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The map label for this gene is cysG [H]

Identifier: 83593268

GI number: 83593268

Start: 2238831

End: 2240330

Strand: Reverse

Name: cysG [H]

Synonym: Rru_A1933

Alternate gene names: 83593268

Gene position: 2240330-2238831 (Counterclockwise)

Preceding gene: 83593270

Following gene: 83593267

Centisome position: 51.47

GC content: 73.53

Gene sequence:

>1500_bases
ATGGACAGCTTCCCGATTTTTCTGACCCTTACCGGGGTCCGCGTTCTTGTCGTCGGCGGCGGCGCCGCCGCGGCCGCCAA
GGCGCGTCTGGCGCTCAAGGCCGGCGCCAGGGTCAGCGTTTTCGCGCCCGCCTTATCGGCCGATTGGCAAGATCTGCGCG
GCCATCCCGCCCTTGATCACCGCCAGGGCTTTCCCGGCCAGGGCGGCGAGGAGGAGTGGCGCGACGTGCGGTTGGTCTAT
GCCGCCGGCGAAAGCCTGGAAGAGGACAGGGCCGTTCATGCCGCCGCCAGCGCCCGGGGGGTGCTGGTCAATGTCGTCGA
TCGCCCCGAATTATGCGATTTCCTGACGCCGGCCATCGTCGATCGCAGCCCGATCGTCGTGGCCATCGGAACTGGGGGGC
GGGCGCCGGTGCTGGCGCGCCGGGTGCGCGCCGCCATCGACCGCTTGCTGCCCGCCCGGCTGGGAGCCCTCGCCCGGCTG
GCCGAGGGCTTTCGCGGCACGGTCGCCCAAGCCCTGCCCGATGGCGACCGGCGCCGGCGCTTCTGGGACCGCTTCTTCGA
CGGCGCCCCGGCCCTGGCCGCCCTGGAAGGCGACGAGCCGCGCGCCCGAACCGCCGCCCTGCGCCTGCTCAATGACGGCG
AGGCCCTGGACAACGGCGCGCCGGCCGCCGGGGTCGTTCATCTGGTCGGCGCCGGACCGGGAGACCCCGATCTTCTGACC
CTGAAGGCCCAGCGCCTGCTCCAGGAGGCCGATGCCCTGGTTTATGACGATCTGGTGGGCGAGGGGATCTTGGATATGGC
CCGGCGCGACGCCGCGCGGATCTACGTCGGCAAGCGCAAGGGCCGGGCGAGCCTGACCCAGGAGCAGATTGGCCGGTTGA
TGTGCGATCTGGCCGCAGCGGGGCGGGTGGTGGTGCGCCTGAAAGGCGGCGACCCGGCGGTTTTCGCCCGCCTGTCCGAG
GAAATCGACGCCCTGGCCGCCGCCGGGGTGGCCTGGACGGTGGTGCCGGGGATCACCGCGGCTTCGGCCGCCGCCGCCGC
CATCGGCATCTCGCTGACCGATCGTGACGGGGCGCCCAGCGTCACCTTGCTGTCGGGCCATCGGCGCGCTCCGGCGGCCG
GCGAGAGCGAGGCCGCCGTCGATTGGCGGGCGGCGGCGCGGACCGGTGGCACCCTGGCGGTCTATATGGGCCTGTCACGG
GCCACGGCGGCGGCCGAGGGGCTGATCGAAGGCGGGCTGTCGGCCGAGACCCCGGTGGCCGTGGTTCATGACGCCAGCCG
CCAGGGCCAGCGCGTTTCGCGCGGAACCCTGGGCGAGCTGCCCCGGCTGGTCGCCCAAGGGGCCTTGGCCGCGCCCGATG
CCCCGGGGCTGGTGCTGGTCGGCAAGGTCGTCGCCAAGGCCGGCCGCCTGCCGGCGATCGCCCCGGTTTTTTCCACCCCG
CGCGCCTTCGCCGGCGATCCGTCCTTCGCCTCCCAAGCCCTGCCGTCCCAGGCGGGCTGA

Upstream 100 bases:

>100_bases
TGATCGGCCGGCCCCCGGGGACCGGTCGCTCTCATCGGAACCCCGCCTTTCGCGATGCTTCCCGTAAGGGATCCTCGCCA
GATTTTTATAGGGCCCGTCC

Downstream 100 bases:

>100_bases
ACGCGGTGTCTTCGCTTTTTAGGACCATGACCATGACCTCCTCCGACCCCGTCAAAGCCGGTTCCGTCTTTTCCGCCGAG
GTGATCACCGCCAATCGCCT

Product: uroporphyrinogen-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MDSFPIFLTLTGVRVLVVGGGAAAAAKARLALKAGARVSVFAPALSADWQDLRGHPALDHRQGFPGQGGEEEWRDVRLVY
AAGESLEEDRAVHAAASARGVLVNVVDRPELCDFLTPAIVDRSPIVVAIGTGGRAPVLARRVRAAIDRLLPARLGALARL
AEGFRGTVAQALPDGDRRRRFWDRFFDGAPALAALEGDEPRARTAALRLLNDGEALDNGAPAAGVVHLVGAGPGDPDLLT
LKAQRLLQEADALVYDDLVGEGILDMARRDAARIYVGKRKGRASLTQEQIGRLMCDLAAAGRVVVRLKGGDPAVFARLSE
EIDALAAAGVAWTVVPGITAASAAAAAIGISLTDRDGAPSVTLLSGHRRAPAAGESEAAVDWRAAARTGGTLAVYMGLSR
ATAAAEGLIEGGLSAETPVAVVHDASRQGQRVSRGTLGELPRLVAQGALAAPDAPGLVLVGKVVAKAGRLPAIAPVFSTP
RAFAGDPSFASQALPSQAG

Sequences:

>Translated_499_residues
MDSFPIFLTLTGVRVLVVGGGAAAAAKARLALKAGARVSVFAPALSADWQDLRGHPALDHRQGFPGQGGEEEWRDVRLVY
AAGESLEEDRAVHAAASARGVLVNVVDRPELCDFLTPAIVDRSPIVVAIGTGGRAPVLARRVRAAIDRLLPARLGALARL
AEGFRGTVAQALPDGDRRRRFWDRFFDGAPALAALEGDEPRARTAALRLLNDGEALDNGAPAAGVVHLVGAGPGDPDLLT
LKAQRLLQEADALVYDDLVGEGILDMARRDAARIYVGKRKGRASLTQEQIGRLMCDLAAAGRVVVRLKGGDPAVFARLSE
EIDALAAAGVAWTVVPGITAASAAAAAIGISLTDRDGAPSVTLLSGHRRAPAAGESEAAVDWRAAARTGGTLAVYMGLSR
ATAAAEGLIEGGLSAETPVAVVHDASRQGQRVSRGTLGELPRLVAQGALAAPDAPGLVLVGKVVAKAGRLPAIAPVFSTP
RAFAGDPSFASQALPSQAG
>Mature_499_residues
MDSFPIFLTLTGVRVLVVGGGAAAAAKARLALKAGARVSVFAPALSADWQDLRGHPALDHRQGFPGQGGEEEWRDVRLVY
AAGESLEEDRAVHAAASARGVLVNVVDRPELCDFLTPAIVDRSPIVVAIGTGGRAPVLARRVRAAIDRLLPARLGALARL
AEGFRGTVAQALPDGDRRRRFWDRFFDGAPALAALEGDEPRARTAALRLLNDGEALDNGAPAAGVVHLVGAGPGDPDLLT
LKAQRLLQEADALVYDDLVGEGILDMARRDAARIYVGKRKGRASLTQEQIGRLMCDLAAAGRVVVRLKGGDPAVFARLSE
EIDALAAAGVAWTVVPGITAASAAAAAIGISLTDRDGAPSVTLLSGHRRAPAAGESEAAVDWRAAARTGGTLAVYMGLSR
ATAAAEGLIEGGLSAETPVAVVHDASRQGQRVSRGTLGELPRLVAQGALAAPDAPGLVLVGKVVAKAGRLPAIAPVFSTP
RAFAGDPSFASQALPSQAG

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=475, Percent_Identity=41.8947368421053, Blast_Score=314, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6322922, Length=273, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 51376; Mature: 51376

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSFPIFLTLTGVRVLVVGGGAAAAAKARLALKAGARVSVFAPALSADWQDLRGHPALDH
CCCCCEEEEEECEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCCCCCC
RQGFPGQGGEEEWRDVRLVYAAGESLEEDRAVHAAASARGVLVNVVDRPELCDFLTPAIV
CCCCCCCCCCHHHHEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHC
DRSPIVVAIGTGGRAPVLARRVRAAIDRLLPARLGALARLAEGFRGTVAQALPDGDRRRR
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
FWDRFFDGAPALAALEGDEPRARTAALRLLNDGEALDNGAPAAGVVHLVGAGPGDPDLLT
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEH
LKAQRLLQEADALVYDDLVGEGILDMARRDAARIYVGKRKGRASLTQEQIGRLMCDLAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEECCCCCCCCCHHHHHHHHHHHHCC
GRVVVRLKGGDPAVFARLSEEIDALAAAGVAWTVVPGITAASAAAAAIGISLTDRDGAPS
CEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHEEEEEECCCCCCC
VTLLSGHRRAPAAGESEAAVDWRAAARTGGTLAVYMGLSRATAAAEGLIEGGLSAETPVA
EEEECCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCEE
VVHDASRQGQRVSRGTLGELPRLVAQGALAAPDAPGLVLVGKVVAKAGRLPAIAPVFSTP
EEECCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHCCCCCCCCHHHCCC
RAFAGDPSFASQALPSQAG
CCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MDSFPIFLTLTGVRVLVVGGGAAAAAKARLALKAGARVSVFAPALSADWQDLRGHPALDH
CCCCCEEEEEECEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCCCCCC
RQGFPGQGGEEEWRDVRLVYAAGESLEEDRAVHAAASARGVLVNVVDRPELCDFLTPAIV
CCCCCCCCCCHHHHEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHC
DRSPIVVAIGTGGRAPVLARRVRAAIDRLLPARLGALARLAEGFRGTVAQALPDGDRRRR
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
FWDRFFDGAPALAALEGDEPRARTAALRLLNDGEALDNGAPAAGVVHLVGAGPGDPDLLT
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEH
LKAQRLLQEADALVYDDLVGEGILDMARRDAARIYVGKRKGRASLTQEQIGRLMCDLAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEEEECCCCCCCCCHHHHHHHHHHHHCC
GRVVVRLKGGDPAVFARLSEEIDALAAAGVAWTVVPGITAASAAAAAIGISLTDRDGAPS
CEEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHEEEEEECCCCCCC
VTLLSGHRRAPAAGESEAAVDWRAAARTGGTLAVYMGLSRATAAAEGLIEGGLSAETPVA
EEEECCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCEE
VVHDASRQGQRVSRGTLGELPRLVAQGALAAPDAPGLVLVGKVVAKAGRLPAIAPVFSTP
EEECCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHCCCCCCCCHHHCCC
RAFAGDPSFASQALPSQAG
CCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA