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The map label for this gene is gor [H]

Identifier: 83592021

GI number: 83592021

Start: 804843

End: 806222

Strand: Direct

Name: gor [H]

Synonym: Rru_A0682

Alternate gene names: 83592021

Gene position: 804843-806222 (Clockwise)

Preceding gene: 83592020

Following gene: 83592022

Centisome position: 18.49

GC content: 65.87

Gene sequence:

>1380_bases
ATGGCCGATTACGATTACGACCTTCTTACCATCGGCGCCGGTTCCGGCGGCGTCCGGGCGTCGCGGCTGGCCGGGGGATT
TGGCGCGCGGGTCGCCGTGGTCGAGGGCAGCCGCATCGGCGGCACCTGCGTCATGCGCGGCTGCGTGCCCAAGAAGCTGT
TGGTCTATGGCGCCCAATACGCCAATGATCTGGAAGACATGATCGGCTACGGCTGGTCGATGGGCGGCGTCGCCTTTGAT
TGGCCAAGCCTGATCACCGCCAAGAACCGCGAGCTTGATCGCCTGGAAGGCGTCTATCGCACGATGCTGCGCAACGGCAA
CGTCGCCTTGCTCGAGGGGCGGGCCCGCTTCCTCGATGCCCATAGCGTCGATATCGACGGCAAGACCGTCACCGCCGACA
AGATCCTGATCGCCGTGGGCGGCTGGCCGCAGATGCCGGTGATTCCGGGCATCGAACACGCCATCACCTCGAACGAGGCG
CTTGATCTGATGGTCATGCCCGAACGCCTGACCATCGTTGGCGGCGGCTTCATCGCCGTGGAATTCGCGTCCATCTTCAA
TGCTCTGGGCGTCGATGTCTCGGTCGTCATCCGCAAGGACAAGATACTGCGCGGCTTTGACGCCGATATCCGCGATACCC
TGACCGAGGAATTGGTCCGTCGCGGCATCACCATCGTGCCCGGCACGGTGATCAACCGCATCGACAAGCGCCCGGGCGGC
GGCTATCGCCTGATCCGCACCCCGGGCGAGGCCATCGATACGGATCTGGTGATGTATGCCACCGGCCGGGCGCCCAATAC
CGCCGGCCTGGGGCTGGAGGCGGCGGGGGTCAAGGTCGCGGCCTCGGGGGCGGTGATCGTCGATGAATGGAATCGCACCA
CTGTCGACACCATCTATGCCATTGGCGACGTCACCGACCGCATCGCCCTGACCCCGGTGGCGATCAACGAGGCGATCGCC
TTCGCCCACACCGTGTTCAACGATACGCCCCGGGTGATGGATTACGAGAACGTGGCTTCGGCCGTGTTCAGCCAGCCGCC
GGTGGGAACGGTGGGGCTGACCGAGGAGCAGGCCCGCGCCCGGGGTCCGGTGCGCATCTTCCGCACCCGCTTCCGCGCCA
TGAAGCACGTGCTGGCCGGGCGCGACGAGAAAACGATGATGAAGCTGGTGGTCGATGCCCGCACCGATCGGGTGCTTGGC
TGCCACATGGTTGGCGCCGACGCCCCCGAGATCATCCAGGGGCTGGCGGTGGCCTTGAAATGCGGGGCGACCAAGGCCCA
GTTCGATGCCACCATCGGCATCCATCCGACCGCCGCCGAGGAATTCGTGACCATGCGCGACCCGGTGCCCGAGCCGGTTT
TCGCCCAGCCCGCCGATTAA

Upstream 100 bases:

>100_bases
TCCCGATCCACGCGGTATGTGAATTGTGGTGTCGGGCGCGGCCCCGCCGCATATGGTAGGCTGGCTGGCTTTTTCTATTC
CTCGCTGACGGACGTGCACC

Downstream 100 bases:

>100_bases
GGCGCCCGTTAAAGCCCTTGGGCCCTTTCCGTTGGGCGGCCGGTGACCAGCGCCAAGCGGGGGAGGGCGCCGTTTTTTCT
GGTCAGGACGAAAGGGCTTC

Product: NADPH-glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MADYDYDLLTIGAGSGGVRASRLAGGFGARVAVVEGSRIGGTCVMRGCVPKKLLVYGAQYANDLEDMIGYGWSMGGVAFD
WPSLITAKNRELDRLEGVYRTMLRNGNVALLEGRARFLDAHSVDIDGKTVTADKILIAVGGWPQMPVIPGIEHAITSNEA
LDLMVMPERLTIVGGGFIAVEFASIFNALGVDVSVVIRKDKILRGFDADIRDTLTEELVRRGITIVPGTVINRIDKRPGG
GYRLIRTPGEAIDTDLVMYATGRAPNTAGLGLEAAGVKVAASGAVIVDEWNRTTVDTIYAIGDVTDRIALTPVAINEAIA
FAHTVFNDTPRVMDYENVASAVFSQPPVGTVGLTEEQARARGPVRIFRTRFRAMKHVLAGRDEKTMMKLVVDARTDRVLG
CHMVGADAPEIIQGLAVALKCGATKAQFDATIGIHPTAAEEFVTMRDPVPEPVFAQPAD

Sequences:

>Translated_459_residues
MADYDYDLLTIGAGSGGVRASRLAGGFGARVAVVEGSRIGGTCVMRGCVPKKLLVYGAQYANDLEDMIGYGWSMGGVAFD
WPSLITAKNRELDRLEGVYRTMLRNGNVALLEGRARFLDAHSVDIDGKTVTADKILIAVGGWPQMPVIPGIEHAITSNEA
LDLMVMPERLTIVGGGFIAVEFASIFNALGVDVSVVIRKDKILRGFDADIRDTLTEELVRRGITIVPGTVINRIDKRPGG
GYRLIRTPGEAIDTDLVMYATGRAPNTAGLGLEAAGVKVAASGAVIVDEWNRTTVDTIYAIGDVTDRIALTPVAINEAIA
FAHTVFNDTPRVMDYENVASAVFSQPPVGTVGLTEEQARARGPVRIFRTRFRAMKHVLAGRDEKTMMKLVVDARTDRVLG
CHMVGADAPEIIQGLAVALKCGATKAQFDATIGIHPTAAEEFVTMRDPVPEPVFAQPAD
>Mature_458_residues
ADYDYDLLTIGAGSGGVRASRLAGGFGARVAVVEGSRIGGTCVMRGCVPKKLLVYGAQYANDLEDMIGYGWSMGGVAFDW
PSLITAKNRELDRLEGVYRTMLRNGNVALLEGRARFLDAHSVDIDGKTVTADKILIAVGGWPQMPVIPGIEHAITSNEAL
DLMVMPERLTIVGGGFIAVEFASIFNALGVDVSVVIRKDKILRGFDADIRDTLTEELVRRGITIVPGTVINRIDKRPGGG
YRLIRTPGEAIDTDLVMYATGRAPNTAGLGLEAAGVKVAASGAVIVDEWNRTTVDTIYAIGDVTDRIALTPVAINEAIAF
AHTVFNDTPRVMDYENVASAVFSQPPVGTVGLTEEQARARGPVRIFRTRFRAMKHVLAGRDEKTMMKLVVDARTDRVLGC
HMVGADAPEIIQGLAVALKCGATKAQFDATIGIHPTAAEEFVTMRDPVPEPVFAQPAD

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=40.0871459694989, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI148277065, Length=474, Percent_Identity=34.1772151898734, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=35.8050847457627, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI148277071, Length=474, Percent_Identity=34.1772151898734, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI33519430, Length=474, Percent_Identity=34.1772151898734, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI33519428, Length=474, Percent_Identity=34.1772151898734, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI33519426, Length=474, Percent_Identity=34.1772151898734, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI291045266, Length=474, Percent_Identity=32.7004219409283, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI291045268, Length=470, Percent_Identity=30.8510638297872, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI91199540, Length=457, Percent_Identity=28.6652078774617, Blast_Score=162, Evalue=8e-40,
Organism=Escherichia coli, GI1789915, Length=429, Percent_Identity=40.3263403263403, Blast_Score=328, Evalue=4e-91,
Organism=Escherichia coli, GI1786307, Length=464, Percent_Identity=28.2327586206897, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081717, Length=449, Percent_Identity=29.1759465478842, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI87082354, Length=452, Percent_Identity=26.7699115044248, Blast_Score=162, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71983419, Length=454, Percent_Identity=39.647577092511, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71983429, Length=454, Percent_Identity=39.647577092511, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17557007, Length=468, Percent_Identity=32.6923076923077, Blast_Score=247, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI71982272, Length=483, Percent_Identity=30.8488612836439, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=28.4782608695652, Blast_Score=174, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=34.9137931034483, Blast_Score=277, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=28.1720430107527, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6325240, Length=467, Percent_Identity=28.6937901498929, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17737741, Length=483, Percent_Identity=33.5403726708075, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24640549, Length=481, Percent_Identity=34.0956340956341, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24640553, Length=481, Percent_Identity=34.0956340956341, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24640551, Length=482, Percent_Identity=33.8174273858921, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI21358499, Length=480, Percent_Identity=29.1666666666667, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 49168; Mature: 49037

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADYDYDLLTIGAGSGGVRASRLAGGFGARVAVVEGSRIGGTCVMRGCVPKKLLVYGAQY
CCCCCCEEEEEECCCCCCCHHHHCCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHCHHH
ANDLEDMIGYGWSMGGVAFDWPSLITAKNRELDRLEGVYRTMLRNGNVALLEGRARFLDA
HHHHHHHHHCCCCCCCEEECCCHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEC
HSVDIDGKTVTADKILIAVGGWPQMPVIPGIEHAITSNEALDLMVMPERLTIVGGGFIAV
EEECCCCCEEEECEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEEECCEEEEEECCCCCH
EFASIFNALGVDVSVVIRKDKILRGFDADIRDTLTEELVRRGITIVPGTVINRIDKRPGG
HHHHHHHHHCCCEEEEEECCHHHCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCC
GYRLIRTPGEAIDTDLVMYATGRAPNTAGLGLEAAGVKVAASGAVIVDEWNRTTVDTIYA
CEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEECCEEEEECCEEEEECCCCCCHHHEEE
IGDVTDRIALTPVAINEAIAFAHTVFNDTPRVMDYENVASAVFSQPPVGTVGLTEEQARA
ECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
RGPVRIFRTRFRAMKHVLAGRDEKTMMKLVVDARTDRVLGCHMVGADAPEIIQGLAVALK
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHH
CGATKAQFDATIGIHPTAAEEFVTMRDPVPEPVFAQPAD
CCCCCHHCCEEECCCCCCHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADYDYDLLTIGAGSGGVRASRLAGGFGARVAVVEGSRIGGTCVMRGCVPKKLLVYGAQY
CCCCCEEEEEECCCCCCCHHHHCCCCCCEEEEEECCCCCCEEEEECCCCHHHHHHCHHH
ANDLEDMIGYGWSMGGVAFDWPSLITAKNRELDRLEGVYRTMLRNGNVALLEGRARFLDA
HHHHHHHHHCCCCCCCEEECCCHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEC
HSVDIDGKTVTADKILIAVGGWPQMPVIPGIEHAITSNEALDLMVMPERLTIVGGGFIAV
EEECCCCCEEEECEEEEEECCCCCCCCCCCCHHHHCCCCCEEEEEECCEEEEEECCCCCH
EFASIFNALGVDVSVVIRKDKILRGFDADIRDTLTEELVRRGITIVPGTVINRIDKRPGG
HHHHHHHHHCCCEEEEEECCHHHCCCCCHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCC
GYRLIRTPGEAIDTDLVMYATGRAPNTAGLGLEAAGVKVAASGAVIVDEWNRTTVDTIYA
CEEEEECCCCCCCCCEEEEEECCCCCCCCCCEEECCEEEEECCEEEEECCCCCCHHHEEE
IGDVTDRIALTPVAINEAIAFAHTVFNDTPRVMDYENVASAVFSQPPVGTVGLTEEQARA
ECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHH
RGPVRIFRTRFRAMKHVLAGRDEKTMMKLVVDARTDRVLGCHMVGADAPEIIQGLAVALK
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHH
CGATKAQFDATIGIHPTAAEEFVTMRDPVPEPVFAQPAD
CCCCCHHCCEEECCCCCCHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1849605; 10984043 [H]