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The map label for this gene is hemA [H]

Identifier: 83592137

GI number: 83592137

Start: 952944

End: 953501

Strand: Reverse

Name: hemA [H]

Synonym: Rru_A0798

Alternate gene names: 83592137

Gene position: 953501-952944 (Counterclockwise)

Preceding gene: 83592143

Following gene: 83592136

Centisome position: 21.91

GC content: 67.56

Gene sequence:

>558_bases
ATGCCAGAGAGCGCGCACGACAGTCCCCTCCGTCCCCCCGCCGTTCCCCCCTTGCGCGAGCCCCCCTCCGGGCAAGCCGT
GGCCGTCATCGGCGCCGGAACCATGGGCCGGGGCATCGCCGCTCCGCAGGCCATTGTCGACGCCGTGCGCTCCTACGCCC
CGGCCTTCGTTTTCAGCACCTCCAGCCCGGCCCCGGTGGTGGCGGCGGCTTTGGCCGCCCTGACCTATAACACCCGCCAC
CCCGAGCTGCGCCGACGCCTGCTCGACCGCGTCGCCGAAGTGAAGGCCGGCTTTAAGCGGCTGGGCATTCCCTTGGTTTC
CGATGACAGCCACGTTCTGCCGGTTCTGGTCGGCGATCCCCATCGTTGCAAGGAGATAAGCCGCAGGTTGCTCGATGACT
TCGGCATCTATGTCCAACCGGTCAACGCCCCGACGGTTCCCGAAGGCACCGAGCGCTTGCGAGTCACACCGACCGCCGCC
CATAGCGGGGACGACGTGAAGGCCTTGCTGTCGGCCTTCGACAAAGTCTGGAACACGGTGACACCAGGAGTCGCATGA

Upstream 100 bases:

>100_bases
AAAAGAGGTCTGTCACAACAAAAACAACACGAGGACTCGTTTTCACCCTTTCAACGGGTCCCCCGCCTCCTCAGCAACAC
CCGACCCGGTCGAGGTTCCC

Downstream 100 bases:

>100_bases
AACCATGACCTCTCTTTCCCATACCGAGCCCGTGAACAAACCGCTGCTCTGGGTCCTTGGGCTTGGCACCTTCGCCATCG
GCACCGATGCCTTCATCGTC

Product: 7-keto-8-aminopelargonate synthetase-like protein

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 185; Mature: 184

Protein sequence:

>185_residues
MPESAHDSPLRPPAVPPLREPPSGQAVAVIGAGTMGRGIAAPQAIVDAVRSYAPAFVFSTSSPAPVVAAALAALTYNTRH
PELRRRLLDRVAEVKAGFKRLGIPLVSDDSHVLPVLVGDPHRCKEISRRLLDDFGIYVQPVNAPTVPEGTERLRVTPTAA
HSGDDVKALLSAFDKVWNTVTPGVA

Sequences:

>Translated_185_residues
MPESAHDSPLRPPAVPPLREPPSGQAVAVIGAGTMGRGIAAPQAIVDAVRSYAPAFVFSTSSPAPVVAAALAALTYNTRH
PELRRRLLDRVAEVKAGFKRLGIPLVSDDSHVLPVLVGDPHRCKEISRRLLDDFGIYVQPVNAPTVPEGTERLRVTPTAA
HSGDDVKALLSAFDKVWNTVTPGVA
>Mature_184_residues
PESAHDSPLRPPAVPPLREPPSGQAVAVIGAGTMGRGIAAPQAIVDAVRSYAPAFVFSTSSPAPVVAAALAALTYNTRHP
ELRRRLLDRVAEVKAGFKRLGIPLVSDDSHVLPVLVGDPHRCKEISRRLLDDFGIYVQPVNAPTVPEGTERLRVTPTAAH
SGDDVKALLSAFDKVWNTVTPGVA

Specific function: Biotin biosynthesis; first step. [C]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502025, Length=150, Percent_Identity=34.6666666666667, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI40316939, Length=150, Percent_Identity=34.6666666666667, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI83977442, Length=150, Percent_Identity=37.3333333333333, Blast_Score=87, Evalue=8e-18,
Organism=Homo sapiens, GI83977440, Length=150, Percent_Identity=37.3333333333333, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI83977444, Length=150, Percent_Identity=37.3333333333333, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1786993, Length=143, Percent_Identity=33.5664335664336, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI1790046, Length=152, Percent_Identity=28.2894736842105, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320438, Length=148, Percent_Identity=41.8918918918919, Blast_Score=124, Evalue=7e-30,
Organism=Drosophila melanogaster, GI17137420, Length=150, Percent_Identity=38, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 19589; Mature: 19457

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESAHDSPLRPPAVPPLREPPSGQAVAVIGAGTMGRGIAAPQAIVDAVRSYAPAFVFST
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEC
SSPAPVVAAALAALTYNTRHPELRRRLLDRVAEVKAGFKRLGIPLVSDDSHVLPVLVGDP
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCC
HRCKEISRRLLDDFGIYVQPVNAPTVPEGTERLRVTPTAAHSGDDVKALLSAFDKVWNTV
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHC
TPGVA
CCCCC
>Mature Secondary Structure 
PESAHDSPLRPPAVPPLREPPSGQAVAVIGAGTMGRGIAAPQAIVDAVRSYAPAFVFST
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCEEEEEC
SSPAPVVAAALAALTYNTRHPELRRRLLDRVAEVKAGFKRLGIPLVSDDSHVLPVLVGDP
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCC
HRCKEISRRLLDDFGIYVQPVNAPTVPEGTERLRVTPTAAHSGDDVKALLSAFDKVWNTV
HHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHC
TPGVA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3609750; 12597275 [H]