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The map label for this gene is kipA [H]

Identifier: 83592841

GI number: 83592841

Start: 1778928

End: 1779989

Strand: Reverse

Name: kipA [H]

Synonym: Rru_A1505

Alternate gene names: 83592841

Gene position: 1779989-1778928 (Counterclockwise)

Preceding gene: 83592842

Following gene: 83592840

Centisome position: 40.89

GC content: 69.77

Gene sequence:

>1062_bases
ATGAACACGCCCCATCTGCGGGTCATCACCCCGGGTCTGCTGACGACGCTCCAGGACCTCGGTCGCTGGGGCTTTCAAGA
TCGCGGGGTACCGGTGGCCGGGGCCCTTGATCCGATCGCGCTGCGCCTTGCCAATGCCCTGGTCGGCAATCCACCGGCCA
TGGCCGGGCTGGAGATCTGTGCCCTGGGCCCGACCCTGGCGGTGGAGGCCGAAAGCCTGCGGCTGGCCTTTTGCGGCGGC
GCGCCGCTTCTCCATCGTCCGGGGGCGGCGCCCGAACGCTTGGCCGGCGGGCGCAGCCATCTTTTGCGGCGCGGCGATCA
GCTGGCGATCGGGACCTTGGACGAAGGCGTCGGGGCTGGCGTACTGGCGATCGCCGGCGGCTTCGCCGTTGCGCCGGTGA
TGGGCAGTTGGTCGACCTACCGCCGCGCCCGGCTGGGACCGCTGGGCGGTGGCCCGTTGCAGGCCGGCCAAAGCCTGCCG
CTTGCGCTGGAGCGGGCGCCCGCAGGATCCGAGCGCGCCCTGCCGCACGCCTTTGAGTATGGAGCGGGGCCGATCCGCGT
CGTTCTTGGCCCCCAGGACGCCGCCTTCACGGCCGAGGCCCTCGCCCTGTTCCTGTCGGCCCGCTATCGGGTGGGACGCA
GCAGCGATCGCATGGGCATGCGCCTGGAGGGCCCACGGCTGACCCACCGCCAAACGGCTGATATCGCGTCGGAAGGTCTG
GCCCATGGCGCCATTCAGGTTCCGGGCGATGGTCTGCCGATCGTCTTGCTCGCCGATCGCCAAACCGTGGGCGGATACGC
CAAGATCGCCACCGTCGCCTCGGTCGATCTGCCGCGCCTGGGGCGGATGCTGCCGGGCGCGGATATGGCTTTCCAAGCGG
TGAGCGTTGAGGCGGCCGAGGCCCTGCGCCGCGACCAAGAGGGGCGATTGCGTGGGCTGATCGCCGCCATCGCCGCGCCC
AAGCCGACCGGCGGTATCGATATAGAGGCGCTTTATACCAATAACCTGATTTCCGGGATGGTCATGTCGGGCGAGGCGGA
CGAGGATGATCCCCCTTATTGA

Upstream 100 bases:

>100_bases
AGCTTCGTTTCTTCGCCGTCAACCGGGCCGAGCATGAGGCCTGGGTCCGCCGCGTCGCCGAGCCGGGCTTCGATCCCGCT
GATTTGATCGACGGCGCGCC

Downstream 100 bases:

>100_bases
AGCACATCCCGAGCACCGAAAGGACCCGGCCATGACCCTGCGGGTGAATGTCAATGCCGATCTGGGGGAGGGCTATGGCG
CCTACCGCATCGGCGACGAC

Product: allophanate hydrolase subunit 2

Products: ADP; phosphate; urea-1-carboxylate

Alternate protein names: Protein kipA [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MNTPHLRVITPGLLTTLQDLGRWGFQDRGVPVAGALDPIALRLANALVGNPPAMAGLEICALGPTLAVEAESLRLAFCGG
APLLHRPGAAPERLAGGRSHLLRRGDQLAIGTLDEGVGAGVLAIAGGFAVAPVMGSWSTYRRARLGPLGGGPLQAGQSLP
LALERAPAGSERALPHAFEYGAGPIRVVLGPQDAAFTAEALALFLSARYRVGRSSDRMGMRLEGPRLTHRQTADIASEGL
AHGAIQVPGDGLPIVLLADRQTVGGYAKIATVASVDLPRLGRMLPGADMAFQAVSVEAAEALRRDQEGRLRGLIAAIAAP
KPTGGIDIEALYTNNLISGMVMSGEADEDDPPY

Sequences:

