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The map label for this gene is argM [C]

Identifier: 83593376

GI number: 83593376

Start: 2360832

End: 2362199

Strand: Reverse

Name: argM [C]

Synonym: Rru_A2041

Alternate gene names: 83593376

Gene position: 2362199-2360832 (Counterclockwise)

Preceding gene: 83593378

Following gene: 83593375

Centisome position: 54.27

GC content: 64.4

Gene sequence:

>1368_bases
ATGGTTTCGAATGCCTTGCGTGATGCCGATCTCAGCTACACCATCCATCCCTATACCAACCTCGTCGCCCATGAGACCAA
GGGGCCGCTGATCGCCGTTCGCGGCGAGGGCGTGCGGGTTTTCGATGACAAGGGCAAGGACTACATCGAGGGGATGGCCG
GGCTGTGGTGCGCCTCGCTGGGCTTTTCCGAGCCGCGGCTGGCCGCCGCCGCCGCCCGCCAGATGGCCGAGCTGCCGTTC
TTCCACATGTTCAGCCACAAGTCCCACGAGCCGGGCATCCGCCTGTCCGAGGAACTGGTCAAGCGCGCCCCGGTGCCGAT
GGCCCGCGCCTTCTTCTGCAATTCCGGGTCGGAAGCCAACGACACCGCGATCAAGATGATCTGGTACATCAACAACGCCC
TGGGCCGGCCGCAGAAGAAAAAGATCATCGCCCGTAAGCGCGCCTATCACGGCGTGACGGTGGCCTCGGCCAGCCTGACC
GGCCTGCCGGCCAATCACCGCGATTTCGATCTGCCGATCGCCAATATCTTGCACACCAGTTCGCCCGATTACTACCGCGA
GGGCAAGCCCGGCGAGAGCGAGGAAGCGTTCGCCAAGCGCTGCGCCGACGAGCTTGAGGCCATGATCCTCGCCGAAGATC
CCAACACCGTGGCCGCCTTCTTCGCCGAGCCGATCATGGGCGCGGGCGGCGTGGTCCTGCCGCCCAAGGGCTATTTCGAG
CACATCCAGGCGGTGCTGAAAAAATACGACATCTTGCTGGTCGCCGACGAGGTGATCTGCGGGTTCGGCCGCACCGGCCA
GTATTGGGGCAGCCAGACCTTCGGCCTGAAGCCCGATATCCTGACCTGCGCCAAGGCGTTGTCTTCGGCCTATATGCCGA
TCTCGGCGGTGCTGGTCACCGAAGAGGTCTATAAGCCGCTGCGCGATAATTCGGGCAAGATCGGCACTTTCGGCCACGGC
TATACCTATTCCGCCCATCCGGTGGCCGCCGCCGTCGCCCTGGAAACCCTGGCGATCTATGACGAGCGCGACATTTTGGG
CAATGTGGCGGTATCGGGGGCGCGGCTGCAAGAGCGCCTGCGGAGCTTCGCCGATCATCCGCTGGTTGGCAATGTGCGCG
GCATCGGTCTGATCGGCGCCATCGAACTGGTCGCCGACAAGGCCACCCATGGCGCCTTCCCGGCCAGCGACGCCGTTGGC
CCCCGGGTGGTGACCAAGGCCGAAGAGGCCGGGGTGATCTTGCGGGCGATGGCCGGCGATGTTGTCGCCTTCAGCCCGCC
GCTGATCATCACCCCCGAAGAGGTCGATCAGATGATGGATCGCTTCACCGTTGCCCTCGAGGCGGTTACCGCCGAGGTCT
TAGGTTAG

Upstream 100 bases:

>100_bases
AAAATAATAAACGGGCGTAGGGTCGAGGCCAAGGGAGCCAAAGACGGCCAAACGCCCGCCAGCGGCCCCGTCCCACCCTG
TGCGCCGGAAGGACAAGCCA

Downstream 100 bases:

