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The map label for this gene is nikC [H]

Identifier: 83593610

GI number: 83593610

Start: 2633732

End: 2634631

Strand: Reverse

Name: nikC [H]

Synonym: Rru_A2275

Alternate gene names: 83593610

Gene position: 2634631-2633732 (Counterclockwise)

Preceding gene: 83593611

Following gene: 83593609

Centisome position: 60.53

GC content: 67.89

Gene sequence:

>900_bases
ATGACCATGCCTGATTGCCAGCAGGGGCATCGCCCGCCAGACGCCGCCCCGCTCCGGGGGTGGCTCGCCCGCCTGCCCAT
CGGCCGAAGCTGGAGCCTGCGCTTGGCCCTTCTGGTGCTGGTCGCCCTGATCGCCAGCGCCATCGTCGGCCAATCTCTGC
TTCCCGGCGATGCCAATGCCATCGACCTCGCGGCGCGCTTGCGGCCGCCGTCTTGGGAGCATTGGCTGGGCACCGATCAC
CTGGGCCGCGACATCTTTTTGCGGCTGCTCGCCGGGGCCGGCGTCTCGCTGGGCTCGGTCGCCCTGTGCCTCGCCCTGGT
GCTGGCGATGGGGATCGCCGTGGGCGGCGCCGCCGGGGTCCTGGGCGGGCGCGCCGATCAGGCGATCATGCGCGTCACCG
ATGTCTTCCTGACCTTTCCCACCCTGGTGCTGTCGTTGTTCATGGTTGGCGTGCTGGGCAGCGGGCTGACCAATGTCATC
ATCGCCATCGCCTTGTCCCATTGGGCTTGGTACGCCCGCATCGTGCGCGGCATCGTTTTGTCGCTGCGCGAGCGCGATTT
CATCCTGGCGGCGCGGCTGTCGGGGGCGGGGCGGGTCTCGATCTTCGTCGAGCATCTGCTGCCCGCCACCGCCTCGCAGC
TTCTGGTGCTGGCCAGTCTCGATATCGGCCACATGATGCTCCATGTCGCCGGCCTGTCGTTCCTGGGATTGGGGGTCGCC
CCGCCGATGGCCGAATGGGGGGTGATGATCAACGACGCCCGCCAGTTCGTCTGGACCCAGCCGATGCTGATGGTCTGGCC
CGGAGTGGCGCTTTTCGTCAGCGTCATGACCTTCAACCTGCTTGGGGACGCCCTGCGCGATCGTCTTGATCCGCACCTCT
GCGCGGAGCATGGACATTGA

Upstream 100 bases:

>100_bases
CGCTGCTGATGGTGCTGATCTTCGTTCTTTGCAATCTGATCGTCGATATCGTCTATGCCTGGGCCGATCCGCGCATCCGG
CTGGCGGCGGAGGGGGCCCA

Downstream 100 bases:

>100_bases
GAAACGATGGTCTGAGGATCGAGGGTCTGACGATCGCCACCCTCGGCGCCCATCCCCTGATGCTGGTGGAGGGGGTCGGC
CTCGAGGTGCGGCGCGGTCG

Product: nickel transporter permease NikC

Products: Ni2; [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTMPDCQQGHRPPDAAPLRGWLARLPIGRSWSLRLALLVLVALIASAIVGQSLLPGDANAIDLAARLRPPSWEHWLGTDH
LGRDIFLRLLAGAGVSLGSVALCLALVLAMGIAVGGAAGVLGGRADQAIMRVTDVFLTFPTLVLSLFMVGVLGSGLTNVI
IAIALSHWAWYARIVRGIVLSLRERDFILAARLSGAGRVSIFVEHLLPATASQLLVLASLDIGHMMLHVAGLSFLGLGVA
PPMAEWGVMINDARQFVWTQPMLMVWPGVALFVSVMTFNLLGDALRDRLDPHLCAEHGH

Sequences:

>Translated_299_residues
MTMPDCQQGHRPPDAAPLRGWLARLPIGRSWSLRLALLVLVALIASAIVGQSLLPGDANAIDLAARLRPPSWEHWLGTDH
LGRDIFLRLLAGAGVSLGSVALCLALVLAMGIAVGGAAGVLGGRADQAIMRVTDVFLTFPTLVLSLFMVGVLGSGLTNVI
IAIALSHWAWYARIVRGIVLSLRERDFILAARLSGAGRVSIFVEHLLPATASQLLVLASLDIGHMMLHVAGLSFLGLGVA
PPMAEWGVMINDARQFVWTQPMLMVWPGVALFVSVMTFNLLGDALRDRLDPHLCAEHGH
>Mature_298_residues
TMPDCQQGHRPPDAAPLRGWLARLPIGRSWSLRLALLVLVALIASAIVGQSLLPGDANAIDLAARLRPPSWEHWLGTDHL
GRDIFLRLLAGAGVSLGSVALCLALVLAMGIAVGGAAGVLGGRADQAIMRVTDVFLTFPTLVLSLFMVGVLGSGLTNVII
AIALSHWAWYARIVRGIVLSLRERDFILAARLSGAGRVSIFVEHLLPATASQLLVLASLDIGHMMLHVAGLSFLGLGVAP
PMAEWGVMINDARQFVWTQPMLMVWPGVALFVSVMTFNLLGDALRDRLDPHLCAEHGH

Specific function: Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane [H]

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789889, Length=269, Percent_Identity=68.4014869888476, Blast_Score=352, Evalue=1e-98,
Organism=Escherichia coli, GI1787054, Length=259, Percent_Identity=43.2432432432432, Blast_Score=200, Evalue=8e-53,
Organism=Escherichia coli, GI1787760, Length=236, Percent_Identity=43.2203389830509, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1789964, Length=235, Percent_Identity=40, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787498, Length=259, Percent_Identity=33.2046332046332, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1787549, Length=230, Percent_Identity=31.7391304347826, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788505, Length=244, Percent_Identity=29.0983606557377, Blast_Score=82, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515
- InterPro:   IPR014157 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 31949; Mature: 31818

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMPDCQQGHRPPDAAPLRGWLARLPIGRSWSLRLALLVLVALIASAIVGQSLLPGDANA
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
IDLAARLRPPSWEHWLGTDHLGRDIFLRLLAGAGVSLGSVALCLALVLAMGIAVGGAAGV
HHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHH
LGGRADQAIMRVTDVFLTFPTLVLSLFMVGVLGSGLTNVIIAIALSHWAWYARIVRGIVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLRERDFILAARLSGAGRVSIFVEHLLPATASQLLVLASLDIGHMMLHVAGLSFLGLGVA
HHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PPMAEWGVMINDARQFVWTQPMLMVWPGVALFVSVMTFNLLGDALRDRLDPHLCAEHGH
CCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC
>Mature Secondary Structure 
TMPDCQQGHRPPDAAPLRGWLARLPIGRSWSLRLALLVLVALIASAIVGQSLLPGDANA
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
IDLAARLRPPSWEHWLGTDHLGRDIFLRLLAGAGVSLGSVALCLALVLAMGIAVGGAAGV
HHHHHHCCCCCCHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHH
LGGRADQAIMRVTDVFLTFPTLVLSLFMVGVLGSGLTNVIIAIALSHWAWYARIVRGIVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SLRERDFILAARLSGAGRVSIFVEHLLPATASQLLVLASLDIGHMMLHVAGLSFLGLGVA
HHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PPMAEWGVMINDARQFVWTQPMLMVWPGVALFVSVMTFNLLGDALRDRLDPHLCAEHGH
CCHHHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; ATP; H2O [C]

Specific reaction: Ni2+ [Periplasm] + ATP + H2O = Ni2+ [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]