Click here to switch to the map view.

The map label for this gene is mrdA [H]

Identifier: 83591813

GI number: 83591813

Start: 554626

End: 556671

Strand: Direct

Name: mrdA [H]

Synonym: Rru_A0473

Alternate gene names: 83591813

Gene position: 554626-556671 (Clockwise)

Preceding gene: 83591812

Following gene: 83591817

Centisome position: 12.74

GC content: 67.89

Gene sequence:

>2046_bases
ATGCGTCGGGATGTGGACCGCGCGAAGCTTTTCACCCGCAGGGCCGTGCTGCTGGGCGGCGCCCAGGCCGGGCTGGTCGG
CGCCTTGGCCGCCCGCATGTACTATCTTCAGGTGATCGAGTCCGATCGCTATCTGACCTTGGCCGAGGAAAACCGCTTCA
ATCTGCGTCTGCTGCCGCCGCCGCGCGGCCATATCGTCGACCGCTTCGGCGACCAACTGGCGGTCAATCGCCAGAATTAC
CGGGTGAGCATCATCGCCGAGGATATCCTGCGGCAGGTGCGCACCGCCGAGGAACGCCAGTTGGCGATCGATGCCACCCT
TGATGCGCTCGGCAAGATCGTGCCTTTGAGCGATTACGACCGGACTCGGGTGCTCCGCGACATGAAGCGTCGGCGCAGTT
TCGTGCCGGTGACCATTCGCGAAAATCTGACCTGGGAGGAGATGGCGGCGATCGAGGTTCACAAGCTCGATCTGCCCGGC
ATCACCATCGACGAGGGGCTGAGCCGCCATTATCCCTATGGCGATCTCGCCGCCCATCTTCTGGGCTATGTTTCAAGCGT
GTCCGAAGAAGAGGTGACCGGCGATCCCTTGCTGGAATTGCCGGGGTTCCGCATCGGCAAGCAGGGGGTGGAGAAGGTTT
ATGATCTGGCCCTGCGCGGGCACGGGGGCACCAGCCGGGTCGAGGTCAACGCCCTTGGCCGGGTGATGGACGAGCAGACC
ACCGAGGACGCCAGCGCCGGCGCCGAGCTGCCGCTGACCATCGACATGCGGCTGCAATCCTTCGCCTCGCGCCGGTTGGC
CAGCGAAAGCGCCTCGGCGGTGATCATCGACATCCATACGGGCGATATCCTGTCGATGGTGTCGATGCCGGCCTATGATC
CCAATGCCTTCACCCGGGGGCTGTCCAGCGCCGAATGGCAGGATCTGGTGCGCAATCCGCGCTCGCCGCTGACCAACAAG
GCGATCGCCGGTCAGTATTCCCCCGGATCGACCTTCAAGATGGTGGTGGCCCTGGCCGCCCTGGAAGGCGGGGTGATCAA
GGCCGATCAGACGGTGTTTTGCCCCGGCCATATGGAACTGGGCGGTCATCGCTTCCACTGCTGGAAAAAGGGCGGACACG
GGTCGCTCAACCTTGTCGGCGCCCTGGCCGAATCCTGCGACGTGTATTTCTATGAGCTGGCGCGGCGCTGCGGCATCGAT
CGCATCGCCGAAATGGCCCGGCGCTTCGGGATCGGCGAGATCCTCGATGTCGGCCTGCCCGGCGAGCGCAGCGGCCTGAT
GCCCACCCGCGCCTGGAAGGCCGCCACCCTGGGCGAAGGCTGGCACCAGGGCGAGACCCTGCTGGCGGGCATCGGTCAGG
GCTATGTTCTGACCACGCCCCTGCAGCTGGCGGTGATGACGGCGCGGATCGCCAATGGCGGGCTGAAGATCATGCCCCGG
CTGTCGCGTTTCGCCGCCAAGCCCGACTCCCCGGGCTTCCTGGCCGCCTCGGCCCAGGAAGTGCCCGCGGTGCCGCCTCT
GGGGGTCGCCAAGGCCCATCTCGACGCCGTGCGCCGGGGGATGTGGGCGGTGGTGAACGGCGATCGTGGCACGGCGCGGC
GGGCGGCGGGCATCCCGGTCGCCGGCTGGGAGATGAGCGGCAAGACCGGCACCACCCAGGTGCGGCGCATTTCCATGCGC
GAACGCGAAACCGGCATCCGCCGCGAGGATCAACTGCCCTGGGAACTGCGCAACCACGCCCTGTTCGTCTGCTACGCCCC
GGAAGACGCGCCGCGCTACGCCGTGGCGCTGTGCGTCGAGCATGGCGGCGGCGGATCGAGCGCCGCCGGCCCGATCGCGC
GCGATATCATGCTGGAAACCCTGCGCCTGGATCCGGCGCGCAAGCGCCCGGGCGAAGAGATCAAGATGGCCGACCTGCCG
CCCGCCGCCCGCGCCCTGGTCGCCCAGGCCCATGCCGCGGCGACGCCGATGGGCCCGCCGCTCCCCCCCGACGGCCTGCC
CGAAGACTCCGAAGAGACCCCGGGCAGCGAGGAGATCGACGGGTAG

Upstream 100 bases:

>100_bases
CGGCGCTGGTCTTCAGCACCTTGTTCACCGTCGCGGTCTATCCTCCTTTCGCCTGGCTGTTCGGCCGGGTTCACCACATG
CTGTTCCGCGAGGCATAGAC

Downstream 100 bases:

>100_bases
GGGGGAGGGCGAAAGCTTCGCTCGCTCTCCCGCCCGCAAATCAGCCGACGGCGACGACCAGCTTGCCGAAATTGCCGCCC
TTGAGCAGGCTGATGAAGGC

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MRRDVDRAKLFTRRAVLLGGAQAGLVGALAARMYYLQVIESDRYLTLAEENRFNLRLLPPPRGHIVDRFGDQLAVNRQNY
RVSIIAEDILRQVRTAEERQLAIDATLDALGKIVPLSDYDRTRVLRDMKRRRSFVPVTIRENLTWEEMAAIEVHKLDLPG
ITIDEGLSRHYPYGDLAAHLLGYVSSVSEEEVTGDPLLELPGFRIGKQGVEKVYDLALRGHGGTSRVEVNALGRVMDEQT
TEDASAGAELPLTIDMRLQSFASRRLASESASAVIIDIHTGDILSMVSMPAYDPNAFTRGLSSAEWQDLVRNPRSPLTNK
AIAGQYSPGSTFKMVVALAALEGGVIKADQTVFCPGHMELGGHRFHCWKKGGHGSLNLVGALAESCDVYFYELARRCGID
RIAEMARRFGIGEILDVGLPGERSGLMPTRAWKAATLGEGWHQGETLLAGIGQGYVLTTPLQLAVMTARIANGGLKIMPR
LSRFAAKPDSPGFLAASAQEVPAVPPLGVAKAHLDAVRRGMWAVVNGDRGTARRAAGIPVAGWEMSGKTGTTQVRRISMR
ERETGIRREDQLPWELRNHALFVCYAPEDAPRYAVALCVEHGGGGSSAAGPIARDIMLETLRLDPARKRPGEEIKMADLP
PAARALVAQAHAAATPMGPPLPPDGLPEDSEETPGSEEIDG

Sequences:

>Translated_681_residues
MRRDVDRAKLFTRRAVLLGGAQAGLVGALAARMYYLQVIESDRYLTLAEENRFNLRLLPPPRGHIVDRFGDQLAVNRQNY
RVSIIAEDILRQVRTAEERQLAIDATLDALGKIVPLSDYDRTRVLRDMKRRRSFVPVTIRENLTWEEMAAIEVHKLDLPG
ITIDEGLSRHYPYGDLAAHLLGYVSSVSEEEVTGDPLLELPGFRIGKQGVEKVYDLALRGHGGTSRVEVNALGRVMDEQT
TEDASAGAELPLTIDMRLQSFASRRLASESASAVIIDIHTGDILSMVSMPAYDPNAFTRGLSSAEWQDLVRNPRSPLTNK
AIAGQYSPGSTFKMVVALAALEGGVIKADQTVFCPGHMELGGHRFHCWKKGGHGSLNLVGALAESCDVYFYELARRCGID
RIAEMARRFGIGEILDVGLPGERSGLMPTRAWKAATLGEGWHQGETLLAGIGQGYVLTTPLQLAVMTARIANGGLKIMPR
LSRFAAKPDSPGFLAASAQEVPAVPPLGVAKAHLDAVRRGMWAVVNGDRGTARRAAGIPVAGWEMSGKTGTTQVRRISMR
ERETGIRREDQLPWELRNHALFVCYAPEDAPRYAVALCVEHGGGGSSAAGPIARDIMLETLRLDPARKRPGEEIKMADLP
PAARALVAQAHAAATPMGPPLPPDGLPEDSEETPGSEEIDG
>Mature_681_residues
MRRDVDRAKLFTRRAVLLGGAQAGLVGALAARMYYLQVIESDRYLTLAEENRFNLRLLPPPRGHIVDRFGDQLAVNRQNY
RVSIIAEDILRQVRTAEERQLAIDATLDALGKIVPLSDYDRTRVLRDMKRRRSFVPVTIRENLTWEEMAAIEVHKLDLPG
ITIDEGLSRHYPYGDLAAHLLGYVSSVSEEEVTGDPLLELPGFRIGKQGVEKVYDLALRGHGGTSRVEVNALGRVMDEQT
TEDASAGAELPLTIDMRLQSFASRRLASESASAVIIDIHTGDILSMVSMPAYDPNAFTRGLSSAEWQDLVRNPRSPLTNK
AIAGQYSPGSTFKMVVALAALEGGVIKADQTVFCPGHMELGGHRFHCWKKGGHGSLNLVGALAESCDVYFYELARRCGID
RIAEMARRFGIGEILDVGLPGERSGLMPTRAWKAATLGEGWHQGETLLAGIGQGYVLTTPLQLAVMTARIANGGLKIMPR
LSRFAAKPDSPGFLAASAQEVPAVPPLGVAKAHLDAVRRGMWAVVNGDRGTARRAAGIPVAGWEMSGKTGTTQVRRISMR
ERETGIRREDQLPWELRNHALFVCYAPEDAPRYAVALCVEHGGGGSSAAGPIARDIMLETLRLDPARKRPGEEIKMADLP
PAARALVAQAHAAATPMGPPLPPDGLPEDSEETPGSEEIDG

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=640, Percent_Identity=35, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI1786272, Length=503, Percent_Identity=29.4234592445328, Blast_Score=168, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 74050; Mature: 74050

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRDVDRAKLFTRRAVLLGGAQAGLVGALAARMYYLQVIESDRYLTLAEENRFNLRLLPP
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCC
PRGHIVDRFGDQLAVNRQNYRVSIIAEDILRQVRTAEERQLAIDATLDALGKIVPLSDYD
CCCHHHHHCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCCCCH
RTRVLRDMKRRRSFVPVTIRENLTWEEMAAIEVHKLDLPGITIDEGLSRHYPYGDLAAHL
HHHHHHHHHHCCCCCEEEEECCCCHHHHHEEEEEEECCCCCCHHCCCHHCCCCHHHHHHH
LGYVSSVSEEEVTGDPLLELPGFRIGKQGVEKVYDLALRGHGGTSRVEVNALGRVMDEQT
HHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHC
TEDASAGAELPLTIDMRLQSFASRRLASESASAVIIDIHTGDILSMVSMPAYDPNAFTRG
CCHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHC
LSSAEWQDLVRNPRSPLTNKAIAGQYSPGSTFKMVVALAALEGGVIKADQTVFCPGHMEL
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCEEECCCCCCC
GGHRFHCWKKGGHGSLNLVGALAESCDVYFYELARRCGIDRIAEMARRFGIGEILDVGLP
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCC
GERSGLMPTRAWKAATLGEGWHQGETLLAGIGQGYVLTTPLQLAVMTARIANGGLKIMPR
CCCCCCCCCCCCCHHHCCCCCCCCCHHEEECCCCEEEECHHHHHHHHHHHHCCCEEEEEH
LSRFAAKPDSPGFLAASAQEVPAVPPLGVAKAHLDAVRRGMWAVVNGDRGTARRAAGIPV
HHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHCCCCE
AGWEMSGKTGTTQVRRISMRERETGIRREDQLPWELRNHALFVCYAPEDAPRYAVALCVE
ECEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCEEEEEECCCCCCCEEEEEEEE
HGGGGSSAAGPIARDIMLETLRLDPARKRPGEEIKMADLPPAARALVAQAHAAATPMGPP
CCCCCCCCCCHHHHHHHHHHHHCCCHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCC
LPPDGLPEDSEETPGSEEIDG
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRDVDRAKLFTRRAVLLGGAQAGLVGALAARMYYLQVIESDRYLTLAEENRFNLRLLPP
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCC
PRGHIVDRFGDQLAVNRQNYRVSIIAEDILRQVRTAEERQLAIDATLDALGKIVPLSDYD
CCCHHHHHCCCCEEECCCCCEEEEEHHHHHHHHHHHHHHHEEHHHHHHHHCCCCCCCCCH
RTRVLRDMKRRRSFVPVTIRENLTWEEMAAIEVHKLDLPGITIDEGLSRHYPYGDLAAHL
HHHHHHHHHHCCCCCEEEEECCCCHHHHHEEEEEEECCCCCCHHCCCHHCCCCHHHHHHH
LGYVSSVSEEEVTGDPLLELPGFRIGKQGVEKVYDLALRGHGGTSRVEVNALGRVMDEQT
HHHHHHCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHC
TEDASAGAELPLTIDMRLQSFASRRLASESASAVIIDIHTGDILSMVSMPAYDPNAFTRG
CCHHCCCCCCCEEEHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHC
LSSAEWQDLVRNPRSPLTNKAIAGQYSPGSTFKMVVALAALEGGVIKADQTVFCPGHMEL
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEECCCEEECCCCCCC
GGHRFHCWKKGGHGSLNLVGALAESCDVYFYELARRCGIDRIAEMARRFGIGEILDVGLP
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCC
GERSGLMPTRAWKAATLGEGWHQGETLLAGIGQGYVLTTPLQLAVMTARIANGGLKIMPR
CCCCCCCCCCCCCHHHCCCCCCCCCHHEEECCCCEEEECHHHHHHHHHHHHCCCEEEEEH
LSRFAAKPDSPGFLAASAQEVPAVPPLGVAKAHLDAVRRGMWAVVNGDRGTARRAAGIPV
HHHHHCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHCCCCE
AGWEMSGKTGTTQVRRISMRERETGIRREDQLPWELRNHALFVCYAPEDAPRYAVALCVE
ECEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEECCCEEEEEECCCCCCCEEEEEEEE
HGGGGSSAAGPIARDIMLETLRLDPARKRPGEEIKMADLPPAARALVAQAHAAATPMGPP
CCCCCCCCCCHHHHHHHHHHHHCCCHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCC
LPPDGLPEDSEETPGSEEIDG
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]