>100_bases
GCGGTTACCGCCGAGGTCCTAGGTTAGGCGGTCACCGCCGAGGTCTTAGGTTAGGCGGTCACCGCCGAGGTCCTGGGTTA
GGCGCTCGGCGCCCCGGGTC

Product: aminotransferase

Products: L-glutamate; N2-succinylglutamic-semialdehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MVSNALRDADLSYTIHPYTNLVAHETKGPLIAVRGEGVRVFDDKGKDYIEGMAGLWCASLGFSEPRLAAAAARQMAELPF
FHMFSHKSHEPGIRLSEELVKRAPVPMARAFFCNSGSEANDTAIKMIWYINNALGRPQKKKIIARKRAYHGVTVASASLT
GLPANHRDFDLPIANILHTSSPDYYREGKPGESEEAFAKRCADELEAMILAEDPNTVAAFFAEPIMGAGGVVLPPKGYFE
HIQAVLKKYDILLVADEVICGFGRTGQYWGSQTFGLKPDILTCAKALSSAYMPISAVLVTEEVYKPLRDNSGKIGTFGHG
YTYSAHPVAAAVALETLAIYDERDILGNVAVSGARLQERLRSFADHPLVGNVRGIGLIGAIELVADKATHGAFPASDAVG
PRVVTKAEEAGVILRAMAGDVVAFSPPLIITPEEVDQMMDRFTVALEAVTAEVLG

Sequences:

>Translated_455_residues
MVSNALRDADLSYTIHPYTNLVAHETKGPLIAVRGEGVRVFDDKGKDYIEGMAGLWCASLGFSEPRLAAAAARQMAELPF
FHMFSHKSHEPGIRLSEELVKRAPVPMARAFFCNSGSEANDTAIKMIWYINNALGRPQKKKIIARKRAYHGVTVASASLT
GLPANHRDFDLPIANILHTSSPDYYREGKPGESEEAFAKRCADELEAMILAEDPNTVAAFFAEPIMGAGGVVLPPKGYFE
HIQAVLKKYDILLVADEVICGFGRTGQYWGSQTFGLKPDILTCAKALSSAYMPISAVLVTEEVYKPLRDNSGKIGTFGHG
YTYSAHPVAAAVALETLAIYDERDILGNVAVSGARLQERLRSFADHPLVGNVRGIGLIGAIELVADKATHGAFPASDAVG
PRVVTKAEEAGVILRAMAGDVVAFSPPLIITPEEVDQMMDRFTVALEAVTAEVLG
>Mature_455_residues
MVSNALRDADLSYTIHPYTNLVAHETKGPLIAVRGEGVRVFDDKGKDYIEGMAGLWCASLGFSEPRLAAAAARQMAELPF
FHMFSHKSHEPGIRLSEELVKRAPVPMARAFFCNSGSEANDTAIKMIWYINNALGRPQKKKIIARKRAYHGVTVASASLT
GLPANHRDFDLPIANILHTSSPDYYREGKPGESEEAFAKRCADELEAMILAEDPNTVAAFFAEPIMGAGGVVLPPKGYFE
HIQAVLKKYDILLVADEVICGFGRTGQYWGSQTFGLKPDILTCAKALSSAYMPISAVLVTEEVYKPLRDNSGKIGTFGHG
YTYSAHPVAAAVALETLAIYDERDILGNVAVSGARLQERLRSFADHPLVGNVRGIGLIGAIELVADKATHGAFPASDAVG
PRVVTKAEEAGVILRAMAGDVVAFSPPLIITPEEVDQMMDRFTVALEAVTAEVLG

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=439, Percent_Identity=30.9794988610478, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI226442705, Length=439, Percent_Identity=30.2961275626424, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI13994255, Length=442, Percent_Identity=28.0542986425339, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI226442709, Length=408, Percent_Identity=31.3725490196078, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI24119277, Length=433, Percent_Identity=27.0207852193995, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI4557809, Length=441, Percent_Identity=25.1700680272109, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=27.5757575757576, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI188536080, Length=386, Percent_Identity=24.3523316062176, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI38679950, Length=386, Percent_Identity=24.3523316062176, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI38679946, Length=386, Percent_Identity=24.3523316062176, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788044, Length=420, Percent_Identity=32.8571428571429, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1789759, Length=421, Percent_Identity=30.4038004750594, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1786991, Length=433, Percent_Identity=30.2540415704388, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI145693181, Length=423, Percent_Identity=30.0236406619385, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789016, Length=425, Percent_Identity=28.4705882352941, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1787560, Length=427, Percent_Identity=27.4004683840749, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25144271, Length=440, Percent_Identity=28.6363636363636, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI32564660, Length=439, Percent_Identity=28.7015945330296, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI71992977, Length=440, Percent_Identity=25.9090909090909, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=268, Percent_Identity=33.5820895522388, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17541228, Length=452, Percent_Identity=22.3451327433628, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324432, Length=433, Percent_Identity=29.0993071593533, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6324386, Length=469, Percent_Identity=26.6524520255864, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323470, Length=435, Percent_Identity=25.7471264367816, Blast_Score=126, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6321456, Length=287, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI161085790, Length=464, Percent_Identity=29.3103448275862, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI28574759, Length=469, Percent_Identity=29.2110874200426, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=29.2906178489703, Blast_Score=158, Evalue=8e-39,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=27.5779376498801, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI281366494, Length=448, Percent_Identity=24.3303571428571, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24667139, Length=448, Percent_Identity=24.3303571428571, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24667143, Length=448, Percent_Identity=24.3303571428571, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.- [C]

Molecular weight: Translated: 49087; Mature: 49087

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSNALRDADLSYTIHPYTNLVAHETKGPLIAVRGEGVRVFDDKGKDYIEGMAGLWCASL
CCCCCCCCCCCEEEECCCHHHHEECCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHC
GFSEPRLAAAAARQMAELPFFHMFSHKSHEPGIRLSEELVKRAPVPMARAFFCNSGSEAN
CCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHEEECCCCCCC
DTAIKMIWYINNALGRPQKKKIIARKRAYHGVTVASASLTGLPANHRDFDLPIANILHTS
CCEEEEEEEEHHHHCCCHHHHHHHHHHHHCCEEEECCEECCCCCCCCCCCCCHHHHHCCC
SPDYYREGKPGESEEAFAKRCADELEAMILAEDPNTVAAFFAEPIMGAGGVVLPPKGYFE
CCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCEEECCCHHHH
HIQAVLKKYDILLVADEVICGFGRTGQYWGSQTFGLKPDILTCAKALSSAYMPISAVLVT
HHHHHHHHCCEEEEECHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
EEVYKPLRDNSGKIGTFGHGYTYSAHPVAAAVALETLAIYDERDILGNVAVSGARLQERL
HHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHH
RSFADHPLVGNVRGIGLIGAIELVADKATHGAFPASDAVGPRVVTKAEEAGVILRAMAGD
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHHCCEEEEECCCC
VVAFSPPLIITPEEVDQMMDRFTVALEAVTAEVLG
EEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVSNALRDADLSYTIHPYTNLVAHETKGPLIAVRGEGVRVFDDKGKDYIEGMAGLWCASL
CCCCCCCCCCCEEEECCCHHHHEECCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHC
GFSEPRLAAAAARQMAELPFFHMFSHKSHEPGIRLSEELVKRAPVPMARAFFCNSGSEAN
CCCCCHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHEEECCCCCCC
DTAIKMIWYINNALGRPQKKKIIARKRAYHGVTVASASLTGLPANHRDFDLPIANILHTS
CCEEEEEEEEHHHHCCCHHHHHHHHHHHHCCEEEECCEECCCCCCCCCCCCCHHHHHCCC
SPDYYREGKPGESEEAFAKRCADELEAMILAEDPNTVAAFFAEPIMGAGGVVLPPKGYFE
CCCCCCCCCCCCHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCEEECCCHHHH
HIQAVLKKYDILLVADEVICGFGRTGQYWGSQTFGLKPDILTCAKALSSAYMPISAVLVT
HHHHHHHHCCEEEEECHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
EEVYKPLRDNSGKIGTFGHGYTYSAHPVAAAVALETLAIYDERDILGNVAVSGARLQERL
HHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHH
RSFADHPLVGNVRGIGLIGAIELVADKATHGAFPASDAVGPRVVTKAEEAGVILRAMAGD
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECHHHCCEEEEECCCC
VVAFSPPLIITPEEVDQMMDRFTVALEAVTAEVLG
EEEECCCEEECHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-alpha-acetylornithine; 2-oxoglutarate [C]

Specific reaction: N-alpha-acetylornithine + 2-oxoglutarate = N-acetylglutamate semialdehyde + L-glutamate N2-succinylornithine + 2-oxoglutarate = N2-succinylglutamic-semialdehyde + L-glutamate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8796346; 9163424 [H]