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The map label for this gene is dxr [H]

Identifier: 83592927

GI number: 83592927

Start: 1875399

End: 1876601

Strand: Direct

Name: dxr [H]

Synonym: Rru_A1592

Alternate gene names: 83592927

Gene position: 1875399-1876601 (Clockwise)

Preceding gene: 83592926

Following gene: 83592928

Centisome position: 43.08

GC content: 67.83

Gene sequence:

>1203_bases
ATGAGCGGCACGGCGAACGGCACCCCCCGGCGGGTCAGCATCCTCGGGTCCACCGGTTCCATCGGCAAGAACACCCTTGA
TCTCATCGGCCGCTCTCCCGAGCGCTATCAGGTGGTCGCCCTGACCGCCAATGGCAATGCCGAGGCCCTGGCCGCCCAGG
CCAAGGCGACGCGGGCCGAGATCGCCGTGGTCGCCGACGAGGCGGCCTATGGCCGGCTGAAAGAGGCCCTGGCCGGCAGT
GGCATCGAAGCCGCCGCCGGGCCGCAAGCGGTGTGCGAGGCCGCCGCGCGGGATGCCGATTGGGTGATGGCCGCCATCGT
CGGCGCCGCCGGTCTGGCCCCGACCCTGGCCGCCGTGGAACGGGGCGCCACCATCGCCCTGGCCAATAAGGAATGCCTGG
TCTGCGCCGGCGATCTGTTCATGGCCGAGATCCGCCGCGCCGGGGCGACCTTCCTGCCCGTTGATTCCGAACACAACGCC
ATCTTCCAAGTCTTTGATTTTGAGAAGAAAGAGCGCATCGAGCGCATCATTTTGACCGCTTCGGGCGGTCCCTTCCGCGA
CTGGACGCGCGAGGCGATGGCCAAGGCCACGCCCGAGCAGGCGGTCGCCCATCCCAATTGGTCGATGGGCGCCAAGATCA
GCGTCGATTCGGCCTCGATGTTCAACAAGGGCCTGGAATTCATTGAGGCCTATCACATTTTCGGCATCGCGCCCGAGCGC
ATCGAGATCCTGGTCCACCCGCAATCGGTGATCCATTCGATGGTCGGCTATGTCGATGGCTCGGTGCTCGCCCAATTGGG
CTCGCCCGATATGCGCACGCCGATCGCCTATTGTCTGGCTTGGCCCGATCGCATGGTGGCCCCGGTGCCCCATCTCGATT
TCCCCAAGCTGGGCCACATGGATTTCCGCGCGCCCGATCCCGATCGCTTCCCGGCGATCCGCATCGTCCGCGAGACCCTG
CGCCGGGGCGGCGTGGCGCCGACGGCGATGAACGCCGCCAACGAGGTGGCGGTGGCCGGCTTCCTTGGCCGCCAGATCGG
CTTCCTCGATATCCCCGCCGTGGTCGAGGCGACGATCAACGATGTCATGGCCGGGCCCCTGGGCAATCAGGCGGTGGACC
ATCTTGACGCCGTGATGGCCGTCGATGGCGAAGCCCGGCGGATCGCCGCCGGTCACGCCCTGGCCCACGCCGCGGCCGCC
TGA

Upstream 100 bases:

>100_bases
GTCACGGGGGACTCCTCGACAGGGTCGACGGACTGCTGGCGGCGGCGCCGCCGGTGGCCTGCGTCGTCGCCCTGCAAGGC
GGCGGCATAGGACTTTGGCA

Downstream 100 bases:

>100_bases
CCGGGGATTGCGTCGGTCGGTTTCTTATCTTTTCCCCCTTGGCCTCGGTCTGGGGCCCCCTTGCGCGACATCGCCGGGTC
GCGCGGGGCGGGTCCGCCGT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSGTANGTPRRVSILGSTGSIGKNTLDLIGRSPERYQVVALTANGNAEALAAQAKATRAEIAVVADEAAYGRLKEALAGS
GIEAAAGPQAVCEAAARDADWVMAAIVGAAGLAPTLAAVERGATIALANKECLVCAGDLFMAEIRRAGATFLPVDSEHNA
IFQVFDFEKKERIERIILTASGGPFRDWTREAMAKATPEQAVAHPNWSMGAKISVDSASMFNKGLEFIEAYHIFGIAPER
IEILVHPQSVIHSMVGYVDGSVLAQLGSPDMRTPIAYCLAWPDRMVAPVPHLDFPKLGHMDFRAPDPDRFPAIRIVRETL
RRGGVAPTAMNAANEVAVAGFLGRQIGFLDIPAVVEATINDVMAGPLGNQAVDHLDAVMAVDGEARRIAAGHALAHAAAA

Sequences:

>Translated_400_residues
MSGTANGTPRRVSILGSTGSIGKNTLDLIGRSPERYQVVALTANGNAEALAAQAKATRAEIAVVADEAAYGRLKEALAGS
GIEAAAGPQAVCEAAARDADWVMAAIVGAAGLAPTLAAVERGATIALANKECLVCAGDLFMAEIRRAGATFLPVDSEHNA
IFQVFDFEKKERIERIILTASGGPFRDWTREAMAKATPEQAVAHPNWSMGAKISVDSASMFNKGLEFIEAYHIFGIAPER
IEILVHPQSVIHSMVGYVDGSVLAQLGSPDMRTPIAYCLAWPDRMVAPVPHLDFPKLGHMDFRAPDPDRFPAIRIVRETL
RRGGVAPTAMNAANEVAVAGFLGRQIGFLDIPAVVEATINDVMAGPLGNQAVDHLDAVMAVDGEARRIAAGHALAHAAAA
>Mature_399_residues
SGTANGTPRRVSILGSTGSIGKNTLDLIGRSPERYQVVALTANGNAEALAAQAKATRAEIAVVADEAAYGRLKEALAGSG
IEAAAGPQAVCEAAARDADWVMAAIVGAAGLAPTLAAVERGATIALANKECLVCAGDLFMAEIRRAGATFLPVDSEHNAI
FQVFDFEKKERIERIILTASGGPFRDWTREAMAKATPEQAVAHPNWSMGAKISVDSASMFNKGLEFIEAYHIFGIAPERI
EILVHPQSVIHSMVGYVDGSVLAQLGSPDMRTPIAYCLAWPDRMVAPVPHLDFPKLGHMDFRAPDPDRFPAIRIVRETLR
RGGVAPTAMNAANEVAVAGFLGRQIGFLDIPAVVEATINDVMAGPLGNQAVDHLDAVMAVDGEARRIAAGHALAHAAAA

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=50.8860759493671, Blast_Score=350, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42070; Mature: 41938

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00435 PEROXIDASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTANGTPRRVSILGSTGSIGKNTLDLIGRSPERYQVVALTANGNAEALAAQAKATRAE
CCCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHCCEE
IAVVADEAAYGRLKEALAGSGIEAAAGPQAVCEAAARDADWVMAAIVGAAGLAPTLAAVE
EEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHH
RGATIALANKECLVCAGDLFMAEIRRAGATFLPVDSEHNAIFQVFDFEKKERIERIILTA
CCCEEEEECCCEEEEEHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCHHHHEEEEEEEE
SGGPFRDWTREAMAKATPEQAVAHPNWSMGAKISVDSASMFNKGLEFIEAYHIFGIAPER
CCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCC
IEILVHPQSVIHSMVGYVDGSVLAQLGSPDMRTPIAYCLAWPDRMVAPVPHLDFPKLGHM
EEEEECCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCCCC
DFRAPDPDRFPAIRIVRETLRRGGVAPTAMNAANEVAVAGFLGRQIGFLDIPAVVEATIN
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCCCCEECHHHHHHHHH
DVMAGPLGNQAVDHLDAVMAVDGEARRIAAGHALAHAAAA
HHHCCCCCCHHHHHHHHHHCCCCCHHEEHHHHHHHHHHCC
>Mature Secondary Structure 
SGTANGTPRRVSILGSTGSIGKNTLDLIGRSPERYQVVALTANGNAEALAAQAKATRAE
CCCCCCCCCEEEEEECCCCCCCHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHCCEE
IAVVADEAAYGRLKEALAGSGIEAAAGPQAVCEAAARDADWVMAAIVGAAGLAPTLAAVE
EEEEECCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHH
RGATIALANKECLVCAGDLFMAEIRRAGATFLPVDSEHNAIFQVFDFEKKERIERIILTA
CCCEEEEECCCEEEEEHHHHHHHHHHCCCEEEECCCCCCEEEEEECCCHHHHEEEEEEEE
SGGPFRDWTREAMAKATPEQAVAHPNWSMGAKISVDSASMFNKGLEFIEAYHIFGIAPER
CCCCCHHHHHHHHHHCCHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCC
IEILVHPQSVIHSMVGYVDGSVLAQLGSPDMRTPIAYCLAWPDRMVAPVPHLDFPKLGHM
EEEEECCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCCCC
DFRAPDPDRFPAIRIVRETLRRGGVAPTAMNAANEVAVAGFLGRQIGFLDIPAVVEATIN
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHCCCCCEECHHHHHHHHH
DVMAGPLGNQAVDHLDAVMAVDGEARRIAAGHALAHAAAA
HHHCCCCCCHHHHHHHHHHCCCCCHHEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA