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The map label for this gene is yngJ [H]

Identifier: 83594394

GI number: 83594394

Start: 3530089

End: 3531780

Strand: Direct

Name: yngJ [H]

Synonym: Rru_A3064

Alternate gene names: 83594394

Gene position: 3530089-3531780 (Clockwise)

Preceding gene: 83594393

Following gene: 83594395

Centisome position: 81.1

GC content: 66.37

Gene sequence:

>1692_bases
ATGAACGCACTGCCCAAGGCAGCGGCCAAGGCCGAGGCTTCCCAGCGAAGCCTGATTCTGCCCGACCTGCTGTATACCTG
CGACCGCGCCTATAACACCGCCGCCCAGGCCTTGACCCAGATCCGCAGCAATGTGGCGGCGCTGGTCTCGGTGGAGGACA
AGATCGACGGCGGTCTGCTGGAGATCCACCAACACGCCGCCCATGGGCTGGCGTGGTTCGCCACCTATGTCGAGGCGCTC
GGCGCCTTGCTGGACTGGGCCCACCGGCTGGAGGCCAAGGGCGGATTGGGCGAGTTGGAAAGCCTGATCCTTCAGGGCGC
CTATTCCGAATACCTCCACCAGATCTTCGGCGGCCTGCCGATGAGCCAGGGGGAATTCGCCCGCCTCGCCGATTTCGGCA
TCGAGGTGCGCGAGCGCGGTCTGCTGCAAACCCCCTATACCACCTTGCTGCGCGAGCATGGCTTCAGCGCCCCGGTCAAG
GCGCGCATCGCCGCCCTGATCGCCGATGGCCATTTCGGCGACCCCGGCCTGGAAGACGAGACCCTGACCCTGGTGCGCGA
GCAGTTCCGCCGCTTCGCCGAAGACAAGGTCGTGCCCCATTGCCACGAATGGCACCTGAGCGACACCCTGATCCCGCTCG
ACGTCATCGCCCAGATGGCCGAGATGGGCGTCTTCGGCCTGACGGTGGCCGAGGAGTACGGCGGCTTGGGTATGGGCAAG
ACGGCGATGTGCGTGGTGACCGAGGAGTTGTCGCGCGCCTATATCGGCGTCGGCTCGCTGGGCACGCGCTCGGAAATCGC
CGCCGAACTGATCAGCCTGGGCGGCACCGAGGAGCAAAAACGCCAGTGGCTGCCCCGGTTGGCCAGCGGCGAGATCCTGC
CCACCGCCGTTTTCACCGAACCCAATACGGGCTCGGACCTCGCCTCGCTGCGCAGCCGGGCCGAACGCGACGGCGATACC
TATCGCGTCACCGGGGCCAAGACCTGGATCACCCATGCCGCGCGCTCGGACCTGATGACCTTGCTGGTGCGGACCAATCC
CCAGGAGGGCGGCTATAAGGGGTTGTCGATGCTGTTGGCGGAAAAGCCGCGCGGCAGCGATGAAGATCCCTTCCCGGCCA
AGGGCATGGCCGGCGGCGAGATCAAGGTTCTCGGCTATCGCGGCATGAAGGAATACGAGCTGAGCTTCGATGGCTTCGAG
GTTCCCGCGGCCAATCTGCTGGGCAGCGAGGAGGGCCAGGGCTTCAAGCAGCTGATGGCGACCTTTGAAAGCGCCCGCAT
CCAAACGGCGGCCCGCGCCGTCGGCGTCGCCCAGAACGCCATGGAGGTCGGGCTGCGCTACGCCCAGGACCGCGTGCAGT
TCGGCAAACCGCTCTACGCCTTCCCGCGCGTTCACGGCAAGCTGGCCTGGATGGCGGTGGAAACCATGGTCGCCCGCCAA
TTGACCTATCGGGCGGGCCGCGAAAAGGACAGCGGCCGGCGCTGCGATATCGAAGCGGGCATGGCCAAGCTGCTGGCCGC
CCGCGTCGCCTGGTCGAATGCCGACAACGCCCTGCAGGTGCATGGCGGCAATGGCTATGCCGAGGAATATCCGATCAGCC
GCATTCTGTGCGACGCCCGCATCCTCAACATCTTCGAGGGCGCCGCCGAGATCCAGGCCCATGTGATCGCCAGGGGGCTT
TTGAGCCGCTGA

Upstream 100 bases:

>100_bases
TGAAGCCGGCCAGGGGGGCGTTCCCCCCCCTGCCGATCATGATCCGCCCTCCCGCTTCCTCCCCGCCCCGCGCAAGGGCC
CAGACGAGGGAATGAGTCCG

Downstream 100 bases:

>100_bases
GCGGGGCGATCACAGAGCATCGCGTTCCCCAACGCGACCCGCCTTGGGGCCGGGGAGATCCTCCCCGGCCTTTTTTTTGC
GCGCCGGGCTTAGGCGGGTG

Product: isovaleryl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 563; Mature: 563

Protein sequence:

