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The map label for this gene is mvaB [H]

Identifier: 83593275

GI number: 83593275

Start: 2247477

End: 2248391

Strand: Reverse

Name: mvaB [H]

Synonym: Rru_A1940

Alternate gene names: 83593275

Gene position: 2248391-2247477 (Counterclockwise)

Preceding gene: 83593276

Following gene: 83593272

Centisome position: 51.65

GC content: 70.71

Gene sequence:

>915_bases
ATGAGCCCCGATGCCGTGCGGCTGGTCGAGGTCGGTCCGCGCGACGGCCTGCAGAACGAGGCCGGGGTGGTGCCGCTGGC
CGCCAAGGTGGCGCTGATCGACGCCCTGTCGGCGGCCGGGCTGCCGGTGATCGAGGCGGGCGCCTTCGTCGCCCCCGGGC
GGGTGCCGCAGATGGCCGATAGCGCCGCCGTTCTGGCGGCCATCCACCGGCGGGCGGGGGTGCGCTATCCGGTTCTGGTG
CCCAATCTCAAGGGCCTGAAGGCGGCGACCGAGGCGGTGGGCGTGGACGATATCGCCGTGTTCGCCGCCGCCTCCGAGAC
CTTTTCAAAAAAGAACATCAACTGCTCGATCGCGGAAAGCCTGGAGCGTCTAGCCGAGGTCGCCGCGCGGGCCAAGGATC
GCGGCATCGCCGTGCGCGGCTATGTGTCGTGCGTGCTTGGTTGTCCCTATGAGGGCGCGGTGGCGATCGACCGGGTGGTC
GAGGTGGCGGCGGCCCTGGCCGCCATGGGCTGCCACGAGATCAGCCTGGGCGATACCATCGGCGTCGGCACGCCGCGTCG
GGCGCGGGAGATGGTCCAGGCGGTGGCCGGAGCGGTGCCGGTCCAGCGGTTGGCCGCCCATTTCCACGACACCTATGGTC
AGGCCCTGGCCAATATCCTGGCGGTGCTCGAAATCGGCGTCACCACCTTTGACTGTTCGGTCGCCGGTCTGGGCGGCTGC
CCCTATGCCCCGGGGGCCAGCGGCAATGTGGCGACCGAGGATGTGGTCTATATGCTTGACGGCATGGGGATCGCCAGCGG
CGTCGATCTAGAGAAGCTGCGCCTCGCCGGTCTGGCGCTTTGCCAGACCCTGGGGCGCCCCCCGGCCTCGCGCGCCGCCC
GCGCGCTGGCAGCGAGGAAAGGGCGTGGCGGCTAA

Upstream 100 bases:

>100_bases
AGGAGGGGCGGGTCCTGGCGGTGATCGAGCCGGCGGGCGAGGAGGGGGGTAAGCCGGCGGGCGAGGGGGTGATCAAGCCG
GTGGGCGCGGAGGCGTCGCC

Downstream 100 bases:

>100_bases
CGGCGGGGAGGGCGCGGCGGTTTGGCGGCGGGGCGGCGACGCGCCGGCAGGCTCGCGGTCTCCTCGCGCCAGCTTCCCGG
CGGCAGGTTCTCCAAGGTCC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MSPDAVRLVEVGPRDGLQNEAGVVPLAAKVALIDALSAAGLPVIEAGAFVAPGRVPQMADSAAVLAAIHRRAGVRYPVLV
PNLKGLKAATEAVGVDDIAVFAAASETFSKKNINCSIAESLERLAEVAARAKDRGIAVRGYVSCVLGCPYEGAVAIDRVV
EVAAALAAMGCHEISLGDTIGVGTPRRAREMVQAVAGAVPVQRLAAHFHDTYGQALANILAVLEIGVTTFDCSVAGLGGC
PYAPGASGNVATEDVVYMLDGMGIASGVDLEKLRLAGLALCQTLGRPPASRAARALAARKGRGG

Sequences:

>Translated_304_residues
MSPDAVRLVEVGPRDGLQNEAGVVPLAAKVALIDALSAAGLPVIEAGAFVAPGRVPQMADSAAVLAAIHRRAGVRYPVLV
PNLKGLKAATEAVGVDDIAVFAAASETFSKKNINCSIAESLERLAEVAARAKDRGIAVRGYVSCVLGCPYEGAVAIDRVV
EVAAALAAMGCHEISLGDTIGVGTPRRAREMVQAVAGAVPVQRLAAHFHDTYGQALANILAVLEIGVTTFDCSVAGLGGC
PYAPGASGNVATEDVVYMLDGMGIASGVDLEKLRLAGLALCQTLGRPPASRAARALAARKGRGG
>Mature_303_residues
SPDAVRLVEVGPRDGLQNEAGVVPLAAKVALIDALSAAGLPVIEAGAFVAPGRVPQMADSAAVLAAIHRRAGVRYPVLVP
NLKGLKAATEAVGVDDIAVFAAASETFSKKNINCSIAESLERLAEVAARAKDRGIAVRGYVSCVLGCPYEGAVAIDRVVE
VAAALAAMGCHEISLGDTIGVGTPRRAREMVQAVAGAVPVQRLAAHFHDTYGQALANILAVLEIGVTTFDCSVAGLGGCP
YAPGASGNVATEDVVYMLDGMGIASGVDLEKLRLAGLALCQTLGRPPASRAARALAARKGRGG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=57.3378839590444, Blast_Score=347, Evalue=8e-96,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=54.9488054607508, Blast_Score=337, Evalue=6e-93,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=54.9488054607508, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI260654708, Length=293, Percent_Identity=38.9078498293515, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17510563, Length=299, Percent_Identity=49.8327759197324, Blast_Score=297, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24582381, Length=299, Percent_Identity=56.5217391304348, Blast_Score=336, Evalue=9e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 30881; Mature: 30750

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: PS01062 HMG_COA_LYASE ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPDAVRLVEVGPRDGLQNEAGVVPLAAKVALIDALSAAGLPVIEAGAFVAPGRVPQMAD
CCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCEECCCCCCHHHH
SAAVLAAIHRRAGVRYPVLVPNLKGLKAATEAVGVDDIAVFAAASETFSKKNINCSIAES
HHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
LERLAEVAARAKDRGIAVRGYVSCVLGCPYEGAVAIDRVVEVAAALAAMGCHEISLGDTI
HHHHHHHHHHHHHCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCC
GVGTPRRAREMVQAVAGAVPVQRLAAHFHDTYGQALANILAVLEIGVTTFDCSVAGLGGC
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECEECCCCCC
PYAPGASGNVATEDVVYMLDGMGIASGVDLEKLRLAGLALCQTLGRPPASRAARALAARK
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GRGG
CCCC
>Mature Secondary Structure 
SPDAVRLVEVGPRDGLQNEAGVVPLAAKVALIDALSAAGLPVIEAGAFVAPGRVPQMAD
CCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCEECCCCCCHHHH
SAAVLAAIHRRAGVRYPVLVPNLKGLKAATEAVGVDDIAVFAAASETFSKKNINCSIAES
HHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHH
LERLAEVAARAKDRGIAVRGYVSCVLGCPYEGAVAIDRVVEVAAALAAMGCHEISLGDTI
HHHHHHHHHHHHHCCEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEECCCCCC
GVGTPRRAREMVQAVAGAVPVQRLAAHFHDTYGQALANILAVLEIGVTTFDCSVAGLGGC
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECEECCCCCC
PYAPGASGNVATEDVVYMLDGMGIASGVDLEKLRLAGLALCQTLGRPPASRAARALAARK
CCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHC
GRGG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]