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The map label for this gene is tpiA [H]

Identifier: 83593224

GI number: 83593224

Start: 2188255

End: 2189013

Strand: Reverse

Name: tpiA [H]

Synonym: Rru_A1889

Alternate gene names: 83593224

Gene position: 2189013-2188255 (Counterclockwise)

Preceding gene: 83593227

Following gene: 83593223

Centisome position: 50.29

GC content: 67.19

Gene sequence:

>759_bases
ATGACCGTGCGTCGTCCGCTTATTGCCGGAAACTGGAAGATGAACGGCCTCAAGGCCGAGGGCCAGGGCCTCGCCCGGGA
TCTTGCCCAGAGGCTTAACAAGGCCGGTGGGGTCGATTTCGACCTTCTTCTTTGTCCGCCTTTTCCGTTGATCAGCACGG
TGGTCGGCGCCGTGGCCGGATCGGGCATCGCCGTTGGCGGCCAGGATTGCCATGCCAAGGCCAAGGGCGCCCATACGGGC
GATGTCTCGGCCCCGATGCTGGCCGATCTCGGCTGCCAGTTCGTCATCGTCGGCCATTCGGAACGCCGGGCCGATCACGG
CGAAACCGATGCCCTGGTCAAGGCCAAGGCCGAGGCCGCCCTGGCCGCCGGTCTGATCGCCGTGATCTGCGTCGGCGAGA
CCGAGGCCCAGCGCGACGCCGGGGAAACCCTGGCCGTGGTCTCGGGCCAATTGGCCGGATCGTTGCCCACCCACGCGGAT
TCGGGCAAGGTGGTCATCGCCTATGAACCCGTCTGGGCCATCGGTACCGGTCGCGTGCCGACGACCGAGGATGTCGCCAA
GGTCCATGGCGCGCTGCGCAAGGATCTGGTCGGCGCCCTGGGGGCGGACGGCAATGGCGTGCGCCTGCTTTACGGCGGAT
CGGTCAAGCCCGACAACGCCGCCGAGCTGATGGCCTTGGAAAACGTCGATGGCGCCCTGGTCGGCGGCGCCAGCCTCAAG
GCCGAGGATTTCTGGGCGATCGCCCAGTCCTGCGCTTAA

Upstream 100 bases:

>100_bases
ATCGGGTCGTCGCCCCCGCCCCCAAGTCCGGGAGATGGCCGGCCCCGGCGCGGGCCCGGCCGCTTTCCGGTCGCCTCTGT
CGAAAGGGAAGCGTCCTCCC

Downstream 100 bases:

>100_bases
GATTTGACGCGTCGGCCCGGACCCCGCCGGCGGTTGGATGCGATCGTCTTCGTCTTGCCTCTGGTAAAGGCGCGACGGGG
ACGCTAAAAGGGCGCCGGGC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTVRRPLIAGNWKMNGLKAEGQGLARDLAQRLNKAGGVDFDLLLCPPFPLISTVVGAVAGSGIAVGGQDCHAKAKGAHTG
DVSAPMLADLGCQFVIVGHSERRADHGETDALVKAKAEAALAAGLIAVICVGETEAQRDAGETLAVVSGQLAGSLPTHAD
SGKVVIAYEPVWAIGTGRVPTTEDVAKVHGALRKDLVGALGADGNGVRLLYGGSVKPDNAAELMALENVDGALVGGASLK
AEDFWAIAQSCA

Sequences:

>Translated_252_residues
MTVRRPLIAGNWKMNGLKAEGQGLARDLAQRLNKAGGVDFDLLLCPPFPLISTVVGAVAGSGIAVGGQDCHAKAKGAHTG
DVSAPMLADLGCQFVIVGHSERRADHGETDALVKAKAEAALAAGLIAVICVGETEAQRDAGETLAVVSGQLAGSLPTHAD
SGKVVIAYEPVWAIGTGRVPTTEDVAKVHGALRKDLVGALGADGNGVRLLYGGSVKPDNAAELMALENVDGALVGGASLK
AEDFWAIAQSCA
>Mature_251_residues
TVRRPLIAGNWKMNGLKAEGQGLARDLAQRLNKAGGVDFDLLLCPPFPLISTVVGAVAGSGIAVGGQDCHAKAKGAHTGD
VSAPMLADLGCQFVIVGHSERRADHGETDALVKAKAEAALAAGLIAVICVGETEAQRDAGETLAVVSGQLAGSLPTHADS
GKVVIAYEPVWAIGTGRVPTTEDVAKVHGALRKDLVGALGADGNGVRLLYGGSVKPDNAAELMALENVDGALVGGASLKA
EDFWAIAQSCA

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=241, Percent_Identity=41.9087136929461, Blast_Score=155, Evalue=3e-38,
Organism=Homo sapiens, GI4507645, Length=241, Percent_Identity=41.9087136929461, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1790353, Length=250, Percent_Identity=42, Blast_Score=178, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17536593, Length=244, Percent_Identity=42.2131147540984, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6320255, Length=241, Percent_Identity=40.6639004149378, Blast_Score=175, Evalue=7e-45,
Organism=Drosophila melanogaster, GI28572004, Length=241, Percent_Identity=41.9087136929461, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28572008, Length=241, Percent_Identity=41.9087136929461, Blast_Score=169, Evalue=1e-42,
Organism=Drosophila melanogaster, GI28572006, Length=241, Percent_Identity=41.9087136929461, Blast_Score=169, Evalue=1e-42,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 25547; Mature: 25416

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRRPLIAGNWKMNGLKAEGQGLARDLAQRLNKAGGVDFDLLLCPPFPLISTVVGAVAG
CCCCCCEEECCCEECCEECCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCC
SGIAVGGQDCHAKAKGAHTGDVSAPMLADLGCQFVIVGHSERRADHGETDALVKAKAEAA
CCEEECCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCHHCCCCCCCHHHHHHHHHHH
LAAGLIAVICVGETEAQRDAGETLAVVSGQLAGSLPTHADSGKVVIAYEPVWAIGTGRVP
HHHCEEEEEEECCCHHHHCCCCEEEEEECHHCCCCCCCCCCCCEEEEECCEEEEECCCCC
TTEDVAKVHGALRKDLVGALGADGNGVRLLYGGSVKPDNAAELMALENVDGALVGGASLK
CHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHEEEEECCCCEEECCCCCC
AEDFWAIAQSCA
HHHHHHHHHHCC
>Mature Secondary Structure 
TVRRPLIAGNWKMNGLKAEGQGLARDLAQRLNKAGGVDFDLLLCPPFPLISTVVGAVAG
CCCCCEEECCCEECCEECCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCC
SGIAVGGQDCHAKAKGAHTGDVSAPMLADLGCQFVIVGHSERRADHGETDALVKAKAEAA
CCEEECCCCCCCCCCCCCCCCCCCCHHHHCCCEEEEEECCHHCCCCCCCHHHHHHHHHHH
LAAGLIAVICVGETEAQRDAGETLAVVSGQLAGSLPTHADSGKVVIAYEPVWAIGTGRVP
HHHCEEEEEEECCCHHHHCCCCEEEEEECHHCCCCCCCCCCCCEEEEECCEEEEECCCCC
TTEDVAKVHGALRKDLVGALGADGNGVRLLYGGSVKPDNAAELMALENVDGALVGGASLK
CHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHEEEEECCCCEEECCCCCC
AEDFWAIAQSCA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA