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The map label for this gene is mepA [H]

Identifier: 83592017

GI number: 83592017

Start: 800799

End: 802190

Strand: Reverse

Name: mepA [H]

Synonym: Rru_A0678

Alternate gene names: 83592017

Gene position: 802190-800799 (Counterclockwise)

Preceding gene: 83592018

Following gene: 83592016

Centisome position: 18.43

GC content: 61.85

Gene sequence:

>1392_bases
ATGTCTGCGCGGCACGCTGCCCAACAGGTTAATCCTTTTCTGACCGTCCCTATCGGGCGGCTGTTTGTGTCAAACGCCCT
TCCTATGGCCGTGGTCATGTCGATGGGCGGGGTTCTTAATGTTGTCGATGGGATTTTCGTCGGCCACTTCATCGGGTCCG
ACGCGCTCGCGGCGGTAAGCTTGGCCTTTCCGGTGGCTATGGTGCTTTCGGCGCTGACGACCTTGACGGGCGGCGGCATG
TCGAGCCTGATGGCGCGGTATCTAGGTGCCGGAGATCGCGGAGCTGCCGGGCGCATCTTTGCCGAGACCCATGGGCTGGT
GTTGGCGATTTCGGTTGGTCTTGTCGTGCTATGGGCGGTGGTTGGCGCTGCGCTTGTCGACTCTATGGCCGCAGGCAATC
CCAAGGTCGCCGGATTGGCGCAGGATTATCTGCAGATCATGATTCTTGGCGCGCCGGCGCAACTGATGCTTGGCGTCCAT
GCCGATGCCCTGCGTAACGAGGGTCGGGCTGGTCTGATCGCCGCCCTGTCCGTGTTGGTCAATCTCTTCAATATCGGCGC
GAACGGGTTGGGGATCGTGGTGCTTGGCCTCGGGATTTCCGGTTCTGCCCTTGGCACGGTTGCAGCGCAAGCCCTTGGCT
TGGCGCTGGTGATTGGCGTGAGGGGACATAGCAAGGGGCTGCTACCGCTGTCCGTTCTGCGCGCGCGGAATTGGCTAGGG
GCGTGGTCACAGATCATTCGGCTGGGCCTGCCGCTGTGCCTCAGTTTCATCGGCATCGCCATGGTTGCCAGTGTCGTGAT
CGTGTCCCTGCGGCTTTCTGCCGGCACGGACTATAACGCCTTGGTCGCCGCTTATGGCGTAGTGACGCGGCTTTTAGGCT
TTGCCTTTCTACCGCAGATGGCAATCGCGCTCGCCACGCAAAGCATTACCGGCAACAATGCTGGTGCGGGAAGGACTGAC
CGGGCGCGGGCCGCGTTGCGGCTGGCGCTGGGAGCGGCTTTCCTCTGGTGCCTGCCGGTGGTGTTGGCCGGAGTCTTTGC
GGGAACCACTCTCGGCAGTTGGTTTAGCGATGACCCTGCCGTGATCGACGCCGTTGCCGAGATATTGCGGCCTATGATGC
TGTTTTACGCAGCCTCCGGCCCGGTCCTTGTCTTGGCGCTATATGTCCACGCTCTTGGTCAACCGGGGCGGACGGCGGCA
CTAACTTTGGTGAAGCCTTGGCTTCTGACACCCCTGCTCATATTGGCGCTTTCTATCGGCTTCGGGGTGTCGGAGATGTG
GTTGGCCTTTCCGATGGCCGACGCGATCATTCTCATGCTCGCCGTGATGATCGGGCGCAACGTCCTACACACCGCTGGCA
CACGGGCCGCCCATGCGGAGGAAGGCGCATGA

Upstream 100 bases:

>100_bases
AAGCCCGGATCGACAAGACACCTCACCCTCGAAGCATTTCGCGCGGTGGGCAATGCAGGCCCCCATTCCACCTTGAAATG
CCTTCCAAGAGGAGTGAGCG

Downstream 100 bases:

>100_bases
CCATTGATGAGGCAAAGGCTCAGGCCAAAGCCTTGCGCGCGGCGCTTGGGGCGCAGGGAACTGTGATCAGCCATGCACAG
GCGTTGGAGTTGATCGCCAA

Product: multi anti extrusion protein MatE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSARHAAQQVNPFLTVPIGRLFVSNALPMAVVMSMGGVLNVVDGIFVGHFIGSDALAAVSLAFPVAMVLSALTTLTGGGM
SSLMARYLGAGDRGAAGRIFAETHGLVLAISVGLVVLWAVVGAALVDSMAAGNPKVAGLAQDYLQIMILGAPAQLMLGVH
ADALRNEGRAGLIAALSVLVNLFNIGANGLGIVVLGLGISGSALGTVAAQALGLALVIGVRGHSKGLLPLSVLRARNWLG
AWSQIIRLGLPLCLSFIGIAMVASVVIVSLRLSAGTDYNALVAAYGVVTRLLGFAFLPQMAIALATQSITGNNAGAGRTD
RARAALRLALGAAFLWCLPVVLAGVFAGTTLGSWFSDDPAVIDAVAEILRPMMLFYAASGPVLVLALYVHALGQPGRTAA
LTLVKPWLLTPLLILALSIGFGVSEMWLAFPMADAIILMLAVMIGRNVLHTAGTRAAHAEEGA

