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The map label for this gene is srrA [H]

Identifier: 83594261

GI number: 83594261

Start: 3374529

End: 3375281

Strand: Direct

Name: srrA [H]

Synonym: Rru_A2929

Alternate gene names: 83594261

Gene position: 3374529-3375281 (Clockwise)

Preceding gene: 83594255

Following gene: 83594262

Centisome position: 77.53

GC content: 65.34

Gene sequence:

>753_bases
ATGGATATGATGGACGAGCCCGGTCTCGGCGCGGCGGAGACCACACCGCCCGACAGGGACGCGCTGATCCTGGTCGTCGA
AGACGAACCCGATATCGCCGACATCCTGAGGGCCTATCTCGAACGCGCCGGAATGCGCGTCGTAAGCGCGCGGGACGGGC
GGCGAGCCTTGGACCTTCACGCCTCGCTCAATCCCGATTTGCTGCTGCTCGATGTGCAGATGCCGGTGATGGACGGATGG
CGGGTGCTCTCCGAGCTACGCCACCGCGGCGACACGCCGGTCATCATGCTGACGGCGCTCGATCAGGACATCGATAAACT
GATGGGCTTGCGCATCGGCGCCGATGATTACGTGGTGAAACCGTTCAATCCGGCGGAAGTCGTCGCCCGGGTCCGCGCCG
TGCTGCGTCGCATGGGCGGAGACGGCGGAGAGCGGGCGCGGCGCGTGCTGCGTTTCGGCACGCTGAGGATCGATCTCGAC
GGGCACGAAGCCATGGTCGAGGACGACGGCGGGCGGTGTCTGGCCATCGATCTCACGCTGACCGAATTTCGCCTTCTGGT
TCACTTGGCCCGGACTCCCAAACGGGTCTTCAGCCGGATGGAGCTTCTGGGCGCCTGCCTGCCCGAGGGCGAGGCCCTGG
AGCGCACCGTTGACAGTCATCTGAGCAAGTTGCGCAAGAAACTCGAAGCCTTCGGCGTGATGGGCGTCCCCACCAATGTT
CGCGGCGTCGGCTATCGCTTCGGAGGGGGATGA

Upstream 100 bases:

>100_bases
CCGGTCGCGATGACGGATGCCCGACCCTGGTGTGGACGAAATCGGTTGCGTTTCGATCGACGGTGTGTGGAGGTATGATG
GAGAGGGAAAAGAAAGCGGG

Downstream 100 bases:

>100_bases
GGTCGATGGCCTCGGGGAAGAAAACTTCGGGATTGCGCCGACAGATTTTCCTTTCGATGACGGTCATGGCCTTCAGTGTC
GTCCTGCTGTCGATATGCGG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MDMMDEPGLGAAETTPPDRDALILVVEDEPDIADILRAYLERAGMRVVSARDGRRALDLHASLNPDLLLLDVQMPVMDGW
RVLSELRHRGDTPVIMLTALDQDIDKLMGLRIGADDYVVKPFNPAEVVARVRAVLRRMGGDGGERARRVLRFGTLRIDLD
GHEAMVEDDGGRCLAIDLTLTEFRLLVHLARTPKRVFSRMELLGACLPEGEALERTVDSHLSKLRKKLEAFGVMGVPTNV
RGVGYRFGGG

Sequences:

>Translated_250_residues
MDMMDEPGLGAAETTPPDRDALILVVEDEPDIADILRAYLERAGMRVVSARDGRRALDLHASLNPDLLLLDVQMPVMDGW
RVLSELRHRGDTPVIMLTALDQDIDKLMGLRIGADDYVVKPFNPAEVVARVRAVLRRMGGDGGERARRVLRFGTLRIDLD
GHEAMVEDDGGRCLAIDLTLTEFRLLVHLARTPKRVFSRMELLGACLPEGEALERTVDSHLSKLRKKLEAFGVMGVPTNV
RGVGYRFGGG
>Mature_250_residues
MDMMDEPGLGAAETTPPDRDALILVVEDEPDIADILRAYLERAGMRVVSARDGRRALDLHASLNPDLLLLDVQMPVMDGW
RVLSELRHRGDTPVIMLTALDQDIDKLMGLRIGADDYVVKPFNPAEVVARVRAVLRRMGGDGGERARRVLRFGTLRIDLD
GHEAMVEDDGGRCLAIDLTLTEFRLLVHLARTPKRVFSRMELLGACLPEGEALERTVDSHLSKLRKKLEAFGVMGVPTNV
RGVGYRFGGG

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=38.7931034482759, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=38.2608695652174, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790860, Length=230, Percent_Identity=36.9565217391304, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1790863, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=34.6320346320346, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=34.061135371179, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI2367329, Length=215, Percent_Identity=40.9302325581395, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=33.4801762114537, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1786911, Length=232, Percent_Identity=34.9137931034483, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1789402, Length=229, Percent_Identity=34.4978165938865, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693140, Length=240, Percent_Identity=30, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1787229, Length=216, Percent_Identity=32.8703703703704, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788550, Length=102, Percent_Identity=42.156862745098, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=34.9344978165939, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787487, Length=108, Percent_Identity=37.962962962963, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790299, Length=112, Percent_Identity=37.5, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27648; Mature: 27648

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMMDEPGLGAAETTPPDRDALILVVEDEPDIADILRAYLERAGMRVVSARDGRRALDLH
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEE
ASLNPDLLLLDVQMPVMDGWRVLSELRHRGDTPVIMLTALDQDIDKLMGLRIGADDYVVK
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHCCEECCCCEEEC
PFNPAEVVARVRAVLRRMGGDGGERARRVLRFGTLRIDLDGHEAMVEDDGGRCLAIDLTL
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEECCCEEEEECCCCEEEEEEEHH
TEFRLLVHLARTPKRVFSRMELLGACLPEGEALERTVDSHLSKLRKKLEAFGVMGVPTNV
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RGVGYRFGGG
CCCCEECCCC
>Mature Secondary Structure
MDMMDEPGLGAAETTPPDRDALILVVEDEPDIADILRAYLERAGMRVVSARDGRRALDLH
CCCCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEE
ASLNPDLLLLDVQMPVMDGWRVLSELRHRGDTPVIMLTALDQDIDKLMGLRIGADDYVVK
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHCCEECCCCEEEC
PFNPAEVVARVRAVLRRMGGDGGERARRVLRFGTLRIDLDGHEAMVEDDGGRCLAIDLTL
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEECCCEEEEECCCCEEEEEEEHH
TEFRLLVHLARTPKRVFSRMELLGACLPEGEALERTVDSHLSKLRKKLEAFGVMGVPTNV
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RGVGYRFGGG
CCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA