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The map label for this gene is lpd [H]

Identifier: 83593213

GI number: 83593213

Start: 2175096

End: 2176496

Strand: Reverse

Name: lpd [H]

Synonym: Rru_A1878

Alternate gene names: 83593213

Gene position: 2176496-2175096 (Counterclockwise)

Preceding gene: 83593214

Following gene: 83593212

Centisome position: 50.0

GC content: 63.74

Gene sequence:

>1401_bases
ATGACCGAGACTTCCTTCGATGTGGTCGTTCTGGGCGCCGGACCCGGCGGCTATGTCGCCGCCATCCGCGCCGCCCAGCT
TGGCCTGAAAACGGCGGTGGTCGAGCGCGAGCACCTGGGCGGCATCTGCCTGAACTGGGGCTGCATTCCGACCAAGGCGC
TGTTGCGCAGCGCCGAGGTCTTCCGCCAGATCCGCCATGCCGGCGCCTATGGCTTAAAGGTGACGGGGGCCGAGGTCGAT
GTGGCCGCCGTGGTCAAGCGCTCGCGCGGGGTGGCCAAACAATTGGCCGGCGGCGTCGGCCATCTTCTCAAGAAGAACAA
GGTCACGGTGATCGATGGCCACGGCCGGCTGGCCGGCGCGGGCAAGCTGACCGTCGAAAAGGACGGCAAGACGACGACCC
TGGCGGCCAAGGCGATCATTTTGGCCACGGGGGGGCGGGCGCGAACCCTGCCCGGGCTCGAGGCCGACGGCAAGCTGGTC
TGGACCTATAAGAACGCCATGATCCCCGAGTCCCTGCCCAAGCGCCTGCTGGTGGTCGGCTCGGGGGCCATCGGCATCGA
ATTCGCCAGCTTCTACACCGATTGCGGCTCGCAAGTGACGGTGGTCGAGGTGTTGGAGCGGGTGCTGCCGGTCGAAGACG
AGGAGATCAGCGCCTTCGCCAAAAAATCCTTTGAAAAGCAGGGGATGACCATCAAGACCGCCACCACGGTCAAAGCCTTG
AAAAAATCCGGCGATGAGGTGACGGCGACCCTGGAGAAGGACGGCAAGACCGAGGAGATCACCGTCGATCGGGTGATCAT
GGCCGTTGGCATCGCCGCCAATATCGAAGATATCGGCCTGGAAACCGTGCCGTCGATCAAGGTCGAGCGCGGCCATGTGG
TGACCGACGCCTTCTGTCGCACCGGCGACCCCGGAATCTTCGCCATCGGCGATTTGACCGCTCCGCCCTGGCTCGCCCAT
AAGGCCAGCCACGAGGGCGTGCTGGTCGCCGAGGTGATCGCCGGCAAGAAGGACCTTCATCCCCTTGATACCATGAAGAT
TCCCGGCTGCACCTATTGCCATCCCCAGGTGGCGAGCATCGGGCTGAGCGAGGCCAAGGCCAAGGCCAAGGGCTTTACGG
TCAAGGTCGGACGCTTCCCCTTCGTCGGCAACGGCAAGGCTATCGCCCTTGGCGAAGCCGAGGGATTGATCAAGACGGTG
TTCGATGCGCGGACGGGCGAATTGCTGGGCGCCCATATGATCGGCGCCGAGGTGACCGAGCTGATTCAGGGCTTCGCCAT
CGCCAAAACCCTGGAGACCACCGAGGAAGATTTGATCCACACCGTCTTCGCCCATCCGACCCTCTCGGAGATGGTGCATG
AATCCGTGCTTGACGCTTACGGTCGCGCCATCCATTTCTAG

Upstream 100 bases:

>100_bases
CCTTAGCGCCTTCAAGATCTTGATCGAAGATCCCATGGCGATGATGCTCTAGTCGCATTCGCCCGTTTCTCTTGCCCACC
CGATCGGAAGGGTATTTGCC

Downstream 100 bases:

>100_bases
GGACACCATGATGGACACTCCAATCATTCGTCACCCCGAGAAGGTTCGCCGGCCCGACAATCCGTCGCCGCGCAAACCCG
AGTGGATTCGCGTGAGGGCC

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTETSFDVVVLGAGPGGYVAAIRAAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEVFRQIRHAGAYGLKVTGAEVD
VAAVVKRSRGVAKQLAGGVGHLLKKNKVTVIDGHGRLAGAGKLTVEKDGKTTTLAAKAIILATGGRARTLPGLEADGKLV
WTYKNAMIPESLPKRLLVVGSGAIGIEFASFYTDCGSQVTVVEVLERVLPVEDEEISAFAKKSFEKQGMTIKTATTVKAL
KKSGDEVTATLEKDGKTEEITVDRVIMAVGIAANIEDIGLETVPSIKVERGHVVTDAFCRTGDPGIFAIGDLTAPPWLAH
KASHEGVLVAEVIAGKKDLHPLDTMKIPGCTYCHPQVASIGLSEAKAKAKGFTVKVGRFPFVGNGKAIALGEAEGLIKTV
FDARTGELLGAHMIGAEVTELIQGFAIAKTLETTEEDLIHTVFAHPTLSEMVHESVLDAYGRAIHF

Sequences:

>Translated_466_residues
MTETSFDVVVLGAGPGGYVAAIRAAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEVFRQIRHAGAYGLKVTGAEVD
VAAVVKRSRGVAKQLAGGVGHLLKKNKVTVIDGHGRLAGAGKLTVEKDGKTTTLAAKAIILATGGRARTLPGLEADGKLV
WTYKNAMIPESLPKRLLVVGSGAIGIEFASFYTDCGSQVTVVEVLERVLPVEDEEISAFAKKSFEKQGMTIKTATTVKAL
KKSGDEVTATLEKDGKTEEITVDRVIMAVGIAANIEDIGLETVPSIKVERGHVVTDAFCRTGDPGIFAIGDLTAPPWLAH
KASHEGVLVAEVIAGKKDLHPLDTMKIPGCTYCHPQVASIGLSEAKAKAKGFTVKVGRFPFVGNGKAIALGEAEGLIKTV
FDARTGELLGAHMIGAEVTELIQGFAIAKTLETTEEDLIHTVFAHPTLSEMVHESVLDAYGRAIHF
>Mature_465_residues
TETSFDVVVLGAGPGGYVAAIRAAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEVFRQIRHAGAYGLKVTGAEVDV
AAVVKRSRGVAKQLAGGVGHLLKKNKVTVIDGHGRLAGAGKLTVEKDGKTTTLAAKAIILATGGRARTLPGLEADGKLVW
TYKNAMIPESLPKRLLVVGSGAIGIEFASFYTDCGSQVTVVEVLERVLPVEDEEISAFAKKSFEKQGMTIKTATTVKALK
KSGDEVTATLEKDGKTEEITVDRVIMAVGIAANIEDIGLETVPSIKVERGHVVTDAFCRTGDPGIFAIGDLTAPPWLAHK
ASHEGVLVAEVIAGKKDLHPLDTMKIPGCTYCHPQVASIGLSEAKAKAKGFTVKVGRFPFVGNGKAIALGEAEGLIKTVF
DARTGELLGAHMIGAEVTELIQGFAIAKTLETTEEDLIHTVFAHPTLSEMVHESVLDAYGRAIHF

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=36.8869936034115, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI50301238, Length=460, Percent_Identity=31.0869565217391, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=27.9661016949153, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI291045266, Length=430, Percent_Identity=25.8139534883721, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI33519430, Length=459, Percent_Identity=26.1437908496732, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI33519428, Length=459, Percent_Identity=26.1437908496732, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI33519426, Length=459, Percent_Identity=26.1437908496732, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI148277065, Length=459, Percent_Identity=26.1437908496732, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI148277071, Length=459, Percent_Identity=26.1437908496732, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI291045268, Length=423, Percent_Identity=24.3498817966903, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=37.8854625550661, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=25.8620689655172, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1789915, Length=438, Percent_Identity=31.0502283105023, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI87081717, Length=456, Percent_Identity=23.9035087719298, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1788892, Length=184, Percent_Identity=32.0652173913043, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI32565766, Length=466, Percent_Identity=37.9828326180258, Blast_Score=292, Evalue=3e-79,
Organism=Caenorhabditis elegans, GI17557007, Length=478, Percent_Identity=25.3138075313808, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71983429, Length=459, Percent_Identity=28.5403050108932, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71983419, Length=459, Percent_Identity=28.5403050108932, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=481, Percent_Identity=25.1559251559252, Blast_Score=97, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321091, Length=475, Percent_Identity=38.3157894736842, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=28.7234042553192, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325166, Length=463, Percent_Identity=27.8617710583153, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21358499, Length=469, Percent_Identity=39.2324093816631, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24640549, Length=468, Percent_Identity=25.8547008547009, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24640553, Length=468, Percent_Identity=25.8547008547009, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=27.4841437632135, Blast_Score=112, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24640551, Length=467, Percent_Identity=26.338329764454, Blast_Score=112, Evalue=8e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49153; Mature: 49021

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00063 ALDOKETO_REDUCTASE_3 ; PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETSFDVVVLGAGPGGYVAAIRAAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEV
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
FRQIRHAGAYGLKVTGAEVDVAAVVKRSRGVAKQLAGGVGHLLKKNKVTVIDGHGRLAGA
HHHHHHCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCEECC
GKLTVEKDGKTTTLAAKAIILATGGRARTLPGLEADGKLVWTYKNAMIPESLPKRLLVVG
CEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHCCEEEEEE
SGAIGIEFASFYTDCGSQVTVVEVLERVLPVEDEEISAFAKKSFEKQGMTIKTATTVKAL
CCCCEEEHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHH
KKSGDEVTATLEKDGKTEEITVDRVIMAVGIAANIEDIGLETVPSIKVERGHVVTDAFCR
HHCCCEEEEEECCCCCCCEEEHHHHHHHHHHHCCHHHCCCCCCCCEEEECCCEEEHHHHC
TGDPGIFAIGDLTAPPWLAHKASHEGVLVAEVIAGKKDLHPLDTMKIPGCTYCHPQVASI
CCCCCEEEEECCCCCCHHHCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHHC
GLSEAKAKAKGFTVKVGRFPFVGNGKAIALGEAEGLIKTVFDARTGELLGAHMIGAEVTE
CHHHHHHHHCCCEEEECCCEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHH
LIQGFAIAKTLETTEEDLIHTVFAHPTLSEMVHESVLDAYGRAIHF
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TETSFDVVVLGAGPGGYVAAIRAAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEV
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHH
FRQIRHAGAYGLKVTGAEVDVAAVVKRSRGVAKQLAGGVGHLLKKNKVTVIDGHGRLAGA
HHHHHHCCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCEECC
GKLTVEKDGKTTTLAAKAIILATGGRARTLPGLEADGKLVWTYKNAMIPESLPKRLLVVG
CEEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCHHCCEEEEEE
SGAIGIEFASFYTDCGSQVTVVEVLERVLPVEDEEISAFAKKSFEKQGMTIKTATTVKAL
CCCCEEEHHHHHHCCCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHH
KKSGDEVTATLEKDGKTEEITVDRVIMAVGIAANIEDIGLETVPSIKVERGHVVTDAFCR
HHCCCEEEEEECCCCCCCEEEHHHHHHHHHHHCCHHHCCCCCCCCEEEECCCEEEHHHHC
TGDPGIFAIGDLTAPPWLAHKASHEGVLVAEVIAGKKDLHPLDTMKIPGCTYCHPQVASI
CCCCCEEEEECCCCCCHHHCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCHHHHC
GLSEAKAKAKGFTVKVGRFPFVGNGKAIALGEAEGLIKTVFDARTGELLGAHMIGAEVTE
CHHHHHHHHCCCEEEECCCEEECCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHH
LIQGFAIAKTLETTEEDLIHTVFAHPTLSEMVHESVLDAYGRAIHF
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]