Sequences:

>Translated_463_residues
MSARHAAQQVNPFLTVPIGRLFVSNALPMAVVMSMGGVLNVVDGIFVGHFIGSDALAAVSLAFPVAMVLSALTTLTGGGM
SSLMARYLGAGDRGAAGRIFAETHGLVLAISVGLVVLWAVVGAALVDSMAAGNPKVAGLAQDYLQIMILGAPAQLMLGVH
ADALRNEGRAGLIAALSVLVNLFNIGANGLGIVVLGLGISGSALGTVAAQALGLALVIGVRGHSKGLLPLSVLRARNWLG
AWSQIIRLGLPLCLSFIGIAMVASVVIVSLRLSAGTDYNALVAAYGVVTRLLGFAFLPQMAIALATQSITGNNAGAGRTD
RARAALRLALGAAFLWCLPVVLAGVFAGTTLGSWFSDDPAVIDAVAEILRPMMLFYAASGPVLVLALYVHALGQPGRTAA
LTLVKPWLLTPLLILALSIGFGVSEMWLAFPMADAIILMLAVMIGRNVLHTAGTRAAHAEEGA
>Mature_462_residues
SARHAAQQVNPFLTVPIGRLFVSNALPMAVVMSMGGVLNVVDGIFVGHFIGSDALAAVSLAFPVAMVLSALTTLTGGGMS
SLMARYLGAGDRGAAGRIFAETHGLVLAISVGLVVLWAVVGAALVDSMAAGNPKVAGLAQDYLQIMILGAPAQLMLGVHA
DALRNEGRAGLIAALSVLVNLFNIGANGLGIVVLGLGISGSALGTVAAQALGLALVIGVRGHSKGLLPLSVLRARNWLGA
WSQIIRLGLPLCLSFIGIAMVASVVIVSLRLSAGTDYNALVAAYGVVTRLLGFAFLPQMAIALATQSITGNNAGAGRTDR
ARAALRLALGAAFLWCLPVVLAGVFAGTTLGSWFSDDPAVIDAVAEILRPMMLFYAASGPVLVLALYVHALGQPGRTAAL
TLVKPWLLTPLLILALSIGFGVSEMWLAFPMADAIILMLAVMIGRNVLHTAGTRAAHAEEGA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47340; Mature: 47209

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARHAAQQVNPFLTVPIGRLFVSNALPMAVVMSMGGVLNVVDGIFVGHFIGSDALAAVS
CCCHHHHHHCCCEEECCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHH
LAFPVAMVLSALTTLTGGGMSSLMARYLGAGDRGAAGRIFAETHGLVLAISVGLVVLWAV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEHHHCCHHHHHHHHHHHHHHH
VGAALVDSMAAGNPKVAGLAQDYLQIMILGAPAQLMLGVHADALRNEGRAGLIAALSVLV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHH
NLFNIGANGLGIVVLGLGISGSALGTVAAQALGLALVIGVRGHSKGLLPLSVLRARNWLG
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHH
AWSQIIRLGLPLCLSFIGIAMVASVVIVSLRLSAGTDYNALVAAYGVVTRLLGFAFLPQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AIALATQSITGNNAGAGRTDRARAALRLALGAAFLWCLPVVLAGVFAGTTLGSWFSDDPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
VIDAVAEILRPMMLFYAASGPVLVLALYVHALGQPGRTAALTLVKPWLLTPLLILALSIG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
FGVSEMWLAFPMADAIILMLAVMIGRNVLHTAGTRAAHAEEGA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SARHAAQQVNPFLTVPIGRLFVSNALPMAVVMSMGGVLNVVDGIFVGHFIGSDALAAVS
CCHHHHHHCCCEEECCHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHH
LAFPVAMVLSALTTLTGGGMSSLMARYLGAGDRGAAGRIFAETHGLVLAISVGLVVLWAV
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCEEHHHCCHHHHHHHHHHHHHHH
VGAALVDSMAAGNPKVAGLAQDYLQIMILGAPAQLMLGVHADALRNEGRAGLIAALSVLV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHCCCCHHHHHHHHHHH
NLFNIGANGLGIVVLGLGISGSALGTVAAQALGLALVIGVRGHSKGLLPLSVLRARNWLG
HHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHH
AWSQIIRLGLPLCLSFIGIAMVASVVIVSLRLSAGTDYNALVAAYGVVTRLLGFAFLPQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AIALATQSITGNNAGAGRTDRARAALRLALGAAFLWCLPVVLAGVFAGTTLGSWFSDDPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
VIDAVAEILRPMMLFYAASGPVLVLALYVHALGQPGRTAALTLVKPWLLTPLLILALSIG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHC
FGVSEMWLAFPMADAIILMLAVMIGRNVLHTAGTRAAHAEEGA
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA