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The map label for this gene is glcD [H]

Identifier: 83592460

GI number: 83592460

Start: 1325101

End: 1326567

Strand: Direct

Name: glcD [H]

Synonym: Rru_A1124

Alternate gene names: 83592460

Gene position: 1325101-1326567 (Clockwise)

Preceding gene: 83592459

Following gene: 83592461

Centisome position: 30.44

GC content: 65.64

Gene sequence:

>1467_bases
ATGCGGGCCGCGTCTTTCGGGGCGGGCCCGGCTTTTGCGTTTTTCCTTACGAAAGTTGCTGTGATGAGGTCCCTGTCGCA
ATCCGCTCCGCGCGATCCCTTGCCCGCCGCCCTGGTCGGCACCCTGGCGGCGCTGCTGGGCGAGCGCTTCTCGACCGCTA
CGGCGGTGCGCGAGCAGCATGGGCGCGATGAAAGCTATCACCCGTCGATGCCGCCCGACGCCGTGGCCTTCGCCCGTTCG
ACCGAGGAGGTGGCGGCGATCGTCACCGCCTGCGCCGCCCATAAGGTGCCGATCATTCCCTTTGGCACCGGAACCTCGTT
GGAAGGCCATATCGCGGCGTTGCGCGGCGGCGTTTGCATCGATGTCTCGGCGATGAACGCCATTCTCGAGGTCCGCCCCG
CCGATATGGACGTGACCGTCCAGGCCGGGGTGACGCGCAAGCAGTTGAACGCCCATCTGCGCGATACCGGGCTGTTCTTC
CCCATCGATCCCGGCGCCGACGCCAGCCTGGGCGGCATGACGGCGACGCGGGCCAGCGGCACCAACGCCGTGCGCTATGG
CACCATGCGCGAGAACGTTTTGGCCTTGAGTGTCGTCACCCCGGAAGGCCGGGTGGTCAAGATCGGCGGCCGGGCGCGCA
AGTCATCGGCCGGCTATGACCTGACGCGGCTGTTCGTCGGCTCGGAAGGCACGCTTGGGGTGATTACCGAGGTGACGCTG
CGCCTGCATGGCATCCCCGAAAAGATCGTCTCGGCGGTTTGTCCGTTTCCCAGCGTGCGCGCCGCCGTCGACACGGTGAT
CGCCACCATCCAGATCGGCGTGCCGGTCGCCCGCATCGAATTTCTCAACGCCCGCCAGATCCTGGCGGTGAACGCCTATT
CCAAACTTGATTACGCCGCCGCCCCCACCTTGTTCTTTGAATTCCACGGCACTCCCGACCATGTGGCCGAACAGGTGCGC
ATGGTTCAAGACCTTGCCGCCGATCAGGGGGCGGCCGGTTTTCGCTGGGCGGAAACCCCCGAAGAACGCGACCGGCTGTG
GACGGCCCGCCATAACGCCTTTTACGCGTCGCTGGCGACCAAGGCCGGCGGCCGGGGCTTTAGCTCCGATGTCTGCGTGC
CGATCTCGCGGCTGACCGAGTGCATCGCCCAGACCGAAGAGGATCTGGCGCGGAGCGCGCTGTTCACCTCGATCGTCGGC
CATGTCGGCGATGGCAATTTCCATGTGATCTTCATCGTCGATCCCGAAAACCCGGCCGAGATCGAAGAAGCCCGCAGGCT
CAACGATCGCATCGTCGCCCGCGCCCTGGCGATGGACGGCACCTGCACCGGCGAGCATGGCGTCGGCCATGGCAAGATGG
ATTTCCTCGAAGACGAACACGGCGAGGCCCTGGACATGATGCGCAAGATCAAGCGCGCCCTTGATCCCGACGACATCATG
AACCCCGGCAAGATCGTCCGCCTGTAA

Upstream 100 bases:

>100_bases
CAGCGCGGCGGATCTGCGGCGGTTCCTCGCCGCCTGCGGCCAGTCCGTCGCCGAGGTCGATCTGGAAACGCCCGAGATCG
CCGGCGCCTGAGCCTTTCCC

Downstream 100 bases:

>100_bases
GGCGGGCAAGCCGGCTCTTGCACCTCGGCCGATCTGCTATTCTCTATAGAAAGCGACTTTTGATAGAGAAAAGTAGATCG
CCCGATGAGCTATGCCACGG

Product: D-lactate dehydrogenase

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MRAASFGAGPAFAFFLTKVAVMRSLSQSAPRDPLPAALVGTLAALLGERFSTATAVREQHGRDESYHPSMPPDAVAFARS
TEEVAAIVTACAAHKVPIIPFGTGTSLEGHIAALRGGVCIDVSAMNAILEVRPADMDVTVQAGVTRKQLNAHLRDTGLFF
PIDPGADASLGGMTATRASGTNAVRYGTMRENVLALSVVTPEGRVVKIGGRARKSSAGYDLTRLFVGSEGTLGVITEVTL
RLHGIPEKIVSAVCPFPSVRAAVDTVIATIQIGVPVARIEFLNARQILAVNAYSKLDYAAAPTLFFEFHGTPDHVAEQVR
MVQDLAADQGAAGFRWAETPEERDRLWTARHNAFYASLATKAGGRGFSSDVCVPISRLTECIAQTEEDLARSALFTSIVG
HVGDGNFHVIFIVDPENPAEIEEARRLNDRIVARALAMDGTCTGEHGVGHGKMDFLEDEHGEALDMMRKIKRALDPDDIM
NPGKIVRL

Sequences:

>Translated_488_residues
MRAASFGAGPAFAFFLTKVAVMRSLSQSAPRDPLPAALVGTLAALLGERFSTATAVREQHGRDESYHPSMPPDAVAFARS
TEEVAAIVTACAAHKVPIIPFGTGTSLEGHIAALRGGVCIDVSAMNAILEVRPADMDVTVQAGVTRKQLNAHLRDTGLFF
PIDPGADASLGGMTATRASGTNAVRYGTMRENVLALSVVTPEGRVVKIGGRARKSSAGYDLTRLFVGSEGTLGVITEVTL
RLHGIPEKIVSAVCPFPSVRAAVDTVIATIQIGVPVARIEFLNARQILAVNAYSKLDYAAAPTLFFEFHGTPDHVAEQVR
MVQDLAADQGAAGFRWAETPEERDRLWTARHNAFYASLATKAGGRGFSSDVCVPISRLTECIAQTEEDLARSALFTSIVG
HVGDGNFHVIFIVDPENPAEIEEARRLNDRIVARALAMDGTCTGEHGVGHGKMDFLEDEHGEALDMMRKIKRALDPDDIM
NPGKIVRL
>Mature_488_residues
MRAASFGAGPAFAFFLTKVAVMRSLSQSAPRDPLPAALVGTLAALLGERFSTATAVREQHGRDESYHPSMPPDAVAFARS
TEEVAAIVTACAAHKVPIIPFGTGTSLEGHIAALRGGVCIDVSAMNAILEVRPADMDVTVQAGVTRKQLNAHLRDTGLFF
PIDPGADASLGGMTATRASGTNAVRYGTMRENVLALSVVTPEGRVVKIGGRARKSSAGYDLTRLFVGSEGTLGVITEVTL
RLHGIPEKIVSAVCPFPSVRAAVDTVIATIQIGVPVARIEFLNARQILAVNAYSKLDYAAAPTLFFEFHGTPDHVAEQVR
MVQDLAADQGAAGFRWAETPEERDRLWTARHNAFYASLATKAGGRGFSSDVCVPISRLTECIAQTEEDLARSALFTSIVG
HVGDGNFHVIFIVDPENPAEIEEARRLNDRIVARALAMDGTCTGEHGVGHGKMDFLEDEHGEALDMMRKIKRALDPDDIM
NPGKIVRL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=444, Percent_Identity=56.7567567567568, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI37595754, Length=467, Percent_Identity=53.9614561027837, Blast_Score=511, Evalue=1e-145,
Organism=Homo sapiens, GI119964728, Length=419, Percent_Identity=28.1622911694511, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI4501993, Length=460, Percent_Identity=26.304347826087, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1789351, Length=418, Percent_Identity=30.1435406698565, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI1787977, Length=514, Percent_Identity=28.2101167315175, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI48994907, Length=451, Percent_Identity=24.1685144124169, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI48994914, Length=299, Percent_Identity=24.7491638795987, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71992373, Length=440, Percent_Identity=48.1818181818182, Blast_Score=431, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71992381, Length=440, Percent_Identity=46.5909090909091, Blast_Score=410, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71992392, Length=376, Percent_Identity=49.7340425531915, Blast_Score=384, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17534361, Length=460, Percent_Identity=26.9565217391304, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17556096, Length=495, Percent_Identity=24.4444444444444, Blast_Score=112, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320027, Length=469, Percent_Identity=40.724946695096, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6320023, Length=508, Percent_Identity=27.5590551181102, Blast_Score=157, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6320764, Length=436, Percent_Identity=26.3761467889908, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI18921117, Length=421, Percent_Identity=26.1282660332542, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24639277, Length=421, Percent_Identity=26.1282660332542, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24639275, Length=421, Percent_Identity=26.1282660332542, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24653753, Length=463, Percent_Identity=26.9978401727862, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 52134; Mature: 52134

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAASFGAGPAFAFFLTKVAVMRSLSQSAPRDPLPAALVGTLAALLGERFSTATAVREQH
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GRDESYHPSMPPDAVAFARSTEEVAAIVTACAAHKVPIIPFGTGTSLEGHIAALRGGVCI
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCCEEE
DVSAMNAILEVRPADMDVTVQAGVTRKQLNAHLRDTGLFFPIDPGADASLGGMTATRASG
EHHHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCCC
TNAVRYGTMRENVLALSVVTPEGRVVKIGGRARKSSAGYDLTRLFVGSEGTLGVITEVTL
CCCEEECCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEHHEEEHH
RLHGIPEKIVSAVCPFPSVRAAVDTVIATIQIGVPVARIEFLNARQILAVNAYSKLDYAA
HCCCCCHHHHHHHCCCCHHHHHHHHHHHHHEECCCEEEHHHCCCCEEEEEECHHHCCHHC
APTLFFEFHGTPDHVAEQVRMVQDLAADQGAAGFRWAETPEERDRLWTARHNAFYASLAT
CCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHH
KAGGRGFSSDVCVPISRLTECIAQTEEDLARSALFTSIVGHVGDGNFHVIFIVDPENPAE
HCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHH
IEEARRLNDRIVARALAMDGTCTGEHGVGHGKMDFLEDEHGEALDMMRKIKRALDPDDIM
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCC
NPGKIVRL
CCCCEEEC
>Mature Secondary Structure
MRAASFGAGPAFAFFLTKVAVMRSLSQSAPRDPLPAALVGTLAALLGERFSTATAVREQH
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GRDESYHPSMPPDAVAFARSTEEVAAIVTACAAHKVPIIPFGTGTSLEGHIAALRGGVCI
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHCCCCEEE
DVSAMNAILEVRPADMDVTVQAGVTRKQLNAHLRDTGLFFPIDPGADASLGGMTATRASG
EHHHHHHHHEECCCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCEEECCCC
TNAVRYGTMRENVLALSVVTPEGRVVKIGGRARKSSAGYDLTRLFVGSEGTLGVITEVTL
CCCEEECCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEHHEEEHH
RLHGIPEKIVSAVCPFPSVRAAVDTVIATIQIGVPVARIEFLNARQILAVNAYSKLDYAA
HCCCCCHHHHHHHCCCCHHHHHHHHHHHHHEECCCEEEHHHCCCCEEEEEECHHHCCHHC
APTLFFEFHGTPDHVAEQVRMVQDLAADQGAAGFRWAETPEERDRLWTARHNAFYASLAT
CCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHH
KAGGRGFSSDVCVPISRLTECIAQTEEDLARSALFTSIVGHVGDGNFHVIFIVDPENPAE
HCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHH
IEEARRLNDRIVARALAMDGTCTGEHGVGHGKMDFLEDEHGEALDMMRKIKRALDPDDIM
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHCC
NPGKIVRL
CCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]