Click here to switch to the map view.

The map label for this gene is folP [H]

Identifier: 83592435

GI number: 83592435

Start: 1289667

End: 1290857

Strand: Direct

Name: folP [H]

Synonym: Rru_A1099

Alternate gene names: 83592435

Gene position: 1289667-1290857 (Clockwise)

Preceding gene: 83592434

Following gene: 83592436

Centisome position: 29.63

GC content: 71.12

Gene sequence:

>1191_bases
ATGCTTGACCACACCAGCGGACCGGGGTCTGATTCCCCGGTCCCGACCATCGGAAGCCCCGCTTTACCGCGGGGCTTCTT
CCATGCGGAGGGGGCGTCGCCGGCCGGGCGGCTTTACCTCCAGCCCGTCGGCCTGCTTGATGGCCAAGCCGCCGCCCAAG
CCGTGGTCGAAGGCTTGGCCCTGCCCTTGGCCGGGCGCGCCGACCACGCTTTTTGTCTGATCGCCGCCCTGTTGCGCGGC
GCGGCCGGGGACGTGATCTTGCGCTGTCTGGTCAGCCCGGCGGCCCTGCGCCAATGGGCGGCAAGCGAGGGCGCCGGCAT
CGCCGCCGAGGTCGAAGCGGTATTGGCCCGCCTGTCCGCCCCGCGTCCGCCCTTCGCCGGCCTGCCCTTGGGCCGGGGGA
ACGCCCTGGTCATGGGCATTCTGAACGTCACCCCCGACAGCTTTTCCGATGGCGGCGACCATGTCGGCTTCGACGCCGCT
TTGGCCGGGGGGCAGGCGATGCTGGCGGCGGGGGCGGCCATCCTTGATGTCGGCGGCGAAAGCACCCGCCCCGGCGCCGC
TCCCGTCGATCCCCAAGACGAGATCGCCCGGGTGGTTCCGGTGATCCGCGCCTTCGCCGAACGCGGCGCGGTGGTCTCGG
TCGATACCCGCAACGCTTCGACCATGGAGGCGGCGCTGGCCGCCGGGGCGCGCATCGTCAATGACGTCACCGCCCTGACC
GGCGATGAGCGGGCGCTGGGCGTGGTGGCGCGCGCGCGCGCTCCGGTGATTTTGATGCATATCCGCGGCGAGCCGCGCAC
CATGCAAAGCGATCCATCCTATGCCAGCGCCCCGCTGGACGTGGTCGACTGGCTGGCCGAACGGCTGGCGTGCTGCCGGG
CCGCCGGGATGGACGACGGTGATCTGTGCGTCGATCCGGGGATCGGCTTTGGCAAGACCGTCGATCATAATCTGGAAGTG
CTGGAAGCCACGACCTTGTTGCACGGCCTGGGGGTTGGCGTTTTGATCGGCGCCAGCCGCAAAAGCTTCATCGGCCGCGT
CGCCGATGTCGGGACGCCCAAGGCCCGCCTGCCCGGATCGTTGGCCGCCGCCCTGGCCGCCGCCCGCCGCGGCGCCGATA
TCGTCCGCGTTCACGACGTGGGCGAAACCGTTCAGGCGCTGCGCGTCGCCGCGGCGATCGAGAGCGCCTAG

Upstream 100 bases:

>100_bases
CCCCGGGACCGCTCGGGCCGTCGGGCCTCGGTTCCCACCAGCGGGCCGGCGGCGGGCGGTGTCGGCGGCGATCCGGAACC
CCAGCCGGGTGCCTGACGTG

Downstream 100 bases:

>100_bases
AGCGGCTTGCGTGACCCAAATTTAACGCACGCCGCTCTCAGCGGTATTAGGCTCCCTTTGACCCGATGGGCGGTGACCAA
GGGGGGCGAAGACCAAAGAC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MLDHTSGPGSDSPVPTIGSPALPRGFFHAEGASPAGRLYLQPVGLLDGQAAAQAVVEGLALPLAGRADHAFCLIAALLRG
AAGDVILRCLVSPAALRQWAASEGAGIAAEVEAVLARLSAPRPPFAGLPLGRGNALVMGILNVTPDSFSDGGDHVGFDAA
LAGGQAMLAAGAAILDVGGESTRPGAAPVDPQDEIARVVPVIRAFAERGAVVSVDTRNASTMEAALAAGARIVNDVTALT
GDERALGVVARARAPVILMHIRGEPRTMQSDPSYASAPLDVVDWLAERLACCRAAGMDDGDLCVDPGIGFGKTVDHNLEV
LEATTLLHGLGVGVLIGASRKSFIGRVADVGTPKARLPGSLAAALAAARRGADIVRVHDVGETVQALRVAAAIESA

Sequences:

>Translated_396_residues
MLDHTSGPGSDSPVPTIGSPALPRGFFHAEGASPAGRLYLQPVGLLDGQAAAQAVVEGLALPLAGRADHAFCLIAALLRG
AAGDVILRCLVSPAALRQWAASEGAGIAAEVEAVLARLSAPRPPFAGLPLGRGNALVMGILNVTPDSFSDGGDHVGFDAA
LAGGQAMLAAGAAILDVGGESTRPGAAPVDPQDEIARVVPVIRAFAERGAVVSVDTRNASTMEAALAAGARIVNDVTALT
GDERALGVVARARAPVILMHIRGEPRTMQSDPSYASAPLDVVDWLAERLACCRAAGMDDGDLCVDPGIGFGKTVDHNLEV
LEATTLLHGLGVGVLIGASRKSFIGRVADVGTPKARLPGSLAAALAAARRGADIVRVHDVGETVQALRVAAAIESA
>Mature_396_residues
MLDHTSGPGSDSPVPTIGSPALPRGFFHAEGASPAGRLYLQPVGLLDGQAAAQAVVEGLALPLAGRADHAFCLIAALLRG
AAGDVILRCLVSPAALRQWAASEGAGIAAEVEAVLARLSAPRPPFAGLPLGRGNALVMGILNVTPDSFSDGGDHVGFDAA
LAGGQAMLAAGAAILDVGGESTRPGAAPVDPQDEIARVVPVIRAFAERGAVVSVDTRNASTMEAALAAGARIVNDVTALT
GDERALGVVARARAPVILMHIRGEPRTMQSDPSYASAPLDVVDWLAERLACCRAAGMDDGDLCVDPGIGFGKTVDHNLEV
LEATTLLHGLGVGVLIGASRKSFIGRVADVGTPKARLPGSLAAALAAARRGADIVRVHDVGETVQALRVAAAIESA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=271, Percent_Identity=46.8634686346863, Blast_Score=232, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=28.4810126582279, Blast_Score=125, Evalue=9e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 40011; Mature: 40011

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDHTSGPGSDSPVPTIGSPALPRGFFHAEGASPAGRLYLQPVGLLDGQAAAQAVVEGLA
CCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
LPLAGRADHAFCLIAALLRGAAGDVILRCLVSPAALRQWAASEGAGIAAEVEAVLARLSA
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHCC
PRPPFAGLPLGRGNALVMGILNVTPDSFSDGGDHVGFDAALAGGQAMLAAGAAILDVGGE
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHCCCHHHHHCCCEEEECCCC
STRPGAAPVDPQDEIARVVPVIRAFAERGAVVSVDTRNASTMEAALAAGARIVNDVTALT
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
GDERALGVVARARAPVILMHIRGEPRTMQSDPSYASAPLDVVDWLAERLACCRAAGMDDG
CCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
DLCVDPGIGFGKTVDHNLEVLEATTLLHGLGVGVLIGASRKSFIGRVADVGTPKARLPGS
CEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCHHCCHH
LAAALAAARRGADIVRVHDVGETVQALRVAAAIESA
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDHTSGPGSDSPVPTIGSPALPRGFFHAEGASPAGRLYLQPVGLLDGQAAAQAVVEGLA
CCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHH
LPLAGRADHAFCLIAALLRGAAGDVILRCLVSPAALRQWAASEGAGIAAEVEAVLARLSA
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHCC
PRPPFAGLPLGRGNALVMGILNVTPDSFSDGGDHVGFDAALAGGQAMLAAGAAILDVGGE
CCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHCCCHHHHHCCCEEEECCCC
STRPGAAPVDPQDEIARVVPVIRAFAERGAVVSVDTRNASTMEAALAAGARIVNDVTALT
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHC
GDERALGVVARARAPVILMHIRGEPRTMQSDPSYASAPLDVVDWLAERLACCRAAGMDDG
CCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCC
DLCVDPGIGFGKTVDHNLEVLEATTLLHGLGVGVLIGASRKSFIGRVADVGTPKARLPGS
CEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHCCCCCHHCCHH
LAAALAAARRGADIVRVHDVGETVQALRVAAAIESA
HHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]