGVIGAGQMGNGIAHICALSGYQVQMMDVNEAALERGMGSLRRNLERQQAKGKISQ
CCCCCCEEECCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCH
EDLESTLARITPTSTMKSFDDCDLVIEAATEDEGVKRKILAELCPVLKPSCIVASNTSSI
HHHHHHHHHCCCHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCEE
SITRLGASTDRPEKFMGMHFMNPVPVMKLVELIRGIATGEETFSLIRQLVLKMGKIPVSA
EEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
EDFPAFIVNRILLPMINEAVYTLYEGVGSVDAIDTAMRLGANHPMGPLELADFIGLDVCL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AVMHVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGKGFYDYSGETPVPTR
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVEKIGVIGAGQMGNGIAHICALSGYQVQMMDVNEAALERGMGSLRRNLERQQAKGKISQ
CCCCCCEEECCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCH
EDLESTLARITPTSTMKSFDDCDLVIEAATEDEGVKRKILAELCPVLKPSCIVASNTSSI
HHHHHHHHHCCCHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEEECCCCEE
SITRLGASTDRPEKFMGMHFMNPVPVMKLVELIRGIATGEETFSLIRQLVLKMGKIPVSA
EEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCC
EDFPAFIVNRILLPMINEAVYTLYEGVGSVDAIDTAMRLGANHPMGPLELADFIGLDVCL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AVMHVLHEGLADTKYRPCPLLVKYVEAGWLGRKTGKGFYDYSGETPVPTR
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]