>563_residues
MNALPKAAAKAEASQRSLILPDLLYTCDRAYNTAAQALTQIRSNVAALVSVEDKIDGGLLEIHQHAAHGLAWFATYVEAL
GALLDWAHRLEAKGGLGELESLILQGAYSEYLHQIFGGLPMSQGEFARLADFGIEVRERGLLQTPYTTLLREHGFSAPVK
ARIAALIADGHFGDPGLEDETLTLVREQFRRFAEDKVVPHCHEWHLSDTLIPLDVIAQMAEMGVFGLTVAEEYGGLGMGK
TAMCVVTEELSRAYIGVGSLGTRSEIAAELISLGGTEEQKRQWLPRLASGEILPTAVFTEPNTGSDLASLRSRAERDGDT
YRVTGAKTWITHAARSDLMTLLVRTNPQEGGYKGLSMLLAEKPRGSDEDPFPAKGMAGGEIKVLGYRGMKEYELSFDGFE
VPAANLLGSEEGQGFKQLMATFESARIQTAARAVGVAQNAMEVGLRYAQDRVQFGKPLYAFPRVHGKLAWMAVETMVARQ
LTYRAGREKDSGRRCDIEAGMAKLLAARVAWSNADNALQVHGGNGYAEEYPISRILCDARILNIFEGAAEIQAHVIARGL
LSR

Sequences:

>Translated_563_residues
MNALPKAAAKAEASQRSLILPDLLYTCDRAYNTAAQALTQIRSNVAALVSVEDKIDGGLLEIHQHAAHGLAWFATYVEAL
GALLDWAHRLEAKGGLGELESLILQGAYSEYLHQIFGGLPMSQGEFARLADFGIEVRERGLLQTPYTTLLREHGFSAPVK
ARIAALIADGHFGDPGLEDETLTLVREQFRRFAEDKVVPHCHEWHLSDTLIPLDVIAQMAEMGVFGLTVAEEYGGLGMGK
TAMCVVTEELSRAYIGVGSLGTRSEIAAELISLGGTEEQKRQWLPRLASGEILPTAVFTEPNTGSDLASLRSRAERDGDT
YRVTGAKTWITHAARSDLMTLLVRTNPQEGGYKGLSMLLAEKPRGSDEDPFPAKGMAGGEIKVLGYRGMKEYELSFDGFE
VPAANLLGSEEGQGFKQLMATFESARIQTAARAVGVAQNAMEVGLRYAQDRVQFGKPLYAFPRVHGKLAWMAVETMVARQ
LTYRAGREKDSGRRCDIEAGMAKLLAARVAWSNADNALQVHGGNGYAEEYPISRILCDARILNIFEGAAEIQAHVIARGL
LSR
>Mature_563_residues
MNALPKAAAKAEASQRSLILPDLLYTCDRAYNTAAQALTQIRSNVAALVSVEDKIDGGLLEIHQHAAHGLAWFATYVEAL
GALLDWAHRLEAKGGLGELESLILQGAYSEYLHQIFGGLPMSQGEFARLADFGIEVRERGLLQTPYTTLLREHGFSAPVK
ARIAALIADGHFGDPGLEDETLTLVREQFRRFAEDKVVPHCHEWHLSDTLIPLDVIAQMAEMGVFGLTVAEEYGGLGMGK
TAMCVVTEELSRAYIGVGSLGTRSEIAAELISLGGTEEQKRQWLPRLASGEILPTAVFTEPNTGSDLASLRSRAERDGDT
YRVTGAKTWITHAARSDLMTLLVRTNPQEGGYKGLSMLLAEKPRGSDEDPFPAKGMAGGEIKVLGYRGMKEYELSFDGFE
VPAANLLGSEEGQGFKQLMATFESARIQTAARAVGVAQNAMEVGLRYAQDRVQFGKPLYAFPRVHGKLAWMAVETMVARQ
LTYRAGREKDSGRRCDIEAGMAKLLAARVAWSNADNALQVHGGNGYAEEYPISRILCDARILNIFEGAAEIQAHVIARGL
LSR

