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The map label for this gene is mmgC [H]

Identifier: 83593283

GI number: 83593283

Start: 2256648

End: 2257811

Strand: Reverse

Name: mmgC [H]

Synonym: Rru_A1948

Alternate gene names: 83593283

Gene position: 2257811-2256648 (Counterclockwise)

Preceding gene: 83593286

Following gene: 83593282

Centisome position: 51.87

GC content: 64.26

Gene sequence:

>1164_bases
ATGGAGTATCCGTCGCTGAGCTTTGATCTGGGCGAAACCGCCCTGATGCTGCGCGCCTCGGTGCGCGCTTTCGCCCGGGC
GGAAATCGCCCCGCGCGCCGCCGAGATCGATCGCGCCAACGCCTTTCCCGCCGACCTCTGGCCCAAGATGGGCGCCTTGG
GGGTGCTTGGGCTGACCGTCGAGGAAAGCGACGGCGGGGCGGGGATGGGATACCTTGACCATTGCCTGGCGATGGAGGAG
ATCAGCCGGGCCTCGGCCAGTGTCGGCCTGAGCTATGGCGCCCATTCCAATCTCTGCGTCAACCAACTGCGCCTGAATGG
TAGCGCCGAGCAGAAGCGACGCTATCTGCCCGGATTGATCGCTGGCACCCATGTCGGCGCCCTGGCGATGAGCGAGACGG
GGGCGGGATCGGATGTGGTGTCGATGCGCACCCGGGCCGAGCGCCGGGGCGACACCTTCGTGCTCAACGGCTCGAAGATG
TGGATCACCAATGGCCCCGACGCCGATGTCCTGGTGGTCTACGCCAAAAGCGACCCGGATCTGAAATCGCGCGGCATCAC
CGCCTTTATCGTTGAAAAGGGCTGGAAAGGTTTCACCACCGGGCCCAAGCTCGACAAATTGGGCATGCGCGGCTCTAACA
CCGGCGAATTGGTCTTCGAGGACTGCGAGGTTCCGGCCGAGAACGTGCTGGGCGGTGTCGGCGAGGGCGTAAAGGTGCTG
ATGAGCGGCCTGGATTACGAGCGGCTGGTGCTGGCCGGCGGGCCGCTTGGCATCATGGAGGCCTGTCTCGACGCCGTGCT
GCCCTATGTCCACGAACGCCAGCAATTCGGCCGGGCGATCGGCTCGTTCCAGCTTATGCAGGGCAAGCTCGCCGATATGT
ATACGACGCTCTGCGCCTGCAAAGCCTATGTCTATGCCGTGGCCCAGGCCTGTGATCGCGGCAAGGCTACCAGCAAGGAC
GCCGCCGGGGCGATTTTGTTCGCCGCCGAGAAAGCCACCTGGATGGCCCTGGAAGCCATTCAGTGTCTGGGGGGAAATGG
GTATATCAACGACTATCCCACCGGACGGCTGTTGCGCGATGCCAAGCTCTATGAGATCGGCGCCGGCACCAGCGAAATCA
GGCGGATGCTGATCGGCCGCGCGCTGTTTGGCGAAACCGCCTGA

Upstream 100 bases:

>100_bases
CCATGCCGGCTTGTCCCTTTCCGGGGTCTTCGGGGTGCCAGGGTTTTTGGCCGATCGAGGGGCCGGAAGGTCGTCAACCG
TCCGGGGAGGGCGCGAAGCC

Downstream 100 bases:

>100_bases
ACCCGTCCGACCCGCCCCATTTTCCAGGAGGGTCGTCCGCATGGTCGACGCCGTGACTAGCCCAAGCCCGCTCCCCACCC
TGTCCCGACCGGTCGCGGAC

Product: isovaleryl-CoA dehydrogenase

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MEYPSLSFDLGETALMLRASVRAFARAEIAPRAAEIDRANAFPADLWPKMGALGVLGLTVEESDGGAGMGYLDHCLAMEE
ISRASASVGLSYGAHSNLCVNQLRLNGSAEQKRRYLPGLIAGTHVGALAMSETGAGSDVVSMRTRAERRGDTFVLNGSKM
WITNGPDADVLVVYAKSDPDLKSRGITAFIVEKGWKGFTTGPKLDKLGMRGSNTGELVFEDCEVPAENVLGGVGEGVKVL
MSGLDYERLVLAGGPLGIMEACLDAVLPYVHERQQFGRAIGSFQLMQGKLADMYTTLCACKAYVYAVAQACDRGKATSKD
AAGAILFAAEKATWMALEAIQCLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRALFGETA

Sequences:

>Translated_387_residues
MEYPSLSFDLGETALMLRASVRAFARAEIAPRAAEIDRANAFPADLWPKMGALGVLGLTVEESDGGAGMGYLDHCLAMEE
ISRASASVGLSYGAHSNLCVNQLRLNGSAEQKRRYLPGLIAGTHVGALAMSETGAGSDVVSMRTRAERRGDTFVLNGSKM
WITNGPDADVLVVYAKSDPDLKSRGITAFIVEKGWKGFTTGPKLDKLGMRGSNTGELVFEDCEVPAENVLGGVGEGVKVL
MSGLDYERLVLAGGPLGIMEACLDAVLPYVHERQQFGRAIGSFQLMQGKLADMYTTLCACKAYVYAVAQACDRGKATSKD
AAGAILFAAEKATWMALEAIQCLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRALFGETA
>Mature_387_residues
MEYPSLSFDLGETALMLRASVRAFARAEIAPRAAEIDRANAFPADLWPKMGALGVLGLTVEESDGGAGMGYLDHCLAMEE
ISRASASVGLSYGAHSNLCVNQLRLNGSAEQKRRYLPGLIAGTHVGALAMSETGAGSDVVSMRTRAERRGDTFVLNGSKM
WITNGPDADVLVVYAKSDPDLKSRGITAFIVEKGWKGFTTGPKLDKLGMRGSNTGELVFEDCEVPAENVLGGVGEGVKVL
MSGLDYERLVLAGGPLGIMEACLDAVLPYVHERQQFGRAIGSFQLMQGKLADMYTTLCACKAYVYAVAQACDRGKATSKD
AAGAILFAAEKATWMALEAIQCLGGNGYINDYPTGRLLRDAKLYEIGAGTSEIRRMLIGRALFGETA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=379, Percent_Identity=64.3799472295514, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI226958414, Length=342, Percent_Identity=67.2514619883041, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=42.741935483871, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI4501859, Length=371, Percent_Identity=35.8490566037736, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=37.5661375661376, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=37.5661375661376, Blast_Score=250, Evalue=1e-66,
Organism=Homo sapiens, GI4501857, Length=369, Percent_Identity=34.6883468834688, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI21361497, Length=386, Percent_Identity=37.3056994818653, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI76496475, Length=340, Percent_Identity=36.1764705882353, Blast_Score=208, Evalue=9e-54,
Organism=Homo sapiens, GI4557235, Length=341, Percent_Identity=36.3636363636364, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI7656849, Length=367, Percent_Identity=33.5149863760218, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4503943, Length=381, Percent_Identity=31.496062992126, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI7669494, Length=375, Percent_Identity=31.7333333333333, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI48976061, Length=282, Percent_Identity=25.531914893617, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI211971008, Length=282, Percent_Identity=25.531914893617, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI38505218, Length=375, Percent_Identity=23.2, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI218563752, Length=228, Percent_Identity=28.0701754385965, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=29.1338582677165, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=29.9479166666667, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI87082384, Length=280, Percent_Identity=28.9285714285714, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87081702, Length=285, Percent_Identity=25.6140350877193, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=62.1052631578947, Blast_Score=497, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17569725, Length=385, Percent_Identity=38.4415584415584, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=36.4829396325459, Blast_Score=247, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI17570075, Length=385, Percent_Identity=36.8831168831169, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=34.0425531914894, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17508101, Length=377, Percent_Identity=32.8912466843501, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=40.2877697841727, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=34.2857142857143, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=33.6814621409922, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17533517, Length=366, Percent_Identity=31.9672131147541, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.2294372294372, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=35.0877192982456, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=33.9416058394161, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=32.8, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=31.7333333333333, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=244, Percent_Identity=30.327868852459, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI86563383, Length=280, Percent_Identity=27.5, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=280, Percent_Identity=27.5, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=62.5, Blast_Score=479, Evalue=1e-135,
Organism=Drosophila melanogaster, GI21356377, Length=378, Percent_Identity=42.5925925925926, Blast_Score=294, Evalue=7e-80,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=38.563829787234, Blast_Score=267, Evalue=8e-72,
Organism=Drosophila melanogaster, GI24660351, Length=380, Percent_Identity=38.9473684210526, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24666513, Length=380, Percent_Identity=34.4736842105263, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI281363737, Length=341, Percent_Identity=36.0703812316716, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI19920834, Length=385, Percent_Identity=32.7272727272727, Blast_Score=178, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 41219; Mature: 41219

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYPSLSFDLGETALMLRASVRAFARAEIAPRAAEIDRANAFPADLWPKMGALGVLGLTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHCCCCCEEEEEEE
EESDGGAGMGYLDHCLAMEEISRASASVGLSYGAHSNLCVNQLRLNGSAEQKRRYLPGLI
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEECCCCHHHHHHHCCCHH
AGTHVGALAMSETGAGSDVVSMRTRAERRGDTFVLNGSKMWITNGPDADVLVVYAKSDPD
HHCHHHHEEECCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCEEEEEECCCCC
LKSRGITAFIVEKGWKGFTTGPKLDKLGMRGSNTGELVFEDCEVPAENVLGGVGEGVKVL
HHHCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEEECCCCCHHHHHCCCCHHHHHH
MSGLDYERLVLAGGPLGIMEACLDAVLPYVHERQQFGRAIGSFQLMQGKLADMYTTLCAC
HHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
KAYVYAVAQACDRGKATSKDAAGAILFAAEKATWMALEAIQCLGGNGYINDYPTGRLLRD
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
AKLYEIGAGTSEIRRMLIGRALFGETA
CEEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEYPSLSFDLGETALMLRASVRAFARAEIAPRAAEIDRANAFPADLWPKMGALGVLGLTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCHHHHHCCCCCEEEEEEE
EESDGGAGMGYLDHCLAMEEISRASASVGLSYGAHSNLCVNQLRLNGSAEQKRRYLPGLI
ECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEECCCCHHHHHHHCCCHH
AGTHVGALAMSETGAGSDVVSMRTRAERRGDTFVLNGSKMWITNGPDADVLVVYAKSDPD
HHCHHHHEEECCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEECCCCCCEEEEEECCCCC
LKSRGITAFIVEKGWKGFTTGPKLDKLGMRGSNTGELVFEDCEVPAENVLGGVGEGVKVL
HHHCCCEEEEEECCCCCCCCCCCHHHCCCCCCCCCCEEEECCCCCHHHHHCCCCHHHHHH
MSGLDYERLVLAGGPLGIMEACLDAVLPYVHERQQFGRAIGSFQLMQGKLADMYTTLCAC
HHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
KAYVYAVAQACDRGKATSKDAAGAILFAAEKATWMALEAIQCLGGNGYINDYPTGRLLRD
HHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
AKLYEIGAGTSEIRRMLIGRALFGETA
CEEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]