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The map label for this gene is bacC [H]

Identifier: 83592843

GI number: 83592843

Start: 1780803

End: 1781570

Strand: Reverse

Name: bacC [H]

Synonym: Rru_A1507

Alternate gene names: 83592843

Gene position: 1781570-1780803 (Counterclockwise)

Preceding gene: 83592845

Following gene: 83592842

Centisome position: 40.93

GC content: 70.83

Gene sequence:

>768_bases
ATGAAGCTGGGCGACAGCGTGATCCTGATCACCGGCGGTGGATCGGGTTTGGGGGCGGCCACGGCGAGGATGGTGGTCGA
AGGCGGCGGCAAGGCGGTGCTGGTCGATGTCGATGAGGCGCGGGGCGCCGCCCTGGCCGGGGACCTGGGCCCCAGCGCCC
GCTTCGTGGCGGCCGATGTCACCGCCGAGGCCGACGGCGAACGGGCGGTGGCGGCGGCGATCGGGGCTTTCGGCGCCTTG
CACGGCCTGTGCAATTGCGCCGGCATCGCCCCGGGCGAAAAAGTGCTGGGCCGCGACGGCCCCCATGGCCTGGACAGCTT
CGCCCGGGTCATCAGCGTCAATCTGATCGGCACCTTCAACATGATCCGCCTCGCCGCCCAGGCGATGGCGCGAAACGCCG
TCAATGCCGAGGGCGAACGCGGGGTGATCATCAACACGGCCTCGGCCGCGGCGTTCGATGGGCAGATCGGTCAGGCGGCC
TATGCGGCGTCGAAAGGCGGGGTCGCCGCCCTGACCCTGCCGGTCGCCCGCGAGATGGCCCGCCACGCCATCCGGGTGAT
GACCATCGCCCCCGGGCTTTTTGAAACGCCGATGCTGCTCGGCATGGCCGCCGAGGTTCAGCGCGCGCTGGCCGCCAGCG
TGCCCTTCCCCCAGCGCCTGGGCAAGCCGGCGGAATATGCCGCCCTGGTCCGCCACATCCTGGAAAACCCCATGCTCAAC
GGCGAGGTCATCCGCCTGGACGGCGCCTTGCGGATGGCCGCCAAATAG

Upstream 100 bases:

>100_bases
GGCGAGCGGAAAAGGAAACAGCGGCTTTCCGCGAGATCACCGCTCTCCTCTTCTGAATTATGATTAGTCCAAAAGCATCA
CCCACAGGGAGGGGAAATCG

Downstream 100 bases:

>100_bases
CACGGCAAACCGTCGGCCGGAATTGCCCCCCGGCCAGGGTCCGGGGTAGCCTGGGGCGTCACGGCGATGGGAAAGGAATA
AACCGGTGACCGACACGCTG

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MKLGDSVILITGGGSGLGAATARMVVEGGGKAVLVDVDEARGAALAGDLGPSARFVAADVTAEADGERAVAAAIGAFGAL
HGLCNCAGIAPGEKVLGRDGPHGLDSFARVISVNLIGTFNMIRLAAQAMARNAVNAEGERGVIINTASAAAFDGQIGQAA
YAASKGGVAALTLPVAREMARHAIRVMTIAPGLFETPMLLGMAAEVQRALAASVPFPQRLGKPAEYAALVRHILENPMLN
GEVIRLDGALRMAAK

Sequences:

>Translated_255_residues
MKLGDSVILITGGGSGLGAATARMVVEGGGKAVLVDVDEARGAALAGDLGPSARFVAADVTAEADGERAVAAAIGAFGAL
HGLCNCAGIAPGEKVLGRDGPHGLDSFARVISVNLIGTFNMIRLAAQAMARNAVNAEGERGVIINTASAAAFDGQIGQAA
YAASKGGVAALTLPVAREMARHAIRVMTIAPGLFETPMLLGMAAEVQRALAASVPFPQRLGKPAEYAALVRHILENPMLN
GEVIRLDGALRMAAK
>Mature_255_residues
MKLGDSVILITGGGSGLGAATARMVVEGGGKAVLVDVDEARGAALAGDLGPSARFVAADVTAEADGERAVAAAIGAFGAL
HGLCNCAGIAPGEKVLGRDGPHGLDSFARVISVNLIGTFNMIRLAAQAMARNAVNAEGERGVIINTASAAAFDGQIGQAA
YAASKGGVAALTLPVAREMARHAIRVMTIAPGLFETPMLLGMAAEVQRALAASVPFPQRLGKPAEYAALVRHILENPMLN
GEVIRLDGALRMAAK

Specific function: Part of the bacABCDE operon responsible for the biosynthesis of bacilysin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=248, Percent_Identity=56.8548387096774, Blast_Score=260, Evalue=7e-70,
Organism=Homo sapiens, GI83715985, Length=248, Percent_Identity=53.6290322580645, Blast_Score=238, Evalue=6e-63,
Organism=Homo sapiens, GI40254992, Length=251, Percent_Identity=30.2788844621514, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=32.4528301886792, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI59889578, Length=219, Percent_Identity=31.0502283105023, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=30.46875, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI32483357, Length=258, Percent_Identity=27.906976744186, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI4504505, Length=208, Percent_Identity=31.25, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=25.2873563218391, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=28.3464566929134, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87082160, Length=246, Percent_Identity=27.6422764227642, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=30.0395256916996, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=30.1587301587302, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=26.7716535433071, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=30.0395256916996, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1786812, Length=227, Percent_Identity=28.6343612334802, Blast_Score=61, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=46.4, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=29.9212598425197, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=257, Percent_Identity=31.9066147859922, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17559104, Length=244, Percent_Identity=23.7704918032787, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=206, Percent_Identity=31.5533980582524, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17737361, Length=252, Percent_Identity=52.3809523809524, Blast_Score=262, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24639444, Length=259, Percent_Identity=33.2046332046332, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24644339, Length=231, Percent_Identity=28.1385281385281, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357041, Length=227, Percent_Identity=28.6343612334802, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28571526, Length=227, Percent_Identity=27.3127753303965, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=31.3432835820896, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 25757; Mature: 25757

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGDSVILITGGGSGLGAATARMVVEGGGKAVLVDVDEARGAALAGDLGPSARFVAADV
CCCCCEEEEEECCCCCCCHHHHEEEEECCCCEEEEECCCCCCCEEECCCCCCCEEEEEEC
TAEADGERAVAAAIGAFGALHGLCNCAGIAPGEKVLGRDGPHGLDSFARVISVNLIGTFN
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHH
MIRLAAQAMARNAVNAEGERGVIINTASAAAFDGQIGQAAYAASKGGVAALTLPVAREMA
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHCCCCEEEEEHHHHHHHH
RHAIRVMTIAPGLFETPMLLGMAAEVQRALAASVPFPQRLGKPAEYAALVRHILENPMLN
HHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCC
GEVIRLDGALRMAAK
CEEEEECCCEEECCC
>Mature Secondary Structure
MKLGDSVILITGGGSGLGAATARMVVEGGGKAVLVDVDEARGAALAGDLGPSARFVAADV
CCCCCEEEEEECCCCCCCHHHHEEEEECCCCEEEEECCCCCCCEEECCCCCCCEEEEEEC
TAEADGERAVAAAIGAFGALHGLCNCAGIAPGEKVLGRDGPHGLDSFARVISVNLIGTFN
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHH
MIRLAAQAMARNAVNAEGERGVIINTASAAAFDGQIGQAAYAASKGGVAALTLPVAREMA
HHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHCCCCEEEEEHHHHHHHH
RHAIRVMTIAPGLFETPMLLGMAAEVQRALAASVPFPQRLGKPAEYAALVRHILENPMLN
HHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCC
GEVIRLDGALRMAAK
CEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA