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The map label for this gene is upp [H]

Identifier: 83593590

GI number: 83593590

Start: 2616633

End: 2617289

Strand: Reverse

Name: upp [H]

Synonym: Rru_A2255

Alternate gene names: 83593590

Gene position: 2617289-2616633 (Counterclockwise)

Preceding gene: 83593593

Following gene: 83593584

Centisome position: 60.13

GC content: 66.36

Gene sequence:

>657_bases
ATGTCCGCCACCGCCCATCCCGACTTCCCCAATCTGTTCGTGCTCGATCACCCGCTGATCCAGCACAAGCTGACCCATAT
GCGCCGCCGCGAGACCTCGACGCGCACCTTCCGCATGTTGCTGCGCGAAATCGCCCTGCTGATGGGCTATGAGGTGACCC
GCTCGCTGCCGCTGACCACCGAATCCATCGAGACGCCCCTGGAGGCCATGGAGGCGCCGGTGATCGGCGGCAAGAAGCTG
GTGGTGGTGCCGATCCTGCGCGCCGGCCAGGGCATGGCCGATGGCCTGCTTGAACTGGTTCCCAGCGCCCGCGTCGGCCA
TATCGGCCTCTATCGCGACGAGGTGACCCGCCAGCCGGTCGAATATCTGGTGAAGCTGCCCGAAACCACCGAGCGCACCT
TCATTTTGGTCGATCCGATGCTGGCCACCGGCCATTCGGGCGCCCATGCCGCCACCGTTTTGCTGCGCCATGGCGTGCCA
GCCGAGCGCATCCGCTTCATGGCCTTGGTCGCCGCCCCCGAGGGCGTGCGCACCTTCCACGCCGCCCATCCCGATGTGCC
GGTCTATGTGGCGGCGCTCGATCGCCAGTTGAACGATCAGGCCTTCATCTGCCCGGGCTTGGGCGATGCCGGCGACCGGC
TGTTTGGCACGAAGTAA

Upstream 100 bases:

>100_bases
TCCACCGGCGAAGGGGTTTCTTGCCGATGACACCGGTTTACGGGCCGCGCCGCCTTGCCTATAACCGGCGCCATTCAAAC
CATAAGGGGGAGCCCACCCG

Downstream 100 bases:

>100_bases
CCGCTTCGCATCGGTCGACAGGGCGAAGGGCCGCGCGATCGGCGCTTAGGGTCTGTCCGCTTGATGCTGAAGCGGACAGA
CCCTGGATCCCTTTGTTTGA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MSATAHPDFPNLFVLDHPLIQHKLTHMRRRETSTRTFRMLLREIALLMGYEVTRSLPLTTESIETPLEAMEAPVIGGKKL
VVVPILRAGQGMADGLLELVPSARVGHIGLYRDEVTRQPVEYLVKLPETTERTFILVDPMLATGHSGAHAATVLLRHGVP
AERIRFMALVAAPEGVRTFHAAHPDVPVYVAALDRQLNDQAFICPGLGDAGDRLFGTK

Sequences:

>Translated_218_residues
MSATAHPDFPNLFVLDHPLIQHKLTHMRRRETSTRTFRMLLREIALLMGYEVTRSLPLTTESIETPLEAMEAPVIGGKKL
VVVPILRAGQGMADGLLELVPSARVGHIGLYRDEVTRQPVEYLVKLPETTERTFILVDPMLATGHSGAHAATVLLRHGVP
AERIRFMALVAAPEGVRTFHAAHPDVPVYVAALDRQLNDQAFICPGLGDAGDRLFGTK
>Mature_217_residues
SATAHPDFPNLFVLDHPLIQHKLTHMRRRETSTRTFRMLLREIALLMGYEVTRSLPLTTESIETPLEAMEAPVIGGKKLV
VVPILRAGQGMADGLLELVPSARVGHIGLYRDEVTRQPVEYLVKLPETTERTFILVDPMLATGHSGAHAATVLLRHGVPA
ERIRFMALVAAPEGVRTFHAAHPDVPVYVAALDRQLNDQAFICPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=221, Percent_Identity=31.6742081447964, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI57863312, Length=221, Percent_Identity=31.6742081447964, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=27.6470588235294, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI87082118, Length=205, Percent_Identity=48.780487804878, Blast_Score=189, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI17539892, Length=212, Percent_Identity=29.7169811320755, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17539894, Length=212, Percent_Identity=29.7169811320755, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=39.0625, Blast_Score=130, Evalue=1e-31,
Organism=Drosophila melanogaster, GI45550449, Length=222, Percent_Identity=31.5315315315315, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28573516, Length=222, Percent_Identity=31.5315315315315, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28573514, Length=222, Percent_Identity=31.5315315315315, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28573512, Length=222, Percent_Identity=31.5315315315315, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21358379, Length=171, Percent_Identity=28.0701754385965, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23994; Mature: 23863

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATAHPDFPNLFVLDHPLIQHKLTHMRRRETSTRTFRMLLREIALLMGYEVTRSLPLTT
CCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ESIETPLEAMEAPVIGGKKLVVVPILRAGQGMADGLLELVPSARVGHIGLYRDEVTRQPV
HHHHCCHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCEEECHHHHHHHHHH
EYLVKLPETTERTFILVDPMLATGHSGAHAATVLLRHGVPAERIRFMALVAAPEGVRTFH
HHHHHCCCCCCCEEEEECCHHHCCCCCHHHHHHHHHCCCCHHHHHHHHEEECCCCHHHHH
AAHPDVPVYVAALDRQLNDQAFICPGLGDAGDRLFGTK
CCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SATAHPDFPNLFVLDHPLIQHKLTHMRRRETSTRTFRMLLREIALLMGYEVTRSLPLTT
CCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
ESIETPLEAMEAPVIGGKKLVVVPILRAGQGMADGLLELVPSARVGHIGLYRDEVTRQPV
HHHHCCHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCEEECHHHHHHHHHH
EYLVKLPETTERTFILVDPMLATGHSGAHAATVLLRHGVPAERIRFMALVAAPEGVRTFH
HHHHHCCCCCCCEEEEECCHHHCCCCCHHHHHHHHHCCCCHHHHHHHHEEECCCCHHHHH
AAHPDVPVYVAALDRQLNDQAFICPGLGDAGDRLFGTK
CCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA