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The map label for this gene is fabF [H]

Identifier: 83591758

GI number: 83591758

Start: 493901

End: 495163

Strand: Direct

Name: fabF [H]

Synonym: Rru_A0418

Alternate gene names: 83591758

Gene position: 493901-495163 (Clockwise)

Preceding gene: 83591757

Following gene: 83591759

Centisome position: 11.35

GC content: 64.69

Gene sequence:

>1263_bases
ATGAGACGTGTTGTCGTCACCGGGTTGGGCATGGTCACGCCCCTCGGATGCGGGGTGAAAACCAATTGGACGAGTCTCGT
CCAGGGCAAATCCGGCATTCGACCCATTCAAAAATTCGACGTATCGGACATGCCGGCCCGCGTTGCCGGACAAATCCCGA
CGGCCGCCGACGGGCCTCACGGCTTTGACCCCGATACGGTCGTGTCCTCCAAGGACCGCCGCCGCATGGACGATTTCATC
GTCTATGGTCTGGCCGCCGCCAAAGAGGCGGTGGAAGACAGCGGCTGGATGCCCGAAGACGAGGAGTCCCGCGAGCGCAC
CGGCGTGATGATCGGCTCTGGCATCGGCGGTTTGACGTCGATCGCCGAGACGGCGTTGATCCTCAAGGAGCACGGGCCGC
GCAAGGTCAGCCCCTTCTTCATTCCCAGCGCGCTGATCAATCTGGTCTCGGGCCATGTCTCGATCCGCTACGGCTTCAAG
GGTCCCAACCACGCGGTGGTGACGGCCTGTTCGACCGGAGCCCATGCCATCGGTGACGCCAGCCGGCTGATCATTCACGG
CGATGCCGATGTGATGGTGGCCGGTGGCGCCGAATCCGCGGTCTGCCGGATCGGCATCGCCGGTTTCGCCGCCGCCCGGG
CGCTGTCGACCCATTACAACGACACCCCGGAAGAGGCCTCGCGCCCCTATGACAAGGGCCGGGACGGCTTCGTCATGGGC
GAGGGCGCGGGCATCGTCGTGCTTGAGGAATACGAGCACGCCAAGGCGCGCGGCGCCCATATCTACGCCGAGATCCTCGG
CTATGGCATGTCGGGCGACGCCTACCACATCACCGCCCCGGCCGAAGACGGCAACGGTGGCTTCCGCGCCATGCGGGCCG
CCCTGGCCAATGCCAAGCTGACCGTCGAAGACATCGATTACGTCAATGCCCATGGCACCTCGACGCCGCTGGGCGACGAG
ATCGAACTGGGCGCGGTCAAGCGGCTGTTTGGCGATCACGCCTATAAGCTGACCATGTCGTCGACCAAATCGGCCATCGG
TCATCTGCTGGGCGCCGCAGGCAGCGTCGAGGCGATTTATTCGATCCTGGCCATTCGTGATCAGGTCGCCCCGCCGACGC
TTAATCTGCACGATCCGTCCGACGCCTGCGACATCGATCTGGCGCCGCTGGTGGCCAAGGAACGGCCGATCCGCAAGGCG
CTGTCGAATTCCTTCGGCTTTGGCGGCACCAATGCCTCGCTGATCTTCGGGGGAGCCCCCTAA

Upstream 100 bases:

>100_bases
CGGGAACGCCGGGCAAGGGCTTAGGATCTCGGCCGCGCGAGTGTGTCGCGCTGCCCGATCCGGCCCGCCAAGGCTGGACA
ATGGGGACTTGTAGCAAGCC

Downstream 100 bases:

>100_bases
CCAGGGGCTCCTTCTTTTCAGGTAAGTCCATGCGGGCCATTCTCGGTGTTTTCCTGGTCGCGGTTCTGGCGGCGCTGACC
GTTTTTGGCGGTTATCTGTA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MRRVVVTGLGMVTPLGCGVKTNWTSLVQGKSGIRPIQKFDVSDMPARVAGQIPTAADGPHGFDPDTVVSSKDRRRMDDFI
VYGLAAAKEAVEDSGWMPEDEESRERTGVMIGSGIGGLTSIAETALILKEHGPRKVSPFFIPSALINLVSGHVSIRYGFK
GPNHAVVTACSTGAHAIGDASRLIIHGDADVMVAGGAESAVCRIGIAGFAAARALSTHYNDTPEEASRPYDKGRDGFVMG
EGAGIVVLEEYEHAKARGAHIYAEILGYGMSGDAYHITAPAEDGNGGFRAMRAALANAKLTVEDIDYVNAHGTSTPLGDE
IELGAVKRLFGDHAYKLTMSSTKSAIGHLLGAAGSVEAIYSILAIRDQVAPPTLNLHDPSDACDIDLAPLVAKERPIRKA
LSNSFGFGGTNASLIFGGAP

Sequences:

>Translated_420_residues
MRRVVVTGLGMVTPLGCGVKTNWTSLVQGKSGIRPIQKFDVSDMPARVAGQIPTAADGPHGFDPDTVVSSKDRRRMDDFI
VYGLAAAKEAVEDSGWMPEDEESRERTGVMIGSGIGGLTSIAETALILKEHGPRKVSPFFIPSALINLVSGHVSIRYGFK
GPNHAVVTACSTGAHAIGDASRLIIHGDADVMVAGGAESAVCRIGIAGFAAARALSTHYNDTPEEASRPYDKGRDGFVMG
EGAGIVVLEEYEHAKARGAHIYAEILGYGMSGDAYHITAPAEDGNGGFRAMRAALANAKLTVEDIDYVNAHGTSTPLGDE
IELGAVKRLFGDHAYKLTMSSTKSAIGHLLGAAGSVEAIYSILAIRDQVAPPTLNLHDPSDACDIDLAPLVAKERPIRKA
LSNSFGFGGTNASLIFGGAP
>Mature_420_residues
MRRVVVTGLGMVTPLGCGVKTNWTSLVQGKSGIRPIQKFDVSDMPARVAGQIPTAADGPHGFDPDTVVSSKDRRRMDDFI
VYGLAAAKEAVEDSGWMPEDEESRERTGVMIGSGIGGLTSIAETALILKEHGPRKVSPFFIPSALINLVSGHVSIRYGFK
GPNHAVVTACSTGAHAIGDASRLIIHGDADVMVAGGAESAVCRIGIAGFAAARALSTHYNDTPEEASRPYDKGRDGFVMG
EGAGIVVLEEYEHAKARGAHIYAEILGYGMSGDAYHITAPAEDGNGGFRAMRAALANAKLTVEDIDYVNAHGTSTPLGDE
IELGAVKRLFGDHAYKLTMSSTKSAIGHLLGAAGSVEAIYSILAIRDQVAPPTLNLHDPSDACDIDLAPLVAKERPIRKA
LSNSFGFGGTNASLIFGGAP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=420, Percent_Identity=52.8571428571429, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI223972627, Length=229, Percent_Identity=42.7947598253275, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI41872631, Length=429, Percent_Identity=26.1072261072261, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1787337, Length=416, Percent_Identity=54.8076923076923, Blast_Score=418, Evalue=1e-118,
Organism=Escherichia coli, GI1788663, Length=420, Percent_Identity=39.5238095238095, Blast_Score=270, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71983541, Length=423, Percent_Identity=41.371158392435, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=46.0076045627376, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI212642053, Length=387, Percent_Identity=26.6149870801034, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17550940, Length=362, Percent_Identity=25.6906077348066, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=441, Percent_Identity=40.5895691609977, Blast_Score=309, Evalue=6e-85,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=47.3684210526316, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19920632, Length=366, Percent_Identity=27.5956284153005, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221330659, Length=366, Percent_Identity=27.5956284153005, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24581345, Length=359, Percent_Identity=24.7910863509749, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43979; Mature: 43979

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGLGMVTPLGCGVKTNWTSLVQGKSGIRPIQKFDVSDMPARVAGQIPTAADGPH
CCEEEEECCCHHCCCCCCCCCCHHHHHCCCCCCCCHHHCCCCCCCHHHHCCCCCCCCCCC
GFDPDTVVSSKDRRRMDDFIVYGLAAAKEAVEDSGWMPEDEESRERTGVMIGSGIGGLTS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCHHHH
IAETALILKEHGPRKVSPFFIPSALINLVSGHVSIRYGFKGPNHAVVTACSTGAHAIGDA
HHHHHHHHHCCCCCCCCCEEHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCC
SRLIIHGDADVMVAGGAESAVCRIGIAGFAAARALSTHYNDTPEEASRPYDKGRDGFVMG
CEEEEECCCCEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEE
EGAGIVVLEEYEHAKARGAHIYAEILGYGMSGDAYHITAPAEDGNGGFRAMRAALANAKL
CCCCEEEEECCCCCHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEE
TVEDIDYVNAHGTSTPLGDEIELGAVKRLFGDHAYKLTMSSTKSAIGHLLGAAGSVEAIY
EEECCCEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCHHHHH
SILAIRDQVAPPTLNLHDPSDACDIDLAPLVAKERPIRKALSNSFGFGGTNASLIFGGAP
HHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCCCCCCCEEEECCCC
>Mature Secondary Structure
MRRVVVTGLGMVTPLGCGVKTNWTSLVQGKSGIRPIQKFDVSDMPARVAGQIPTAADGPH
CCEEEEECCCHHCCCCCCCCCCHHHHHCCCCCCCCHHHCCCCCCCHHHHCCCCCCCCCCC
GFDPDTVVSSKDRRRMDDFIVYGLAAAKEAVEDSGWMPEDEESRERTGVMIGSGIGGLTS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCEEEECCCCHHHH
IAETALILKEHGPRKVSPFFIPSALINLVSGHVSIRYGFKGPNHAVVTACSTGAHAIGDA
HHHHHHHHHCCCCCCCCCEEHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCCCCC
SRLIIHGDADVMVAGGAESAVCRIGIAGFAAARALSTHYNDTPEEASRPYDKGRDGFVMG
CEEEEECCCCEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCEEEE
EGAGIVVLEEYEHAKARGAHIYAEILGYGMSGDAYHITAPAEDGNGGFRAMRAALANAKL
CCCCEEEEECCCCCHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEE
TVEDIDYVNAHGTSTPLGDEIELGAVKRLFGDHAYKLTMSSTKSAIGHLLGAAGSVEAIY
EEECCCEECCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCHHHHH
SILAIRDQVAPPTLNLHDPSDACDIDLAPLVAKERPIRKALSNSFGFGGTNASLIFGGAP
HHHHHHHHCCCCEEECCCCCCCCCCCCHHHHHCCCHHHHHHHCCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]