>Translated_353_residues
MNTPHLRVITPGLLTTLQDLGRWGFQDRGVPVAGALDPIALRLANALVGNPPAMAGLEICALGPTLAVEAESLRLAFCGG
APLLHRPGAAPERLAGGRSHLLRRGDQLAIGTLDEGVGAGVLAIAGGFAVAPVMGSWSTYRRARLGPLGGGPLQAGQSLP
LALERAPAGSERALPHAFEYGAGPIRVVLGPQDAAFTAEALALFLSARYRVGRSSDRMGMRLEGPRLTHRQTADIASEGL
AHGAIQVPGDGLPIVLLADRQTVGGYAKIATVASVDLPRLGRMLPGADMAFQAVSVEAAEALRRDQEGRLRGLIAAIAAP
KPTGGIDIEALYTNNLISGMVMSGEADEDDPPY
>Mature_353_residues
MNTPHLRVITPGLLTTLQDLGRWGFQDRGVPVAGALDPIALRLANALVGNPPAMAGLEICALGPTLAVEAESLRLAFCGG
APLLHRPGAAPERLAGGRSHLLRRGDQLAIGTLDEGVGAGVLAIAGGFAVAPVMGSWSTYRRARLGPLGGGPLQAGQSLP
LALERAPAGSERALPHAFEYGAGPIRVVLGPQDAAFTAEALALFLSARYRVGRSSDRMGMRLEGPRLTHRQTADIASEGL
AHGAIQVPGDGLPIVLLADRQTVGGYAKIATVASVDLPRLGRMLPGADMAFQAVSVEAAEALRRDQEGRLRGLIAAIAAP
KPTGGIDIEALYTNNLISGMVMSGEADEDDPPY

Specific function: Counteracts the inhibitory action of kipI on sporulation. May bind to kipI, preventing its function as an inhibitor of kinase A [H]

COG id: COG1984

COG function: function code E; Allophanate hydrolase subunit 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786930, Length=302, Percent_Identity=34.7682119205298, Blast_Score=137, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6319685, Length=330, Percent_Identity=29.3939393939394, Blast_Score=122, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003778 [H]

Pfam domain/function: PF02626 AHS2 [H]

EC number: 6.3.4.6

Molecular weight: Translated: 36530; Mature: 36530

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPHLRVITPGLLTTLQDLGRWGFQDRGVPVAGALDPIALRLANALVGNPPAMAGLEIC
CCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCEEEE
ALGPTLAVEAESLRLAFCGGAPLLHRPGAAPERLAGGRSHLLRRGDQLAIGTLDEGVGAG
ECCCCEEEECCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHCCCEEEEEECCCCCCCC
VLAIAGGFAVAPVMGSWSTYRRARLGPLGGGPLQAGQSLPLALERAPAGSERALPHAFEY
HHHHHCCHHEEHHHCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHC
GAGPIRVVLGPQDAAFTAEALALFLSARYRVGRSSDRMGMRLEGPRLTHRQTADIASEGL
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHH
AHGAIQVPGDGLPIVLLADRQTVGGYAKIATVASVDLPRLGRMLPGADMAFQAVSVEAAE
CCCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHH
ALRRDQEGRLRGLIAAIAAPKPTGGIDIEALYTNNLISGMVMSGEADEDDPPY
HHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCHHCEEECCCCCCCCCCC
>Mature Secondary Structure
MNTPHLRVITPGLLTTLQDLGRWGFQDRGVPVAGALDPIALRLANALVGNPPAMAGLEIC
CCCCCEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCEEEE
ALGPTLAVEAESLRLAFCGGAPLLHRPGAAPERLAGGRSHLLRRGDQLAIGTLDEGVGAG
ECCCCEEEECCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHCCCEEEEEECCCCCCCC
VLAIAGGFAVAPVMGSWSTYRRARLGPLGGGPLQAGQSLPLALERAPAGSERALPHAFEY
HHHHHCCHHEEHHHCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHC
GAGPIRVVLGPQDAAFTAEALALFLSARYRVGRSSDRMGMRLEGPRLTHRQTADIASEGL
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHH
AHGAIQVPGDGLPIVLLADRQTVGGYAKIATVASVDLPRLGRMLPGADMAFQAVSVEAAE
CCCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHH
ALRRDQEGRLRGLIAAIAAPKPTGGIDIEALYTNNLISGMVMSGEADEDDPPY
HHHCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCHHCEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; urea; CO2

Specific reaction: ATP + urea + CO2 = ADP + phosphate + urea-1-carboxylate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]