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The map label for this gene is pepA [H]

Identifier: 83593508

GI number: 83593508

Start: 2523497

End: 2524906

Strand: Reverse

Name: pepA [H]

Synonym: Rru_A2173

Alternate gene names: 83593508

Gene position: 2524906-2523497 (Counterclockwise)

Preceding gene: 83593509

Following gene: 83593507

Centisome position: 58.01

GC content: 70.21

Gene sequence:

>1410_bases
ATGGATAGCTTTCCCTTGGGCGTCGCCCCCCATAGCGCGGTAACCATCCGTTTCGTTGAAGCCTTGCCCGATCCCTCGCC
GGTCATCGCCGAGATCATCGGCGGCGGCCGCTCGCCGGGGCGGGCCGATCGCTATTGCGCCGGGCCGTGGGGGCTGACGG
TGGTGGTCGGGCTGGCCGCCGATGCCACCCCCGCCCAGGCGGCCAAGGCCGGCGCCCTGGCGGCGGCGGCGCTGATCGGC
GAGGCCATCGAAGAGGCGGTTTGCGCCATCGCCTTGTCGACCGAGGCCTCGGTGGCCTTCGCCCGCGCCTTTCGCGCCCG
GCTGTTCCGGCCGTTGTCGCTGAAGCGGGCGCCGCGCGCCGAGGATCTGTGCCGGCTGGGCGCCCTGACCCTGGTCGCGG
CCAAGCCAAAGGACGCCGCCCGCGCCTGGGCGCCGTGGCAGGCGATCGCCGAAGGCACGGAATGGGCGCGCAGCCTGTGC
GCCGAGCCGGGCAACCGCCTCAACCCCACCACCTTCGCCCGTATTCTGGGCGGTCTTGGCGATCTGGGGGTCGAGGTCGA
GGTTCTGGATGCGGCGGCGATGGCCCGCGAGGGGCTTAATCTGCATCTCGCCGTTGGCCGGGGCAGCGCCACGCCGCCTT
GCGTGGTGGTGCTGCGCTGGCGGGGCGGCGAGAACGACGCGGCGCCAAGTCTTTTGGTCGGCAAGGGCATCACCTTCGAT
GCCGGCGGCATCTGCCTGAAGCGCGCCGCCCATATGGAGGATATGCGCGGCGACATGGCCGGAGCGGCGGCGGTCGCCGG
GGCGATCCGCGCCCTGGCCCTGCTCAAAAGCCCGGTCAATGTGACCGCCGTTCTGGCCCTGGCCGAGAATATGCCGGGCT
CGCGGGCCCAGCGGCCGGGCGATGTCTGGCTTGGCCACGCCGGCAAAACCGTCGAAGTCATTGATACCGATGCCGAGGGG
CGTCTGGTGTTGGCCGATGCCCTGTCGTGGGGGTGCGCCACGCAAAAGCCCCGGCAGGTCGCGGCGCTGTCAACCCTGAC
CTATGCCATCATGGCCGCGCTCGGCTCCCATTACGCCGGATTGTTCGCCACCGACGATAATCTGGCTTCGGCCCTGCTGA
GCAGCGGCGAGGCTTCGGGCGATCGCTTGTGGCGGATGCCCTTCACCCCGGCCGATGATCCGGCCCTGAAGTCCGAAATC
GCCGATCTGCGCAATTGTCCGCCGGTCGGTCCGCCCGACGCCATGAACGCCGCCGGCTTCCTGCGCGTCTTCGTGCCCGA
GGATATCCCCTTCGCCCATCTCGATATCGCGGCGATGACCCTGAAGGCCGAAGCCGACGACACCCTGCCGGCCGGCCCCA
CCGGCTTTGGCGTCGCCTGTCTGGTGCTGTGGCTGATGGCAAAGGGATAA

Upstream 100 bases:

>100_bases
CGGCGGCCGAACGGGGTCGCCTCGTCGCTTGTCATAAGCCATTATAGATCGCACCCCTTCCCCCGGCGCGTGTCGCCCCG
GTCTTCCAGGTCAGGATGTC

Downstream 100 bases:

>100_bases
GGCCTATTGTGCGAGCGGGGCGGGCATCCGATTTTTAGATCCGTATGGCACCGCCCCCTTCGCCTGGAGAGCCCTTTTGC
TGTTTCTTACGTCCGCCAAG

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MDSFPLGVAPHSAVTIRFVEALPDPSPVIAEIIGGGRSPGRADRYCAGPWGLTVVVGLAADATPAQAAKAGALAAAALIG
EAIEEAVCAIALSTEASVAFARAFRARLFRPLSLKRAPRAEDLCRLGALTLVAAKPKDAARAWAPWQAIAEGTEWARSLC
AEPGNRLNPTTFARILGGLGDLGVEVEVLDAAAMAREGLNLHLAVGRGSATPPCVVVLRWRGGENDAAPSLLVGKGITFD
AGGICLKRAAHMEDMRGDMAGAAAVAGAIRALALLKSPVNVTAVLALAENMPGSRAQRPGDVWLGHAGKTVEVIDTDAEG
RLVLADALSWGCATQKPRQVAALSTLTYAIMAALGSHYAGLFATDDNLASALLSSGEASGDRLWRMPFTPADDPALKSEI
ADLRNCPPVGPPDAMNAAGFLRVFVPEDIPFAHLDIAAMTLKAEADDTLPAGPTGFGVACLVLWLMAKG

Sequences:

>Translated_469_residues
MDSFPLGVAPHSAVTIRFVEALPDPSPVIAEIIGGGRSPGRADRYCAGPWGLTVVVGLAADATPAQAAKAGALAAAALIG
EAIEEAVCAIALSTEASVAFARAFRARLFRPLSLKRAPRAEDLCRLGALTLVAAKPKDAARAWAPWQAIAEGTEWARSLC
AEPGNRLNPTTFARILGGLGDLGVEVEVLDAAAMAREGLNLHLAVGRGSATPPCVVVLRWRGGENDAAPSLLVGKGITFD
AGGICLKRAAHMEDMRGDMAGAAAVAGAIRALALLKSPVNVTAVLALAENMPGSRAQRPGDVWLGHAGKTVEVIDTDAEG
RLVLADALSWGCATQKPRQVAALSTLTYAIMAALGSHYAGLFATDDNLASALLSSGEASGDRLWRMPFTPADDPALKSEI
ADLRNCPPVGPPDAMNAAGFLRVFVPEDIPFAHLDIAAMTLKAEADDTLPAGPTGFGVACLVLWLMAKG
>Mature_469_residues
MDSFPLGVAPHSAVTIRFVEALPDPSPVIAEIIGGGRSPGRADRYCAGPWGLTVVVGLAADATPAQAAKAGALAAAALIG
EAIEEAVCAIALSTEASVAFARAFRARLFRPLSLKRAPRAEDLCRLGALTLVAAKPKDAARAWAPWQAIAEGTEWARSLC
AEPGNRLNPTTFARILGGLGDLGVEVEVLDAAAMAREGLNLHLAVGRGSATPPCVVVLRWRGGENDAAPSLLVGKGITFD
AGGICLKRAAHMEDMRGDMAGAAAVAGAIRALALLKSPVNVTAVLALAENMPGSRAQRPGDVWLGHAGKTVEVIDTDAEG
RLVLADALSWGCATQKPRQVAALSTLTYAIMAALGSHYAGLFATDDNLASALLSSGEASGDRLWRMPFTPADDPALKSEI
ADLRNCPPVGPPDAMNAAGFLRVFVPEDIPFAHLDIAAMTLKAEADDTLPAGPTGFGVACLVLWLMAKG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=331, Percent_Identity=37.1601208459215, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI47155554, Length=319, Percent_Identity=33.2288401253918, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790710, Length=299, Percent_Identity=42.1404682274247, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI87082123, Length=389, Percent_Identity=33.9331619537275, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17556903, Length=268, Percent_Identity=34.3283582089552, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17565172, Length=236, Percent_Identity=29.2372881355932, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI20129963, Length=323, Percent_Identity=37.7708978328173, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24661038, Length=303, Percent_Identity=35.3135313531353, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI21355725, Length=273, Percent_Identity=36.6300366300366, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24662227, Length=288, Percent_Identity=33.3333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI161077148, Length=297, Percent_Identity=36.026936026936, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI20130057, Length=297, Percent_Identity=36.026936026936, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI20129969, Length=288, Percent_Identity=35.0694444444444, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI19922386, Length=271, Percent_Identity=36.1623616236162, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI21355645, Length=296, Percent_Identity=33.1081081081081, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24662223, Length=296, Percent_Identity=33.1081081081081, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21357381, Length=307, Percent_Identity=31.5960912052117, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI221379063, Length=307, Percent_Identity=31.5960912052117, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221379062, Length=307, Percent_Identity=31.5960912052117, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24646701, Length=230, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24646703, Length=230, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358201, Length=230, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 48374; Mature: 48374

