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The map label for this gene is ilvC

Identifier: 83591809

GI number: 83591809

Start: 550038

End: 551057

Strand: Direct

Name: ilvC

Synonym: Rru_A0469

Alternate gene names: 83591809

Gene position: 550038-551057 (Clockwise)

Preceding gene: 83591808

Following gene: 83591810

Centisome position: 12.64

GC content: 65.0

Gene sequence:

>1020_bases
ATGCGTGTTTATTACGACCGTGACGCCGACGTGAACCTGATCAAGGGCAAGAAGGTTGCCGTGGTCGGCTATGGCTCCCA
GGGGCATGCCCATGTCCTTAATCTGCGCGATTCCGGCGTTACCGAGGTGTGCGTGGCCCTGCGCGAGGGCTCGCCCTCGG
CCAAGAAGGCGACCGGCCAGGGCCTCGTCGTCAAGACTCCGGCCGAGGCCGCCGCCTGGGCCGATGTGGTGATGATCCTC
ACCCCCGACGAGCTGCAGGGCGATCTCTATAAGGATCACCTGCACGCCAATATGAAGCAGGGCGCCGCCCTGGCCTTCGC
CCATGGCCTGAACATCCATTTCGCCCTGATCGAGCCGCGCCCCGATCTTGATGTGTTCATGATCGCCCCCAAGGGCCCCG
GTCACACCGTGCGCAGCGAATACGTGCGCGGCGGCGGCGTGCCCTGTCTGGTCGCCGTGGCCCAGGACGCCAGCGGCAAC
GCCATGGAGATCGCCCTGTCCTATGCCTCGGCGATCGGCGGCGGGCGCTCGGGCATCATCGAGACCACCTTCCGCGAGGA
ATGCGAGACCGATCTGTTCGGCGAGCAGGCGGTGCTGTGCGGCGGCCTGACCGAGCTGATCAAGAACGGCTTCGAGACCC
TGGTCGAAGCCGGCTACGCCCCCGAGATGGCCTATTTCGAGTGCCTGCACGAGGTCAAGCTGATCGTCGACCTGATGTAC
GAGGGCGGCATGGCCAATATGCGCTACTCGATCTCCAACACCGCCGAATATGGCGATTACGTCACCGGTCCGCGCATCGT
CACCCCGGAAACCAAGGCCGAGATGAAGCGCGTGCTCGATGACATCCAGTCCGGCCGCTTCGTCCGCGACTGGATGATCG
AATGCAAGGCCGGTCAGCCGTCGTTCAAGGCCACCCGCCGCCGCAACGCCGAGCACCAGATCGAAGAGGTTGGCGGCCGG
CTGCGCGCCATGATGCCGTGGATCGCCGCCAACCGGCTGGTCGACAAGGACAAGAACTGA

Upstream 100 bases:

>100_bases
CCGGGCGGTAGCCGGCGCCCTTAAGGGATCGGCGAAGACGAAGCCGCGGAGGCGGCCGTTTCAAGAAAGCCACCCCTTTG
TTTCACTGAAGGAACAGACC

Downstream 100 bases:

>100_bases
TCCGTCGCCCCAAAGGGGCGTGTGATCCATCGCCCCAAAGGGGCGCGTCATAGGTCGCCCCAAAGGGGCGCGTGATTGAT
CGCCCCCAGGGGCGTGCGAC

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MRVYYDRDADVNLIKGKKVAVVGYGSQGHAHVLNLRDSGVTEVCVALREGSPSAKKATGQGLVVKTPAEAAAWADVVMIL
TPDELQGDLYKDHLHANMKQGAALAFAHGLNIHFALIEPRPDLDVFMIAPKGPGHTVRSEYVRGGGVPCLVAVAQDASGN
AMEIALSYASAIGGGRSGIIETTFREECETDLFGEQAVLCGGLTELIKNGFETLVEAGYAPEMAYFECLHEVKLIVDLMY
EGGMANMRYSISNTAEYGDYVTGPRIVTPETKAEMKRVLDDIQSGRFVRDWMIECKAGQPSFKATRRRNAEHQIEEVGGR
LRAMMPWIAANRLVDKDKN

Sequences:

>Translated_339_residues
MRVYYDRDADVNLIKGKKVAVVGYGSQGHAHVLNLRDSGVTEVCVALREGSPSAKKATGQGLVVKTPAEAAAWADVVMIL
TPDELQGDLYKDHLHANMKQGAALAFAHGLNIHFALIEPRPDLDVFMIAPKGPGHTVRSEYVRGGGVPCLVAVAQDASGN
AMEIALSYASAIGGGRSGIIETTFREECETDLFGEQAVLCGGLTELIKNGFETLVEAGYAPEMAYFECLHEVKLIVDLMY
EGGMANMRYSISNTAEYGDYVTGPRIVTPETKAEMKRVLDDIQSGRFVRDWMIECKAGQPSFKATRRRNAEHQIEEVGGR
LRAMMPWIAANRLVDKDKN
>Mature_339_residues
MRVYYDRDADVNLIKGKKVAVVGYGSQGHAHVLNLRDSGVTEVCVALREGSPSAKKATGQGLVVKTPAEAAAWADVVMIL
TPDELQGDLYKDHLHANMKQGAALAFAHGLNIHFALIEPRPDLDVFMIAPKGPGHTVRSEYVRGGGVPCLVAVAQDASGN
AMEIALSYASAIGGGRSGIIETTFREECETDLFGEQAVLCGGLTELIKNGFETLVEAGYAPEMAYFECLHEVKLIVDLMY
EGGMANMRYSISNTAEYGDYVTGPRIVTPETKAEMKRVLDDIQSGRFVRDWMIECKAGQPSFKATRRRNAEHQIEEVGGR
LRAMMPWIAANRLVDKDKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=301, Percent_Identity=39.8671096345515, Blast_Score=161, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6323387, Length=265, Percent_Identity=34.3396226415094, Blast_Score=116, Evalue=5e-27,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_RHORT (Q2RX71)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_425561.1
- HSSP:   P05793
- ProteinModelPortal:   Q2RX71
- SMR:   Q2RX71
- STRING:   Q2RX71
- GeneID:   3834072
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0469
- NMPDR:   fig|1085.1.peg.1866
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q2RX71
- ProtClustDB:   PRK05479
- BioCyc:   RRUB269796:RRU_A0469-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36966; Mature: 36966

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDRDADVNLIKGKKVAVVGYGSQGHAHVLNLRDSGVTEVCVALREGSPSAKKATGQ
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHCCCC
GLVVKTPAEAAAWADVVMILTPDELQGDLYKDHLHANMKQGAALAFAHGLNIHFALIEPR
CEEEECCHHHHHHEEEEEEECCCHHCCHHHHHHHHCCHHCCCEEEEEECCEEEEEEECCC
PDLDVFMIAPKGPGHTVRSEYVRGGGVPCLVAVAQDASGNAMEIALSYASAIGGGRSGII
CCCCEEEECCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEEHHHHCCCCCCCCE
ETTFREECETDLFGEQAVLCGGLTELIKNGFETLVEAGYAPEMAYFECLHEVKLIVDLMY
EHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGMANMRYSISNTAEYGDYVTGPRIVTPETKAEMKRVLDDIQSGRFVRDWMIECKAGQP
CCCCCCEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHEEECCCCC
SFKATRRRNAEHQIEEVGGRLRAMMPWIAANRLVDKDKN
CHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRVYYDRDADVNLIKGKKVAVVGYGSQGHAHVLNLRDSGVTEVCVALREGSPSAKKATGQ
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHCCCC
GLVVKTPAEAAAWADVVMILTPDELQGDLYKDHLHANMKQGAALAFAHGLNIHFALIEPR
CEEEECCHHHHHHEEEEEEECCCHHCCHHHHHHHHCCHHCCCEEEEEECCEEEEEEECCC
PDLDVFMIAPKGPGHTVRSEYVRGGGVPCLVAVAQDASGNAMEIALSYASAIGGGRSGII
CCCCEEEECCCCCCCCHHHHHHCCCCCEEEEEEECCCCCCEEEEEEEHHHHCCCCCCCCE
ETTFREECETDLFGEQAVLCGGLTELIKNGFETLVEAGYAPEMAYFECLHEVKLIVDLMY
EHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EGGMANMRYSISNTAEYGDYVTGPRIVTPETKAEMKRVLDDIQSGRFVRDWMIECKAGQP
CCCCCCEEEEECCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHEEECCCCC
SFKATRRRNAEHQIEEVGGRLRAMMPWIAANRLVDKDKN
CHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA