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The map label for this gene is purK [H]

Identifier: 83592387

GI number: 83592387

Start: 1243796

End: 1244890

Strand: Direct

Name: purK [H]

Synonym: Rru_A1051

Alternate gene names: 83592387

Gene position: 1243796-1244890 (Clockwise)

Preceding gene: 83592386

Following gene: 83592388

Centisome position: 28.57

GC content: 68.31

Gene sequence:

>1095_bases
ATGGCCATGGTTGGACGGCTGGCGGCCTTGGGGCCTGTGGGGCCGGGCGCGCGATTGGGAATTCTGGGCGGTGGCCAGCT
TGGCCGGATGACGGCGCTGGCGGCGGCCCGCCTTGGCATCTCCTGCCACATCTTCACCCCCGAGGATAACGGACCGGCCT
CGCAGGTTTGTCCGATGGTCACCCTGGCGGCTTACGACGACCTAGACGCGCTGTCGCGCTTCGCCGCCTCGGTCGATGTC
ATCACCTTTGAATTCGAGAACATCCCGGCGGCCAGCGTCGCCCATCTCGCCGCCTTGCGGCCGGTCCGCCCCGGCTGGAA
AGCCCTGGAAACCGCCCAGGACCGCATTCTTGAAAAGCGTTTTTTCAACGATTTGGGGATCGCCACGGCCCCCTGGGCGC
CGGTCACCGACGGCCCGCAGTCCCTGGCCGAGGCGGTGGCGAAGATCGGCTGTCCGGCCATTCTCAAGACCACGCGCCTG
GGCTATGACGGCAAGGGGCAGGTGCGGCTGAACGCCCCGGGCGACTCGGCGGCGGCCTGGGCTGCCTTGGGCAACCGGCC
GGCGGTGCTCGAGGGGTTGGTGCCCTTCGTCTCCGAGATCTCGGTGATCATCGCCCGCGCCCCCGACGGGGCGACGGCCT
GTTTCGAGCCGACGTTGAACCACCACCGCGAGGGCATCTTGCATACCTCGTCGGTGCCCGCGCCGATCCGTCCGCAAACG
GCGATCGCCGCCCGCGCCATCGCCGAGAGCGCCGCCCTGGCCCTTGATCTGGTCGGGCTGCTGGCCGTCGAGTTGTTCGT
GCTGGCCGATGGCTCGTTGTTGGTCAACGAAATGGCGCCGCGCCCCCACAACAGCGGTCATTGGACGATGGACGCCTGCC
ACACCGATCAATTCGAGCAATTCGTGCGCGCCGTCTGCGGCCTGCCCTTGGGCGATCCGTCCCGCTTCCGGGCGATGCGG
ATGACCAATCTGATCGGCGACGAGGTCCATGACTGGCCGCTTCTGATGGCGACGCCGGGCGCCCGCCTGCACCTGTATGG
CAAGGTGGAAAGCCGCCGGGGCCGCAAGATGGGCCACGTCAATACGCCGGTGTAG

Upstream 100 bases:

>100_bases
GGTCGCGCTGTCGCGACCCGATATCGAGGCGAAGCTGATCTCCTGGCGCGACCGCCAGACGGCCGAGGTCGCCGAAGAAC
CGGTGGATGAGGGTTAAGTG

Downstream 100 bases:

>100_bases
ATTTCACGCGCGTCGGATTGATTTCCCTTTCTGGCAAACATCTTTCGTCGATAAACTAGCAAAATCGGGTGATAGACGAA
TGGTCAGGGGGTAGGAATGG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MAMVGRLAALGPVGPGARLGILGGGQLGRMTALAAARLGISCHIFTPEDNGPASQVCPMVTLAAYDDLDALSRFAASVDV
ITFEFENIPAASVAHLAALRPVRPGWKALETAQDRILEKRFFNDLGIATAPWAPVTDGPQSLAEAVAKIGCPAILKTTRL
GYDGKGQVRLNAPGDSAAAWAALGNRPAVLEGLVPFVSEISVIIARAPDGATACFEPTLNHHREGILHTSSVPAPIRPQT
AIAARAIAESAALALDLVGLLAVELFVLADGSLLVNEMAPRPHNSGHWTMDACHTDQFEQFVRAVCGLPLGDPSRFRAMR
MTNLIGDEVHDWPLLMATPGARLHLYGKVESRRGRKMGHVNTPV

Sequences:

>Translated_364_residues
MAMVGRLAALGPVGPGARLGILGGGQLGRMTALAAARLGISCHIFTPEDNGPASQVCPMVTLAAYDDLDALSRFAASVDV
ITFEFENIPAASVAHLAALRPVRPGWKALETAQDRILEKRFFNDLGIATAPWAPVTDGPQSLAEAVAKIGCPAILKTTRL
GYDGKGQVRLNAPGDSAAAWAALGNRPAVLEGLVPFVSEISVIIARAPDGATACFEPTLNHHREGILHTSSVPAPIRPQT
AIAARAIAESAALALDLVGLLAVELFVLADGSLLVNEMAPRPHNSGHWTMDACHTDQFEQFVRAVCGLPLGDPSRFRAMR
MTNLIGDEVHDWPLLMATPGARLHLYGKVESRRGRKMGHVNTPV
>Mature_363_residues
AMVGRLAALGPVGPGARLGILGGGQLGRMTALAAARLGISCHIFTPEDNGPASQVCPMVTLAAYDDLDALSRFAASVDVI
TFEFENIPAASVAHLAALRPVRPGWKALETAQDRILEKRFFNDLGIATAPWAPVTDGPQSLAEAVAKIGCPAILKTTRLG
YDGKGQVRLNAPGDSAAAWAALGNRPAVLEGLVPFVSEISVIIARAPDGATACFEPTLNHHREGILHTSSVPAPIRPQTA
IAARAIAESAALALDLVGLLAVELFVLADGSLLVNEMAPRPHNSGHWTMDACHTDQFEQFVRAVCGLPLGDPSRFRAMRM
TNLIGDEVHDWPLLMATPGARLHLYGKVESRRGRKMGHVNTPV

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=342, Percent_Identity=35.3801169590643, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1788155, Length=358, Percent_Identity=29.3296089385475, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324702, Length=363, Percent_Identity=34.7107438016529, Blast_Score=202, Evalue=7e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 38476; Mature: 38345

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMVGRLAALGPVGPGARLGILGGGQLGRMTALAAARLGISCHIFTPEDNGPASQVCPMV
CCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH
TLAAYDDLDALSRFAASVDVITFEFENIPAASVAHLAALRPVRPGWKALETAQDRILEKR
HHHHHCCHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FFNDLGIATAPWAPVTDGPQSLAEAVAKIGCPAILKTTRLGYDGKGQVRLNAPGDSAAAW
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCHHHH
AALGNRPAVLEGLVPFVSEISVIIARAPDGATACFEPTLNHHREGILHTSSVPAPIRPQT
HHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCEEECCCHHHHHCCCEECCCCCCCCCCHH
AIAARAIAESAALALDLVGLLAVELFVLADGSLLVNEMAPRPHNSGHWTMDACHTDQFEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCEEEECCCHHHHHH
FVRAVCGLPLGDPSRFRAMRMTNLIGDEVHDWPLLMATPGARLHLYGKVESRRGRKMGHV
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCC
NTPV
CCCC
>Mature Secondary Structure 
AMVGRLAALGPVGPGARLGILGGGQLGRMTALAAARLGISCHIFTPEDNGPASQVCPMV
CCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHH
TLAAYDDLDALSRFAASVDVITFEFENIPAASVAHLAALRPVRPGWKALETAQDRILEKR
HHHHHCCHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
FFNDLGIATAPWAPVTDGPQSLAEAVAKIGCPAILKTTRLGYDGKGQVRLNAPGDSAAAW
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEEEECCCCCHHHH
AALGNRPAVLEGLVPFVSEISVIIARAPDGATACFEPTLNHHREGILHTSSVPAPIRPQT
HHHCCCCHHHHHHHHHHHHHEEEEEECCCCCCEEECCCHHHHHCCCEECCCCCCCCCCHH
AIAARAIAESAALALDLVGLLAVELFVLADGSLLVNEMAPRPHNSGHWTMDACHTDQFEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHCCCCCCCCCCEEEECCCHHHHHH
FVRAVCGLPLGDPSRFRAMRMTNLIGDEVHDWPLLMATPGARLHLYGKVESRRGRKMGHV
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCC
NTPV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]