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFPLGVAPHSAVTIRFVEALPDPSPVIAEIIGGGRSPGRADRYCAGPWGLTVVVGLAA
CCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCEECCCCCEEEEEEECC
DATPAQAAKAGALAAAALIGEAIEEAVCAIALSTEASVAFARAFRARLFRPLSLKRAPRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCCH
EDLCRLGALTLVAAKPKDAARAWAPWQAIAEGTEWARSLCAEPGNRLNPTTFARILGGLG
HHHHHHHHEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
DLGVEVEVLDAAAMAREGLNLHLAVGRGSATPPCVVVLRWRGGENDAAPSLLVGKGITFD
CCCCEEEEHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCEEECCCCEEC
AGGICLKRAAHMEDMRGDMAGAAAVAGAIRALALLKSPVNVTAVLALAENMPGSRAQRPG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
DVWLGHAGKTVEVIDTDAEGRLVLADALSWGCATQKPRQVAALSTLTYAIMAALGSHYAG
CEEECCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCE
LFATDDNLASALLSSGEASGDRLWRMPFTPADDPALKSEIADLRNCPPVGPPDAMNAAGF
EEECCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCE
LRVFVPEDIPFAHLDIAAMTLKAEADDTLPAGPTGFGVACLVLWLMAKG
EEEECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDSFPLGVAPHSAVTIRFVEALPDPSPVIAEIIGGGRSPGRADRYCAGPWGLTVVVGLAA
CCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCCEECCCCCEEEEEEECC
DATPAQAAKAGALAAAALIGEAIEEAVCAIALSTEASVAFARAFRARLFRPLSLKRAPRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCCH
EDLCRLGALTLVAAKPKDAARAWAPWQAIAEGTEWARSLCAEPGNRLNPTTFARILGGLG
HHHHHHHHEEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
DLGVEVEVLDAAAMAREGLNLHLAVGRGSATPPCVVVLRWRGGENDAAPSLLVGKGITFD
CCCCEEEEHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCEEECCCCEEC
AGGICLKRAAHMEDMRGDMAGAAAVAGAIRALALLKSPVNVTAVLALAENMPGSRAQRPG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCC
DVWLGHAGKTVEVIDTDAEGRLVLADALSWGCATQKPRQVAALSTLTYAIMAALGSHYAG
CEEECCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCE
LFATDDNLASALLSSGEASGDRLWRMPFTPADDPALKSEIADLRNCPPVGPPDAMNAAGF
EEECCHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCE
LRVFVPEDIPFAHLDIAAMTLKAEADDTLPAGPTGFGVACLVLWLMAKG
EEEECCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA