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The map label for this gene is hflC [H]

Identifier: 83593537

GI number: 83593537

Start: 2557173

End: 2558054

Strand: Reverse

Name: hflC [H]

Synonym: Rru_A2202

Alternate gene names: 83593537

Gene position: 2558054-2557173 (Counterclockwise)

Preceding gene: 83593538

Following gene: 83593536

Centisome position: 58.77

GC content: 62.81

Gene sequence:

>882_bases
ATGAGAAAGTCCCTGGTGGCTCTTGGCGTCGTCGCCGTCCTCGCGGTGATCGGACTCTATTCGTCGCTTTTCATCGTCAA
CCAGACCCAGCAGGCGCTGGTCTTCCAGTTCGGTGAGTATGTTCGCACCGTTCAGGACCCTGGCCTGAAGTTCAAAGTGC
CGTTCATTCAGAACACGGTGCTTTACGACAAGCGCGTGCTGGCCCTTGATCCGCCGGCCGAACAGCTGATCCTCGCCGAT
CAGAAGCGTTTGGTCGCCGATACCTTCATGCGCTATCGCATCGCCGATCCCTTGCGCTTCTATCAGGCGGTCAACAACGA
GGCCCAGGCCGCCTCGCGGCTGTCTGATATCGTCATCTCGGCGCTGCGCCGGGTTCTGGGCAACACCACCCTGGCCACGC
TGCTGTCCAAGGAGCGGACCCAGATCATGGTCGATATCCGCAATGCGGTGGATCATGAGGCCAAGAACCTGGGCATCGCC
GTGACCGACGTGCGCATCCGTCGGGCCGATTTGCCCGAGGAAACCAGCCAGTCGATCTTTGATCGCATGCGCTCGGAGCG
CGAACGCGAAGCCCGCGAATTCCGCGCCCAGGGTCAGGAACTGGCCCAGCAGATCCGGGCCCGGGCCGATCGCGAAAAGA
CCGTGCTGGTGGCCGAGGCCCAGAACCGCTCGCAGGTGTTGCGCGGCGAGGGCGACGGCATGGCGGTGAAGATCTACGCC
GAGTCCTTTGGCGCCGATCCGCAGTTCTTCTCGTTCTACCGGTCGATGGAAGCCTATCGCAAGGCGCTATCCGATAGCAG
CACCACCATGGTGTTGTCGCCCGACAGCGATTTCTTCCGCTACTTCGGCACCCAGGGCGGAACGGCCCCGGCGCCGCGCT
GA

Upstream 100 bases:

>100_bases
GTGGCGCCGCCGCGATCGCCCCCTCGGGCCTGTCCGGGGCGCCCCTGCGGCCGATGTCCCAGCCGATTCCGGGGCTTCCC
GCCGCGCAGGGAGGCGGCCG

Downstream 100 bases:

>100_bases
CCGGCCTGACGGGCTGCACGCGAAACGATCAGACGACGGCGGTTCGAACCAGGGTTCGGGCCGCCGTTGGCGTCTTCGGC
CGGAAAAAGACCGGTATCGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MRKSLVALGVVAVLAVIGLYSSLFIVNQTQQALVFQFGEYVRTVQDPGLKFKVPFIQNTVLYDKRVLALDPPAEQLILAD
QKRLVADTFMRYRIADPLRFYQAVNNEAQAASRLSDIVISALRRVLGNTTLATLLSKERTQIMVDIRNAVDHEAKNLGIA
VTDVRIRRADLPEETSQSIFDRMRSEREREAREFRAQGQELAQQIRARADREKTVLVAEAQNRSQVLRGEGDGMAVKIYA
ESFGADPQFFSFYRSMEAYRKALSDSSTTMVLSPDSDFFRYFGTQGGTAPAPR

Sequences:

>Translated_293_residues
MRKSLVALGVVAVLAVIGLYSSLFIVNQTQQALVFQFGEYVRTVQDPGLKFKVPFIQNTVLYDKRVLALDPPAEQLILAD
QKRLVADTFMRYRIADPLRFYQAVNNEAQAASRLSDIVISALRRVLGNTTLATLLSKERTQIMVDIRNAVDHEAKNLGIA
VTDVRIRRADLPEETSQSIFDRMRSEREREAREFRAQGQELAQQIRARADREKTVLVAEAQNRSQVLRGEGDGMAVKIYA
ESFGADPQFFSFYRSMEAYRKALSDSSTTMVLSPDSDFFRYFGTQGGTAPAPR
>Mature_293_residues
MRKSLVALGVVAVLAVIGLYSSLFIVNQTQQALVFQFGEYVRTVQDPGLKFKVPFIQNTVLYDKRVLALDPPAEQLILAD
QKRLVADTFMRYRIADPLRFYQAVNNEAQAASRLSDIVISALRRVLGNTTLATLLSKERTQIMVDIRNAVDHEAKNLGIA
VTDVRIRRADLPEETSQSIFDRMRSEREREAREFRAQGQELAQQIRARADREKTVLVAEAQNRSQVLRGEGDGMAVKIYA
ESFGADPQFFSFYRSMEAYRKALSDSSTTMVLSPDSDFFRYFGTQGGTAPAPR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=312, Percent_Identity=33.974358974359, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1786697, Length=288, Percent_Identity=27.4305555555556, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1790616, Length=279, Percent_Identity=23.2974910394265, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17569493, Length=183, Percent_Identity=26.2295081967213, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193209764, Length=183, Percent_Identity=26.2295081967213, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17569497, Length=187, Percent_Identity=28.3422459893048, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71989955, Length=162, Percent_Identity=29.0123456790123, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71989948, Length=162, Percent_Identity=29.0123456790123, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356845, Length=219, Percent_Identity=26.027397260274, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45556022, Length=171, Percent_Identity=26.3157894736842, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33011; Mature: 33011

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKSLVALGVVAVLAVIGLYSSLFIVNQTQQALVFQFGEYVRTVQDPGLKFKVPFIQNTV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHH
LYDKRVLALDPPAEQLILADQKRLVADTFMRYRIADPLRFYQAVNNEAQAASRLSDIVIS
HHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ALRRVLGNTTLATLLSKERTQIMVDIRNAVDHEAKNLGIAVTDVRIRRADLPEETSQSIF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHH
DRMRSEREREAREFRAQGQELAQQIRARADREKTVLVAEAQNRSQVLRGEGDGMAVKIYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCEEEEEEE
ESFGADPQFFSFYRSMEAYRKALSDSSTTMVLSPDSDFFRYFGTQGGTAPAPR
HHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRKSLVALGVVAVLAVIGLYSSLFIVNQTQQALVFQFGEYVRTVQDPGLKFKVPFIQNTV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHH
LYDKRVLALDPPAEQLILADQKRLVADTFMRYRIADPLRFYQAVNNEAQAASRLSDIVIS
HHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
ALRRVLGNTTLATLLSKERTQIMVDIRNAVDHEAKNLGIAVTDVRIRRADLPEETSQSIF
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHHHH
DRMRSEREREAREFRAQGQELAQQIRARADREKTVLVAEAQNRSQVLRGEGDGMAVKIYA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHCCCCCCEEEEEEE
ESFGADPQFFSFYRSMEAYRKALSDSSTTMVLSPDSDFFRYFGTQGGTAPAPR
HHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]