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=354, Percent_Identity=36.7231638418079, Blast_Score=199, Evalue=8e-51,
Organism=Homo sapiens, GI187960098, Length=371, Percent_Identity=32.3450134770889, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI4557231, Length=371, Percent_Identity=32.3450134770889, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI4501859, Length=381, Percent_Identity=31.496062992126, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI4557233, Length=387, Percent_Identity=34.3669250645995, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI226958412, Length=392, Percent_Identity=31.6326530612245, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI226958414, Length=349, Percent_Identity=32.6647564469914, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4557235, Length=341, Percent_Identity=33.4310850439883, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI76496475, Length=341, Percent_Identity=33.4310850439883, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI7656849, Length=407, Percent_Identity=30.4668304668305, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4501857, Length=380, Percent_Identity=28.6842105263158, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI4503943, Length=394, Percent_Identity=28.9340101522843, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI7669494, Length=384, Percent_Identity=29.1666666666667, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI38505218, Length=333, Percent_Identity=28.2282282282282, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI211971008, Length=301, Percent_Identity=27.906976744186, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI48976061, Length=301, Percent_Identity=27.906976744186, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1786223, Length=364, Percent_Identity=28.2967032967033, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081958, Length=350, Percent_Identity=28.2857142857143, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI87082384, Length=272, Percent_Identity=27.2058823529412, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=32.2834645669291, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17538396, Length=410, Percent_Identity=31.219512195122, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17534899, Length=373, Percent_Identity=32.7077747989276, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17569725, Length=389, Percent_Identity=32.3907455012853, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI71985184, Length=354, Percent_Identity=34.180790960452, Blast_Score=189, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=32.6145552560647, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17508101, Length=398, Percent_Identity=30.4020100502513, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17533517, Length=385, Percent_Identity=29.6103896103896, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=384, Percent_Identity=27.34375, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17551932, Length=385, Percent_Identity=26.2337662337662, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71985192, Length=301, Percent_Identity=31.8936877076412, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71990804, Length=295, Percent_Identity=32.2033898305085, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=27.4666666666667, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=241, Percent_Identity=31.5352697095436, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=277, Percent_Identity=27.0758122743682, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562446, Length=379, Percent_Identity=24.2744063324538, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17531909, Length=254, Percent_Identity=24.4094488188976, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=271, Percent_Identity=27.6752767527675, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI86563381, Length=271, Percent_Identity=27.6752767527675, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=31.5245478036176, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24646207, Length=400, Percent_Identity=32.5, Blast_Score=189, Evalue=6e-48,
Organism=Drosophila melanogaster, GI21356377, Length=385, Percent_Identity=33.5064935064935, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355753, Length=400, Percent_Identity=32.25, Blast_Score=185, Evalue=9e-47,
Organism=Drosophila melanogaster, GI281363737, Length=379, Percent_Identity=30.3430079155673, Blast_Score=173, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24666513, Length=378, Percent_Identity=29.8941798941799, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI19920834, Length=385, Percent_Identity=28.5714285714286, Blast_Score=130, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 61278; Mature: 61278

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALPKAAAKAEASQRSLILPDLLYTCDRAYNTAAQALTQIRSNVAALVSVEDKIDGGLL
CCCCCCHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCHH
EIHQHAAHGLAWFATYVEALGALLDWAHRLEAKGGLGELESLILQGAYSEYLHQIFGGLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
MSQGEFARLADFGIEVRERGLLQTPYTTLLREHGFSAPVKARIAALIADGHFGDPGLEDE
CCCCCHHHHHHHCHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHH
TLTLVREQFRRFAEDKVVPHCHEWHLSDTLIPLDVIAQMAEMGVFGLTVAEEYGGLGMGK
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHEEHHHHHCCCCCCC
TAMCVVTEELSRAYIGVGSLGTRSEIAAELISLGGTEEQKRQWLPRLASGEILPTAVFTE
CEEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEECEEEEEC
PNTGSDLASLRSRAERDGDTYRVTGAKTWITHAARSDLMTLLVRTNPQEGGYKGLSMLLA
CCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
EKPRGSDEDPFPAKGMAGGEIKVLGYRGMKEYELSFDGFEVPAANLLGSEEGQGFKQLMA
CCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCHHHHCCCCCCCHHHHHHH
TFESARIQTAARAVGVAQNAMEVGLRYAQDRVQFGKPLYAFPRVHGKLAWMAVETMVARQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHH
LTYRAGREKDSGRRCDIEAGMAKLLAARVAWSNADNALQVHGGNGYAEEYPISRILCDAR
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHCCHHHHHHHHH
ILNIFEGAAEIQAHVIARGLLSR
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNALPKAAAKAEASQRSLILPDLLYTCDRAYNTAAQALTQIRSNVAALVSVEDKIDGGLL
CCCCCCHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHCCCCHH
EIHQHAAHGLAWFATYVEALGALLDWAHRLEAKGGLGELESLILQGAYSEYLHQIFGGLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
MSQGEFARLADFGIEVRERGLLQTPYTTLLREHGFSAPVKARIAALIADGHFGDPGLEDE
CCCCCHHHHHHHCHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCHH
TLTLVREQFRRFAEDKVVPHCHEWHLSDTLIPLDVIAQMAEMGVFGLTVAEEYGGLGMGK
HHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHHHHCCHHHEEHHHHHCCCCCCC
TAMCVVTEELSRAYIGVGSLGTRSEIAAELISLGGTEEQKRQWLPRLASGEILPTAVFTE
CEEEEEHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEECEEEEEC
PNTGSDLASLRSRAERDGDTYRVTGAKTWITHAARSDLMTLLVRTNPQEGGYKGLSMLLA
CCCCHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
EKPRGSDEDPFPAKGMAGGEIKVLGYRGMKEYELSFDGFEVPAANLLGSEEGQGFKQLMA
CCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCCCHHHHCCCCCCCHHHHHHH
TFESARIQTAARAVGVAQNAMEVGLRYAQDRVQFGKPLYAFPRVHGKLAWMAVETMVARQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHH
LTYRAGREKDSGRRCDIEAGMAKLLAARVAWSNADNALQVHGGNGYAEEYPISRILCDAR
HHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHCCHHHHHHHHH
ILNIFEGAAEIQAHVIARGLLSR
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]